Leon Adams

Associate Professor, MB BS PhD W.Aust., FRACP

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 10664 Citations
  • 39 h-Index
20052020

Research output per year

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Research Output

2020

Advances in non-invasive assessment of hepatic fibrosis

Loomba, R. & Adams, L. A., Jul 2020, In : Gut. 317593.

Research output: Contribution to journalReview article

2 Citations (Scopus)

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J. F., Schattenberg, J. M., Kawaguchi, T., Arrese, M., Valenti, L., Shiha, G., Tiribelli, C., Yki-Järvinen, H., Fan, J. G., Grønbæk, H., Yilmaz, Y., Cortez-Pinto, H. & 12 others, Oliveira, C. P., Bedossa, P., Adams, L. A., Zheng, M. H., Fouad, Y., Chan, W. K., Mendez-Sanchez, N., Ahn, S. H., Castera, L., Bugianesi, E., Ratziu, V. & George, J., Jul 2020, In : Journal of Hepatology. 73, 1, p. 202-209 8 p.

Research output: Contribution to journalReview article

29 Citations (Scopus)
File
4 Downloads (Pure)

Baseline and Post-treatment 18F-Fluorocholine PET/CT Predicts Outcomes in Hepatocellular Carcinoma Following Locoregional Therapy

Wallace, M. C., Sek, K., Francis, R. J., Samuelson, S., Ferguson, J., Tibballs, J., Asad, A., Preen, D. B., MacQuillan, G., Garas, G., Adams, L. A. & Jeffrey, G. P., Feb 2020, In : Digestive Diseases and Sciences. 65, 2, p. 647-657

Research output: Contribution to journalArticle

Bile acids associate with specific gut microbiota, low level alcohol consumption and liver fibrosis in patients with non-alcoholic fatty liver disease

Adams, L. A., Wang, Z., Liddle, C., Melton, P. E., Ariff, A., Chandraratna, H., Tan, J., Ching, H., Coulter, S., de Boer, B., Christophersen, C. T., O'Sullivan, T. A., Morrison, M. & Jeffrey, G. P., 3 Apr 2020, In : Liver International.

Research output: Contribution to journalArticle

Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability

Mitchell, T., McKinnon, E., Ayonrinde, O., Adams, L. A., Trinder, D., Chua, A. C. G., Newton, R. U., Straker, L. & Olynyk, J. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1584-1591 8 p.

Research output: Contribution to journalArticle

Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

Chen, F., Esmaili, S., Rogers, G. B., Bugianesi, E., Petta, S., Marchesini, G., Bayoumi, A., Metwally, M., Azardaryany, M. K., Coulter, S., Choo, J. M., Younes, R., Rosso, C., Liddle, C., Adams, L. A., Craxì, A., George, J. & Eslam, M., 1 Apr 2020, In : Hepatology. 71, 4, p. 1213-1227 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Long-term Liver-related Outcomes of Patients With Chronic Liver Diseases in Australia

Huang, Y., Joseph, J., de Boer, W. B., Cheng, W., Adams, L. A., MacQuillan, G., Garas, G., Raftopoulos, S. & Jeffrey, G. P., Feb 2020, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 496-504.e3

Research output: Contribution to journalArticle

2 Citations (Scopus)

Screening for non-alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter-transient elastography

Teeratorn, N., Piyachaturawat, P., Thanapirom, K., Chaiteerakij, R., Sonsiri, K., Komolmit, P., Tangkijvanich, P., Rerknimitr, R., Adams, L. & Treeprasertsuk, S., Apr 2020, In : JGH Open. 4, 2, p. 245-250

Research output: Contribution to journalArticle

Open Access

The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study

Ayonrinde, O. T., Ayonrinde, O. A., Adams, L. A., Sanfilippo, F. M., O’ Sullivan, T. A., Robinson, M., Oddy, W. H. & Olynyk, J. K., 1 Dec 2020, In : Scientific Reports. 10, 1, 1646.

Research output: Contribution to journalArticle

Open Access
2019

ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis

Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., Karsdal, M. A., Grove, J. I., Neil Guha, I., Kawaguchi, T., Torimura, T., McLeod, D., Akiba, J., Kaye, P., de Boer, B., Aithal, G. P., Adams, L. A. & George, J., 1 Mar 2019, In : Hepatology. 69, 3, p. 1075-1086 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

Metwally, M., Bayoumi, A., Romero-Gomez, M., Thabet, K., John, M., Adams, L. A., Huo, X., Aller, R., García-Monzón, C., Teresa Arias-Loste, M., Bugianesi, E., Miele, L., Gallego-Durán, R., Fischer, J., Berg, T., Liddle, C., Qiao, L., George, J. & Eslam, M., 1 Mar 2019, In : Journal of Hepatology. 70, 3, p. 494-500 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Associations between remnant lipoprotein cholesterol and non-alcoholic fatty liver disease

Ayonrinde, O., Chin, J., Mori, T., Olynyk, J., Adams, L. & Beilin, L., Sep 2019, In : Journal of Gastroenterology and Hepatology. 34, p. 60-61 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

ASSOCIATIONS BETWEEN REMNANT LIPOPROTEIN CHOLESTEROL AND NONALCOHOLIC FATTY LIVER DISEASE IN ADOLESCENTS

Ayonrinde, O. T., Chin, J., Adams, L., Mori, T., Olynyk, J. & Beilin, L., Oct 2019, In : Hepatology. 70, p. 1070A-1071A

Research output: Contribution to journalAbstract/Meeting Abstract

A systematic review and network meta-analysis comparing the effects of nucleos(t)ide analogues on the incidence of hepatocellular carcinoma in patients with chronic hepatitis B

Dave, S., Park, S., Murad, M. H., Barnard, A., Prokop, L., Adams, L. A., Singh, S. & Loomba, R., Oct 2019, In : Hepatology. 70, p. 291A-292A 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Bowel patterns, gastrointestinal symptoms, and emotional well-being in adolescents - A cohort study: Gastrointestinal symptoms in adolescents

Ayonrinde, O. T., Sanfilippo, F. M., O'Sullivan, T. A., Adams, L. A., Ayonrinde, O. A., Robinson, M., Oddy, W. H. & Olynyk, J. K., 1 Jul 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, 11, p. 1946-1954 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effects of calcium supplementation on circulating osteocalcin and glycated haemoglobin in older women

Lewis, J. R., Brennan-Speranza, T. C., Levinger, I., Byrnes, E., Lim, E. M., Blekkenhorst, L. C., Sim, M., Hodgson, J. M., Zhu, K., Lim, W. H., Adams, L. A. & Prince, R. L., 1 Jan 2019, In : Osteoporosis International.

Research output: Contribution to journalArticle

1 Citation (Scopus)

End-points for drug treatment in NASH

Adams, L. A., May 2019, In : Hepatology International. 13, 3, p. 253-258 6 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age

Hart, R. J., Doherty, D. A., Mori, T. A., Adams, L. A., Huang, R-C., Minaee, N., Handelsman, D. J., McLachlan, R., Norman, R. J., Dickinson, J. E., Olynyk, J. K. & Beilin, L. J., 1 Mar 2019, In : Human Reproduction. 34, 3, p. 389-402 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Hepatocellular carcinoma in Australia 1982-2014: Increasing incidence and improving survival

Wallace, M. C., Preen, D. B., Short, M. W., Adams, L. A. & Jeffrey, G. P., 1 Mar 2019, In : Liver International. 39, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand

Calzadilla-Bertot, L., Jeffrey, G. P., Jacques, B., McCaughan, G., Crawford, M., Angus, P., Jones, R., Gane, E., Munn, S., Macdonald, G., Fawcett, J., Wigg, A., Chen, J., Fink, M. & Adams, L. A., Jan 2019, In : Liver Transplantation. 25, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Lean non-alcoholic fatty liver disease: A distinct entity shaped by differential metabolic adaptation

Chen, F., Esmaili, S., Rogers, G., Bugianesi, E., Petta, S., Marchesini, G., Bayoumi, A., Metwally, M., Azadaryany, M., Coulter, S., Choo, J., Younes, R., Rosso, C., Liddle, C., Adams, L., Craxi, A., George, J. & Eslam, M., Sep 2019, In : Journal of Gastroenterology and Hepatology. 34, p. 49-49 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

8 Citations (Scopus)

Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials

Pai, R. K., Kleiner, D. E., Hart, J., Adeyi, O. A., Clouston, A. D., Behling, C. A., Jain, D., Kakar, S., Brahmania, M., Burgart, L., Batts, K. P., Valasek, M. A., Torbenson, M. S., Guindi, M., Wang, H. L., Ajmera, V., Adams, L. A., Parker, C. E., Feagan, B. G., Loomba, R. & 1 others, Jairath, V., Nov 2019, In : Alimentary pharmacology & therapeutics. 50, 10, p. 1100-1111 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The 20% Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis Caused by NASH

Loomba, R. & Adams, L. A., 1 Dec 2019, In : Hepatology. 70, 6, p. 1885-1888 4 p.

Research output: Contribution to journalEditorial

5 Citations (Scopus)

The MAPPE score predicts survival in those treated with yttrium-90 selective internal radiotherapy in hepatocellular carcinoma

Wallace, M. C., Samuelson, S., Khoo, T., Ooi, J., Tibballs, J., Ferguson, J., Preen, D. B., Knuiman, M., Garas, G., MacQuillan, G. C., Adams, L. A. & Jeffrey, G. P., Oct 2019, In : Hepatology. 70, p. 237A-237A 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease

Bertot, L. C. & Adams, L. A., 1 Feb 2019, In : Expert Review of Gastroenterology and Hepatology. 13, 2, p. 179-187 9 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)
2018

Abide: A Novel Predictive Model of Liver Decompensation in Patients with Non-Alcoholic Fatty Liver Related Cirrhosis.

Bertot, L., Vilar-Gomez, E., Wong, V. W-S., Romero-Gomez, M., Aller-De La Fuente, R., Lai, G., Fernandez, M., Eslam, M., George, J. & Adams, L. A., Oct 2018, In : Hepatology. 68, p. 87A-87A 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial

Properzi, C., O'Sullivan, T. A., Sherriff, J. L., Ching, H. L., Jeffrey, G. P., Buckley, R. F., Tibballs, J., MacQuillan, G. C., Garas, G. & Adams, L. A., 1 Nov 2018, In : Hepatology. 68, 5, p. 1741-1754 14 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Bile Acids, Hepatic Steatosis and Gut Microbiome in Patients Undergoing Dietary Intervention for Non-Alcoholic Fatty Liver Disease

Wang, Z., Properzi, C., Liddle, C., Melton, P., Ariff, A., O'Sullivan, T., Sherriff, J., Coulter, S., Christophersen, C., Morrison, M., Jeffrey, G. P. & Adams, L. A., Oct 2018, In : Hepatology. 68, p. 972A-972A 1 p., 1706.

Research output: Contribution to journalAbstract/Meeting Abstract

Burden of non-alcoholic fatty liver disease in Australia

Mahady, S. E. & Adams, L. A., 1 Jun 2018, In : Journal of Gastroenterology and Hepatology (Australia). 33, p. 1-11 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Decreased Physical Working Capacity in Adolescents with Non-Alcoholic Fatty Liver Disease Reflects Reduced Iron Bioavailability

Mitchell, T., McKinnon, E., Ayonrinde, O. T., Adams, L. A., Trinder, D., Chua, A., Newton, R., Strakers, L. & Olynyk, J. K., Oct 2018, In : Hepatology. 68, p. 1317A-1318A 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Diabetes but Not Metabolic Syndrome Adversely Impact Survival or Liver Decompensation in Patients with Non-Alcoholic Fatty Liver Related Cirrhosis.

Bertot, L., Vilar-Gomez, E., Wong, V. W-S., Romero-Gomez, M., Aller-De La Fuente, R., Lai, G., Fernandez, M., Eslam, M., George, J. & Adams, L. A., Oct 2018, In : Hepatology. 68, p. 20A-21A 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

16 Citations (Scopus)

Features of metabolic disorder in late adolescence are negatively associated with testicular function aT 20 years of age; evidence from a birth cohort

Hart, R., Doherty, D., Adams, L., Huang, R. C., Mori, T., Minae, N., MacLachlan, R., Skakkebaek, N., Norman, R., Handelsman, D., Olynyk, J. & Beilin, L., Jul 2018, In : Human Reproduction. 33, p. 30-31 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Fibroblast growth factor 21 for non-alcoholic steatohepatitis

Wong, V. W. S. & Adams, L. A., 22 Dec 2018, In : The Lancet. 392, 10165, p. 2658-2660 3 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study

Vilar-Gomez, E., Calzadilla-Bertot, L., Wai-Sun Wong, V., Castellanos, M., Aller-de la Fuente, R., Metwally, M., Eslam, M., Gonzalez-Fabian, L., Alvarez-Quiñones Sanz, M., Conde-Martin, A. F., De Boer, B., McLeod, D., Hung Chan, A. W., Chalasani, N., George, J., Adams, L. A. & Romero-Gomez, M., 1 Aug 2018, In : Gastroenterology. 155, 2, p. 443-457.e17

Research output: Contribution to journalArticle

108 Citations (Scopus)

Hepatic Iron Concentration Correlates With Insulin Sensitivity in Nonalcoholic Fatty Liver Disease

Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Stuart, K., Subramaniam, V. N., Jeffrey, G., St Pierre, T., House, M., Gummer, J., Trengove, R., Olynyk, J., Crawford, D. & Adams, L., Jun 2018, In : Hepatology Communications. 2, 6, p. 644-653 10 p.

Research output: Contribution to journalArticle

Open Access

Liver Transplantation in Adults With Liver Disease Due to Common Variable Immunodeficiency Leads to Early Recurrent Disease and Poor Outcome

Ramlaul, N., Ooi, J., Jeffrey, G. P., MacQuillan, G., Garas, G., Adams, L. A., Iqbal, M., Nolan, N., Houlihan, D. D., McCormick, P. A. & Mac Nicholas, R., Nov 2018, In : Liver Transplantation. 24, 11, p. 1622-1626 5 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Long Term Clinical Outcomes for Patients with Chronic Liver Disease: An Australian Cohort Study

Huang, Y., Joseph, J., De Boer, B., Cheng, W., Adams, L. A., MacQuillan, G., Garas, G. & Jeffrey, G. P., Oct 2018, In : Hepatology. 68, p. 777A-778A 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Noninvasive biomarkers in NAFLD and NASH — current progress and future promise

Wong, V. W. S., Adams, L. A., de Lédinghen, V., Wong, G. L. H. & Sookoian, S., 1 Aug 2018, In : Nature Reviews Gastroenterology and Hepatology. 15, 8, p. 461-478 18 p.

Research output: Contribution to journalReview article

69 Citations (Scopus)

Prevalence of restless legs syndrome in a tertiary cohort of ambulant patients with chronic liver disease

Ma, M. X., Huang, Y., Adams, L. A., Gilpin, R., Garas, G., MacQuillan, G., Jeffrey, G. P. & Nicholas, R. M., 1 Mar 2018, In : Internal Medicine Journal. 48, 3, p. 347-350 4 p.

Research output: Contribution to journalArticle

Rate of Nonsurveillance and Advanced Hepatocellular Carcinoma at Diagnosis in Chronic Liver Disease

Huang, Y., Wallace, M. C., Adams, L. A., MacQuillan, G., Garas, G., Ferguson, J., Samuelson, S., Tibballs, J. & Jeffrey, G. P., Jul 2018, In : Journal of Clinical Gastroenterology. 52, 6, p. 551-556 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis

Alkhouri, N., Johnson, C., Adams, L., Kitajima, S., Tsuruno, C., Colpitts, T. L., Hatcho, K., Lawitz, E., Lopez, R. & Feldstein, A., 1 Aug 2018, In : PLoS One. 13, 8, e0202226.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
File
13 Citations (Scopus)
450 Downloads (Pure)

Stereotactic Body Radiotherapy (Cyberknife) for Early Stage Hepatocellular Carcinoma: A Single Center Experience of 43 Patients and 58 Lesions

Lim, Z., Tan, H., Soares, J., Wallace, M. C., Adams, L. A., Garas, G., MacQuillan, G. C., Tibbals, J., Samuelson, S., Ferguson, J., Tang, C. & Jeffrey, G. P., Oct 2018, In : Hepatology. 68, p. 552A-553A 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

11 Citations (Scopus)
2017

A protease assay that may speed the diagnosis of fibrosis in non-alcoholic fatty liver disease

Zhang, H. E., Brewer, K., Jeffrey, G. P., Twigg, S. M., Mccaughan, G. W., Williams, K. H., Adams, L. A. & Gorrell, M. D., Aug 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, p. 115-115 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

5 Citations (Scopus)