Lea-Ann Kirkham

Search results

• 2020

  Bacterial Reservoirs in the Middle Ear of Otitis-prone Children Are Associated with Repeat Ventilation Tube Insertion

  Seppanen, E. J., Thornton, R. B., North, H. J. D., Corscadden, K. J., Wiertsema, S. P., Vijayasekaran, S., Coates, H. L., Jacoby, P., Richmond, P. C. & Kirkham, L. A. S., Feb 2020, In : Pediatric Infectious Disease Journal. 39, 2, p. 91-96 6 p.

  Research output: Contribution to journal › Article

  • Otitis
  • Middle Ear
  • Ventilation
  • Otitis Media with Effusion
  • Child

• Panel 4: Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures

  Marsh, R. L., Aho, C., Beissbarth, J., Bialasiewicz, S., Binks, M., Cervin, A., Kirkham, L. A. S., Lemon, K. P., Slack, M. P. E. & Smith-Vaughan, H. C., Mar 2020, In : International Journal of Pediatric Otorhinolaryngology. 130, Suppl. 1, 109836.

  Research output: Contribution to journal › Article

  • Otitis Media
  • Microbiota
  • Middle Ear
  • Pressure
  • Mycobiome
  3 Citations (Scopus)

• Panel 8: Vaccines and immunology

  Alderson, M. R., Murphy, T., Pelton, S. I., Novotny, L. A., Hammitt, L. L., Kurabi, A., Li, J. D., Thornton, R. B. & Kirkham, L. A. S., Mar 2020, In : International Journal of Pediatric Otorhinolaryngology. 130, Suppl. 1, 109839.

  Research output: Contribution to journal › Article

  • Otitis Media
  • Allergy and Immunology
  • Vaccines
  • Moraxella (Branhamella) catarrhalis
  • Vaccination
  1 Citation (Scopus)

• Pneumococcal conjugate vaccine primes mucosal immune responses to pneumococcal polysaccharide vaccine booster in Papua New Guinean children

  Orami, T., Ford, R., Kirkham, L. A., Thornton, R., Corscadden, K., Richmond, P. C., Pomat, W. S., van den Biggelaar, A. H. J. & Lehmann, D., 25 Nov 2020, In : Vaccine. 38, 50, p. 7977-7988

  Research output: Contribution to journal › Article

  Open Access

  • mucosal immunity
  • Mucosal Immunity
  • Pneumococcal Vaccines
  • Conjugate Vaccines
  • vaccines
• 2019

  Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children

  Bhuiyan, M. U., Blyth, C. C., West, R., Lang, J., Rahman, T., Granland, C., de Gier, C., Borland, M. L., Thornton, R. B., Kirkham, L-A. S., Martin, A., Richmond, P. C., Smith, D. W., Jaffe, A. & Snelling, T. L., 2 Apr 2019, In : BMC Pulmonary Medicine. 19, 1, 9 p., 71.

  Research output: Contribution to journal › Article

  Open Access
  11 Citations (Scopus)

• High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media

  Seppanen, E. J., Thornton, R. B., Corscadden, K. J., Granland, C. M., Hibbert, J., Fuery, A., Wiertsema, S. P., Vijayasekaran, S., Coates, H. L., Jacoby, P., Currie, A., Richmond, P. C. & Kirkham, L. A. S., 26 Dec 2019, In : PLoS One. 14, 12, e0227080.

  Research output: Contribution to journal › Article

  Open Access

  • antimicrobial proteins
  • otitis media
  • Pathogens
  • Otitis Media with Effusion
  • antimicrobial peptides
  4 Citations (Scopus)

• Immunogenicity and immune memory after a pneumococcal polysaccharide vaccine booster in a high-risk population primed with 10-valent or 13-valent pneumococcal conjugate vaccine: A randomized controlled trial in Papua New Guinean children

  van den Biggelaar, A. H. J., Pomat, W. S., Masiria, G., Wana, S., Nivio, B., Francis, J., Ford, R., Passey, M., Kirkham, L. A., Jacoby, P., Lehmann, D. & Richmond, P., 4 Feb 2019, In : Vaccines. 7, 1, 14 p., 17.

  Research output: Contribution to journal › Article

  Open Access

  • 13-valent pneumococcal vaccine
  • Pneumococcal Vaccines
  • Conjugate Vaccines
  • 10-valent pneumococcal conjugate vaccine
  • Randomized Controlled Trials
  2 Citations (Scopus)

• PCV7- and PCV10-Vaccinated Otitis-Prone Children in New Zealand Have Similar Pneumococcal and Haemophilus influenzae Densities in Their Nasopharynx and Middle Ear

  de Gier, C., Granland, C. M., Pickering, J. L., Walls, T., Bhuiyan, M., Mills, N., Richmond, P. C., Best, E. J., Thornton, R. B. & Kirkham, L-A. S., 31 Jan 2019, In : Vaccines. 7, 1, 14 p., 14.

  Research output: Contribution to journal › Article

  Open Access
  5 Citations (Scopus)

• Production of IgG2 antibodies to pneumococcal polysaccharides after vaccination of treated HIV patients may be augmented by IL-7Rα signaling in ICOS+ circulating T follicular-helper cells

  Abudulai, L., Fernandez, S., Corscadden, K., Kirkham, L-A., Hunter, M., Post, J. J. & French, M., 24 Apr 2019, In : Frontiers in Immunology. 10, 9 p.

  Research output: Contribution to journal › Article

  Open Access

  • Helper-Inducer T-Lymphocytes
  • Polysaccharides
  • Antibody Formation
  • Vaccination
  • Immunoglobulin G

• Safety and immunogenicity of pneumococcal conjugate vaccines in a high-risk population: A randomized controlled trial of 10-valent and 13-valent pneumococcal conjugate vaccine in Papua New Guinean infants

  Pomat, W. S., Van Den Biggelaar, A. H. J., Wana, S., Francis, J. P., Solomon, V., Greenhill, A. R., Ford, R., Orami, T., Passey, M., Jacoby, P., Kirkham, L. A., Lehmann, D. & Richmond, P. C., 1 May 2019, In : Clinical Infectious Diseases. 68, 9, p. 1472-1481 10 p.

  Research output: Contribution to journal › Article

  Open Access

  • 10-valent pneumococcal conjugate vaccine
  • 13-valent pneumococcal vaccine
  • Pneumococcal Vaccines
  • Conjugate Vaccines
  • Randomized Controlled Trials
  9 Citations (Scopus)

• The contribution of geogenic particulate matter to lung disease in indigenous children

  Shepherd, C. C. J., Clifford, H. D., Mitrou, F., Melody, S. M., Bennett, E. J., Johnston, F. H., Knibbs, L. D., Pereira, G., Pickering, J. L., Teo, T. H., Kirkham, L. A. S., Thornton, R. B., Kicic, A., Ling, K. M., Alach, Z., Lester, M., Franklin, P., Reid, D. & Zosky, G. R., 1 Aug 2019, In : International Journal of Environmental Research and Public Health. 16, 15, 12 p., 2636.

  Research output: Contribution to journal › Article

  Open Access

  • Pulmonary diseases
  • Particulate Matter
  • Lung Diseases
  • Epithelial Cells
  • Dust
  2 Citations (Scopus)

• The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: A case - Control study

  Bhuiyan, M. U., Snelling, T. L., West, R., Lang, J., Rahman, T., Granland, C., De Gier, C., Borland, M. L., Thornton, R. B., Kirkham, L. A. S., Sikazwe, C., Martin, A. C., Richmond, P. C., Smith, D. W., Jaffe, A. & Blyth, C. C., Mar 2019, In : Thorax. 74, 3, p. 261-269 9 p.

  Research output: Contribution to journal › Article

  Open Access

  • Pneumonia
  • Case-Control Studies
  • Bacteria
  • Viruses
  • Child
  13 Citations (Scopus)
• 2018

  Bacillus licheniformis in geogenic dust induces inflammation in respiratory epithelium

  Pickering, J., Teo, T. H., Thornton, R. B., Kirkham, L. A., Zosky, G. R. & Clifford, H. D., 1 Jul 2018, In : Environmental Research. 164, p. 248-254 7 p.

  Research output: Contribution to journal › Article

  • Bacillus licheniformis
  • Bacilli
  • Respiratory Mucosa
  • Dust
  • dust
  2 Citations (Scopus)

• Evidence of functional cell-mediated immune responses to nontypeable Haemophilus influenzae in otitis-prone children

  Seppanen, E., Tan, D., Corscadden, K. J., Currie, A. J., Richmond, P. C., Thornton, R. B. & Kirkham, L-AS., 1 Apr 2018, In : PLoS One. 13, 4, e0193962.

  Research output: Contribution to journal › Article

  Open Access

  • otitis
  • Otitis
  • T-cells
  • Haemophilus influenzae
  • cell-mediated immunity
  5 Citations (Scopus)

• Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease

  Blakeway, L. V., Tan, A., Lappan, R., Ariff, A., Pickering, J. L., Peacock, C. S., Blyth, C. C., Kahler, C. M., Chang, B. J., Lehmann, D., Kirkham, L-A. S., Murphy, T. F., Jennings, M. P., Bakaletz, L. O., Atack, J. M., Peak, I. R. & Seib, K. L., 1 Nov 2018, In : Genome Biology and Evolution. 10, 11, p. 2932-2946 15 p.

  Research output: Contribution to journal › Article

  Open Access

  • DNA Restriction-Modification Enzymes
  • Moraxella catarrhalis
  • Moraxella (Branhamella) catarrhalis
  • restriction endonucleases
  • phylogenetics
  9 Citations (Scopus)

• Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: A case-control study protocol

  Bhuiyan, M. U., Snelling, T. L., West, R., Lang, J., Rahman, T., Borland, M. L., Thornton, R., Kirkham, L. A., Sikazwe, C., Martin, A. C., Richmond, P. C., Smith, D. W., Jaffe, A. & Blyth, C. C., 1 Mar 2018, In : BMJ Open. 8, 3, e020646.

  Research output: Contribution to journal › Article

  Open Access

  • Pneumonia
  • Case-Control Studies
  • Child
  • Pneumococcal Vaccines
  • Viruses
  6 Citations (Scopus)
• 2017

  Australian Aboriginal children with otitis media have reduced antibody titers to specific nontypeable Haemophilus influenzae vaccine antigens

  Thornton, R. B., Kirkham, L. A. S., Corscadden, K. J., Wiertsema, S. P., Fuery, A., Jones, B. J., Coates, H. L., Vijayasekaran, S., Zhang, G., Keil, A. & Richmond, P. C., 1 Apr 2017, In : Clinical and Vaccine Immunology. 24, 4, 10 p., 00556-16.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Haemophilus Vaccines
  • Otitis Media
  • Antigens
  • Haemophilus influenzae
  • Antibodies
  6 Citations (Scopus)

  391 Downloads (Pure)

• Increased CTLA-4⁺ T cells may contribute to impaired T helper type 1 immune responses in patients with chronic obstructive pulmonary disease

  Tan, D., Teo, T. H., Setiawan, A. M., Ong, N., Zimmermann, M., Price, P., Kirkham, L. A. S. & Moodley, Y. P., Jun 2017, In : Immunology. 151, 2, p. 219-226

  Research output: Contribution to journal › Article

  • CTLA-4 Antigen
  • Chronic Obstructive Pulmonary Disease
  • T-Lymphocytes
  • Regulatory T-Lymphocytes
  • Blood Cells
  6 Citations (Scopus)

• No evidence for impaired humoral immunity to pneumococcal proteins in Australian Aboriginal children with otitis media

  Thornton, R. B., Kirkham, L-A. S., Corscadden, K. J., Coates, H. L., Vijayasekaran, S., Hillwood, J., Toster, S., Edminston, P., Zhang, G., Keil, A. & Richmond, P. C., 1 Jan 2017, In : International Journal of Pediatric Otorhinolaryngology. 92, p. 119-125 7 p.

  Research output: Contribution to journal › Article

  Open Access

  • Otitis Media
  • Humoral Immunity
  • Child
  • Proteins
  • Streptococcus pneumoniae
  4 Citations (Scopus)

• Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides

  Kirkham, L-A. S., Wiertsema, S. P., Corscadden, K. J., Mateus, T., Mullaney, G. L., Zhang, G., Richmond, P. C. & Thornton, R. B., Mar 2017, In : Clinical and Vaccine Immunology. 24, 3, 11 p., 00497.

  Research output: Contribution to journal › Article

  Open Access
  5 Citations (Scopus)

• Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection

  Abudulai, L., Fernandez, S., Corscadden, K., Burrows, S., Hunter, M., Tjiam, M. C., Kirkham, L-A., Post, J. J. & French, M., May 2017, In : PLoS One. 12, 5, 22 p., e0176641.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Helper-Inducer T-Lymphocytes
  • Polysaccharides
  • Antibody Formation
  • HIV Infections
  • Immunoglobulin G
  16 Citations (Scopus)

  862 Downloads (Pure)

• Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea

  Lehmann, D., Kirarock, W., van den Biggelaar, A. H. J., Passey, M., Jacoby, P., Saleu, G., Masiria, G., Nivio, B., Greenhill, A., Orami, T., Francis, J., Ford, R., Kirkham, L-A., Solomon, V., Richmond, P. C., Pomat, W. S. & 10v13v PCV Trial Team, 25 Dec 2017, In : Pneumonia. 9, 15 p., 20.

  Research output: Contribution to journal › Article

  Open Access

• Understanding the aetiology and resolution of chronic otitis media from animal and human studies

  Bhutta, M. F., Thornton, R. B., Kirkham, L. A. S., Kerschner, J. E. & Cheeseman, M. T., 1 Nov 2017, In : DMM Disease Models and Mechanisms. 10, 11, p. 1289-1300 12 p.

  Research output: Contribution to journal › Article

  Open Access

  • Otitis Media
  • Animals
  • Eustachian Tube
  • Pathogens
  • Glues
  26 Citations (Scopus)
• 2016

  Chronic HIV-1 infection induces B-cell dysfunction that is incompletely resolved by long-term antiretroviral therapy

  Abudulai, L., Fernandez, S., Corscadden, K., Hunter, M., Kirkham, L-A., Post, J. J. & French, M., 1 Apr 2016, In : JAIDS: Journal of Acquired Immune Deficiency Syndromes. 71, 4, p. 381-389 9 p.

  Research output: Contribution to journal › Article

  • HIV Infections
  • HIV-1
  • B-Lymphocytes
  • Immunoglobulin G
  • HIV
  17 Citations (Scopus)

• Duplex quantitative PCR assay for detection of haemophilus influenzae that distinguishes fucose-and protein d-negative strains

  De Gier, C., Pickering, J. L., Richmond, P. C., Thornton, R. B. & Kirkham, L-A. S., Sep 2016, In : Journal of Clinical Microbiology. 54, 9, p. 2380-2383

  Research output: Contribution to journal › Article

  Open Access

  File

  • Fucose
  • Haemophilus influenzae
  • Haemophilus
  • Confidence Intervals
  • Polymerase Chain Reaction
  5 Citations (Scopus)

  277 Downloads (Pure)

• Haemophilus haemolyticus interaction with host cells is different to nontypeable haemophilus influenzae and prevents NTHi association with epithelial cells

  Pickering, J., Prosser, A., Corscadden, K., De Gier, C., Richmond, P., Zhang, B., Thornton, R. & Kirkham, L-A., 9 May 2016, In : Frontiers in Cellular and Infection Microbiology. 6, p. 1-12 50.

  Research output: Contribution to journal › Article

  Open Access
  17 Citations (Scopus)
• 2015

  Complete deletion of the fucose operon in haemophilus influenzae is associated with a cluster in multilocus sequence analysis-based phylogenetic group II related to haemophilus haemolyticus: Implications for identification and typing

  De Gier, C., Kirkham, L-A. & Nørskov-Lauritsen, N., 2015, In : Journal of Clinical Microbiology. 53, 12, p. 3773-3778

  Research output: Contribution to journal › Article

  • Haemophilus
  • Multilocus Sequence Typing
  • Fucose
  • Haemophilus influenzae
  • Operon
  6 Citations (Scopus)

• Haemophilus influenzae: using comparative genomics to accurately identify a highly recombinogenic human pathogen

  Price, E. P., Sarovich, D. S., Nosworthy, E., Beissbarth, J., Marsh, R. L., Pickering, J., Kirkham, L-A., Keil, A. D., Chang, A. B. & Smith-Vaughan, H. C., 27 Aug 2015, In : BMC Genomics. 16, 1, p. 1-10

  Research output: Contribution to journal › Article

  Open Access

  • Haemophilus influenzae
  • Genomics
  • Haemophilus
  • Phylogeny
  • Genome
  27 Citations (Scopus)
• 2014

  A PCR–High-Resolution Melt Assay for Rapid Differentiation of Nontypeable Haemophilus influenzae and Haemophilus haemolyticus

  Pickering, J., Binks, M. J., Beissbarth, J., Hare, K. M., Kirkham, L-A. & Smith-Vaughan, H., 2014, In : Journal of Clinical Microbiology. 52, 2, p. 663-667

  Research output: Contribution to journal › Article

  Open Access
  14 Citations (Scopus)

• Diversity of Nontypeable Haemophilus influenzae Strains Colonizing Australian Aboriginal and Non-Aboriginal Children

  Pickering, J., Smith-Vaughan, H., Beissbarth, J., Bowman, J. M., Wiertsema, S., Riley, T., Leach, A. J., Richmond, P., Lehmann, D. & Kirkham, L-A., May 2014, In : Journal of Clinical Microbiology. 52, 5, p. 1352-1357

  Research output: Contribution to journal › Article

  Open Access

  • Haemophilus influenzae
  • Child
  • Ribotyping
  • rRNA Genes
  • Polymerase Chain Reaction
  10 Citations (Scopus)
• 2013

  A practical method for preparation of pneumococcal and nontypeable Haemophilus influenzae inocula that preserves viability and immunostimulatory activity

  Kirkham, L-A., Corscadden, K. J., Wiertsema, S., Currie, A. & Richmond, P., 2013, In : BMC Research Notes. 6, p. 5pp

  Research output: Contribution to journal › Article

  Open Access
  8 Citations (Scopus)

• High pneumococcal serotype specific IgG, IgG1 and IgG2 levels in serum and the middle ear of children with recurrent acute otitis media receiving ventilation tubes

  Corscadden, K., Kirkham, L-A., Thornton, R., Vijayasekaran, S., Coates, H., Richmond, P. & Wiertsema, S., 2013, In : Vaccine. 31, 10, p. 1393-1399

  Research output: Contribution to journal › Article

  • otitis media
  • Otitis Media
  • Middle Ear
  • Serogroup
  • Ventilation
  13 Citations (Scopus)

• Neutrophil Extracellular Traps and Bacterial Biofilms in Middle Ear Effusion of Children with Recurrent Acute Otitis Media - A Potential Treatment Target

  Thornton, R., Wiertsema, S., Kirkham, L-A., Rigby, P., Vijayasekaran, S., Coates, H. & Richmond, P., 2013, In : PLoS One. 8, p. 10pp

  Research output: Contribution to journal › Article

  Open Access
  53 Citations (Scopus)
• 2012

  Children with otitis media mount a pneumococcal serotype specific serum IgG and IgA response comparable to healthy controls after pneumococcal conjugate vaccination

  Menon, V. J., Corscadden, K. J., Fuery, A., Thornton, R., Kirkham, L-A., Richmond, P. & Wiertsema, S., 2012, In : Vaccine. 30, 20, p. 3136-3144

  Research output: Contribution to journal › Article
  10 Citations (Scopus)

• IgG responses to pneumococcal and haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media

  Wiertsema, S., Corscadden, K., Mowe, E., Zhang, B., Vijayasekaran, S., Coates, H., Mitchell, T. J., Thomas, W., Richmond, P. & Kirkham, L-A., 12 Dec 2012, In : PLoS One. 7, 11, p. e49061

  Research output: Contribution to journal › Article

  Open Access

  File

  • Haemophilus influenzae
  • Otitis Media
  • Immunoglobulin G
  • Antigens
  • Child
  15 Citations (Scopus)

  69 Downloads (Pure)

• Molecular surveillance of true nontypeable haemophilus influenzae: An evaluation of pcr screening assays

  Binks, M. J., Temple, B., Kirkham, L-A., Wiertsema, S., Dunne, E. M., Richmond, P., Marsh, R. L., Leach, A. J. & Smith-Vaughan, H. C., 2012, In : PLoS One. 7, 3, p. 8pp

  Research output: Contribution to journal › Article

  Open Access
  58 Citations (Scopus)

• New findings in the pathogenesis of otitis media

  Vijayasekaran, S., Coates, H., Thornton, R., Wiertsema, S., Kirkham, L-A., Jamieson, S., Rye, M. & Richmond, P., 2012, In : Laryngoscope. 122, S61-S62, p. 61-62

  Research output: Contribution to journal › Article
  3 Citations (Scopus)
• 2011

  High detection rates of nucleic acids of a wide range of respiratory viruses in the nasopharynx and the middle ear of children with a history of recurrent acute otitis media

  Wiertsema, S., Chidlow, G. R., Kirkham, L-A., Corscadden, K. J., Mowe, E. N., Vijayasekaran, S., Coates, H., Harnett, G. B. & Richmond, P., 2011, In : Journal of Medical Virology. 83, 11, p. 2008-2017

  Research output: Contribution to journal › Article
  36 Citations (Scopus)

• Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule

  Wiertsema, S., Kirkham, L-A., Corscadden, K. J., Mowe, E. N., Bowman, J. M., Jacoby, P., Francis, R., Vijayasekaran, S., Coates, H., Riley, T. & Richmond, P., 2011, In : Vaccine. 29, 32, p. 5163-5170

  Research output: Contribution to journal › Article

  • otitis media
  • Pneumococcal Vaccines
  • Conjugate Vaccines
  • Haemophilus influenzae
  • Otitis Media
  67 Citations (Scopus)

• Trivalent influenza vaccine and febrile adverse events in australia, 2010: Clinical features and potential mechanisms

  Blyth, C., Currie, A. J., Wiertsema, S., Conway, N. T., Kirkham, L-A., Fuery, A., Mascaro, F., Geelhoed, G. C. & Richmond, P., 2011, In : Vaccine. 29, 32, p. 5107-5113

  Research output: Contribution to journal › Article
  41 Citations (Scopus)
• 2010

  Nasopharyngeal carriage of Haemophilus haemolyticus in Otitis-Prone and Healthy Children

  Kirkham, L-A., Wiertsema, S., Mowe, E. N., Bowman, J. M., Riley, T. & Richmond, P., 2010, In : Journal of Clinical Microbiology. 48, 7, p. 2557-2559

  Research output: Contribution to journal › Article
  19 Citations (Scopus)
• 2007

  Identification of a secreted cholesterol dependant cytolysin (mitilysin) from Steptococcus mitis

  Jefferies, J., Nieminen, L., Kirkham, L-A., Johnston, C., Smith, A. & Mitchell, T. J., 2007, In : Journal of Bacteriology. 189, 2, p. 627-632

  Research output: Contribution to journal › Article
  25 Citations (Scopus)

• Presence of non-haemolytic pneumolysin in serotypes of streptococcus pnuemoniae associated with disease outbreaks

  Jefferies, M. C., Johnston, C. H. G., Kirkham, L-A., Cowan, G. J. M., Ross, K. S., Smith, A., Clarke, S. C., Brueggemann, AB., George, R. C., Pichon, B., Pluschke, G., Pfluger, V. & Mitchell, T., 2007, In : Journal of Infectious Diseases. 196, p. 936-944

  Research output: Contribution to journal › Article
  62 Citations (Scopus)
• 2006

  Construction and Immunological Characterization of a Novel Nontoxic Protective Pneumolysin Mutant for Use in Future Pneumococcal Vaccines

  Kirkham, L-A., Kerr, A. R., Douce, G. R., Paterson, G. K., Dilts, D. A., Liu, D. & Mitchell, T., 2006, In : Infection and Immunity. 74, 1, p. 586-593

  Research output: Contribution to journal › Article

  • Streptococcus pneumoniae plY protein
  • Pneumococcal Vaccines
  • Streptococcus pneumoniae
  • Conjugate Vaccines
  • Pneumococcal Infections
  79 Citations (Scopus)

• Identification of Invasive serotype 1 Pneumococcal Isolates That Express Nonhemolytic Pneumolysin

  Kirkham, L-A., Jefferies, J. M. C., Kerr, A. R., Jing, Y., Clarke, S. C., Smith, A. & Mitchell, T. J., 2006, In : Journal of Clinical Microbiology. 44, 1, p. 151-159

  Research output: Contribution to journal › Article

  • Streptococcus pneumoniae plY protein
  • Serogroup
  • Pneumococcal Infections
  • Streptococcus pneumoniae
  • Mutation
  61 Citations (Scopus)
• 2005

  Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts

  Kerr, A. R., Kirkham, L-A., Kadioglu, A., Andrew, P. W., Garside, P., Thompson, H. & Mitchell, T. J., 2005, In : Microbes and Infection: a jorunal on infectious agents and host defenses. 7, p. 845-852

  Research output: Contribution to journal › Article
  44 Citations (Scopus)