Laurens Manning

Dr, BSc MBChB (Otago), DTM&H (London), FRACP, PhD

  • The University of Western Australia (M582), 35 Stirling Highway,

    6009 Perth

    Australia

  • 829 Citations
  • 15 h-Index
20022019
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Research Output 2002 2019

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Article
2019
1 Citation (Scopus)

Acquisition of Antibodies Against Endothelial Protein C Receptor-Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria

Rambhatla, J. S., Turner, L., Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, T. G., Lavstsen, T. & Rogerson, S. J., 1 Mar 2019, In : Journal of Infectious Diseases. 219, 5, p. 808-818 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Antibody targets on the surface of plasmodium falciparum- infected erythrocytes that are associated with immunity to severe malaria in young children

Chan, J. A., Boyle, M. J., Moore, K. A., Reiling, L., Lin, Z., Hasang, W., Avril, M., Manning, L., Mueller, I., Laman, M., Davis, T., Smith, J. D., Rogerson, S. J., Simpson, J. A., Fowkes, F. J. I. & Beeson, J. G., 15 Feb 2019, In : Journal of Infectious Diseases. 219, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Malaria
Immunity
Erythrocytes
Antibodies

Antimicrobial stewardship opportunities among inpatients with diabetic foot infections: microbiology results from a tertiary hospital multidisciplinary unit

Hand, R., Manning, L., Ritter, J. C., Norman, P., Lamb, L., Makepeace, A., Sankhesara, D., Hamilton, E. & Ingram, P., 1 Apr 2019, In : Internal Medicine Journal. 49, 4, p. 533-536 4 p.

Research output: Contribution to journalArticle

Diabetic Foot
Hospital Units
Methicillin-Resistant Staphylococcus aureus
Microbiology
Tertiary Care Centers
1 Citation (Scopus)

A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies

Hand, R. M., Salman, S., Newall, N., Vine, J., Page-Sharp, M., Bowen, A. C., Gray, K., Baker, A., Kado, J., Joseph, J., Marsh, J., Ramsay, J., Sika-Paotonu, D., Batty, K. T., Manning, L. & Carapetis, J., 1 Jul 2019, In : Journal of Antimicrobial Chemotherapy. 74, 7, p. 1984-1991 8 p.

Research output: Contribution to journalArticle

Open Access
Penicillin G Benzathine
Rheumatic Heart Disease
Penicillin G
Pharmacokinetics
Population

CASSETTE-clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: Study protocol for a randomised controlled trial

Dotel, R., Tong, S. Y. C., Bowen, A., Nelson, J. N., O'sullivan, M. V. N., Campbell, A. J., McMullan, B. J., Britton, P. N., Francis, J. R., Eisen, D. P., Robinson, O., Manning, L. & Davis, J. S., 13 Jun 2019, In : Trials. 20, 1, 353.

Research output: Contribution to journalArticle

Open Access
Clindamycin
Staphylococcus aureus
Randomized Controlled Trials
Exotoxins
Infection

Ertapenem for osteoarticular infections in obese patients: a pharmacokinetic study of plasma and bone concentrations

Chambers, J., Page-Sharp, M., Salman, S., Dyer, J., Davis, T. M. E., Batty, K. T. & Manning, L., Apr 2019, In : European Journal of Clinical Pharmacology. 75, 4, p. 511-517 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Bone and Bones
Infection
Microbial Sensitivity Tests
Enterobacteriaceae Infections

Non-adherence to antimicrobial stewardship prospective audit and feedback advice: Risk factors and clinical consequences

Horton, C. D., Rawlins, M. D. M., Manning, L. & Ingram, P. R., 1 Jun 2019, In : Journal of Infection and Chemotherapy. 25, 6, p. 485-488 4 p.

Research output: Contribution to journalArticle

Liver Diseases
Infection
Therapeutics
tazobactam drug combination piperacillin

Seasonal and regional patterns of lower leg cellulitis in Western Australia

Manning, L., Cannon, J., Dyer, J. & Carapetis, J., Feb 2019, In : Internal Medicine Journal. 49, 2, p. 212-216 5 p.

Research output: Contribution to journalArticle

2018
2 Citations (Scopus)
meropenem
Melioidosis
Burkholderia pseudomallei
Disease Outbreaks
Anti-Bacterial Agents

Electrocardiographic Safety of Repeated Monthly Dihydroartemisinin-Piperaquine as a Candidate for Mass Drug Administration

Millat-Martínez, P., Ila, R., Laman, M., Robinson, L., Karunajeewa, H., Abel, H., Pulai, K., Sanz, S., Manning, L., Moore, B., Bassat, Q. & Mitjà, O., 1 Dec 2018, In : Antimicrobial Agents and Chemotherapy. 62, 12, e01153-18.

Research output: Contribution to journalArticle

dihydroartemisinin
Electrocardiography
Antimalarials
Safety
Malaria
2 Citations (Scopus)

Epidemiology and risk factors for recurrent severe lower limb cellulitis: a longitudinal cohort study

Cannon, J., Dyer, J., Carapetis, J. & Manning, L., 1 Oct 2018, In : Clinical Microbiology and Infection. 24, 10, p. 1084-1088 5 p.

Research output: Contribution to journalArticle

Cellulitis
Longitudinal Studies
Lower Extremity
Leg
Epidemiology
2 Citations (Scopus)

Managing diabetic foot infections: A survey of Australasian infectious diseases clinicians

Commons, R. J., Raby, E., Athan, E., Bhally, H., Chen, S., Guy, S., Ingram, P. R., Lai, K., Lemoh, C., Lim, L. L., Manning, L., Miyakis, S., O'Reilly, M., Roberts, A., Sehu, M., Torda, A., Vicaretti, M. & Lazzarini, P. A., 10 Apr 2018, In : Journal of Foot and Ankle Research. 11, 1, 13.

Research output: Contribution to journalArticle

Open Access
Diabetic Foot
Communicable Diseases
Infection
New Zealand
Physicians
5 Citations (Scopus)
Open Access
Dihydrotestosterone
Luteinizing Hormone
Testosterone
Sex Hormone-Binding Globulin
Independent Living
3 Citations (Scopus)

Severe lower limb cellulitis: defining the epidemiology and risk factors for primary episodes in a population-based case-control study

Cannon, J., Rajakaruna, G., Dyer, J., Carapetis, J. & Manning, L., 1 Oct 2018, In : Clinical Microbiology and Infection. 24, 10, p. 1089-1094 6 p.

Research output: Contribution to journalArticle

Cellulitis
Case-Control Studies
Lower Extremity
Leg
Epidemiology
1 Citation (Scopus)

Validation of a dried blood spot ceftriaxone assay in Papua New Guinean children with severe bacterial infections

Mukap, M., Sprod, C., Teguarani, N., Laman, M., Page-Sharp, M., Salman, S., Moore, B., Batty, K., Davis, T. & Manning, L., Oct 2018, In : Antimicrobial Agents and Chemotherapy. 62, 10, e00940.

Research output: Contribution to journalArticle

Ceftriaxone
Bacterial Infections
Papua New Guinea
Pharmacokinetics
Bacterial Meningitides
2017
21 Citations (Scopus)

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

MalariaGEN Consortium, 9 Jan 2017, In : eLife. 6, e15085.

Research output: Contribution to journalArticle

Open Access
Cerebral Malaria
Glucosephosphate Dehydrogenase Deficiency
Glucosephosphate Dehydrogenase
Anemia
Malaria
1 Citation (Scopus)

Methicillin-resistant Staphylococcus aureus in Papua New Guinea: A community nasal colonization prevalence study

Laman, M., Greenhill, A., Coombs, G. W., Robinson, O., Pearson, J., Davis, T. M. E. & Manning, L., 1 Aug 2017, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 111, 8, p. 360-362 3 p.

Research output: Contribution to journalArticle

Papua New Guinea
Methicillin-Resistant Staphylococcus aureus
Nose
Cross-Sectional Studies
Clone Cells
3 Citations (Scopus)
81 Downloads (Pure)
Open Access
File
Penicillin G Benzathine
Penicillin G
Rheumatic Fever
Penicillins
Rheumatic Heart Disease
6 Citations (Scopus)
Open Access
Men's Health
Thyrotropin
Thyroxine
Reference Values
Hyperthyroidism
5 Citations (Scopus)
lisofylline
Pentoxifylline
Pharmacokinetics
Metabolites
Caffeine
2016
4 Citations (Scopus)

A Toll-like receptor-1 variant and its characteristic cellular phenotype is associated with severe malaria in Papua New Guinean children

Manning, L., Cutts, J., Stanisic, D. I., Laman, M., Carmagnac, A., Allen, S., O'Donnell, A., Karunajeewa, H., Rosanas-Urgell, A., Siba, P., Davis, T., Michon, P., Schofield, L., Rockett, K., Kwiatkowski, D. & Mueller, I., Jan 2016, In : Genes and Immunity. 17, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 1
Malaria
Phenotype
Single Nucleotide Polymorphism
Genotype

Tigecycline use in the outpatient parenteral antibiotic therapy setting

Ingram, P., Rawlins, M. D. M., Murray, R., Roberts, J. A. & Manning, L., Oct 2016, In : European Journal of Clinical Microbiology and Infectious Diseases. 35, 10, p. 1673-1677 5 p.

Research output: Contribution to journalArticle

Outpatients
Anti-Bacterial Agents
Nausea
Therapeutics
Infection
2 Citations (Scopus)

Use of quantitative pharmacology tools to improve malaria treatments

Davis, T., Moore, B., Salman, S., Page-Sharp, M., Batty, K. T. & Manning, L., Feb 2016, In : Expert Review of Clinical Pharmacology. 9, 2, p. 303-316 15 p.

Research output: Contribution to journalArticle

Malaria
Pharmacology
Antimalarials
Therapeutics
Pharmacokinetics
5 Citations (Scopus)

Validation and application of a dried blood spot assay for biofilm-active antibiotics commonly used for treatment of prosthetic implant infections

Knippenberg, B., Page-Sharp, M., Salman, S., Clark, B., Dyer, J., Batty, K. T., Davis, T. M. E. & Manning, L., Aug 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4940-4955

Research output: Contribution to journalArticle

Biofilms
Anti-Bacterial Agents
Rifampin
Infection
Pharmacokinetics
14 Citations (Scopus)

Validation and application of a dried blood spot ceftriaxone assay

Page-Sharp, M., Nunn, T., Salman, S., Moore, B., Batty, K. T., Davis, T. & Manning, L., Jan 2016, In : Antimicrobial Agents and Chemotherapy. 60, 1, p. 14-23 10 p.

Research output: Contribution to journalArticle

Open Access
Ceftriaxone
Hematocrit
Pharmacokinetics
Chad
Microbiology
2015
Bacteremia
C-Reactive Protein
Staphylococcus aureus
Kinetics
Heart valve prostheses
22 Citations (Scopus)
276 Downloads (Pure)
Open Access
File
Men's Health
Bone Remodeling
Osteocalcin
Hip Fractures
Bone
3 Citations (Scopus)

Ultrasonographic assessment of splenic volume at presentation and after anti-malarial therapy in children with malarial anaemia

Laman, M., Aipit, S., Bona, C., Siba, P. M., Robinson, L. J., Manning, L. & Davis, T., 28 May 2015, In : Malaria Journal. 14, 219, p. 1-9

Research output: Contribution to journalArticle

Open Access
Antimalarials
Anemia
Hemoglobins
Malaria
Therapeutics
2014
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

Accuracy of initial clinical diagnosis of acute bacterial meningitis in children from a malaria-endemic area of Papua New Guinea

Aipit, J., Laman, M., Hwaiwhanje, I., Bona, C., Pomat, N., Siba, P. M., Davis, T. & Manning, L., Jul 2014, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 108, 7, p. 444-448

Research output: Contribution to journalArticle

Papua New Guinea
Bacterial Meningitides
Malaria
Viral Encephalitis
Cerebral Malaria
21 Citations (Scopus)

Artemisinin-Naphthoquine versus Artemether-Lumefantrine for Uncomplicated Malaria in Papua New Guinean Children: An Open-Label Randomized Trial

Laman, M., Moore, B., Benjamin, J. M., Yadi, G., Bona, C., Warrel, J., Kattenberg, J. H., Koleala, T., Manning, L., Kasian, B., Robinson, L. J., Sambale, N., Lorry, L., Karl, S., Davis, W., Rosanas-Urgell, A., Müeller, I., Siba, P. M., Betuela, I. & Davis, T., 2014, In : PLoS Medicine. 11, 12, p. 1-18

Research output: Contribution to journalArticle

Open Access
Malaria
Vivax Malaria
Papua New Guinea
Therapeutics
Safety
13 Citations (Scopus)

Clinical Features and Outcome in Children with Severe Plasmodium falciparum Malaria: A Meta-Analysis

Manning, L., Laman, M., Davis, W. & Davis, T., 6 Feb 2014, In : PLoS One. 9, 2, 11 p., e86737.

Research output: Contribution to journalArticle

Open Access
Moderators
Falciparum Malaria
Plasmodium falciparum
meta-analysis
malaria
15 Citations (Scopus)

Continuous infusions of meropenem in ambulatory care: Clinical efficacy, safety and stability

Manning, L., Wright, C., Ingram, P., Whitmore, T. J., Heath, C., Manson, I., Page-Sharp, M., Salman, S., Dyer, J. R. & Davis, T., 14 Jul 2014, In : PLoS One. 9, 7, 7 p., e102023.

Research output: Contribution to journalArticle

Open Access
meropenem
Ambulatory Care
Safety
drug therapy
ambient temperature
92 Citations (Scopus)

Reappraisal of known malaria resistance loci in a large multicenter study

Rockett, K. A., Clarke, G. M., Fitzpatrick, K., Hubbart, C., Jeffreys, A. E., Rowlands, K., Craik, R., Jallow, M., Conway, D. J., Bojang, K. A., Pinder, M., Usen, S., Sisay-Joof, F., Sirugo, G., Toure, O., Thera, M. A., Konate, S., Sissoko, S., Niangaly, A., Poudiougou, B. & 62 othersMangano, V. D., Bougouma, E. C., Sirima, S. B., Modiano, D., Amenga-Etego, L. N., Ghansah, A., Koram, K. A., Wilson, M. D., Enimil, A., Evans, J., Amodu, O., Olaniyan, S., Apinjoh, T., Mugri, R., Ndi, A., Ndila, C. M., Uyoga, S., Macharia, A., Peshu, N., Williams, T. N., Manjurano, A., Riley, E., Drakeley, C., Reyburn, H., Nyirongo, V., Kachala, D., Molyneux, M., Dunstan, S. J., Phu, N. H., Quyen, N. T. N., Thai, C. Q., Hien, T. T., Manning, L., Laman, M., Siba, P., Karunajeewa, H., Allen, S., Allen, A., Davis, T., Michon, P., Mueller, I., Green, A., Molloy, S., Johnson, K. J., Kerasidou, A., Cornelius, V., Hart, L., Vanderwal, A., Joaquin, M., Band, G., Le, S. Q., Pirinen, M., Sepúlveda, N., Spencer, C. C. A., Clark, T. G., Agbenyega, T., Achidi, E., Doumbo, O., Farrar, J., Marsh, K., Taylor, T. & Kwiatkowski, D. P., Nov 2014, In : Nature Genetics. 46, p. 1197-1206 11 p., 3107.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access
5 Citations (Scopus)

Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea

Laman, M., Hwaiwhanje, I., Bona, C., Warrel, J., Aipit, S., Smith, D., Noronha, J., Siba, P., Mueller, I., Betuela, I., Davis, T. & Manning, L., 26 Nov 2014, In : BMC Infectious Diseases. 14, p. 1-8 9 p., 630.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

γδ T cells and CD14+ monocytes are predominant cellular sources of cytokines and chemokines associated with severe malaria

Stanisic, D. I., Cutts, J., Eriksson, E. M. Y., Fowkes, F. J. I., Rosanas-Urgell, A., Siba, P. M., Laman, M., Davis, T., Manning, L., Müeller, I. & Schofield, L. D., 15 Jul 2014, In : Journal of Infectious Diseases. 210, 2, p. 295-305

Research output: Contribution to journalArticle

Open Access
Chemokines
Malaria
Monocytes
Cytokines
T-Lymphocytes
2013
3 Citations (Scopus)
Hospitalized Child
Leukocytosis
Malaria
Cerebrospinal Fluid
Seizures
2012
8 Citations (Scopus)

Predictors of Acute Bacterial Meningitis in Children from a Malaria-Endemic Area of Papua New Guinea

Laman, M., Manning, L., Greenhill, A. R., Mare, T., Michael, A., Shem, S., Vince, J., Lagani, W., Hwaiwhanje, I., Siba, P., Mueller, I. & Davis, T., 2012, In : American Journal of Tropical Medicine and Hygiene. 86, 2, p. 240-245

Research output: Contribution to journalArticle

13 Citations (Scopus)
19 Downloads (Pure)

Rapid Antigen Detection Tests for Malaria Diagnosis in Severely Ill Papua New Guinean Children: A Comparative Study Using Bayesian Latent Class Models

Manning, L., Laman, M., Rosanas-Urgell, A., Turlach, B., Aipit, S., Bona, C., Warrell, J., Siba, P., Mueller, I. & Davis, T., 5 Nov 2012, In : PLoS One. 7, 11, p. 7pp

Research output: Contribution to journalArticle

Open Access
File
antigen detection
Routine Diagnostic Tests
malaria
diagnostic techniques
Malaria
34 Citations (Scopus)

Reduced risk of plasmodium vivax malaria in Papua New Guinean children with South East Asian Ovalocytosis in two cohorts and a case-control study

Rosanas-Urgell, A., Lin, E., Manning, L., Rarau, P., Laman, M., Senn, N., Grimberg, B., Tavul, L., Stanisic, D., Robinson, L., Aponte, J., Dabod, E., Reeder, J. C., Siba, P., Zimmerman, P. A., Davis, T., King, C. L., Michon, P. & Mueller, I., 4 Sep 2012, In : PLoS Medicine. 9, 9, p. 1-11

Research output: Contribution to journalArticle

Open Access
Vivax Malaria
Plasmodium vivax
Case-Control Studies
Malaria
Erythrocytes
27 Citations (Scopus)

Severe Anemia in Papua New Guinean Children from a Malaria-Endemic Area: A Case-Control Etiologic Study

Manning, L., Laman, M., Rosanas-Urgell, A., Michon, P., Aipit, S., Bona, C., Siba, P., Mueller, I. & Davis, T., 13 Dec 2012, In : PLoS Neglected Tropical Diseases. 6, 12, p. 1-10

Research output: Contribution to journalArticle

Open Access
Malaria
Case-Control Studies
Anemia
Vaccination
Infection
2011
53 Citations (Scopus)

Features and Prognosis of Severe Malaria Caused by Plasmodium falciparum, Plasmodium vivax and Mixed Plasmodium Species in Papua New Guinean Children.

Manning, L., Laman, M., Law, I., Bona, C., Aipit, S., Teine, D., Warrell, J., Rosanas-Urgell, A., Lin, E., Kiniboro, B., Vince, J., Hwaiwhanje, I., Karunajeewa, H. A., Michon, P., Siba, P., Mueller, I. & Davis, T., 2011, In : PLoS One. 6, 12, p. 9pp

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Increasing Chloramphenicol Resistance in Streptococcus pneumoniae Isolates from Papua New Guinean Children with Acute Bacterial Meningitis

Manning, L. A., Laman, M., Greenhill, A. R., Michael, A., Siba, P., Mueller, I. & Davis, T., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 9, p. 4454-4456

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Meningeal inflammation increases artemether concentrations in cerebrospinal fluid in Papua New Guinean children treated with intramuscular artemether

Manning, L., Laman, M., Page-Sharp, M., Salman, S., Hwaiwhanje, I., Morep, N., Siba, P., Mueller, I., Karunajeewa, H. A. & Davis, T., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5027-5033

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Plasma Plasmodium falciparum histidine-rich protein-2 concentrations do not reflect severity of malaria in Papua New Guinean children

Manning, L., Laman, M., Stanisic, D., Rosanas-Urgell, A., Bona, C., Teine, D., Siba, P., Mueller, I. & Davis, T., 2011, In : Clinical Infectious Diseases. 52, p. 440-446

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Reference intervals for common laboratory tests in Melanesian children

Manning, L., Laman, M., Townsend, M. A., Chubb, S. P., Siba, P. M., Mueller, I. & Davis, T., 2011, In : American Journal of Tropical Medicine and Hygiene. 85, 1, p. 50-54

Research output: Contribution to journalArticle

Open Access