Research Output per year
Research Output 2002 2019
Complex Formation between VEGFR2 and the β2-Adrenoceptor
Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841.e9Research output: Contribution to journal › Article
Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex
Hemming, I. A., Clément, O., Gladwyn-Ng, I. E., Cullen, H. D., Ng, H. L., See, H. B., Ngo, L., Ulgiati, D., Pfleger, K. D. G., Agostino, M. & Heng, J. I. T., 21 May 2019, In : Human Mutation. 15 p.Research output: Contribution to journal › Article
NanoBRET ligand binding at a GPCR under endogenous promotion facilitated by CRISPR/Cas9 genome editing
White, C. W., Johnstone, E. K. M., See, H. B. & Pfleger, K. D. G., Feb 2019, In : Cellular Signalling. 54, p. 27-34 8 p.Research output: Contribution to journal › Article
Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis
Pickering, R., Tikellis, C., Rosado, C., Tsorotes, D., Dimitrropoulos, A., Smith, M., Huet, O., Seeber, R., Abhayawardana, R., Johnstone, E., Golledge, J., Wang, Y., Jandeleit-Dahm, K., Cooper, M., Pfleger, K. & Thomas, M. C., 2 Jan 2019, In : The Journal of clinical investigation. 129, 1, p. 406-421 CI99987.Research output: Contribution to journal › Article
BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes
O'Brien, S. L., Johnstone, E. K. M., Devost, D., Conroy, J., Reichelt, M. E., Purdue, B. W., Ayoub, M. A., Kawai, T., Inoue, A., Eguchi, S., Hébert, T. E., Pfleger, K. D. G. & Thomas, W. G., 1 Dec 2018, In : Biochemical Pharmacology. 158, p. 232-242 11 p.Research output: Contribution to journal › Article
Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression
Sampaio, N. G., Kocan, M., Schofield, L., Pfleger, K. D. G. & Eriksson, E. M., 1 Aug 2018, In : PLoS One. 13, 8, e0202408.Research output: Contribution to journal › Article
Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2
Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J., 23 May 2017, In : Science Signaling. 10, 480, eaai8529.Research output: Contribution to journal › Article
Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time
White, C. W., Vanyai, H. K., See, H. B., Johnstone, E. K. M. & Pfleger, K. D. G., 9 Jun 2017, In : Scientific Reports. 7, 1, 3187.Research output: Contribution to journal › Article
Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding
Stoddart, L. A., White, C., Nguyen, K., Hill, S. & Pfleger, K., 1 Oct 2016, In : British Journal of Pharmacology. 173, 20, p. 3028-3037 10 p.Research output: Contribution to journal › Article
G Protein-Coupled Receptor Heteromers
Gomes, I., Ayoub, M. A., Fujita, W., Jaeger, W., Pfleger, K. & Devi, L. A., 2016, In : Annual Review of Pharmacology and Toxicology. 56, p. 403-425Research output: Contribution to journal › Article
i-bodies, human single domain antibodies that antagonize chemokine receptor CXCR4
Griffiths, K., Dolezal, O., Cao, B., Nilsson, S. K., See, E. B., Pfleger, K. D. G., Roche, M., Gorry, P. R., Pow, A., Viduka, K., Lim, K., Lu, B. G. C., Chang, D. H. C., Murray-Rust, T., Kvansakul, M., Perugini, M. A., Dogovski, C., Doerflinger, M., Zhang, Y., Parisi, K. & 3 others , 2016, In : Journal of Biological Chemistry. 291, 24, p. 12641-12657 17 p.Research output: Contribution to journal › Article
Mutations of vasopressin receptor 2 including novel L312S have differential effects on trafficking
Tiulpakov, A., White, C., Abhayawardana, R., See, H. B., Chan, A., Seeber, R., Heng, J., Dedov, I., Pavlos, N. & Pfleger, K., 1 Aug 2016, In : Molecular Endocrinology. 30, 8, p. 889-904Research output: Contribution to journal › Article
Application of BRET to monitor ligand binding to GPCRs
Stoddart, L. A., Johnstone, E., Wheal, A. J., Goulding, J., Robers, M. B., Machleidt, T., Wood, K. V., Hill, S. & Pfleger, K., Jul 2015, In : Nature Methods. 12, 7, p. 661-663 3 p.Research output: Contribution to journal › Article
Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C motif) Receptor 2 with Implications for Chronic Kidney Disease
Ayoub, M., Zhang, Y., Kelly, R. S., See, E., Johnstone, E., Mccall, E. A., Williams, J. H., Kelly, D. J. & Pfleger, K., 25 Mar 2015, In : PLoS One. 10, 3, 22 p., e0119803.Research output: Contribution to journal › Article
Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format
Ayoub, M., Trebaux, J., Vallaghe, J., Charrier-Savournin, F., Al-Hosaini, K., Gonzalez Moya, A., Pin, J-P., Pfleger, K. & Trinquet, E., 2014, In : Frontiers in Endocrinology. 5, p. 1-11Research output: Contribution to journal › Article
Molecular determinants of orexin receptor-arrestin-ubiquitin complex formation
Jaeger, W., Seeber, R., Eidne, K. & Pfleger, K., Jan 2014, In : British Journal of Pharmacology. 171, 2, p. 364-374Research output: Contribution to journal › Article
AIGaN/GaN-based biosensor for label-free detection of biological activity
Podolska, A., Hool, L., Pfleger, K., Mishra, U. K., Parish, G. & Nener, B., 2013, In : SENSORS AND ACTUATORS B-CHEMICAL. 177, p. 577-582Research output: Contribution to journal › Article
Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V)
Armstrong, S., Seeber, R., Ayoub, M., Feldman, B. J. & Pfleger, K., 2013, In : PLoS One. 8, 6, p. 9pp e65885.Research output: Contribution to journal › Article
Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes
Watts, A. O., Van Lipzig, M. M. H., Jaeger, W., Seeber, R., Van Zwam, M., Vinet, J., Van Der Lee, M. M. C., Siderius, M. H., Zaman, G. J. R., Boddeke, H. W. G. M., Smit, M. J., Pfleger, K., Leurs, R. & Vischer, H. F., 2013, In : British Journal of Pharmacology. 168, 7, p. 1662-1674Research output: Contribution to journal › Article
Profiling Epidermal Growth Factor Receptor and Heregulin Receptor 3 Heteromerization Using Receptor Tyrosine Kinase Heteromer Investigation Technology
Ayoub, M., See, E., Seeber, R., Armstrong, S. & Pfleger, K., 2013, In : PLoS One. 8, 5, p. 10pp e64672.Research output: Contribution to journal › Article
Quantitative Förster resonance energy transfer efficiency measurements using simultaneous spectral unmixing of excitation and emission spectra
Mustafa, S., Hannagan, J., Rigby, P., Pfleger, K. & Corry, B., 2013, In : Journal of Biomedical Optics. 18, 2, p. 026024-1 - 026024-14Research output: Contribution to journal › Article
Biocompatibility of semiconducting AIGaN/GaN material with living cells
Podolska, A., Tham, S., Hart, R. D., Seeber, R., Kocan, M., Kocan, M., Mishra, U. K., Pfleger, K., Parish, G. & Nener, B., 2012, In : SENSORS AND ACTUATORS B-CHEMICAL. 169, p. 401-406Research output: Contribution to journal › Article
Deleterious GRM1 Mutations in Schizophrenia
Ayoub, M., Angelicheva, D., Vile, D., Chandler, D., Morar, B., Cavanaugh, J. A., Visscher, P. M., Jablensky, A., Pfleger, K. & Kalaydjieva, L., 2012, In : PLoS One. 7, p. 8pp e32849.Research output: Contribution to journal › Article
Effect of enhanced Renilla luciferase and fluorescent protein variants on the Förster distance of Bioluminescence resonance energy transfer (BRET)
Dacres, H., Michie, M., Wang, J., Pfleger, K. & Trowell, S. C., 2012, In : Biochemical and Biophysical Research Communications. 425, p. 625-629Research output: Contribution to journal › Article
Identification and profiling of novel α 1A-adrenoceptor-CXC chemokine receptor 2 heteromer
Mustafa, S., See, E., Seeber, R., Armstrong, S. P., White, C. W., Ventura, S., Ayoub, M. & Pfleger, K., 2012, In : Journal of Biological Chemistry. 287, 16, p. 12952-12965Research output: Contribution to journal › Article
Application of G Protein-Coupled Receptor-Heteromer Identification Technology to Monitor beta-arrestin Recruitment to G Protein-Coupled Receptor Heteromers
See, E., Seeber, R., Kocan, M., Eidne, K. & Pfleger, K., 2011, In : Assay and Drug Development Technologies. 9, 1, p. 21-30Research output: Contribution to journal › Article
Enhanced BRET technology for the monitoring of agonist-induced and agonist-independent interactions between GPCRs and β-arrestins
Kocan, M., Dalrymple, M., Seeber, R., Feldman, B. J. & Pfleger, K., 2011, In : Frontiers in Endocrinology. 1, p. 1-9 12.Research output: Contribution to journal › Article
G Protein-Coupled Receptor Heteromer Identification Technology: Identification and Profiling of GPCR Heteromers
Mustafa, S. & Pfleger, K., 2011, In : Journal of Laboratory Automation. 16, p. 285-291Research output: Contribution to journal › Article
Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles
Porrello, E. R., Pfleger, K., Seeber, R., Qian, H., Oro, C., Abogadie, F., Delbridge, L. M. D. & Thomas, W. G., 2011, In : Cellular Signalling. 23, p. 1767-1776Research output: Contribution to journal › Article
Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes
Dalrymple, M., Jaeger, W., Eidne, K. & Pfleger, K., 2011, In : Journal of Biological Chemistry. 286, p. 16726-16733Research output: Contribution to journal › Article
Differential association modes of the thrombin receptor PAR1 with Gαi1, Gα12, and β-arrestin 1
Ayoub, M., Trinquet, E., Pfleger, K. & Pin, J-P., 2010, In : FASEB Journal. 24, p. 3522-3535Research output: Contribution to journal › Article
Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization
Ayoub, M. & Pfleger, K., 2010, In : Current Opinion in Pharmacology. 10, p. 44-52Research output: Contribution to journal › Article
Uncovering GPCR heteromer-biased ligands
Mustafa, S., Ayoub, M. & Pfleger, K., 2010, In : Drug Discovery Today. 7, p. 77-85Research output: Contribution to journal › Article
Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis
Kocan, M., See, E., Sampaio, N., Eidne, K., Feldman, B. J. & Pfleger, K., 2009, In : Molecular Endocrinology. 23, 4, p. 559-571Research output: Contribution to journal › Article
Building a new conceptual framework for receptor heteromers
Ferré, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Fuxw, K., Durroux, T., Javitch, J. A., George, S. R., Lohse, M. J., Mackie, K., Milligan, G., Pfleger, K., Pin, J. P., Volkow, N. D., Waldhoer, M., Woods, A. S. & Franco, R., 2009, In : Nature Chemical Biology. 5, 3, p. 131-134Research output: Contribution to journal › Article
G-protein-coupled receptors in drug discovery - seventh annual Informa conference
Pfleger, K., 2009, In : IDRUGS. 12, 5, p. 288-290Research output: Contribution to journal › Article
Changes to Gonadotropin-Releasing Hormone (GnRH) Receptor Extracellular Loops Differtially Affect GnRH Analog Binding and Activation : Evidence for Distinct Ligand-Stabilized Receptor Conformations
Pfleger, K., Pawson, A. J. & Millar, R. P., 2008, In : Endocrinology. 149, 6, p. 3118-3129Research output: Contribution to journal › Article
Demonstration of Improvements to the Bioluminescence Resonance Energy Transfer (BRET) Technology for the Monitoring of G Protein-Coupled Receptors in Live Cells
Kocan, M., See, E., Seeber, R., Eidne, K. & Pfleger, K., 2008, In : Journal of Biomolecular Screening. 13, 9, p. 888-898Research output: Contribution to journal › Article
G protein-coupled receptor dimers: Functional consequences, disease states and drug targets
Dalrymple, M., Pfleger, K. & Eidne, K., 2008, In : Pharmacology & Therapeutics. 118, 3, p. 359-371Research output: Contribution to journal › Article
G Protein Coupled Receptors as Drug Targets: The Role of scientific symbols beta-Arrestins
Dromey, J. & Pfleger, K., 2008, In : Endocrine, Metabolic & Immune Disorders - Drug Targets. 7, p. 51-61Research output: Contribution to journal › Article
Monitoring interactions between G-protein-coupled receptors and ß-arrestins
Pfleger, K., Dalrymple, M., Dromey, J. & Eidne, K., 2007, In : Biochemical Society Transactions. 35, 4, p. 764-766Research output: Contribution to journal › Article
Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions
Pfleger, K., Seeber, R. & Eidne, K., 2006, In : Nature Protocols. 1, 1, p. 336-345Research output: Contribution to journal › Article
Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells
Pfleger, K., Dromey, J., Dalrymple, M., Lim, E., Thomas, W. G. & Eidne, K., 2006, In : Cellular Signalling. 18, 10, p. 1664-1670Research output: Contribution to journal › Article
Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)
Pfleger, K. & Eidne, K., 2006, In : Nature Methods. 3, 3, p. 165-174Research output: Contribution to journal › Article
Helix I of beta-arrestin is involved in postendocytic trafficking but is not required for membrane translocation, receptor binding, and internalization
Dinh, D. T., Qian, H., Seeber, R., Lim, E., Pfleger, K., Eidne, K. & Thomas, W. G., 2005, In : Molecular Pharmacology. 67, 2, p. 375-382Research output: Contribution to journal › Article
Gonadotropin-Releasing Hormone Receptor-Mediated Growth Suppression of Immortalized LβT2 Gonadotrope and Stable HEK293 Cell Lines
Miles, L. E. C., Hanyaloglu, A. C., Dromey, J., Pfleger, K. & Eidne, K., 2004, In : Endocrinology. 145, 1, p. 194-204Research output: Contribution to journal › Article
G-protein coupled receptor oligomerization in neuroendocrine pathways
Kroeger, K. M., Pfleger, K. & Eidne, K., 2003, In : Frontiers in Neuroendocrinology. 24, 4, p. 254-278Research output: Contribution to journal › Article
New Technologies: Bioluminescence Resonance Energy Transfer (BRET) for the Detection of Real Time Interactions Involving G-Protein Coupled Receptors
Pfleger, K. & Eidne, K. A., 2003, In : Pituitary. 6, 3, p. 141-151Research output: Contribution to journal › Article
Conformational Constraint of Mammalian, Chicken, and Salmon GnRHs, But Not GnRH II, Enhances Binding at Mammalian and Nonmammalian Receptors: Evidence for Preconfiguration of GnRH II
Pfleger, K., Bogerd, J. & Millar, R. P., 2002, In : Molecular Endocrinology. 16, p. 2155-2162Research output: Contribution to journal › Article