Kevin Pfleger

Associate Professor

  • The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • 2043 Citations
  • 23 h-Index
20022022
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Personal profile

Biography

Associate Professor Kevin Pfleger is Head of Molecular Endocrinology and Pharmacology at the Harry Perkins Institute of Medical Research and the Centre for Medical Research, The University of Western Australia (UWA). He is a National Health and Medical Research Council (NHMRC) RD Wright Fellow (Level 2) and Chief Scientific Advisor of Dimerix Limited, an ASX-listed spin-out company from the Perkins and UWA. A/Prof Pfleger was awarded his MA and PhD from Cambridge and Edinburgh Universities respectively, and relocated to Western Australia in October 2002. He was a NHMRC Peter Doherty Research Fellow from 2005 to 2008 and an Australian Research Council (ARC) Future Fellow from 2011 to 2014.

Roles and responsibilities

Head of Molecular Endocrinology and Pharmacology

Teaching Molecular Pharmacology of GPCRs and Molecular Neuroendocrinology

Chair of Accelerating Australia Executive Committee

Chair of the Scientific Advisory Committee of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)

Member of the International Advisory Group of the British Pharmacological Society

Member of the WA Branch Committee of AusBiotech

Commercialisation Representative on the WAHTN Management Committee

Education/Academic qualification

Natural Sciences - Pharmacology, MA, University of Cambridge

Molecular Endocrinology and Pharmacology, PhD, University of Edinburgh

External positions

Chief Scientific Advisor, Dimerix Limited

Keywords

  • Assay technology
  • Endocrinology—receptors
  • Molecular pharmacology
  • Protein interactions
  • Bioluminescence resonance energy transfer (BRET)
  • G protein-coupled receptors (GPCR)
  • Dimerisation
  • Heteromerisation
  • Arrestin

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2005 2022

Research Output 2002 2018

1 Citations

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes

O'Brien, S. L., Johnstone, E. K. M., Devost, D., Conroy, J., Reichelt, M. E., Purdue, B. W., Ayoub, M. A., Kawai, T., Inoue, A., Eguchi, S., Hébert, T. E., Pfleger, K. D. G. & Thomas, W. G., 1 Dec 2018, In : Biochemical Pharmacology. 158, p. 232-242 11 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Bioluminescence
Energy Transfer
Epidermal Growth Factor Receptor
Energy transfer

Experiential Training Courses for Medical Technology and Pharmaceutical Translation

Bradley, R. & Pfleger, K., 28 Nov 2018.

Research output: Contribution to conferencePoster

Pharmaceutical Technology
Ecosystem
Biomedical Research
Aptitude
Organized Financing

Investigating microRNA-7 as a potential therapeutic in cancer

Horsham, J., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
MicroRNAs
Neoplasms
Nanoparticles
Therapeutics
Second Primary Neoplasms

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression

Sampaio, N. G., Kocan, M., Schofield, L., Pfleger, K. D. G. & Eriksson, E. M., 1 Aug 2018, In : PLoS One. 13, 8, e0202408.

Research output: Contribution to journalArticle

Open Access
Bioluminescence
bioluminescence
Energy Transfer
energy transfer
Artifacts

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Pickering, R., Tikellis, C., Rosado, C., Tsorotes, D., Dimitrropoulos, A., Smith, M., Huet, O., Bradley, R., Abhayawardana, R., Sargent, E., Golledge, J., Wang, Y., Jandeleit-Dahm, K., Cooper, M., Pfleger, K. & Thomas, M. C., 10 Dec 2018, In : The Journal of clinical investigation. 129, 1

Research output: Contribution to journalArticle

Angiotensins
Transcriptional Activation
Atherosclerosis
Inflammation
Angiotensin II