Kevin Pfleger

Professor

  • The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • 2235 Citations
  • 23 h-Index
20022022
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Personal profile

Biography

Professor Kevin Pfleger is Director, Biomedical Innovation at The University of Western Australia (UWA) and the MTPConnect WA Life Sciences Innovation Hub, as well as Head of Molecular Endocrinology and Pharmacology at the UWA Centre for Medical Research (Harry Perkins Institute of Medical Research). He is also Chief Scientific Advisor of Dimerix Limited, an ASX-listed spin-out company from UWA. Prof Pfleger was awarded his MA and PhD from Cambridge and Edinburgh Universities respectively, and relocated to Western Australia in October 2002. He was a National Health and Medical Research Council (NHMRC) Peter Doherty Research Fellow from 2005 to 2008, an Australian Research Council (ARC) Future Fellow from 2011 to 2014, and NHMRC RD Wright Fellow (Level 2) from 2015 to 2018.

Roles and responsibilities

Director, Biomedical Innovation

Head of Molecular Endocrinology and Pharmacology

Teaching Molecular Pharmacology of GPCRs and Molecular Neuroendocrinology

Chair of Accelerating Australia Executive Committee

Board Member of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)

Member of the International Advisory Group of the British Pharmacological Society

Member of the WA Branch Committee of AusBiotech

Commercialisation Representative on the WAHTN Management Committee

Education/Academic qualification

Natural Sciences - Pharmacology, MA, University of Cambridge

Molecular Endocrinology and Pharmacology, PhD, University of Edinburgh

External positions

Chief Scientific Advisor, Dimerix Limited

Keywords

  • Assay technology
  • Endocrinology—receptors
  • Molecular pharmacology
  • Protein interactions
  • Bioluminescence resonance energy transfer (BRET)
  • G protein-coupled receptors (GPCR)
  • Dimerisation
  • Heteromerisation
  • Arrestin

Fingerprint Dive into the research topics where Kevin Pfleger is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output 2002 2019

1 Citation (Scopus)

Complex Formation between VEGFR2 and the β2-Adrenoceptor

Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841.e9

Research output: Contribution to journalArticle

Open Access
Adrenergic Receptors
Intracellular Signaling Peptides and Proteins
Bioluminescence
Endosomes
Energy Transfer

Detection and characterisation of GPCR heteromers using NanoBRET ligand binding

Johnstone, E. K., See, H. B., Abhayawardana, R. S., Song, A., Rosengren, K. J., Hill, S. J. & Pfleger, K. D., Aug 2019, In : British Journal of Pharmacology. 176, 16, p. 3046-3046 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex

Hemming, I. A., Clément, O., Gladwyn-Ng, I. E., Cullen, H. D., Ng, H. L., See, H. B., Ngo, L., Ulgiati, D., Pfleger, K. D. G., Agostino, M. & Heng, J. I. T., 21 May 2019, In : Human Mutation. 15 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
DNA
Zinc Fingers
Brain Diseases
1 Citation (Scopus)

NanoBRET: The Bright Future of Proximity-Based Assays

Dale, N. C., Johnstone, E. K. M., White, C. W. & Pfleger, K. D. G., 26 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, MAR, 13 p., 56.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)

NanoBRET ligand binding at a GPCR under endogenous promotion facilitated by CRISPR/Cas9 genome editing

White, C. W., Johnstone, E. K. M., See, H. B. & Pfleger, K. D. G., Feb 2019, In : Cellular Signalling. 54, p. 27-34 8 p.

Research output: Contribution to journalArticle

Projects 2005 2022