Kevin Pfleger

Associate Professor

  • The University of Western Australia (M519), 35 Stirling Highway,

    6009 Crawley

    Australia

  • 1848 Citations
  • 22 h-Index
20022018
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Personal profile

Biography

Associate Professor Kevin Pfleger is Head of Molecular Endocrinology and Pharmacology at the Harry Perkins Institute of Medical Research and the Centre for Medical Research, The University of Western Australia (UWA). He is a National Health and Medical Research Council (NHMRC) RD Wright Fellow (Level 2) and Chief Scientific Advisor of Dimerix Limited, an ASX-listed spin-out company from the Perkins and UWA. A/Prof Pfleger was awarded his MA and PhD from Cambridge and Edinburgh Universities respectively, and relocated to Western Australia in October 2002. He was a NHMRC Peter Doherty Research Fellow from 2005 to 2008 and an Australian Research Council (ARC) Future Fellow from 2011 to 2014.

Roles and responsibilities

Chair-Elect of the Scientific Advisory Committee of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
President of the UWA Researchers' Association

Keywords

  • Assay technology
  • Endocrinology—receptors
  • Molecular pharmacology
  • Protein interactions
  • Bioluminescence resonance energy transfer (BRET)
  • G protein-coupled receptors (GPCR)
  • Dimerisation
  • Heteromerisation
  • Arrestin

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Chemokine Receptors Medicine & Life Sciences
Proteins Medicine & Life Sciences

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Projects 2005 2018

Research Output 2002 2018

Investigating microRNA-7 as a potential therapeutic in cancer

Horsham, J. 2018 (Unpublished)

Research output: ThesisDoctoral Thesis

File
MicroRNAs
Neoplasms
Nanoparticles
Therapeutics
Second Primary Neoplasms

Disease-associated mutations in RP58 disrupt its neuronal functions through a mechanism involving transcriptional regulation

Hemming, I. A., Clement, O., Gladwyn-Ng, I. E., Ng, H. L., See, E., Ngo, L., Ulgiati, D., Pfleger, K. D. G. & Heng, J. I. -T. Aug 2017 In : Journal of Neurochemistry. 142, p. 90-90 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

5 Citations

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J. 23 May 2017 In : Science Signaling. 10, 480, eaai8529

Research output: Contribution to journalArticle

Monocyte Chemoattractant Proteins
Chemokine Receptors
Chemokines
Chemical activation
Chemokine CCL2
3 Citations

Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time

White, C. W., Vanyai, H. K., See, H. B., Johnstone, E. K. M. & Pfleger, K. D. G. 9 Jun 2017 In : Scientific Reports. 7, 1, 3187

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Energy Transfer
Genome
G-Protein-Coupled Receptors
Proteins
18 Citations

Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding

Stoddart, L. A., White, C., Nguyen, K., Hill, S. & Pfleger, K. 1 Oct 2016 In : British Journal of Pharmacology. 173, 20, p. 3028-3037 10 p.

Research output: Contribution to journalArticle

Open Access
Fluorescence
Ligands
Fluorescence Resonance Energy Transfer
Pharmacology
Fluorescence Polarization