Kevin Pfleger

Associate Professor

  • The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • 1957 Citations
  • 23 h-Index
20022022
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Associate Professor Kevin Pfleger is Head of Molecular Endocrinology and Pharmacology at the Harry Perkins Institute of Medical Research and the Centre for Medical Research, The University of Western Australia (UWA). He is a National Health and Medical Research Council (NHMRC) RD Wright Fellow (Level 2) and Chief Scientific Advisor of Dimerix Limited, an ASX-listed spin-out company from the Perkins and UWA. A/Prof Pfleger was awarded his MA and PhD from Cambridge and Edinburgh Universities respectively, and relocated to Western Australia in October 2002. He was a NHMRC Peter Doherty Research Fellow from 2005 to 2008 and an Australian Research Council (ARC) Future Fellow from 2011 to 2014.

Roles and responsibilities

Head of Molecular Endocrinology and Pharmacology

Teaching Molecular Pharmacology of GPCRs and Molecular Neuroendocrinology

Chair of Accelerating Australia Executive Committee

Chair of the Scientific Advisory Committee of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)

Member of the International Advisory Group of the British Pharmacological Society

Member of the WA Branch Committee of AusBiotech

Commercialisation Representative on the WAHTN Management Committee

Education/Academic qualification

Natural Sciences - Pharmacology, MA, University of Cambridge

Molecular Endocrinology and Pharmacology, PhD, University of Edinburgh

External positions

Chief Scientific Advisor, Dimerix Limited

Keywords

  • Assay technology
  • Endocrinology—receptors
  • Molecular pharmacology
  • Protein interactions
  • Bioluminescence resonance energy transfer (BRET)
  • G protein-coupled receptors (GPCR)
  • Dimerisation
  • Heteromerisation
  • Arrestin

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Energy Transfer Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Bioluminescence Chemical Compounds
Energy transfer Chemical Compounds
Proteins Medicine & Life Sciences
Ligands Medicine & Life Sciences
LHRH Receptors Medicine & Life Sciences
Chemokine Receptors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2005 2022

Research Output 2002 2018

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes

O'Brien, S. L., Johnstone, E. K. M., Devost, D., Conroy, J., Reichelt, M. E., Purdue, B. W., Ayoub, M. A., Kawai, T., Inoue, A., Eguchi, S., Hébert, T. E., Pfleger, K. D. G. & Thomas, W. G., 1 Dec 2018, In : Biochemical Pharmacology. 158, p. 232-242 11 p.

Research output: Contribution to journalArticle

Bioluminescence
Energy Transfer
Epidermal Growth Factor Receptor
Energy transfer
Transcriptional Activation

Investigating microRNA-7 as a potential therapeutic in cancer

Horsham, J., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
MicroRNAs
Neoplasms
Nanoparticles
Therapeutics
Second Primary Neoplasms

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression

Sampaio, N. G., Kocan, M., Schofield, L., Pfleger, K. D. G. & Eriksson, E. M., 1 Aug 2018, In : PLoS One. 13, 8, e0202408

Research output: Contribution to journalArticle

Open Access
Bioluminescence
bioluminescence
Energy Transfer
energy transfer
Artifacts

Disease-associated mutations in RP58 disrupt its neuronal functions through a mechanism involving transcriptional regulation

Hemming, I. A., Clement, O., Gladwyn-Ng, I. E., Ng, H. L., See, E., Ngo, L., Ulgiati, D., Pfleger, K. D. G. & Heng, J. I. -T., Aug 2017, In : Journal of Neurochemistry. 142, p. 90-90 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

7 Citations

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J., 23 May 2017, In : Science Signaling. 10, 480, eaai8529

Research output: Contribution to journalArticle

Monocyte Chemoattractant Proteins
Chemokine Receptors
Chemokines
Chemical activation
Chemokine CCL2