Kevin Pfleger


  • The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth


  • 2163 Citations
  • 23 h-Index
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Personal profile


Professor Kevin Pfleger is Director of the WA Life Sciences Innovation Hub, Office of the Deputy Vice-Chancellor (Research), The University of Western Australia (UWA), as well as Head of Molecular Endocrinology and Pharmacology at the UWA Centre for Medical Research (Harry Perkins Institute of Medical Research). He is also Chief Scientific Advisor of Dimerix Limited, an ASX-listed spin-out company from UWA. Prof Pfleger was awarded his MA and PhD from Cambridge and Edinburgh Universities respectively, and relocated to Western Australia in October 2002. He was a National Health and Medical Research Council (NHMRC) Peter Doherty Research Fellow from 2005 to 2008, an Australian Research Council (ARC) Future Fellow from 2011 to 2014, and NHMRC RD Wright Fellow (Level 2) from 2015 to 2018.

Roles and responsibilities

Director, WA Life Sciences Innovation Hub

Head of Molecular Endocrinology and Pharmacology

Teaching Molecular Pharmacology of GPCRs and Molecular Neuroendocrinology

Chair of Accelerating Australia Executive Committee

Board Member of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)

Member of the International Advisory Group of the British Pharmacological Society

Member of the WA Branch Committee of AusBiotech

Commercialisation Representative on the WAHTN Management Committee

Education/Academic qualification

Natural Sciences - Pharmacology, MA, University of Cambridge

Molecular Endocrinology and Pharmacology, PhD, University of Edinburgh

External positions

Chief Scientific Advisor, Dimerix Limited


  • Assay technology
  • Endocrinology—receptors
  • Molecular pharmacology
  • Protein interactions
  • Bioluminescence resonance energy transfer (BRET)
  • G protein-coupled receptors (GPCR)
  • Dimerisation
  • Heteromerisation
  • Arrestin

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2002 2019

Complex Formation between VEGFR2 and the β2-Adrenoceptor

Kilpatrick, L. E., Alcobia, D. C., White, C. W., Peach, C. J., Glenn, J. R., Zimmerman, K., Kondrashov, A., Pfleger, K. D. G., Ohana, R. F., Robers, M. B., Wood, K. V., Sloan, E. K., Woolard, J. & Hill, S. J., 20 Jun 2019, In : Cell Chemical Biology. 26, 6, p. 830-841.e9

Research output: Contribution to journalArticle

Open Access
Adrenergic Receptors
Intracellular Signaling Peptides and Proteins
Energy Transfer

NanoBRET: The Bright Future of Proximity-Based Assays

Dale, N. C., Johnstone, E. K. M., White, C. W. & Pfleger, K. D. G., 26 Mar 2019, In : Frontiers in Bioengineering and Biotechnology. 7, MAR, 13 p., 56.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

NanoBRET ligand binding at a GPCR under endogenous promotion facilitated by CRISPR/Cas9 genome editing

White, C. W., Johnstone, E. K. M., See, H. B. & Pfleger, K. D. G., Feb 2019, In : Cellular Signalling. 54, p. 27-34 8 p.

Research output: Contribution to journalArticle

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Pickering, R., Tikellis, C., Rosado, C., Tsorotes, D., Dimitrropoulos, A., Smith, M., Huet, O., Seeber, R., Abhayawardana, R., Johnstone, E., Golledge, J., Wang, Y., Jandeleit-Dahm, K., Cooper, M., Pfleger, K. & Thomas, M. C., 2 Jan 2019, In : The Journal of clinical investigation. 129, 1, p. 406-421 CI99987.

Research output: Contribution to journalArticle

Transcriptional Activation
Angiotensin II
1 Citation (Scopus)

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes

O'Brien, S. L., Johnstone, E. K. M., Devost, D., Conroy, J., Reichelt, M. E., Purdue, B. W., Ayoub, M. A., Kawai, T., Inoue, A., Eguchi, S., Hébert, T. E., Pfleger, K. D. G. & Thomas, W. G., 1 Dec 2018, In : Biochemical Pharmacology. 158, p. 232-242 11 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Energy Transfer
Epidermal Growth Factor Receptor
Energy transfer

Projects 2005 2022