Kenneth Ilett

Emeritus Professor

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth

    Australia

  • 6536 Citations
  • 46 h-Index
19922017
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Research Output 1992 2017

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Article
2017
1 Citation (Scopus)

Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling

Salman, S., Baiwog, F., Page-Sharp, M., Kose, K., Karunajeewa, H. A., Mueller, I., Rogerson, S. J., Siba, P. M., Ilett, K. F. & Davis, T. M. E., Oct 2017, In : International Journal of Antimicrobial Agents. 50, 4, p. 542–551

Research output: Contribution to journalArticle

Chloroquine
Antimalarials
Pharmacokinetics
Pregnancy
Population
1 Citation (Scopus)
68 Downloads (Pure)

Optimal antimalarial dose regimens for sulfadoxine-pyrimethamine with and without azithromycin in pregnancy based on population pharmacokinetic modeling

Salman, S., Baiwog, F., Page-Sharp, M., Griffin, S., Karunajeewa, H. A., Mueller, I., Rogerson, S. J., Siba, P., Ilett, K. & Davis, T., May 2017, In : Antimicrobial Agents and Chemotherapy. 61, 5, e02291.

Research output: Contribution to journalArticle

Open Access
File
Azithromycin
Antimalarials
Pharmacokinetics
Pregnancy
Population
2014
6 Citations (Scopus)

Population PK modeling and simulation based on fluoxetine and norfluoxetine concentrations in milk: A milk concentration-based prediction model

Tanoshima, R., Bournissen, F. G., Tanigawara, Y., Kristensen, J. H., Taddio, A., Ilett, K., Begg, E. J., Wallach, I. & Ito, S., 2014, In : British Journal of Clinical Pharmacology. 78, 4, p. 918–928

Research output: Contribution to journalArticle

8 Citations (Scopus)

The wellbeing of infants exposed to buprenorphine via breast milk at 4 weeks of age

Gower, S., Bartu, A. E., Ilett, K., Doherty, D., Mclaurin, R. & Hamilton, D., 2014, In : Journal of Human Lactation. 30, 2, p. 217-223

Research output: Contribution to journalArticle

Buprenorphine
Human Milk
Skin Pigmentation
Feeding Behavior
Sleep
2013
5 Citations (Scopus)

Mass or molar? Recommendations for reporting concentrations of therapeutic drugs

Jones, G. R. D., Bryant, S., Fullinfaw, R. O., Ilett, K., Miners, J. O., Morris, R. G. & Doogue, M. P., 2013, In : Medical Journal of Australia. 198, 7, p. 1-4

Research output: Contribution to journalArticle

Pharmaceutical Preparations
ferrous sulfate
New Zealand
Therapeutics
Australasia
2012
29 Citations (Scopus)

Artemisinin-Naphthoquine Combinations therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study

Batty, K., Salman, S., Moore, B., Benjamin, J., Lee, S. T., Page-Sharp, M., Pitus, N., Ilett, K., Mueller, I., Hombhanje, F., Siba, P. & Davis, T., 2012, In : Antimicrobial Agents and Chemotherapy. 56, p. 2472-2484

Research output: Contribution to journalArticle

9 Citations (Scopus)

Buprenorphine exposure in infants of opioid-dependent mothers at birth

Bartu, A. E., Ilett, K., Hackett, L. P., Doherty, D. & Hamilton, D., 2012, In : Australian and New Zealand Journal of Obstetrics and Gynaecology. 52, 4, p. 342-347

Research output: Contribution to journalArticle

13 Citations (Scopus)
28 Citations (Scopus)

Estimated dose exposure of the neonate to buprenorphine and its metabolite norbuprenorphine via breastmilk during maternal buprenorphine substitution treatment

Ilett, K., Hackett, L. P., Gower, S., Doherty, D., Hamilton, D. & Bartu, A. E., 2012, In : Breastfeeding Medicine. 7, 4, p. 269-274

Research output: Contribution to journalArticle

22 Citations (Scopus)

Pharmacokinetic Comparison of Two Piperaquine-Containing Artemisinin Combination Therapies in Papua New Guinean Children with Uncomplicated Malaria

Salman, S., Page-Sharp, M., Batty, K., Kose, K., Griffin, S., Siba, P. M., Ilett, K., Mueller, I. & Davis, T., 2012, In : Antimicrobial Agents and Chemotherapy. 56, p. 3288-3297

Research output: Contribution to journalArticle

12 Citations (Scopus)
2011
37 Citations (Scopus)
Antimalarials
dihydroartemisinin
Confidence Intervals
artemether
lumefantrine
13 Citations (Scopus)

Estimation of desvenlafaxine transfer into milk and infant exposure during its use in lactating women with postnatal depression

Rampono, J., Teoh, S., Hackett, L. P., Kohan, R. & Ilett, K., 2011, In : ARCHIVES OF WOMENS MENTAL HEALTH. 14, p. 49-53

Research output: Contribution to journalArticle

10 Citations (Scopus)

Pharmacokinetic Properties of Conventional and Double-Dose Sulfadoxine-Pyrimethamine Given as Intermittent Preventive Treatment in Infancy

Salman, S., Griffin, S., Kose, K., Pitus, N., Winmai, J., Moore, B., Siba, P., Ilett, K., Mueller, I. & Davis, T., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 4, p. 1693-1700

Research output: Contribution to journalArticle

37 Citations (Scopus)

Pharmacokinetics, Pharmacodynamics, and Allometric Scaling of Chloroquine in a Murine Malaria Model

Moore, B. R., Page-Sharp, M., Stoney, J. R., Ilett, K., Jago, J. D. & Batty, K. T., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 8, p. 3899-3907

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

Salman, S., Sy, S. K. B., Ilett, K., Page-Sharp, M. & Paech, M., 2011, In : European Journal of Clinical Pharmacology. 67, p. 899-908

Research output: Contribution to journalArticle

41 Citations (Scopus)

Population pharmacokinetics of artemether, lumefantrine and their respective metabolites in Papua New Guinean children with uncomplicated malaria

Salman, S., Page-Sharp, M., Griffin, S., Kose, K., Siba, P. M., Ilett, K., Mueller, I. & Davis, T., 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5306-5313

Research output: Contribution to journalArticle

15 Citations (Scopus)

Prediction of Infant Drug Exposure Through Breastfeeding: Population PK Modeling and Simulation of Fluoxetine Exposure

Panchaud, A., Garcia-Bournissen, F., Csajka, C., Kristensen, J. H., Taddio, A., Ilett, K., Begg, E. J. & Ito, S., 2011, In : Clinical pharmacology & therapeutics. 89, 6, p. 830-836

Research output: Contribution to journalArticle

2010
13 Citations (Scopus)

Assessment of infant dose through milk in a lactating woman taking Amisulpride and Desvenlafaxine for treatment-resistant depression

Ilett, K., Watt, F., Hackett, L. P., Kohan, R. & Teoh, S., 2010, In : Therapeutic Drug Monitoring. 32, p. 704-707

Research output: Contribution to journalArticle

13 Citations (Scopus)

CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess

Von Ahsen, N., Tzvetkov, M., Karunajeewa, H., Gomorrai, S., Ura, A., Brockmoller, J., Davis, T., Mueller, I., Ilett, K. & Oellerich, M., 2010, In : International Journal of Molecular Epidemiology and Genetics. 1, 4, p. 310-319

Research output: Contribution to journalArticle

8 Citations (Scopus)

Effective clearance of Ara-U the major metabolite of cytosine arabinoside (Ara-C) by hemodialysis in a patient with lymphoma and end-stage renal failure

Radeski, D., Cull, G. M., Cain, M., Hackett, L. P. & Ilett, K., 2010, In : Cancer Chemotherapy and Pharmacology. 67, 4, p. 765-768

Research output: Contribution to journalArticle

11 Citations (Scopus)

Investigation of reproductive toxicity of piperaquine in mice

Batty, K. T., Moore, B., Stirling, V., Ilett, K., Page-Sharp, M., Shilkin, K., Mueller, I., Rogerson, S. J., Karunajeewa, H. A. & Davis, T., 2010, In : Reproductive Toxicology. 29, p. 206-213

Research output: Contribution to journalArticle

21 Citations (Scopus)

In virto sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea

Wong, R. P. M., Lautu, D., Tavul, L., Hackett, S. L., Siba, P., Karunajeewa, H. A., Ilett, K., Mueller, I. & Davis, T., 2010, In : TROPICAL MEDICINE & INTERNATIONAL HEALTH. 15, 3, p. 342-349

Research output: Contribution to journalArticle

30 Citations (Scopus)

Pharmacokinetic Properties of Azithromycin in Pregnancy

Salman, S., Rogerson, S. J., Kose, K., Griffin, S., Gomoria, S., Baiwog, F., Winmai, J., Kandai, J., Karunajeewa, H., O'Halloran, S. J., Siba, P., Ilett, K., Mueller, I. & Davis, T., 2010, In : Antimicrobial Agents and Chemotherapy. 54, 1, p. 360-366

Research output: Contribution to journalArticle

29 Citations (Scopus)

Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy

Karunajeewa, H. A., Salman, S., Mueller, I., Baiwog, F., Gomorrai, S., Law, I., Page-Sharp, M., Rogerson, S., Siba, P., Ilett, K. & Davis, T., 2010, In : Antimicrobial Agents and Chemotherapy. 54, 3, p. 1186-1192

Research output: Contribution to journalArticle

6 Citations (Scopus)

Stability and Tolerability of High Concentrations of Intrathecal Bupivacaine and Opioid Mixtures in Chronic Noncancer Pain: An Open-Label Pilot Study

Goucke, R., Dusci, L. J., Van Leeuwen, S., Fairclough, D. & Ilett, K., 2010, In : Pain Medicine. 11, p. 1612-1618

Research output: Contribution to journalArticle

2009
43 Citations (Scopus)
Ketamine
Neuralgia
Cross-Over Studies
Sublingual Administration
Biological Availability
45 Citations (Scopus)

Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women

Karunajeewa, H. A., Salman, S., Mueller, I., Baiwog, F., Gomorrai, S., Law, I., Page-Sharp, M., Rogerson, S., Siba, P., Ilett, K. & Davis, T., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 10, p. 4368-4376

Research output: Contribution to journalArticle

Pyrimethamine
Sulfadoxine
Pregnant Women
Pharmacokinetics
Pregnancy
8 Citations (Scopus)

Piperaquine pharmacodynamics and parasite viability in a murine malaria model

Moore, B. R., Ilett, K., Page-Sharp, M., Jago, J. D. & Batty, K. T., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2707-2713

Research output: Contribution to journalArticle

Malaria
Parasites
Plasmodium berghei
Antimalarials
Pharmaceutical Preparations
37 Citations (Scopus)

Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine

Bartu, A., Dusci, L. J. & Ilett, K., 2009, In : British Journal of Clinical Pharmacology. 67, 4, p. 455-459

Research output: Contribution to journalArticle

Methamphetamine
Human Milk
Milk
Breast Feeding
Amphetamines
1 Citation (Scopus)

Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk

Hotham, N. J., Ilett, K., Hackett, L. P., Morton, M. R., Muller, P. & Hague, W. M., 2009, In : Journal of Human Lactation. 25, 4, p. 451-454

Research output: Contribution to journalArticle

Metyrapone
Human Milk
Milk
Adrenocortical Hyperfunction
Breast Feeding
2008
144 Citations (Scopus)

A Trial of Combination Antimalarial Therapies in Children from Papua New Guinea

Karunajeewa, H., Mueller, I., Senn, M., Lin, E., Law, I., Servina Gomorrai, P., Oa, O., Griffin, S., Kotab, K., Suano, P., Tarongka, N., Ura, A., Lautu, D., Page-Sharp, M., Wong, R. P., Salman, S., Siba, P., Ilett, K. & Davis, T., 2008, In : The New England Journal of Medicine. 359, 24, p. 2545 - 2557

Research output: Contribution to journalArticle

dihydroartemisinin
Papua New Guinea
Antimalarials
Chloroquine
Plasmodium falciparum
15 Citations (Scopus)

Disposition and clinical outcome after intraperitoneal meperidine and ropivacaine administration during laparoscopic surgery

Paech, M., Ilett, K., Hackett, L. P., Page-Sharp, M. & Parsons, R. W., 2008, In : Anesthesia and Analgesia. 106, 1, p. 278-286

Research output: Contribution to journalArticle

Meperidine
Laparoscopy
Pain
Opioid Analgesics
Postoperative Care
48 Citations (Scopus)
Domperidone
Milk
Mothers
Prolactin
Breast Feeding
27 Citations (Scopus)
Electrospray ionization
Electrospray Ionization Mass Spectrometry
Deuterium
Sirolimus
Tandem Mass Spectrometry
60 Citations (Scopus)

Pharmacokinetics and Efficacy of Piperaquine and Chloroquine in Melanesian Children with Uncomplicated Malaria

Karunajeewa, H., Ilett, K., Mueller, I., Siba, P., Law, I., Page-Sharp, M., Lin, E., Lammey, J., Batty, K. T. & Davis, T., 2008, In : Antimicrobial Agents and Chemotherapy. 52, 1, p. 237-243

Research output: Contribution to journalArticle

Chloroquine
Malaria
Pharmacokinetics
dihydroartemisinin
Half-Life
19 Citations (Scopus)

Pharmacokinetics and Pharmacodynamics of Piperaquine in a Murine Malaria Model

Moore, B. R., Batty, K. T., Andrzejewski, C., Jago, J. D., Page-Sharp, M. & Ilett, K., 2008, In : Antimicrobial Agents and Chemotherapy. 52, 1, p. 306-311

Research output: Contribution to journalArticle

Malaria
Pharmacokinetics
Phosphates
Plasmodium berghei
dihydroartemisinin
11 Citations (Scopus)

Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model

Batty, KT., Gibbons, P., Davis, T., Tme, N. V. & Ilett, K., 2008, In : American Journal of Tropical Medicine and Hygiene. 78, 4, p. 641-642

Research output: Contribution to journalArticle

dihydroartemisinin
Malaria
Pharmacokinetics
Half-Life
7 Citations (Scopus)

Toxicology and pharmacokinetics of piperaquine in mice

Batty, K. T., Moore, B., Stirling, V., Ilett, K., Page-Sharp, M., Shilkin, K. B., Mueller, I., Karunajeewa, H. A. & Davis, T., 2008, In : Toxicology. 249, 1, p. 55-61

Research output: Contribution to journalArticle

Pharmacokinetics
Toxicology
Liver
Kidney
Phosphates
24 Citations (Scopus)

Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers

Law, I., Ilett, K., Hackett, L. P., Page-Sharp, M., Baiwog, F., Gomorrai, S., Mueller, I., Karunajeewa, H. & Davis, T., 2008, In : British Journal of Clinical Pharmacology. 65, 5, p. 674-679

Research output: Contribution to journalArticle

Chloroquine
Placenta
Milk
Mothers
Papua New Guinea
44 Citations (Scopus)

Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk

Ilett, K., Paech, M., Page-Sharp, M., Sy, S. K., Kristensen, J. H., Goy, R., Chua, S., Christmas, T. & Scott, K. L., 2008, In : British Journal of Clinical Pharmacology. 65, 5, p. 661-666

Research output: Contribution to journalArticle

Tramadol
Sampling Studies
Human Milk
Milk
Breast Feeding
2007
14 Citations (Scopus)

Assessment of the Effect of Mefloquine on Artesunate Pharmacokinetics in Healthy Male Volunteers

Davis, T., England, M., Dunlop, A., Page-Sharp, M., Cambon, N., Keller, T. G., Heidecker, J. L. & Ilett, K., 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 1099-1101

Research output: Contribution to journalArticle

Mefloquine
Healthy Volunteers
dihydroartemisinin
Pharmacokinetics
Volunteers
6 Citations (Scopus)
Enflurane
Cardiopulmonary Bypass
Membrane Oxygenators
Rewarming
Hypothermia
11 Citations (Scopus)

Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin

Gibbons, P. L., Batty, K. T., Barrett, H., Davis, T. & Ilett, K., 2007, In : International Journal for Parasitology. 37, 14, p. 1569-1576

Research output: Contribution to journalArticle

dihydroartemisinin
Parasitemia
Antimalarials
Malaria
Parasites
37 Citations (Scopus)

Rectal administration of Artemisinin derivatives for the treatment of malaria

Karunajeewa, H., Manning, L. A., Mueller, I., Ilett, K. & Davis, T., 2007, In : JAMA: The Journal of the American Medical Association. 297, 21, p. 2381-2390

Research output: Contribution to journalArticle

Rectal Administration
Malaria
dihydroartemisinin
Pharmacokinetics
Parasites
33 Citations (Scopus)

Transfer of the antidepressant mirtazapine into breast milk

Kristensen, J. H., Ilett, K., Rampono, J., Kohan, R. & Hackett, L. P., 2007, In : British Journal of Clinical Pharmacology. 63, 3, p. 322-327

Research output: Contribution to journalArticle

Human Milk
Antidepressive Agents
Milk
Breast
mirtazapine
2006
37 Citations (Scopus)

Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea

Karunajeewa, H. A., Reeder, J., Lorry, K., Dabod, E., Hamzah, J., Page-Sharp, M., Chiswell, G. M., Ilett, K. & Davis, T., 2006, In : Antimicrobial Agents and Chemotherapy. 50, 3, p. 968-974

Research output: Contribution to journalArticle

Papua New Guinea
Suppositories
Malaria
dihydroartemisinin
Parasites