Keith Stubbs

Dr, BSc PhD W.Aust.

  • The University of Western Australia (M313), 35 Stirling Highway, Room 410, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 2638 Citations
  • 24 h-Index
20012021

Research output per year

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Research Output

2020

Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum

Li, H., Wei, H., Hu, J., Lacey, E., Sobolev, A. N., Stubbs, K. A., Solomon, P. S. & Chooi, Y. H., 17 Jan 2020, In : ACS Chemical Biology. 15, 1, p. 226-233

Research output: Contribution to journalArticle

2019

Biosynthesis of a Tricyclo[6.2.2.02,7]dodecane System by a Berberine Bridge Enzyme-Like Aldolase

Li, H., Hu, J., Wei, H., Solomon, P. S., Stubbs, K. A. & Chooi, Y. H., 25 Sep 2019, In : Chemistry - A European Journal.

Research output: Contribution to journalArticle

1 Citation (Scopus)

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

Li, H., Marceau, M., Yang, T., Liao, T., Tang, X., Hu, R., Xie, Y., Tang, H., Tay, A., Shi, Y., Shen, Y., Yang, T., Pi, X., Lamichhane, B., Luo, Y., Debowski, A. W., Nilsson, H. O., Haslam, S. M., Mulloy, B., Dell, A. & 3 others, Stubbs, K. A., Marshall, B. J. & Benghezal, M., 1 Jan 2019, In : PLoS Genetics. 15, 11, e1008497.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

General Synthesis of 3,4-Dinitrophenyl α-Glycopyranosides

Wallace, M. D. & Stubbs, K. A., 24 Oct 2019, In : ChemistrySelect. 4, 39, p. 11427-11429 3 p.

Research output: Contribution to journalArticle

Open Access
File
236 Downloads (Pure)

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system

Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K. A., Lacey, E., Stewart, S. G., Karton, A., Piggott, A. M. & Chooi, Y-H., 7 Feb 2019, In : Chemical Science. 10, 5, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors

Coyle, T., Wu, L., Debowski, A. W., Davies, G. J. & Stubbs, K. A., 3 Jun 2019, In : ChemBioChem. 20, 11, p. 1365-1368 4 p.

Research output: Contribution to journalArticle

Open Access
2018

A herbicide structure–activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 1 Jul 2018, In : Pest Management Science. 74, 7, p. 1558-1563 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

Ho, L. A., Winogrodzki, J. L., Debowski, A. W., Madden, Z., Vocadlo, D. J., Mark, B. L. & Stubbs, K. A., 1 Jan 2018, In : Chemical Communications. 54, 75, p. 10630-10633 4 p.

Research output: Contribution to journalArticle

File
3 Citations (Scopus)
304 Downloads (Pure)

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Ho, L. A., Raston, C. L. & Stubbs, K. A., 21 Jun 2018, In : Chemistry - A European Journal. 24, 35, p. 8869-8874 6 p.

Research output: Contribution to journalArticle

File
5 Citations (Scopus)
203 Downloads (Pure)

Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum

Li, H., Hu, J., Wei, H., Solomon, P. S., Vuong, D., Lacey, E., Stubbs, K. A., Piggott, A. M. & Chooi, Y. H., 5 Oct 2018, In : Organic Letters. 20, 19, p. 6148-6152 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Wallace, M. D., Waraich, N. F., Debowski, A. W., Corral, M. G., Maxwell, A., Mylne, J. S. & Stubbs, K. A., 21 Feb 2018, In : Chemical Communications. 54, 15, p. 1869-1872 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Enzyme targets for drug design of new anti-virulence therapeutics

Kahler, C. M., Sarkar-Tyson, M., Kibble, E. A., Stubbs, K. A. & Vrielink, A., 1 Dec 2018, In : Current Opinion in Structural Biology. 53, p. 140-150 11 p.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
364 Downloads (Pure)

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: A potent inhibitor of α-N-acetylgalctosaminidases

Wills, S. S., Raston, C. L. & Stubbs, K. A., 15 Dec 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 23-24, p. 3748-3751 4 p.

Research output: Contribution to journalArticle

Lipopolysaccharide structural differences between western and Asian Helicobacter pylori strains

Li, H., Tang, H., Debowski, A. W., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 8 Sep 2018, In : Toxins. 10, 9, 364.

Research output: Contribution to journalReview article

Open Access
5 Citations (Scopus)

Potent inhibition of a GH20 exo-β-N-acetylglucosaminidase from marine Vibrio bacteria by reaction intermediate analogues

Meekrathok, P., Stubbs, K. A. & Suginta, W., 1 Aug 2018, In : International Journal of Biological Macromolecules. 115, p. 1165-1173 9 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
138 Downloads (Pure)

Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25A° resolution

Moroz, O. V., Sobala, L. F., Blagova, E., Coyle, T., Peng, W., Krogh, K. B. R. M., Stubbs, K. A., Wilson, K. S. & Davies, G. J., 1 Aug 2018, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 8, p. 490-495 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance

Corral, M. G., Haywood, J., Stehl, L. H., Stubbs, K. A., Murcha, M. W. & Mylne, J. S., 1 Aug 2018, In : Plant Journal. 95, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
192 Downloads (Pure)
2017

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

Bartley, S. N., Mowlaboccus, S., Mullally, C. A., Stubbs, K. A., Vrielink, A., Maiden, M. C. J., Harrison, O. B., Perkins, T. T. & Kahler, C. M., 14 Mar 2017, In : Scientific Reports. 7, 14 p., 44442.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria

Ficko-Blean, E., Préchoux, A., Thomas, F., Rochat, T., Larocque, R., Zhu, Y., Stam, M., Génicot, S., Jam, M., Calteau, A., Viart, B., Ropartz, D., Pérez-Pascual, D., Correc, G., Matard-Mann, M., Stubbs, K. A., Rogniaux, H., Jeudy, A., Barbeyron, T., Médigue, C. & 5 others, Czjzek, M., Vallenet, D., McBride, M. J., Duchaud, E. & Michel, G., 1 Dec 2017, In : Nature Communications. 8, 1, 1685.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

Vadlamani, G., Stubbs, K. A., Désiré, J., Blériot, Y., Vocadlo, D. J. & Mark, B. L., 1 Jun 2017, In : Protein Science. 26, 6, p. 1161-1170 10 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Exploiting sp2-Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors

Coyle, T., Debowski, A. W., Varrot, A. & Stubbs, K. A., 1 Jun 2017, In : ChemBioChem. 18, 11, p. 974-978 5 p.

Research output: Contribution to journalArticle

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 7 Aug 2017, In : Angewandte Chemie - International Edition. 56, 33, p. 9881-9885 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection

Debowski, A. W., Walton, S. M., Chua, E-G., Tay, A. C-Y., Liao, T., Lamichhane, B., Himbeck, R., Stubbs, K. A., Marshall, B. J., Fulurija, A. & Benghezal, M., Jun 2017, In : PLoS Pathogens. 13, 6, 21 p., 1006464.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Herbicidal properties of antimalarial drugs

Corral, M. G., Leroux, J., Stubbs, K. A. & Mylne, J. S., 31 Mar 2017, In : Scientific Reports. 7, 45871.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Yap, H. Y. Y., Muria-Gonzalez, M. J., Kong, B. H., Stubbs, K. A., Tan, C. S., Ng, S. T., Tan, N. H., Solomon, P. S., Fung, S. Y. & Chooi, Y. H., 12 Jun 2017, In : Microbial Cell Factories. 16, 1, 103.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H-O., Haslam, S. M., Dell, A., Stubbs, K. A., Marshall, B. J. & Benghezal, M., May 2017, In : Microbial Cell. 4, 5, p. 175-178 4 p.

Research output: Contribution to journalEditorial

Open Access
3 Citations (Scopus)

Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum

Yamada, C., Gotoh, A., Sakanaka, M., Hattie, M., Stubbs, K. A., Katayama-Ikegami, A., Hirose, J., Kurihara, S., Arakawa, T., Kitaoka, M., Okuda, S., Katayama, T. & Fushinobu, S., 6 Apr 2017, In : Cell Chemical Biology. 24, 4, p. 515–524 e5.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

Anandan, A., Evans, G. L., Condic-Jurkic, K., O'Mara, M. L., John, C. M., Phillips, N. J., Jarvis, G. A., Wills, S. S., Stubbs, K. A., Moraes, I., Kahler, C. M. & Vrielink, A., 28 Feb 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa

Hamou-Segarra, M., Zamorano, L., Vadlamani, G., Chu, M., Sanchez-Diener, I., Juan, C., Blazquez, J., Hattie, M., Stubbs, K. A., Mark, B. L. & Oliver, A., 1 Feb 2017, In : Journal of Antimicrobial Chemotherapy. 72, 2, p. 448-454 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors

Sato, M., Liebschner, D., Yamada, Y., Matsugaki, N., Arakawa, T., Wills, S. S., Hattie, M., Stubbs, K. A., Ito, T., Senda, T., Ashida, H. & Fushinobu, S., 21 Jul 2017, In : Journal of Biological Chemistry. 292, 29, p. 12126-12138 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H., Fulurija, A., Haslam, S., Mulloy, B., Dell, A., Stubbs, K. A., Marshall, B. J. & Benghezal, M., Sep 2017, In : Helicobacter. 22, 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H. O., Fulurija, A., Haslam, S. M., Mulloy, B., Dell, A., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 17 Mar 2017, In : PLoS Pathogens. 13, 3, e1006280.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Understanding protein glycosylation pathways in bacteria

Li, H., Debowski, A. W., Liao, T., Tang, H., Nilsson, H-O., Marshall, B. J., Stubbs, K. A. & Benghezal, M., 1 Jan 2017, In : Future Microbiology. 12, 1, p. 59-72 14 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
568 Downloads (Pure)

Vortex Fluidic Chemical Transformations

Britton, J., Stubbs, K. A., Weiss, G. A. & Raston, C. L., 27 Sep 2017, In : Chemistry: A European Journal. 23, 54, p. 13270–13278 9 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)
2016

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance

Perley-Robertson, G. E., Yadav, A. K., Winogrodzki, J. L., Stubbs, K., Mark, B. L. & Vocadlo, D. J., 2016, In : ACS Chemical Biology. 11, 9, p. 2626-2635

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human: O-GlcNAcase

Cekic, N., Heinonen, J. E., Stubbs, K., Roth, C., He, Y., Bennet, A. J., Mceachern, E. J., Davies, G. J. & Vocadlo, D. J., 2016, In : Chemical Science. 7, 6, p. 3742-3750

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori

Li, H., Liao, T., Debowski, A., Tang, H., Nilsson, H. O., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 1 Dec 2016, In : Helicobacter. 21, 6, p. 445-461 17 p.

Research output: Contribution to journalReview article

Open Access
File
20 Citations (Scopus)
426 Downloads (Pure)

Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

Hattie, M., Cekic, N., Debowski, A., Vocadlo, D. J. & Stubbs, K., 23 Feb 2016, In : Organic and Biomolecular Chemistry. 14, 12, p. 3193-3197

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
257 Downloads (Pure)

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut

Hemsworth, G. R., Thompson, A. J., Stepper, J., Sobala, T. F., Coyle, T., Larsbrink, J., Spadiut, O., Goddard-Borger, E. D., Stubbs, K., Brumer, H. & Davies, G. J., 27 Jul 2016, In : Open Biology. 6, 7, p. 1-14

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Transition-Metal-Free Cross-Coupling Reactions in Dynamic Thin Films To Access Pyrimidine and Quinoxaline Analogues

Ho, L. A., Raston, C. L. & Stubbs, K. A., Dec 2016, In : European Journal of Organic Chemistry. 2016, 36, p. 5957-5963

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

An improved preparation of some aryl α- L -arabinofuranosides for use as chromogenic substrates for α- L -arabinofuranosidases

Coyle, T., Brumer, H. & Stubbs, K., Nov 2015, In : Canadian Journal of Chemistry. 93, 11, p. 1176-1180 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An interactive database to explore herbicide physicochemical properties

Gandy, M., Corral, M., Mylne, J. & Stubbs, K., 28 May 2015, In : Organic and Biomolecular Chemistry. 13, 20, p. 5586-5590

Research output: Contribution to journalArticle

17 Citations (Scopus)

A simple and robust preparation of N-acetylindoxyls: Precursors for indigogenic substrates

Gandy, M., Byrne, L. & Stubbs, K., 21 Jan 2015, In : Organic and Biomolecular Chemistry. 13, 3, p. 905-908 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori

Debowski, A., Sehnal, M., Liao, T. T., Stubbs, K., Marshall, B. & Benghezal, M., Dec 2015, In : Applied and Environmental Microbiology. 81, 23, p. 7969-7980 12 p.

Research output: Contribution to journalArticle

Open Access

Fluorescence application to hydrocarbon monitoring in North West Shelf marine waters

Harrison, F., Mcauliffe, R., Romero, J., Stubbs, K. & Oldham, C., 2015, Proceedings of the 2015 Appea Conference. Australia: Media Dynamics, Vol. 1. p. 1-6

Research output: Chapter in Book/Conference paperConference paper

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

Hattie, M., Ito, T., Debowski, A., Arakawa, T., Katayama, T., Yamamoto, K., Fushinobu, S. & Stubbs, K., 18 Oct 2015, In : Chemical Communications. 51, 81, p. 15008-15011 4 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
241 Downloads (Pure)

Glycosylation-related diagnostic and therapeutic drug target markers in hepatocellular carcinoma

Watson, M., Diepeveen, L., Stubbs, K. & Yeoh, G., Sep 2015, In : Journal of Gastrointestinal and Liver Diseases. 24, 3, p. 349-357

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Photoredox catalysis under shear using thin film vortex microfluidics

Gandy, M., Raston, C. L. & Stubbs, K., 14 Jul 2015, In : Chemical Communications. 51, 55, p. 11041-11044

Research output: Contribution to journalArticle

40 Citations (Scopus)

The synthesis and fluorescence profile of novel thalidomide analogues

Kampmann, S., Skelton, B., Yeoh, G., Abraham, L., Lengkeek, N. A., Stubbs, K., Heath, C. & Stewart, S., 21 Oct 2015, In : Tetrahedron. 71, 42, p. 8140-8149 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014
15 Citations (Scopus)