Keith Stubbs

Dr, BSc PhD W.Aust.

  • The University of Western Australia (M313), 35 Stirling Highway, Room 414, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 2083 Citations
  • 21 h-Index
20012019
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Research Output 2001 2018

2018
2 Citations

A herbicide structure–activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 1 Jul 2018, In : Pest Management Science. 74, 7, p. 1558-1563 6 p.

Research output: Contribution to journalArticle

antimalarials
mechanism of action
Arabidopsis thaliana
herbicides
herbicide-resistant weeds

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

Ho, L. A., Winogrodzki, J. L., Debowski, A. W., Madden, Z., Vocadlo, D. J., Mark, B. L. & Stubbs, K. A., 1 Jan 2018, In : Chemical Communications. 54, 75, p. 10630-10633 4 p.

Research output: Contribution to journalArticle

Peptidoglycan
beta-Lactams
Recycling
Bacteria
Enzymes
1 Citations
Fluidic devices
Fluidics
Transition metals
Vortex flow
Microfluidics

Antimalarial herbicides and herbicidal antimalarials: Exploiting the plant-Plasmodium connection

Corral, M., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
antimalarials
Plasmodium
herbicides
parasites
herbicide resistance

Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum

Li, H., Hu, J., Wei, H., Solomon, P. S., Vuong, D., Lacey, E., Stubbs, K. A., Piggott, A. M. & Chooi, Y. H., 5 Oct 2018, In : Organic Letters. 20, 19, p. 6148-6152 5 p.

Research output: Contribution to journalArticle

Pyrones
Polyketide Synthases
Polyketides
Oxygenases
wheat
1 Citations

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Wallace, M. D., Waraich, N. F., Debowski, A. W., Corral, M. G., Maxwell, A., Mylne, J. S. & Stubbs, K. A., 21 Feb 2018, In : Chemical Communications. 54, 15, p. 1869-1872 4 p.

Research output: Contribution to journalArticle

Enzyme targets for drug design of new anti-virulence therapeutics

Kahler, C. M., Sarkar-Tyson, M., Kibble, E. A., Stubbs, K. A. & Vrielink, A., 1 Dec 2018, In : Current Opinion in Structural Biology. 53, p. 140-150 11 p.

Research output: Contribution to journalReview article

Drug Design
Virulence
Enzymes
cis-trans-Isomerases
Protein Disulfide Reductase (Glutathione)

Investigations into carbohydrate-based scaffolds for biological and synthetic applications

Wills, S., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

Lipopolysaccharide structural differences between western and Asian Helicobacter pylori strains

Li, H., Tang, H., Debowski, A. W., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 8 Sep 2018, In : Toxins. 10, 9, 364

Research output: Contribution to journalReview article

Open Access
Helicobacter pylori
Lipopolysaccharides
O Antigens
Glucans
Oligosaccharides

Potent inhibition of a GH20 exo-β-N-acetylglucosaminidase from marine Vibrio bacteria by reaction intermediate analogues

Meekrathok, P., Stubbs, K. A. & Suginta, W., 1 Aug 2018, In : International Journal of Biological Macromolecules. 115, p. 1165-1173 9 p.

Research output: Contribution to journalArticle

Acetylglucosaminidase
Reaction intermediates
Vibrio
Calorimetry
Bacteria
1 Citations

Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25A° resolution

Moroz, O. V., Sobala, L. F., Blagova, E., Coyle, T., Peng, W., Krogh, K. B. R. M., Stubbs, K. A., Wilson, K. S. & Davies, G. J., 1 Aug 2018, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 8, p. 490-495 6 p.

Research output: Contribution to journalArticle

Open Access
Talaromyces
Xylans
biomass
inhibitors
enzymes

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance

Corral, M. G., Haywood, J., Stehl, L. H., Stubbs, K. A., Murcha, M. W. & Mylne, J. S., 1 Aug 2018, In : Plant Journal. 95, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

dihydrofolate reductase
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
genetic resistance
thymidylate synthase
2017
2 Citations

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

Bartley, S. N., Mowlaboccus, S., Mullally, C. A., Stubbs, K. A., Vrielink, A., Maiden, M. C. J., Harrison, O. B., Perkins, T. T. & Kahler, C. M., 14 Mar 2017, In : Scientific Reports. 7, 14 p., 44442

Research output: Contribution to journalArticle

Open Access
Horizontal Gene Transfer
Uridine Diphosphate
Neisseria meningitidis
Capsules
Islands
11 Citations

Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria

Ficko-Blean, E. , Préchoux, A. , Thomas, F. , Rochat, T. , Larocque, R. , Zhu, Y. , Stam, M. , Génicot, S. , Jam, M. , Calteau, A. , Viart, B. , Ropartz, D. , Pérez-Pascual, D. , Correc, G. , Matard-Mann, M. , Stubbs, K. A. , Rogniaux, H. , Jeudy, A. , Barbeyron, T. , Médigue, C. & 5 others Czjzek, M., Vallenet, D., McBride, M. J., Duchaud, E. & Michel, G., 1 Dec 2017, In : Nature Communications. 8, 1, 1685

Research output: Contribution to journalArticle

Open Access
catabolism
Regulon
Carrageenan
polysaccharides
bacteria
3 Citations

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

Vadlamani, G., Stubbs, K. A., Désiré, J., Blériot, Y., Vocadlo, D. J. & Mark, B. L., 1 Jun 2017, In : Protein Science. 26, 6, p. 1161-1170 10 p.

Research output: Contribution to journalArticle

Open Access
Phenylcarbamates
beta-Lactam Resistance
Glycoside Hydrolases
beta-Lactams
Microbial Drug Resistance

Exploiting sp2-Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors

Coyle, T., Debowski, A. W., Varrot, A. & Stubbs, K. A., 1 Jun 2017, In : ChemBioChem. 18, 11, p. 974-978 5 p.

Research output: Contribution to journalArticle

Chromogenic Compounds
Fusarium
X-Rays
X rays
5 Citations

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 7 Aug 2017, In : Angewandte Chemie - International Edition. 56, 33, p. 9881-9885 5 p.

Research output: Contribution to journalArticle

Herbicides
Parasites
Antimalarials
Malaria
Scaffolds
5 Citations

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection

Debowski, A. W., Walton, S. M., Chua, E-G., Tay, A. C-Y., Liao, T., Lamichhane, B., Himbeck, R., Stubbs, K. A., Marshall, B. J., Fulurija, A. & Benghezal, M., Jun 2017, In : PLoS Pathogens. 13, 6, 21 p., 1006464

Research output: Contribution to journalArticle

Open Access
6 Citations

Herbicidal properties of antimalarial drugs

Corral, M. G., Leroux, J., Stubbs, K. A. & Mylne, J. S., 31 Mar 2017, In : Scientific Reports. 7, 45871

Research output: Contribution to journalArticle

Open Access
Antimalarials
Herbicides
Plasmodium falciparum
glyphosate
Arabidopsis
3 Citations

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Yap, H. Y. Y., Muria-Gonzalez, M. J., Kong, B. H., Stubbs, K. A., Tan, C. S., Ng, S. T., Tan, N. H., Solomon, P. S., Fung, S. Y. & Chooi, Y. H., 12 Jun 2017, In : Microbial Cell Factories. 16, 1, 103

Research output: Contribution to journalArticle

Open Access
Sesquiterpenes
Agaricales
Yeast
Genes
Yeasts

Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H-O., Haslam, S. M., Dell, A., Stubbs, K. A., Marshall, B. J. & Benghezal, M., May 2017, In : Microbial Cell. 4, 5, p. 175-178 4 p.

Research output: Contribution to journalEditorial

Open Access
8 Citations

Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum

Yamada, C., Gotoh, A., Sakanaka, M., Hattie, M., Stubbs, K. A., Katayama-Ikegami, A., Hirose, J., Kurihara, S., Arakawa, T., Kitaoka, M., Okuda, S., Katayama, T. & Fushinobu, S., 6 Apr 2017, In : Cell Chemical Biology. 24, 4, p. 515–524 e5

Research output: Contribution to journalArticle

Symbiosis
Microbiota
Human Milk
Breast
Oligosaccharides
26 Citations

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

Anandan, A., Evans, G. L., Condic-Jurkic, K., O'Mara, M. L., John, C. M., Phillips, N. J., Jarvis, G. A., Wills, S. S., Stubbs, K. A., Moraes, I., Kahler, C. M. & Vrielink, A., 28 Feb 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

Open Access
Lipid A
Transferases
Membranes
Endotoxins
Antimicrobial Cationic Peptides
6 Citations

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa

Hamou-Segarra, M., Zamorano, L., Vadlamani, G., Chu, M., Sanchez-Diener, I., Juan, C., Blazquez, J., Hattie, M., Stubbs, K. A., Mark, B. L. & Oliver, A., 1 Feb 2017, In : Journal of Antimicrobial Chemotherapy. 72, 2, p. 448-454 7 p.

Research output: Contribution to journalArticle

Fosfomycin
Peptidoglycan
beta-Lactams
Pseudomonas aeruginosa
Imipenem
2 Citations

The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors

Sato, M., Liebschner, D., Yamada, Y., Matsugaki, N., Arakawa, T., Wills, S. S., Hattie, M., Stubbs, K. A., Ito, T., Senda, T., Ashida, H. & Fushinobu, S., 21 Jul 2017, In : Journal of Biological Chemistry. 292, 29, p. 12126-12138 13 p.

Research output: Contribution to journalArticle

5 Citations

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H. O., Fulurija, A., Haslam, S. M., Mulloy, B., Dell, A., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 17 Mar 2017, In : PLoS Pathogens. 13, 3, e1006280

Research output: Contribution to journalArticle

Open Access
O Antigens
Oligosaccharides
Heptoses
Ligases
Helicobacter pylori

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Li, H., Yang, T., Liao, T., Debowski, A. W., Nilsson, H., Fulurija, A., Haslam, S., Mulloy, B., Dell, A., Stubbs, K. A., Marshall, B. J. & Benghezal, M., Sep 2017, In : Helicobacter. 22, 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citations

Understanding protein glycosylation pathways in bacteria

Li, H., Debowski, A. W., Liao, T., Tang, H., Nilsson, H-O., Marshall, B. J., Stubbs, K. A. & Benghezal, M., 1 Jan 2017, In : Future Microbiology. 12, 1, p. 59-72 14 p.

Research output: Contribution to journalReview article

Open Access
File
Glycosylation
Bacteria
Bacterial Proteins
Glycoproteins
Peptidoglycan
10 Citations

Vortex Fluidic Chemical Transformations

Britton, J., Stubbs, K. A., Weiss, G. A. & Raston, C. L., 27 Sep 2017, In : Chemistry: A European Journal. 23, 54, p. 13270–13278 9 p.

Research output: Contribution to journalReview article

2016
3 Citations

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance

Perley-Robertson, G. E., Yadav, A. K., Winogrodzki, J. L., Stubbs, K., Mark, B. L. & Vocadlo, D. J., 2016, In : ACS Chemical Biology. 11, 9, p. 2626-2635

Research output: Contribution to journalArticle

Open Access
Lactams
Membrane Transport Proteins
Peptidoglycan
Recycling
Microbial Drug Resistance
10 Citations

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human: O-GlcNAcase

Cekic, N., Heinonen, J. E., Stubbs, K., Roth, C., He, Y., Bennet, A. J., Mceachern, E. J., Davies, G. J. & Vocadlo, D. J., 2016, In : Chemical Science. 7, 6, p. 3742-3750

Research output: Contribution to journalArticle

Hydrolases
Catalysis
beta-N-Acetylhexosaminidases
Acetylglucosamine
Protonation
8 Citations

Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori

Li, H., Liao, T., Debowski, A., Tang, H., Nilsson, H. O., Stubbs, K. A., Marshall, B. J. & Benghezal, M., 1 Dec 2016, In : Helicobacter. 21, 6, p. 445-461 17 p.

Research output: Contribution to journalReview article

Open Access
File
O Antigens
Helicobacter pylori
Lipopolysaccharides
Stomach
Heptoses
5 Citations

Modifying the phenyl group of PUGNAc: Reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases

Hattie, M., Cekic, N., Debowski, A., Vocadlo, D. J. & Stubbs, K., 23 Feb 2016, In : Organic and Biomolecular Chemistry. 14, 12, p. 3193-3197

Research output: Contribution to journalArticle

Open Access
File
Hexosaminidases
inhibitors
reactivity
Tuning
selectivity
8 Citations

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut

Hemsworth, G. R., Thompson, A. J., Stepper, J., Sobala, T. F., Coyle, T., Larsbrink, J., Spadiut, O., Goddard-Borger, E. D., Stubbs, K., Brumer, H. & Davies, G. J., 27 Jul 2016, In : Open Biology. 6, 7, p. 1-14

Research output: Contribution to journalArticle

Open Access
Dissection
Bacteroides
Metabolism
Genes
Polysaccharides
1 Citations
quinoxalines
Quinoxalines
cross coupling
pyrimidines
Transition metals
2015

An improved preparation of some aryl α- L -arabinofuranosides for use as chromogenic substrates for α- L -arabinofuranosidases

Coyle, T., Brumer, H. & Stubbs, K., Nov 2015, In : Canadian Journal of Chemistry. 93, 11, p. 1176-1180 5 p.

Research output: Contribution to journalArticle

Chromogenics
Chromogenic Compounds
Glycosides
Phenols
Substrates
11 Citations

An interactive database to explore herbicide physicochemical properties

Gandy, M., Corral, M., Mylne, J. & Stubbs, K., 28 May 2015, In : Organic and Biomolecular Chemistry. 13, 20, p. 5586-5590

Research output: Contribution to journalArticle

herbicides
Herbicides
Databases
chemical properties
Chemical properties
5 Citations

A simple and robust preparation of N-acetylindoxyls: Precursors for indigogenic substrates

Gandy, M., Byrne, L. & Stubbs, K., 21 Jan 2015, In : Organic and Biomolecular Chemistry. 13, 3, p. 905-908 4 p.

Research output: Contribution to journalArticle

preparation
Substrates
synthesis
activity (biology)
Bioactivity

Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori

Debowski, A., Sehnal, M., Liao, T. T., Stubbs, K., Marshall, B. & Benghezal, M., Dec 2015, In : Applied and Environmental Microbiology. 81, 23, p. 7969-7980 12 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter pylori
Tetracycline
tetracycline
Essential Genes
promoter regions

Fluorescence application to hydrocarbon monitoring in North West Shelf marine waters

Harrison, F., Mcauliffe, R., Romero, J., Stubbs, K. & Oldham, C., 2015, Proceedings of the 2015 Appea Conference. Australia: Media Dynamics, Vol. 1, p. 1-6

Research output: Chapter in Book/Conference paperConference paper

7 Citations

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

Hattie, M., Ito, T., Debowski, A., Arakawa, T., Katayama, T., Yamamoto, K., Fushinobu, S. & Stubbs, K., 18 Oct 2015, In : Chemical Communications. 51, 81, p. 15008-15011 4 p.

Research output: Contribution to journalArticle

Open Access
File
Structural analysis
Catalysis
X rays
Molecules
lacto-N-biosidase
9 Citations

Glycosylation-related diagnostic and therapeutic drug target markers in hepatocellular carcinoma

Watson, M., Diepeveen, L., Stubbs, K. & Yeoh, G., Sep 2015, In : Journal of Gastrointestinal and Liver Diseases. 24, 3, p. 349-357

Research output: Contribution to journalArticle

Open Access
Glycosylation
Hepatocellular Carcinoma
Pharmaceutical Preparations
Apoptosis
Therapeutics
26 Citations

Photoredox catalysis under shear using thin film vortex microfluidics

Gandy, M., Raston, C. L. & Stubbs, K., 14 Jul 2015, In : Chemical Communications. 51, 55, p. 11041-11044

Research output: Contribution to journalArticle

Microfluidics
Catalysis
Vortex flow
Thin films
Processing
1 Citations

The synthesis and fluorescence profile of novel thalidomide analogues

Kampmann, S., Skelton, B., Yeoh, G., Abraham, L., Lengkeek, N. A., Stubbs, K., Heath, C. & Stewart, S., 21 Oct 2015, In : Tetrahedron. 71, 42, p. 8140-8149 10 p.

Research output: Contribution to journalArticle

Thalidomide
Fluorescence
Derivatives
Azides
Cycloaddition
2014
14 Citations
Proteomics
Carbohydrates
Biological systems
Enzymes
Processing

General Preparation of Imidazole-1-Sulfonate Esters

Coyle, T., Richardson, M. B., Stubbs, K. & Hattie, M., 2014, Carbohydrate Chemistry Proven Synthetic Methods. Marel, G. D. & Codee, J. (eds.). USA: CRC Press, Vol. 2, p. 53-58 (Carbohydrate Chemistry Proven Synthetic Methods)

Research output: Chapter in Book/Conference paperChapter

Letter to the glycoforum transforming glycoscience: An Australian perspective

Coombe, D. R., Davis, C., Fincher, G. B., Mcconville, M. J., Packer, N. H., Stubbs, K., Williams, S. J. & Dell, . E., 2014, In : Glycobiology. 24, 1, p. 1-3

Research output: Contribution to journalLetter

1 Citations

Nitrate uptake by p-phosphonic acid or p-(trimethylammonium)methyl calix[8]arene stablized laminar materials

Eggers, P., Eroglu, E., Becker, T. L., Chen, X., Vimalanathan, K., Stubbs, K., Smith, S. & Raston, C. L., Sep 2014, In : RSC Advances. 4, 89, p. 48348-48352

Research output: Contribution to journalArticle

Open Access
Nitrates
Acids
Sonication
Graphite
Recycling
8 Citations

Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway

Kim, R. Q., Offen, W. A., Davies, G. J. & Stubbs, K., Jan 2014, In : Acta Crystallographica Section D: Structural Biology. 70, 1, p. 177-185 8 p.

Research output: Contribution to journalArticle

Vitamin K 2
Helicobacter pylori
Catalytic Domain
N-Glycosyl Hydrolases
Anti-Bacterial Agents
1 Citations

Synthesis of Carbohydrate-based Natural Products from Leonurus japonicus and their Biological evaluation as Anti-oxidants

Clayton, E., Hattie, M., Debowski, A. & Stubbs, K., Oct 2014, In : Australian Journal of Chemistry. 67, 10, p. 1461-1470 10 p.

Research output: Contribution to journalArticle

Biological Products
Oxidants
Medicine
Carbohydrates