Research output per year
Research output per year
Personal profile
Biography
Dr Kai Chen is currently a Research Associate at the School of Molecular Sciences, UWA. He finished his medical and orthopaedic surgery training in China (2007 - 2015). Supported by Australian Government International Research Training Program (RTP) Scholarships, he completed his PhD studies (2019) in Bone Biology under the supervision of Winthrop/Prof Jiake Xu, A/Prof Nathan Pavlos, and Dr Jennifer Tickner at UWA.
His current research interests include nutrient metabolism in the bone, angiogenesis and bone repair, the pathogenesis of bone disorders such as ageing- and estrogen deficiency-induced osteoporosis. Dr Chen has recently developed a first-of-its-kind approach, based on ion microscopy, to achieve the metabolic imaging of single bone cells at the nanoscale. By using a stable isotope-labelled tracer, Dr Chen is interested to advance the understanding of bone collagen turnover and drug transport in the bone.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Bone biology, PhD, The University of Western Australia
14 Mar 2016 → 14 Nov 2019
Award Date: 14 Nov 2019
Orthopaedic Surgery, Master degree, Wenzhou Medical University
Sep 2012 → Jun 2015
Award Date: 30 Jun 2015
Medicine, Bachelor of Medicine, Wenzhou Medical University
Sep 2007 → Jun 2012
Award Date: 15 Jun 2012
External positions
Resident Doctor, Wenzhou Medical University
Jul 2015 → Mar 2016
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Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species
Chen, K., Qiu, P., Yuan, Y., Zheng, L., He, J., Wang, C., Guo, Q., Kenny, J., Liu, Q., Zhao, J., Chen, J., Tickner, J., Fan, S., Lin, X. & Xu, J., 28 Feb 2019, In: Theranostics. 9, 6, p. 1634-1650 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile115 Citations (Scopus)250 Downloads (Pure) -
High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)
He, C., Migawa, M. T., Chen, K., Weston, T. A., Tanowitz, M., Song, W., Guagliardo, P., Iyer, K. S., Bennett, C. F., Fong, L. G., Seth, P. P., Young, S. G. & Jiang, H., 11 Jan 2021, In: Nucleic Acids Research. 49, 1, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair
Chen, K., Liao, S., Li, Y., Jiang, H., Liu, Y., Wang, C., Kuek, V., Kenny, J., Li, B., Huang, Q., Hong, J., Huang, Y., Chim, S. M., Tickner, J., Pavlos, N. J., Zhao, J., Liu, Q., Qin, A. & Xu, J., 2021, In: Theranostics. 11, 20, p. 9738-9751 14 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Web of Science) -
Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis
Qiu, P., Li, M., Chen, K., Fang, B., Chen, P., Tang, Z., Lin, X. & Fan, S., Jan 2020, In: Biomaterials. 227, p. 119552 119552.Research output: Contribution to journal › Article › peer-review
149 Citations (Scopus) -
Decellularized periosteum as a potential biologic scaffold for bone tissue engineering
Chen, K., Lin, X., Zhang, Q., Ni, J., Li, J., Xiao, J., Wang, Y., Ye, Y., Chen, L., Jin, K. & Chen, L., Jun 2015, In: Acta Biomaterialia. 19, p. 46-55 10 p.Research output: Contribution to journal › Article › peer-review
60 Citations (Scopus)
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Defining the nutrient substrates for bone remodelling
Chen, K., Jiang, H., Swaminatha Iyer, K., Xu, J., Greenblatt, M. & Pavlos, N.
1/01/23 → 31/12/24
Project: Research
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Zeiss Celldiscoverer7 for automated high resolution imaging of complex biomedical samples
Fox, A., Choi, Y. S., Rodger, J., Tang, A., Hool, L., Pillow, J., Lister, R., Bond, C., Hodgetts, S., Chen, K., Blancafort, P., Redfern, A., Swaminatha Iyer, K., Smith, N., Marshall, A., Fear, M., Wood, F., Evans, C., Chooi, H. & Rassell, A.
National Health & Medical Research Council NHMRC
1/07/22 → 31/10/23
Project: Research
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iXon Life Camera with SRFF-Stream for High-Speed Live-Cell Single Molecule Imaging
Swaminatha Iyer, K., Lister, R., Fox, A., Smith, N., Choi, Y. S., Stubbs, K., Lesterhuis, W., Blancafort, P., Bond, C., Jiang, H., Geddes, D., Chooi, H., Sarkar-Tyson, M., Evans, C., Chen, K., Rassell, A., Waryah, C., Golden, E. & Woodward, E.
National Health & Medical Research Council NHMRC
3/01/22 → 6/06/22
Project: Research
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Fat or fuel: investigating the bone marrow adipose tissue in the osteoporotic bone
Chen, K., Jiang, H., Pavlos, N. & Xu, J.
Arthritis Foundation of Australia
1/01/22 → 31/12/22
Project: Research
Prizes
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2019 Australia and New Zealand Orthopaedic Society (ANZORS) Travel Grant
Chen, Kai (Recipient), 2019
Prize: Award