Julian Heng

Associate Professor

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 728 Citations
  • 14 h-Index
20092022
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Research Output 2009 2019

2019
3 Citations (Scopus)

Atypical nested 22q11.2 duplications between LCR22B and LCR22D are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetrance

Woodward, K. J., Stampalia, J., Vanyai, H., Rijhumal, H., Potts, K., Taylor, F., Peverall, J., Grumball, T., Sivamoorthy, S., Alinejad-Rokny, H., Wray, J., Whitehouse, A., Nagarajan, L., Scurlock, J., Afchani, S., Edwards, M., Murch, A., Beilby, J., Baynam, G., Kiraly-Borri, C. & 2 othersMcKenzie, F. & Heng, J. I. T., Feb 2019, In : Molecular genetics & genomic medicine. 7, 2, 17 p., 507.

Research output: Contribution to journalArticle

Open Access

Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex

Hemming, I. A., Clément, O., Gladwyn-Ng, I. E., Cullen, H. D., Ng, H. L., See, H. B., Ngo, L., Ulgiati, D., Pfleger, K. D. G., Agostino, M. & Heng, J. I. T., 21 May 2019, In : Human Mutation. 15 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
DNA
Zinc Fingers
Brain Diseases
2018
1 Citation (Scopus)

A review of structural brain abnormalities in Pallister-Killian syndrome

Poulton, C., Baynam, G., Yates, C., Alinejad-Rokny, H., Williams, S., Wright, H., Woodward, K. J., Sivamoorthy, S., Peverall, J., Shipman, P., Ravine, D., Beilby, J. & Heng, J. I-T., Jan 2018, In : Molecular genetics & genomic medicine. 6, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

Open Access
2017
11 Citations (Scopus)

Disease-associated mutations in RP58 disrupt its neuronal functions through a mechanism involving transcriptional regulation

Hemming, I. A., Clement, O., Gladwyn-Ng, I. E., Ng, H. L., See, E., Ngo, L., Ulgiati, D., Pfleger, K. D. G. & Heng, J. I. -T., Aug 2017, In : Journal of Neurochemistry. 142, p. 90-90 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Identification and characterisation of a novel mirror movement gene

Marsh, A., Edwards, T., Raabus, M., Stephenson, S., Richards, L., Galea, C., Heng, J., Farlie, P., Leventer, R. & Lockhart, P., Aug 2017, In : Journal of Neurochemistry. 142, p. 70-70 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

6 Citations (Scopus)

Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex

Clément, O., Hemming, I. A., Gladwyn-Ng, I. E., Qu, Z., Li, S. S., Piper, M. & Heng, J. I. T., 15 May 2017, In : Neural Development. 12, 1, 8.

Research output: Contribution to journalArticle

Open Access
Cerebral Cortex
Cell Cycle
Cyclin-Dependent Kinases
Neurons
Neural Stem Cells
8 Citations (Scopus)

Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

Cruickshank, M. N., Ford, J., Cheung, L. C., Heng, J., Singh, S., Wells, J., Failes, T. W., Arndt, G. M., Smithers, N., Prinjha, R. K., Anderson, D., Carter, K. W., Gout, A. M., Lassmann, T., O'Reilly, J., Cole, C. H., Kotecha, R. S. & Kees, U. R., 1 Jan 2017, In : Leukemia. 31, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

Open Access
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Histone Deacetylase Inhibitors
Cell Line
Pharmaceutical Preparations
2016
12 Citations (Scopus)
337 Downloads (Pure)

Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons

Gladwyn-Ng, I., Huang, L., Ngo, L., Li, S. S., Qu, Z., Vanyai, H., Cullen, H., Davis, J. M. & Heng, J., 11 Mar 2016, In : Neural Development. 11, p. 1-8 7.

Research output: Contribution to journalArticle

Open Access
File
Neurons
Cerebral Cortex
Dendritic Spines
Proteins
Electroporation
16 Citations (Scopus)

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R. R., Featherby, T. J. J., Qu, Z., Giousoh, A., Borg, N. A. A., Heng, J. I., Whisstock, J. C. C. & Bird, P. I. I., 2016, In : Molecular Autism. 7, 20 p., 22.

Research output: Contribution to journalArticle

13 Citations (Scopus)

De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation

Haas, M. A., Ngo, L., Li, S. S., Schleich, S., Qu, Z., Vanyai, H. K., Cullen, H. D., Cardona-Alberich, A., Gladwyn-Ng, I. E., Pagnamenta, A. T., Taylor, J. C., Stewart, H., Kini, U., Duncan, K. E., Teleman, A. A., Keays, D. A. & Heng, J. I. T., 2016, In : Cell Reports. 15, 10, p. 2251-2265 15 p.

Research output: Contribution to journalArticle

Open Access
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Protein Biosynthesis
Nervous System Diseases
Neurons
Messenger RNA
56 Citations (Scopus)

Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3

Sim, J. C., Scerri, T., Fanjul-Fernández, M., Riseley, J. R., Gillies, G., Pope, K., Van Roozendaal, H., Heng, J., Mandelstam, S. A., Mcgillivray, G., Macgregor, D., Kannan, L., Maixner, W., Harvey, A. S., Amor, D. J., Delatycki, M. B., Crino, P. B., Bahlo, M., Lockhart, P. J. & Leventer, R. J., Jan 2016, In : Annals of Neurology. 79, 1, p. 132-137 6 p.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Membrane Transport Proteins
Sirolimus
Nitrogen
Mutation
14 Citations (Scopus)

Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway

Edvardson, S., Tian, G., Cullen, H., Vanyai, H., Ngo, L., Bhat, S., Aran, A., Daana, M., Da'amseh, N., Abu-Libdeh, B., Cowan, N. J. J., Heng, J. I. T. & Elpeleg, O., 2016, In : Human Molecular Genetics. 25, 21, p. 4635-4648 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Insights into the Biology and Therapeutic Applications of Neural Stem Cells

Harris, L., Zalucki, O., Piper, M. & Heng, J. I-T., Feb 2016, In : Stem Cells International. 2016, p. 1-18 18 p., 9745315.

Research output: Contribution to journalLiterature review

Open Access
11 Citations (Scopus)

Mutations of vasopressin receptor 2 including novel L312S have differential effects on trafficking

Tiulpakov, A., White, C., Abhayawardana, R., See, H. B., Chan, A., Seeber, R., Heng, J., Dedov, I., Pavlos, N. & Pfleger, K., 1 Aug 2016, In : Molecular Endocrinology. 30, 8, p. 889-904

Research output: Contribution to journalArticle

Open Access
Vasopressin Receptors
Mutation
Hyponatremia
Nephrogenic Diabetes Insipidus
Natriuresis
14 Citations (Scopus)

Reinforcing the association between distal 1q CNVs and structural brain disorder: A case of a complex 1q43-q44 CNV and a review of the literature

Hemming, I. A., Forrest, A., Shipman, P., Woodward, K. J., Walsh, P., Ravine, D. G. & Heng, J., 2016, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 171, 3, p. 458-467

Research output: Contribution to journalArticle

Microcephaly
Brain Diseases
Viverridae
Seizures
Group II Malformations of Cortical Development
5 Citations (Scopus)

The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome

Li, S. S., Qu, Z., Haas, M., Ngo, L., Heo, Y. J., Kang, H. J., Britto, J. M., Cullen, H., Vanyai, H., Tan, S. S., Chan-Ling, T., Gunnersen, J. M. & Heng, J., 11 Jul 2016, In : Scientific Reports. 6, p. 1-14 14 p., 29514.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Down Syndrome
Cerebral Cortex
Catenins
Genes
17 Citations (Scopus)

Transcriptional regulation of intermediate progenitor cell generation during hippocampal development

Harris, L., Zalucki, O., Gobius, I., McDonald, H., Osinki, J., Harvey, T. J. J., Essebier, A., Vidovic, D., Gladwyn-Ng, I., Burne, T. H. H., Heng, J. I., Richards, L. J. J., Gronostajski, R. M. M. & Piper, M., 2016, In : Development. 143, p. 4620-4630 11 p.

Research output: Contribution to journalArticle

2015
14 Citations (Scopus)

14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders

Xu, X., Jaehne, E. J., Greenberg, Z., Mccarthy, P., Saleh, E., Parish, C. L., Camera, D., Heng, J., Haas, M., Baune, B. T., Ratnayake, U., Van Den Buuse, M., Lopez, A. F., Ramshaw, H. S. & Schwarz, Q., 2015, In : Scientific Reports. 5, p. 1-15 15 p., 12434.

Research output: Contribution to journalArticle

Open Access
Hippocampus
Schizophrenia
Dopamine Plasma Membrane Transport Proteins
Pyramidal Cells
Lateral Ventricles
9 Citations (Scopus)
225 Downloads (Pure)

Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex

Gladwyn-Ng, I., Li, S. S., Qu, Z., Davis, J. M., Ngo, L., Haas, M., Singer, J. & Heng, J., 31 Mar 2015, In : Neural Development. 10, 9, 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cerebral Cortex
Neurons
Cell Movement
BTB-POZ Domain
GTP Phosphohydrolases
24 Citations (Scopus)

The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development

Heng, J., Qu, Z., Ohtaka-Maruyama, C., Okado, H., Kasai, M., Castro, D., Guillemot, F. & Tan, S. S., 2015, In : Cerebral Cortex. 25, 3, p. 806-816

Research output: Contribution to journalArticle

Zinc Fingers
Transcription Factors
Neurons
Cerebral Cortex
Cell Movement
2014
18 Citations (Scopus)

TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons

Ngo, L., Haas, M., Qu, Z., Li, S. S., Zenker, J., Teng, K. S. L., Gunnersen, J. M., Breuss, M., Habgood, M., Keays, D. A. & Heng, J., 2014, In : Human Molecular Genetics. 23, p. 5147-5158

Research output: Contribution to journalArticle

Open Access
2013
7 Citations (Scopus)

Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice

Haas, M., Qu, Z., Kim, T. H., Vargas, E., Campbell, K., Petrou, S., Tan, S-S., Reid, C. A. & Heng, J., 2013, In : European Journal of Neuroscience. 37, 10, p. 1584-1593

Research output: Contribution to journalArticle

3 Citations (Scopus)

Proneural Proteins and the Development of the Cerebral Cortex.

Heng, J. & Guillemot, F., 2013, Cortical Development: Neural Diversity and Neocortical Organization.. Kageyama, R. & Yamamori, T. (eds.). Japan

Research output: Chapter in Book/Conference paperOther chapter contribution

44 Citations (Scopus)

RP58 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Cerebral Cortex

Ohtaka-Maruyama, C., Hirai, S., Miwa, A., Heng, J., Shitara, H., Ishii, R., Taya, C., Kawano, H., Kasai, M., Nakajima, K. & Okado, H., 2013, In : Cell Reports. 3, 2, p. 458-471

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility

Kim, T. H., Richards, K., Heng, J., Petrou, S. & Reid, C. A., 2013, In : Epilepsy Research. 104, 1-2, p. 11-16

Research output: Contribution to journalArticle

2012
99 Citations (Scopus)

Mutations in the β-Tubulin Gene TUBB5 Cause Microcephaly with Structural Brain Abnormalities

Breuss, M., Heng, J., Poirier, K., Tian, G., Jaglin, X., Qu, Z., Braun, A., Gstrein, T., Ngo, L., Haas, M., Bahi-Buisson, N., Moutard, M-L., Passemard, S., Verloes, A., Gressens, P., Xie, Y., Robson, K., Rani, D., Thangaraj, K., Clausen, T. & 3 othersChelly, J., Cowan, N. & Keays, D., 2012, In : Cell Reports. 2, 6, p. 1554-1562

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

Bogoyevitch, M. A., Yeap, Y. Y. C., Qu, Z., Ngoei, K. R., Yip, Y. Y., Zhao, T. T., Heng, J. & Ng, D. C. H., 2012, In : Journal of Cell Science. 125, 21, p. 5096-5109

Research output: Contribution to journalArticle

2011
33 Citations (Scopus)

COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression

Alfano, C., Viola, L., Heng, J., Pirozzi, M., Clarkson, M., Flore, G., De Maio, A., Schedl, A., Guillemot, F. & Studer, M., 2011, In : Development. 138, 21, p. 4685-4697

Research output: Contribution to journalArticle

132 Citations (Scopus)

Proneural transcription factors regulate different steps of cortical neuron migration through rnd-mediated inhibition of RhoA signaling

Pacary, E., Heng, J., Azzarelli, R., Riou, P., Castro, D., Lebel-Potter, M., Parras, C., Bell, D., Ridley, A., Parsons, M. & Guillemot, F., 2011, In : Neuron. 69, 6, p. 1069-1084

Research output: Contribution to journalArticle

Open Access
2010
71 Citations (Scopus)

Molecular layers underlying cytoskeletal remodelling during cortical development

Heng, J., Chariot, A. & Nguyen, L., 2010, In : Trends in Neurosciences. 33, 1, p. 38

Research output: Contribution to journalReview article

2009
20 Citations (Scopus)

Molecular mechanisms of projection neuron production and maturation in the developing cerebral cortex

Mérot, Y., Rétaux, S. & Heng, J., 2009, In : Seminars in Cell and Developmental Biology. 20, 6, p. 726-734

Research output: Contribution to journalReview article