Research output per year
Research output per year
Personal profile
Biography
Dr. Joshua Clayton completed his PhD in Genetics at the University of Western Australia in 2018. This work investigated how microRNAs and enhancers regulate complement receptor gene expression in human immune cells. Since joining the team of Prof. Nigel Laing and A/Prof Gina Ravenscroft in 2018, he has contributed to a range of projects including: characterisation of disease-causing short tandem repeat expansions, development of splicing assays to assess whether variants of unknown significance impact mRNA splicing, development of cell and animal models of muscle disease, and development and testing of therapies for the treatment of neuromuscular diseases.
His current research focus centres around the use of induced pluripotent stem cells (iPSCs) to model muscle diseases and test treatments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Generation of a human ACTA1-tdTomato reporter iPSC line using CRISPR/Cas9 editing
Houweling, P. J., Crossman, V., Tiong, C. F., Coles, C. A., Taylor, R. L., Clayton, J. S., Graham, A., Vlahos, K., Howden, S. E. & North, K. N., Mar 2024, In: Stem Cell Research. 75, 7 p., 103313.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of iPSC lines from three Laing distal myopathy patients with a recurrent MYH7 p.Lys1617del variant
Clayton, J. S., Vo, C., Crane, J., Scriba, C. K., Saker, S., Larmonier, T., Malfatti, E., Romero, N. B., Ravenscroft, G., Laing, N. G. & Taylor, R. L., Oct 2024, In: Stem Cell Research. 80, 6 p., 103491.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of two iPSC lines from adult central core disease patients with dominant missense variants in the RYR1 gene
Clayton, J. S., Vo, C., Crane, J., Scriba, C. K., Saker, S., Larmonier, T., Malfatti, E., Romero, N. B., Ravenscroft, G., Laing, N. G. & Taylor, R. L., Jun 2024, In: Stem Cell Research. 77, 103411.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of two iPSC lines from patients with inherited central core disease and concurrent malignant hyperthermia caused by dominant missense variants in the RYR1 gene
Clayton, J. S., Vo, C., Crane, J., Scriba, C. K., Saker, S., Larmonier, T., Malfatti, E., Romero, N. B., Ravenscroft, G., Laing, N. G. & Taylor, R. L., Jun 2024, In: Stem Cell Research. 77, 6 p., 103410.Research output: Contribution to journal › Article › peer-review
Open Access -
A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism
Dofash, L. N. H., Monahan, G., Servian-Morilla, E., Rivas, E., Faiz, F., Sullivan, P., Oates, E., Clayton, J., Taylor, R. L., Davis, M. R., Beilharz, T., Laing, N. G., Cabrera-Serrano, M. & Ravenscroft, G., 1 Apr 2023, In: Human Molecular Genetics. 32, 7, p. 1127-1136 10 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
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Building translational capacity in WA; Establishing the tools needed to develop treatments for Australian children with muscle disease.
Taylor, R., Ravenscroft, G., Clayton, J., Kuznetsova, I., Elaskalani, O., Endersby, R. & Forrest, A.
Stan Perron Charitable Foundation
2/07/23 → 4/07/27
Project: Research