• The University of Western Australia (M310), 35 Stirling Highway,

    6009 Perth

    Australia

  • 2617 Citations
  • 21 h-Index
19982021
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Research Output 1998 2018

  • 2617 Citations
  • 21 h-Index
  • 52 Article
  • 4 Review article
  • 2 Doctoral Thesis
  • 1 Literature review
2018

A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch

Fisher, M. F., Zhang, J., Taylor, N. L., Howard, M. J., Berkowitz, O., Debowski, A. W., Behsaz, B., Whelan, J., Pevzner, P. A. & Mylne, J. S., Feb 2018, In : Plant Direct. 2, 2, e00042

Research output: Contribution to journalArticle

Open Access
Cyclic Peptides
Peptides
asparaginylendopeptidase
Transcriptome
Albumins
3 Citations

A herbicide structure–activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 1 Jul 2018, In : Pest Management Science. 74, 7, p. 1558-1563 6 p.

Research output: Contribution to journalArticle

antimalarials
mechanism of action
Arabidopsis thaliana
herbicides
herbicide-resistant weeds

Antimalarial herbicides and herbicidal antimalarials: Exploiting the plant-Plasmodium connection

Corral, M., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
antimalarials
Plasmodium
herbicides
parasites
herbicide resistance
2 Citations

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins

Franke, B., Mylne, J. S. & Rosengren, K. J., Feb 2018, In : Natural Product Reports. 35, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

1 Citations

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Wallace, M. D., Waraich, N. F., Debowski, A. W., Corral, M. G., Maxwell, A., Mylne, J. S. & Stubbs, K. A., 21 Feb 2018, In : Chemical Communications. 54, 15, p. 1869-1872 4 p.

Research output: Contribution to journalArticle

4 Citations

Macrocyclization by asparaginyl endopeptidases

James, A. M., Haywood, J. & Mylne, J. S., May 2018, In : New Phytologist. 218, 3, p. 923-928

Research output: Contribution to journalReview article

asparaginylendopeptidase
proteinases
Cyclic Peptides
peptides
cyclic peptides
2 Citations

Structural basis of ribosomal peptide macrocyclization in plants

Haywood, J., Schmidberger, J. W., James, A. M., Nonis, S. G., Sukhoverkov, K. V., Elias, M., Bond, C. S. & Mylne, J. S., 31 Jan 2018, In : eLife. 7, e32955

Research output: Contribution to journalArticle

Open Access
asparaginylendopeptidase
Cyclic Peptides
Helianthus
Peptides
Plant Structures

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance

Corral, M. G., Haywood, J., Stehl, L. H., Stubbs, K. A., Murcha, M. W. & Mylne, J. S., 1 Aug 2018, In : Plant Journal. 95, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

dihydrofolate reductase
Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase
genetic resistance
thymidylate synthase
2017
1 Citations

Evidence for ancient origins of bowman-birk inhibitors from Selaginella moellendorffii

James, A. M., Jayasena, A. S., Zhang, J., Berkowitz, O., Secco, D., Knott, G. J., Whelan, J., Bond, C. S. & Mylne, J. S., 1 Mar 2017, In : The Plant Cell. 29, 3, p. 461-473 13 p.

Research output: Contribution to journalArticle

Open Access
File
Selaginellaceae
Bowman-Birk inhibitor
Selaginella
Fabaceae
Angiosperms

Evolutionary insights into two plant protein families: Bowman-Birk inhibitors and asparaginyl endopeptidases

James, A. M., 2017, (Unpublished)

Research output: ThesisDoctoral Thesis

File
inhibitor
enzyme
seed
protein
thesis
5 Citations

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 7 Aug 2017, In : Angewandte Chemie - International Edition. 56, 33, p. 9881-9885 5 p.

Research output: Contribution to journalArticle

Herbicides
Parasites
Antimalarials
Malaria
Scaffolds
6 Citations

Herbicidal properties of antimalarial drugs

Corral, M. G., Leroux, J., Stubbs, K. A. & Mylne, J. S., 31 Mar 2017, In : Scientific Reports. 7, 45871

Research output: Contribution to journalArticle

Open Access
Antimalarials
Herbicides
Plasmodium falciparum
glyphosate
Arabidopsis
2 Citations

Natural structural diversity within a conserved cyclic peptide scaffold

Elliott, A. G., Franke, B., Armstrong, D. A., Craik, D. J., Mylne, J. S. & Rosengren, K. J., 1 Jan 2017, In : Amino Acids. 49, 1, p. 103-116 14 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Scaffolds
Peptides
Helianthus
Disulfides
3 Citations

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR

Grage, S. L., Sani, M-A., Cheneval, O., Henriques, S. T., Schalck, C., Heinzmann, R., Mylne, J. S., Mykhailiuk, P. K., Afonin, S., Komarov, I. V., Separovic, F., Craik, D. J. & Ulrich, A. S., 28 Feb 2017, In : Biophysical Journal. 112, 4, p. 630-642 13 p.

Research output: Contribution to journalArticle

Open Access
5 Citations

Stepwise Evolution of a Buried Inhibitor Peptide over 45 My

Jayasena, A. S., Fisher, M. F., Panero, J. L., Secco, D., Bernath-Levin, K., Berkowitz, O., Taylor, N. L., Schilling, E. E., Whelan, J. & Mylne, J., 1 Jun 2017, In : Molecular Biology and Evolution. 34, 6, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

Open Access
File
peptide
inhibitor
Helianthus annuus
peptides
Peptides
2 Citations

Two Proteins for the Price of One: Structural Studies of the Dual Destiny Preproalbumin with Sunflower Trypsin Inhibitor-1

Franke, B., James, A. M., Mobli, M., Colgrave, M. L., Mylne, J. S. & Rosengren, K. J., 28 Jul 2017, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Open Access
File
Helianthus
Albumins
Proteins
Protein Precursors
Seed
2016
5 Citations

A tripartite approach identifies the major sunflower seed albumins.

Jayasena, A. S., Franke, B., Rosengren, K. J. & Mylne, J. S., Mar 2016, In : Theoretical and Applied Genetics. 129, 3, p. 613–629

Research output: Contribution to journalArticle

Open Access
File
sunflower seed
Helianthus
albumins
Albumins
Seeds
2 Citations

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana)

Franke, B., Jayasena, A. S., Fisher, M. F., Swedberg, J. E., Taylor, N. L., Mylne, J. S. & Rosengren, K. J., 1 Nov 2016, In : Biopolymers. 106, 6, p. 806-817 12 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Peptides
Seed
Seeds
Helianthus
12 Citations

DNA gyrase is the target for the quinolone drug ciprofloxacin in arabidopsis thaliana

Evans-Roberts, K. M., Mitchenall, L. A., Wall, M. K., Leroux, J., Mylne, J. & Maxwell, A., 12 Feb 2016, In : Journal of Biological Chemistry. 291, 7, p. 3136-3144 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Gyrase
Quinolones
Ciprofloxacin
Arabidopsis
Genes
3 Citations

Mature forms of the major seed storage albumins in sunflower: A mass spectrometric approach

Franke, B., Colgrave, M. L., Mylne, J. & Rosengren, K. J., 16 Sep 2016, In : Journal of Proteomics. 147, p. 177-186

Research output: Contribution to journalArticle

Helianthus
Seed
Albumins
Seeds
Monomers

Protein scissors that also learned to glue

Mylne, J. S., 2016, Australasian Science, 37, p. 34-35 2 p.

Research output: Contribution to specialist publicationArticle

2015
13 Citations

An interactive database to explore herbicide physicochemical properties

Gandy, M., Corral, M., Mylne, J. & Stubbs, K., 28 May 2015, In : Organic and Biomolecular Chemistry. 13, 20, p. 5586-5590

Research output: Contribution to journalArticle

herbicides
Herbicides
Databases
chemical properties
Chemical properties
23 Citations

Peptide macrocyclization by a bifunctional endoprotease

Bernath-Levin, K., Nelson, C., Elliott, A. G., Jayasena, A. S., Millar, H., Craik, D. J. & Mylne, J., May 2015, In : Chemistry and Biology. 22, 5, p. 571-582

Research output: Contribution to journalArticle

Open Access
asparaginylendopeptidase
Jacks
Helianthus
Peptides
Masks
9 Citations

The Evolution of Momordica Cyclic Peptides

Mahatmanto, T., Mylne, J., Poth, A. G., Swedberg, J., Kaas, Q., Schaefer, H. & Craik, D. J., 2 Feb 2015, In : Molecular Biology and Evolution. 32, 2, p. 392-405

Research output: Contribution to journalArticle

Momordica
cyclic peptides
Cyclic Peptides
peptide
Cucurbitaceae
2014
6 Citations

A comparative study of extraction methods reveals preferred solvents for cystine knot peptide isolation from Momordica cochinchinensis seeds

Mahatmanto, T., Poth, A. G., Mylne, J. & Craik, D. J., Jun 2014, In : Fitoterapia. 95, p. 22-33

Research output: Contribution to journalArticle

Momordica
formic acid
Cystine
Seeds
Peptides

A protein is born

Mylne, J., 2014, In : Australasian Science. 35, 7, p. 28-30

Research output: Contribution to journalArticle

16 Citations

Evolutionary origins of a bioactive peptide buried within Preproalbumin

Elliott, A. G., Delay, C., Liu, H., Phua, Z., Rosengren, K. J., Benfield, A. H., Panero, J. L., Colgrave, M. L., Mederian Kotuwe, A., Dunse, K. M., Anderson, M. A., Schilling, E. E., Ortiz-Barrientos, D. & Mylne, J. S., 28 Mar 2014, In : The Plant Cell. 26, 3, p. 981-995 15 p.

Research output: Contribution to journalArticle

Open Access

Genes that cuddle in the cold

Mylne, J., 2014, In : Australasian Science. 35, 4, p. 16-18

Research output: Contribution to journalArticle

Next generation sequencing and de novo transcriptomics to study gene evolution

Jayasena, A. S., Secco, D., Bernath-Levin, K., Berkowitz, O., Whelan, J. & Mylne, J., 20 Oct 2014, In : Plant Methods. 10, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Open Access
transcriptomics
Genes
genes
Seeds
peptides
13 Citations

Seed storage albumins: Biosynthesis, trafficking and structures

Mylne, J., Hara-Nishimura, I. & Rosengren, K. J., 2014, In : Functional Plant Biology. 41, 7, p. 671-677 7 p.

Research output: Contribution to journalLiterature review

Open Access
seed storage
albumins
biosynthesis
seed maturation
post-translational modification
2013
51 Citations

Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization

Rosa, S., De Lucia, F., Mylne, J., Zhu, D., Ohmido, N., Pendle, A., Kato, N., Shaw, P. & Dean, C., 2013, In : Genes and Development. 27, 17, p. 1845-1850

Research output: Contribution to journalArticle

Open Access
13 Citations

The Arabidopsis B3 Domain Protein VERNALIZATION1 (VRN1) Is Involved in Processes Essential for Development, with Structural and Mutational Studies Revealing Its DNA-binding Surface

King, G. J., Chanson, A. H., Mccallum, E. J., Ohme-Takagi, M., Byriel, K., Hill, J. M., Martin, J. L. & Mylne, J., 2013, In : Journal of Biological Chemistry. 288, p. 3198–3207

Research output: Contribution to journalArticle

2012
64 Citations

Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase-Mediated Biosynthesis

Mylne, J., Chan, L. Y., Chanson, A. H., Daly, N. L., Schaefer, H., Bailey, T. L., Nguyencong, P., Cascales, L. & Craik, D. J., 2012, In : Plant Cell. 24, p. 2765-2778

Research output: Contribution to journalArticle

Open Access
12 Citations

Cyclotide Isolation and Characterization

Craik, D. J., Henriques, S. T., Mylne, J. & Wang, C. K., 2012, In : Methods in Enzymology. 516, p. 37-62

Research output: Contribution to journalArticle

70 Citations

Cyclotides as a basis for drug design

Craik, D. J., Swedberg, J. E., Mylne, J. & Cemazar, M., 2012, In : Expert Opinion on Drug Discovery. 7, p. 179-194

Research output: Contribution to journalReview article

68 Citations

Cyclotides Associate with Leaf Vasculature and Are the Products of a Novel Precursor in Petunia (Solanaceae)

Poth, A. G., Mylne, J., Grassl, J., Lyons, R. E., Millar, H., Colgrave, M. L. & Craik, D. J., 2012, In : Journal of Biological Chemistry. 287, 32, p. 27033-27046

Research output: Contribution to journalArticle

2 Citations
2011
73 Citations

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

Mylne, J., Colgrave, M. L., Daly, N. L., Chanson, A. H., Elliott, A. G., Mccallum, E. J., Jones, A. & Craik, D. J., 2011, In : Nature Chemical Biology. 7, p. 257-259

Research output: Contribution to journalArticle

26 Citations

Cycloquest: Identification of Cyclopeptides via Database Search of Their Mass Spectra against Genome Databases

Mohimani, H., Liu, W-T., Mylne, J., Poth, A. G., Colgrave, M. L., Tran, D., Selsted, M. E., Dorrestein, P. C. & Pevzner, P. A., 2011, In : Journal of Proteome Research. 10, 10, p. 4505-4512

Research output: Contribution to journalArticle

3 Citations

Plant chemical biology: Florigen takes two to tango

Mylne, J. & Wigge, P. A., 2011, In : Nature Chemical Biology. 7, p. 665-666

Research output: Contribution to journalArticle

32 Citations

Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis

Box, M. S., Coustham, V., Dean, C. & Mylne, J., 2011, In : Plant Methods. 7, 7, p. 10pp

Research output: Contribution to journalArticle

Open Access
2010
51 Citations

Cyclotides: Macrocyclic peptides with applications in drug design and agriculture

Craik, D. J., Mylne, J. & Daly, N. L., 2010, In : Cellular and Molecular Life Sciences. 67, p. 9-16

Research output: Contribution to journalReview article

29 Citations

Cyclotides are a component of the innate defense of Oldenlandia affinis

Mylne, J., Wang, C. K., Van Der Weerden, N. L. & Craik, D. J., 2010, In : Biopolymers. 94, p. 635-646

Research output: Contribution to journalArticle

23 Citations

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

Qin, Q., Mccallum, E. J., Kaas, Q., Suda, J., Saska, I., Craik, D. J. & Mylne, J., 2010, In : BMC Genomics. 11, p. 11pp

Research output: Contribution to journalArticle

Open Access
2009
28 Citations

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides

Trabi, M., Mylne, J., Sando, L. & Craik, D. J., 2009, In : Organic and Biomolecular Chemistry. 7, p. 2378-2388

Research output: Contribution to journalArticle

2008
9 Citations

15N cyclotides by whole plant labeling

Mylne, J. & Craik, D. J., 2008, In : Biopolymers - Peptide Science Section. 90, p. 575-580

Research output: Contribution to journalArticle

156 Citations

ARABIDOPSIS TRITHORAX1 Dynamically Regulates FLOWERING LOCUS C Activation via Histone 3 Lysine 4 Trimethylation

Pien, S., Fleury, D., Mylne, J., Crevillen, P., Inzé, D., Avramova, Z., Dean, C. & Grossniklaus, U., 2008, In : Plant Cell. 20, p. 580-588

Research output: Contribution to journalArticle

79 Citations

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

Herrmann, A., Burman, R., Mylne, J., Karlsson, G., Gullbo, J., Craik, D. J., Clark, R. J. & Göransson, U., 2008, In : Phytochemistry. 69, p. 939-952

Research output: Contribution to journalArticle

2007
148 Citations

The PHD Finger Protein VRN5 Functions in the Epigenetic Silencing of Arabidopsis FLC

Greb, T., Mylne, J., Crevillen, P., Geraldo, N., An, H., Gendall, A. R. & Dean, C., 2007, In : Current Biology. 17, p. 73

Research output: Contribution to journalArticle