• The University of Western Australia (M310), 35 Stirling Highway,

    6009 Perth

    Australia

  • 2605 Citations
  • 21 h-Index
19982018
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Personal profile

Biography

Dr Mylne (PhD, Botany) worked at the John Innes Centre (2001-2005), using molecular genetics to study proteins that accelerate flowering in response to prolonged cold (vernalization). In 2006 he moved to the Division of Chemistry & Structural Biology at The Institute for Molecular Bioscience (IMB, UQ) where he held a QEII Fellowship (2008-2012) and was the inaugural John S. Mattick Fellow (2010-2012). In 2013 he joined the faculty at The University of Western Australia and took up an ARC Future Fellowship in the School of Chemistry & Biochemistry and The ARC Centre of Excellence in Plant Energy Biology. His research interests are protein evolution, molecular mechanisms underlying the biosynthesis of bioactive peptides and increasing the discovery of novel herbicides and novel modes of action.

Roles and responsibilities

2017-2019: Honours Coordinator (Biochemistry, Molecular Biology and Genetics), School of Molecular Sciences, UWA

Funding overview

CSIRO Research+ Postdoctoral Fellowships (2017-2019) Generating novel RNA carrying peptides for control of agricultural diseases. Anderson, Singh, Mylne.
Australian Research Council Discovery Project (2016-2018) How scissors learn to glue: the catalysis of ligation by proteases. Mylne & Tawfik.
UWA Research Collaboration Award (2015) The structural enzymology behind a ligating protease. Mylne, Bernath-Levin.
Australian Research Council LIEF Grant (2014) Biomolecular Interaction Facility. Bond, Vrielink, Filipovska, Mylne, Small, Mancera, Oliver.
UQ-UWA Bilateral Research Collaboration Award (2014) How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene? Rosengren & Mylne.
Australian Research Council Discovery Project (2013-2015) A new and rapidly evolving class of plant peptides. Mylne, Panero & Schilling.
Australian Research Council Future Fellowship (2013-2016) Genetic evolution of plant proteins with biomedical applications. Mylne.
Australian Research Council Discovery Project (2012-2014) How do sunflowers make protein drugs in their seeds? Mylne, Rosengren & Suga.
UQ-UWA Bilateral Research Collaboration Award (2012) Exploring the genetic origin of a protein hijack event in daisies with next-generation sequencing. Mylne & Whelan.
National Health & Medical Research Council Project Grant (2011-2013) Harnessing plants to produce peptide drugs. Craik & Mylne.
Australian Research Council Discovery Project (2008-2012) Circular plant proteins with pharmaceutical applications. Mylne.

Previous positions

2017-2018: Senior Lecturer, School of Molecular Sciences, The University of Western Australia, Crawley, Perth, Australia
2012-2016: Australian Research Council Future Fellow, appointly jointly to the School of Chemistry & Biochemistry and the ARC Centre of Excellence in Plant Energy Biology
2013-2015: Honorary and Adjunct appointment, Institute for Molecular Bioscience (IMB), UQ, Brisbane, Australia
2010-2012: The John S. Mattick Fellow, IMB, UQ Brisbane, Australia
2008-2012: Australian Research Council Queen Elizabeth II (QEII) Fellow, Division of Chemistry & Structural Biology, Institute for Molecular Bioscience (IMB), UQ, Brisbane, Australia
2008-2012: Australian Army Specialist Service Officer, Research Scientist, Division of Drug Resistance & Diagnostics, Army Malaria Institute, Enoggera, Australia
2007: University of Queensland (UQ) Post-Doctoral Research Fellow, IMB, UQ, Brisbane, Australia
2006: Post-Doctoral Research Officer with Prof. David Craik, IMB, UQ, Brisbane, Australia
2001-2005: Project Scientist with Prof. Caroline Dean (FRS, NAS, OBE), Department of Cell & Developmental Biology, John Innes Centre, Norwich, England, UK
2001: Visiting Scientist with Victoriano Valpuesta, Dpto. de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Spain
1999-2000: Visiting Scientist with Phil Benfey, Department of Biology, New York University, Manhattan, New York, USA

Teaching overview

2017-now: SCIE4481 Good, Bogus and Corrupted Science, Course lecturer
2017-now: GENE2230 Molecular Genetics, Course lecturer
2015-now: BIOC2001 Biochemistry and Molecular Biology of the Cell, Course lecturer
2015-now: MSCI4006 Advanced Techniques in Molecular Sciences, Course lecturer
2015-now: SCIE4001 The Objectives and Applications of Genomics, Course lecturer
2015-2017: GENE4001 Advanced Studies in Genetics and Genomics, Course lecturer
2015: MSCI4098 Seminar Appraisal and Presentation Part 1, Co-Coordinator
2015: MSCI4099 Seminar Appraisal and Presentation Part 2, Co-Coordinator
2014-now: BIOC3001 Molecular Biology, Course lecturer
2013-now: CHEM3001 Essential Chemical Skills, Guest lecturer

Research

Plant peptide biosynthesis
Protease evolution
Herbicides

Keywords

  • Biochemistry seed proteins
  • Protein evolution
  • Peptide biosynthesis
  • Protein mass spectrometry
  • Plant genetics
  • Flowering time
  • Vernalisation
  • Proteolysis
  • Plant biology and biochemistry

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
asparaginylendopeptidase Medicine & Life Sciences
Cyclic Peptides Medicine & Life Sciences
Helianthus Medicine & Life Sciences
Peptides Medicine & Life Sciences
Seeds Medicine & Life Sciences
Momordica Medicine & Life Sciences
Herbicides Medicine & Life Sciences
Albumins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2018

Research Output 1998 2018

  • 2605 Citations
  • 21 h-Index
  • 51 Article
  • 4 Review article
  • 2 Doctoral Thesis
  • 1 Literature review
2 Citations

A herbicide structure–activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana

Corral, M. G., Leroux, J., Tresch, S., Newton, T., Stubbs, K. A. & Mylne, J. S., 1 Jul 2018, In : Pest Management Science. 74, 7, p. 1558-1563 6 p.

Research output: Contribution to journalArticle

antimalarials
mechanism of action
Arabidopsis thaliana
herbicides
herbicide-resistant weeds

Antimalarial herbicides and herbicidal antimalarials: Exploiting the plant-Plasmodium connection

Corral, M., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
antimalarials
Plasmodium
herbicides
parasites
herbicide resistance
2 Citations

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins

Franke, B., Mylne, J. S. & Rosengren, K. J., Feb 2018, In : Natural Product Reports. 35, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

1 Citations

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Wallace, M. D., Waraich, N. F., Debowski, A. W., Corral, M. G., Maxwell, A., Mylne, J. S. & Stubbs, K. A., 21 Feb 2018, In : Chemical Communications. 54, 15, p. 1869-1872 4 p.

Research output: Contribution to journalArticle

4 Citations

Macrocyclization by asparaginyl endopeptidases

James, A. M., Haywood, J. & Mylne, J. S., May 2018, In : New Phytologist. 218, 3, p. 923-928

Research output: Contribution to journalReview article

asparaginylendopeptidase
proteinases
Cyclic Peptides
peptides
cyclic peptides

Prizes

Fulbright Professional Scholarship

Joshua Mylne (Recipient), 3 Nov 2017

Prize/award: Prize