Personal profile
Biography
Joseph joined the WA Node of the National Imaging Facility (WA NIF) in 2022 as the inaugural Radiochemistry Facility Fellow. This academic appointment involves supporting PET and MRI imaging research trials at WA NIF while remaining a key part of the RAPID team for the provision of novel radiopharmaceuticals. Joseph was involved in the fit-out and commissioning of the WA NIF Facility (Official Opening October 2023) and the new RAPID GMP Cyclotron Facility (Planned Opening 2025). This facility houses specialist radiochemistry infrastructure co-funded by UWA and NIF.
Joseph is a certified radiopharmaceutical scientist registered with the Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM), and is a current Supervisor and Assessor for RPS registrars. His research interests are in:
- Novel 18F synthesis and quality control methods
- Preclinical PET imaging, uptake and biodistribution
- Technology transfer and development of new radiopharmaceuticals for imaging infection and inflammation, imaging and treating cancer, and for studying neurodegenerative/neuroinflammatory disorders.
Joseph completed his PhD at The University of Sydney in 2011 under the supervision of Prof. Lou Rendina and Prof. Michael Kassiou (Thesis “Boron-Containing Phosphonium Salts for Boron Neutron Capture Therapy and Imaging”). His post-doctoral work with Prof. John Valliant at McMaster University was to explore new gallium-67/68 tracers for imaging infection. After returning to Australia, as lead quality control chemist he played an integral role in the establishment and GMP licensing of the Molecular Imaging and Therapy Research Unit (MITRU) at the South Australian Health and Medical Research Institute (SAHMRI), the first cyclotron facility for that state.
In 2016 he joined the RAPID team at Sir Charles Gairdner Hospital (NHMS), taking part in the production and quality control of clinical 11C, 18F, 68Ga, 89Zr and 177Lu radiopharmaceuticals as well as FDG. Key projects included the production and test method validation of new tracers such as [18F]PSMA-1007, leading pre-clinical imaging and biodistribution projects, and introducing aluminium-fluoride labelling of novel peptides.
Education/Academic qualification
Chemistry, PhD, Carborane-Containing Phosphonium Salt for Boron Neutron Therapy of Cancer, University of Sydney
Award Date: 10 Jun 2011
Chemistry, Physics, BSc (Adv. Hons.)
Award Date: 16 Jun 2006
External positions
Senior Radiochemist, Sir Charles Gairdner Hospital
2016 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Morandeau, L., Ioppolo, J. A., Alvarez de Eulate, E., Mohamed, S., Cullen, D., Asad, A. H., Francis, R. J. & Atkinson, J., 24 May 2024, In: Journal of Visualized Experiments. 2024, 207, e66708.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus) -
Development of a high-performance liquid chromatography method for rapid radiochemical purity measurement of [18F]PSMA-1007, a PET radiopharmaceutical for detection of prostate cancer
Ioppolo, J. A., Alvarez de Eulate, E., Cullen, D. R., Mohamed, S. & Morandeau, L., Mar 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 3, p. 58-72 15 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
Investigation of Zinc Impurities on [(68)GA]-PSMA-11 Synthesis and Quality Control Validation
Grenik, E., Ioppolo, J., Asad, A. & Morandeau, L., May 2021, In: Internal Medicine Journal. 51, p. 23-23 1 p.Research output: Contribution to journal › Abstract/Meeting Abstract › peer-review
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Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts
Ioppolo, J. A., Nezich, R. A., Richardson, K. L., Morandeau, L., Leedman, P. J. & Price, R. I., Jul 2020, In: Applied Radiation and Isotopes. 161, 109164.Research output: Contribution to journal › Article › peer-review
23 Link opens in a new tab Citations (Scopus) -
Delivery of 18F-PSMA-1007 Through an Automatic Infusion Device
Culleton, S. & Ioppolo, J., Apr 2019, In: Internal Medicine Journal. 49, p. 25-25 1 p.Research output: Contribution to journal › Abstract/Meeting Abstract › peer-review
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On-site Radiochemical Analysis at WA NIF Node
Ioppolo, J. (Chief Investigator), Bellinge, J. (CoPI), Cook, A. (CoPI), Creaney, J. (CoPI), Espedal, H. (CoPI), Hoang, T. (CoPI), Lam, V. (CoPI), Mamo, J. (CoPI), Morandeau, L. (CoPI) & Power, C. (CoPI)
The University of Western Australia
1/01/26 → 31/12/26
Project: Research
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Imaging Mesothelioma with Girentuximab: Evolution and Revolution (IMAGER)
Francis, R. (Investigator 01), Creaney, J. (Investigator 02), Lee, G. (Investigator 03), Chin, M. (Investigator 04), Espedal, H. (Investigator 05) & Ioppolo, J. (Investigator 06)
MRFF Medical Research Future Fund
1/10/25 → 30/09/27
Project: Research
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Tracking PD-L1 modulation in mesothelioma using advanced in vivo imaging
Hoang, T. (Investigator 01), Mohamed, S. (Investigator 02), Ioppolo, J. (Investigator 03), Espedal, H. (Investigator 04), Richardson, K. (Investigator 05), Cook, A. (Investigator 06), Morandeau, L. (Investigator 07), Chin, M. (Investigator 08), Francis, R. (Investigator 09), Nowak, A. (Investigator 10) & Ward, T. (Investigator 11)
8/01/24 → 8/07/26
Project: Research
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Australian Research Network for Translation of Targeted Alpha Therapies
Ioppolo, J. (Investigator 01)
MRFF Medical Research Future Fund
3/07/23 → 3/07/28
Project: Research
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Zirconium-89 labelled antibodies for imaging PD-L1 dynamics in mesothelioma in response to immunotherapy and chemotherapy
Cook, A. (Investigator 01), Mohamed, S. (Investigator 02), Hoang, T. (Investigator 03), Espedal, H. (Investigator 04), Morandeau, L. (Investigator 05), Francis, R. (Investigator 06), Nowak, A. (Investigator 07) & Ioppolo, J. (Investigator 08)
Australian and New Zealand Society of Nuclear Medicine (ANZSNM)
3/07/23 → 24/09/26
Project: Research