• The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 154 Citations
  • 8 h-Index
20112021
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Personal profile

Biography

I graduated with a BSc (Hons) from the University of Melbourne. I undertook my PhD at the St Vincent’s Institute (Melbourne), where I studied the development and function of islet-specific T cells in autoimmune diabetes. I was also part of the Tom Mandel Islet Transplantation Programme, which offered access to islet transplantation for people with type 1 diabetes. After successfully completing my PhD, I joined the National Centre of Asbestos Related Disease (NCARD) in November 2014, and am currently a Cancer Council Western Australia Postdoctoral Fellow. 

Research interests

My research interests are in understanding the immunology mechanisms that underlie why some mesothelioma patients respond better to immunotherapy/chemotherapy but not others. The end goal is to utilise this knowledge to develop novel therapies and accurate predictors of treatment outcomes. I am particularly interested in understanding how the T cell repertoire influences treatment outcomes in cancer patients. 

Current projects

  1. The integration of mathematics and TCR sequencing to understand how an individual’s immune system contributes to therapy success
  2. The development of preclinical models to study why some patients develop severe autoimmunity after cancer immunotherapy
  3. The development of novel epigenetic targeting tools to improve mesothelioma therapy outcomes

 

Roles and responsibilities

  • Co-ordinate and co-lead the murine TCR program at NCARD
  • Manage and maintain preclinical models at NCARD 
  • Organise NCARD scientific meetings
  • Supervision of PhD and Honours students

Teaching overview

 Tumour Immunology Lecture

"Vaccines to immune checkpoint blockade" PATH3309 

Languages

English, Mandarin

Education/Academic qualification

Autoimmune Diabetes, Immunology, PhD, University of Melbourne

Science, BSc (Hons), University of Melbourne

Biomedical Science, BBiomedSc, University of Melbourne

Fingerprint Dive into the research topics where Jonathan Chee is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 28 Similar Profiles
Inbred NOD Mouse Medicine & Life Sciences
Type 1 Diabetes Mellitus Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
Proinsulin Medicine & Life Sciences
Antigens Medicine & Life Sciences
Mesothelioma Medicine & Life Sciences
Receptors, Tumor Necrosis Factor, Type I Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2011 2019

  • 154 Citations
  • 8 h-Index
  • 14 Article
  • 2 Review article
Open Access
Lymphocytes
Mesothelioma
Pleural Effusion
Tumors
Blood
1 Citation (Scopus)

Combination immune checkpoint blockade as an effective therapy for mesothelioma

Fear, V., Tilsed, C. M., Chee, H. E. J., Forbes, C., Casey, T., Solin, J., Lansley, S., Lesterhuis, W., Dick, I., Nowak, A., Robinson, B., Lake, R. & Fisher, S., 30 Jul 2018, In : Oncolmmunology. 14 p., e1494111.

Research output: Contribution to journalArticle

Open Access
Mesothelioma
Neoplasms
Therapeutics
Asbestos
Regulatory T-Lymphocytes

Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

Jhala, G., Chee, H. E. J., Trivedi, P. M., Selck, C., Gurzov, E. N., Graham, K. L., Thomas, H. E., Kay, T. WH. & Krishnamurthy, B., Jul 2016, In : JCI Insight. 1, 10, p. 1-11 11 p.

Research output: Contribution to journalArticle

Proinsulin
Type 1 Diabetes Mellitus
T-Lymphocytes
Inbred NOD Mouse
Antigen-Presenting Cells
17 Citations (Scopus)

Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes

Chee, J., Ko, H. J., Skowera, A., Jhala, G., Catterall, T., Graham, K. L., Sutherland, R. M., Thomas, H. E., Lew, A. M., Peakman, M., Kay, T. W. H. & Krishnamurthy, B., 15 Jan 2014, In : Journal of Immunology. 192, 2, p. 572-580 9 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Pathology
T-Lymphocytes
Lymphoid Tissue
Inbred NOD Mouse

Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigens

Wylie, B., Chee, J., Forbes, C. A., Booth, M., Stone, S. R., Buzzai, A., Abad, A., Foley, B., Cruickshank, M. N. & Waithman, J., 31 May 2019, In : OncoImmunology. 11 p.

Research output: Contribution to journalArticle

Open Access

Projects 2016 2021