Research output per year
Research output per year
Personal profile
Biography
Dr Jiake Xu is currently Adjunct Professor. He was Winthrop Professor, Head of Molecular Laboratory, School of Biomedical Science, at the University of Western Australia (2011-2023). He served as Head of the Division of Regenerative Medicine (2017-2021).
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, Fellow of American Society of Bone and Mineral Research (ASBMR); Fellow of International Orthopedic Research (FIOR), and ex-president of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
Roles and responsibilities
Prof Xu serves as a scientific program committee member for the Australian and New Zealand Orthopaedic Research Society (ANZORS), and as an elected member of the Board of Directors for the International Chinese Hard Tissue Society (ICHTS) since 2005. He also serves as a committee member in the Research Committee of the Australian and New Zealand Bone and Mineral Society (ANZBMS).
Funding overview
From 2000 to 2023 received
20 NHMRC as a chief investigator
1 ARC as a chief investigator
Research
• Osteoimmunology, osteolysis, and mechanisms of bone resorption.
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
Teaching overview
Teaching and/or teaching Coordinator for
PATH2210 (Coordinator and teaching)
IMED3001, 3002, 3003, 3004
DENT3001, 3002, 3003, 3004
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research expertise keywords
- Bone biology
- Degenerative diseases
- Molecular biology and pathogenesis of bone disease
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Active fraction of Polyrhachis vicina (Rogers) inhibits osteoclastogenesis by targeting Trim38 mediated proteasomal degradation of TRAF6
Feng, X., Wei, G., Su, Y., Xian, Y., Liu, Z., Gao, Y., Liang, J., Lian, H., Xu, J., Zhao, J., Liu, Q. & Song, F., Sept 2024, In: Phytomedicine. 132, 15 p., 155890.Research output: Contribution to journal › Article › peer-review
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Antioxidant enzyme Prdx1 inhibits osteoclastogenesis via suppressing ROS and NFATc1 signaling pathways
Wang, C., Wang, G., Song, F., Zhao, J., Liu, Q. & Xu, J., 12 Sept 2024, (E-pub ahead of print) In: Journal of Cellular Physiology. e31431.Research output: Contribution to journal › Article › peer-review
Open Access -
Bacterial heat shock protein: A new crosstalk between T lymphocyte and macrophage via JAK2/STAT1 pathway in bloodstream infection
Yin, S., Peng, Y., Lin, Y. R., Wu, H., Wang, B., Wang, X., Chen, W., Liu, T., Peng, H., Li, X., Xu, J. & Wang, M., May 2024, In: Microbiological Research. 282, 19 p., 127626.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Cadherin-responsive hydrogel combined with dental pulp stem cells and fibroblast growth factor 21 promotes diabetic scald repair via regulating epithelial-mesenchymal transition and necroptosis
Lu, W., Zhao, J., Cai, X., Wang, Y., Lin, W., Fang, Y., Wang, Y., Ao, J., Shou, J., Xu, J. & Zhu, S., Feb 2024, In: Materials Today Bio. 24, 100919.Research output: Contribution to journal › Article › peer-review
Open Access -
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss
Xian, Y., Gao, Y., Su, Y., Su, Y., Lian, H., Feng, X., Liu, Z., Zhao, J., Xu, J., Liu, Q. & Song, F., Apr 2024, In: Phytotherapy Research. 38, 4, p. 1971-1989 19 p.Research output: Contribution to journal › Article › peer-review
Datasets
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sj-csv-2-cix-10.1177_11769351221140101 – Supplemental material for Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues
Rothzerg, E. (Creator), Feng, W. (Creator), Song, D. (Creator), Li, H. (Creator), Wei, Q. (Creator), Fox, A. (Creator), Wood, D. (Creator), Xu, J. (Creator) & Liu, Y. (Creator), SAGE Publications Ltd, 2022
DOI: 10.25384/sage.21685541.v1, https://sage.figshare.com/articles/dataset/sj-csv-2-cix-10_1177_11769351221140101_Supplemental_material_for_Single-Cell_Transcriptome_Analysis_Reveals_Paraspeckles_Expression_in_Osteosarcoma_Tissues/21685541/1
Dataset
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Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
Mullin, B. (Creator), Tickner, J. (Creator), Zhu, K. (Creator), Kenny, J. (Creator), Mullin, S. (Creator), Brown, S. J. (Creator), Dudbridge, F. (Creator), Pavlos, N. (Creator), Mocarski, E. S. (Creator), Walsh, J. (Creator), Xu, J. (Creator) & Wilson, S. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.4909641.v1, https://springernature.figshare.com/collections/Characterisation_of_genetic_regulatory_effects_for_osteoporosis_risk_variants_in_human_osteoclasts/4909641/1
Dataset
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sj-csv-2-cix-10.1177_11769351221140101 – Supplemental material for Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues
Rothzerg, E. (Creator), Feng, W. (Creator), Song, D. (Creator), Li, H. (Creator), Wei, Q. (Creator), Fox, A. (Creator), Wood, D. (Creator), Xu, J. (Creator) & Liu, Y. (Creator), SAGE Publications Ltd, 5 Dec 2022
DOI: 10.25384/sage.21685541, https://sage.figshare.com/articles/dataset/sj-csv-2-cix-10_1177_11769351221140101_Supplemental_material_for_Single-Cell_Transcriptome_Analysis_Reveals_Paraspeckles_Expression_in_Osteosarcoma_Tissues/21685541
Dataset
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World’s first chemical antibody-based intraoperative diagnostic platform for surgical pathology
1/02/24 → 31/01/25
Project: Research
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NHMRC Equipment - Cytek laser and loader
Davern, K., Lister, R., Ganss, R., Leedman, P., Xu, J., Redwood, A., Winteringham, L., Hamzah, J., Rackham, O. & Morahan, G.
NHMRC National Health and Medical Research Council
1/07/23 → 31/10/24
Project: Research
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Defining the nutrient substrates for bone remodelling
Chen, K., Jiang, H., Swaminatha Iyer, I., Xu, J., Greenblatt, M. & Pavlos, N.
1/01/23 → 31/12/25
Project: Research
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Prizes
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Fellow - American Society of Bone and Mineral Research (ASBMR)
Xu, Jiake (Recipient), 2020
Prize: Fellowship
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Activities
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Theranostics (Journal)
Jiake Xu (Member of editorial board)
2022 → …Activity: Editorial work or peer review of publications › Editorial activity
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Australia and New Zealand Bone and Mineral Society (ANZBMS) annual scientific meeting (ASM)
Jiake Xu (Member of programme committee)
1 Aug 2022 → 4 Aug 2022Activity: Conferences and workshops › Contribution or participation in a conference
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Taming the Osteoclast: New Therapies for Bone Diseases
Jiake Xu (Invited speaker)
16 Mar 2022Activity: Service and engagement › Public lecture, debate or seminar
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The Journal of Biological Chemistry (Journal)
Jiake Xu (Member of editorial board)
2021Activity: Editorial work or peer review of publications › Editorial activity
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Journal Cellular Physiology (Journal)
Jiake Xu (Member of editorial board)
2021Activity: Editorial work or peer review of publications › Editorial activity
Press/Media
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Study offers hope for potential new treatment for osteoporosis
20/01/23
1 Media contribution
Press/Media: Press / Media
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Study points to potential new treatment for osteoporosis
18/01/23
1 item of Media coverage
Press/Media: Press / Media