Research Output per year
Personal profile
Biography
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, and has been appointed the President of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
Roles and responsibilities
Funding overview
18 NHMRC as a chief investigator
1 ARC as a chief investigator
Teaching overview
PATH2210
PATH3304
Research
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
Keywords
- Bone biology
- Degenerative diseases
- Molecular biology and pathogenesis of bone disease
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1994 2019
A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis
Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 others , 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13Research output: Contribution to journal › Article
Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human
Yuan, J., Tickner, J., Mullin, B. H., Zhao, J., Zeng, Z., Morahan, G. & Xu, J., 2 Apr 2019, In : Frontiers in Genetics. 10, 13 p., 288.Research output: Contribution to journal › Review article
Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways
He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.Research output: Contribution to journal › Article
Asperpyrone A attenuates RANKL-induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress
Chen, X., Wang, C., Qiu, H., Yuan, Y., Chen, K., Cao, Z., Xiang Tan, R., Tickner, J., Xu, J. & Zou, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8269-8279 11 p.Research output: Contribution to journal › Article
Astilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis
Jin, H., Wang, Q., Chen, K., Xu, K., Pan, H., Chu, F., Ye, Z., Wang, Z., Tickner, J., Qiu, H., Wang, C., Kenny, J., Xu, H., Wang, T. & Xu, J., 1 Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8355-8368 14 p.Research output: Contribution to journal › Article
Projects 2001 2022
‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/19 → 31/12/22
Project: Research
The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
Pavlos, N., Xu, J. & Teasdale, R.
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/20
Project: Research
NT-3 as an upstream and potentially master regulator promoting bone fracture healing
Xu, J., Xian, C. & Foster, B.
National Health & Medical Research Council NHMRC
1/01/17 → 31/12/19
Project: Research
Gene mining for novel molecular determinants of the skeleton
Xu, J., Pavlos, N., Tickner, J., Wilson, S. & Walsh, J.
National Health & Medical Research Council NHMRC
1/01/17 → 31/12/19
Project: Research