Projects per year
Personal profile
Biography
Dr Jiake Xu is currently Winthrop Professor, Head of Molecular Laboratory, and Head of the Division of Regenerative Medicine, School of Biomedical Science, at the University of Western Australia.
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, and has been appointed the President of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, and has been appointed the President of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
Roles and responsibilities
Prof Xu serves as a scientific program committee member for the Australian and New Zealand Orthopaedic Research Society (ANZORS), and as an elected member of the Board of Directors for the International Chinese Hard Tissue Society (ICHTS) since 2005. He also serves as a committee member in the Research Committee of the Australian and New Zealand Bone and Mineral Society (ANZBMS).
Funding overview
From 2000 to 2017 received
18 NHMRC as a chief investigator
1 ARC as a chief investigator
18 NHMRC as a chief investigator
1 ARC as a chief investigator
Teaching overview
Teaching and/or teaching Coordinator for
PATH2210
PATH3304
PATH2210
PATH3304
Research
• Osteoimmunology, osteolysis, and mechanisms of bone resorption.
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
Keywords
- Bone biology
- Degenerative diseases
- Molecular biology and pathogenesis of bone disease
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2001 2021
2017 - The iCelligence system
Xu, J., Mullin, B., Pavlos, N., Meehan, K., Jiang, H. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/18
Project: Research
The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/21
Project: Research
NT-3 as an upstream and potentially master regulator promoting bone fracture healing
1/01/17 → 31/12/19
Project: Research
Gene mining for novel molecular determinants of the skeleton
Wilson, S., Tickner, J., Pavlos, N., Xu, J. & Walsh, J.
National Health & Medical Research Council NHMRC
1/01/17 → 31/12/19
Project: Research
Furin: Carving-up vital substrates for bone remodelling and homeostasis
Tickner, J., Xu, J. & Pavlos, N.
National Health & Medical Research Council NHMRC
1/01/16 → 31/12/19
Project: Research
Research Output 1994 2018
Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo
Wei, C. M., Liu, Q., Song, F. M., Lin, X. X., Su, Y. J., Xu, J., Huang, L., Zong, S. H. & Zhao, J. M. 1 Jan 2018 In : Journal of Cellular Physiology. 233, 1, p. 476-485 10 p.Research output: Contribution to journal › Article
Bone Resorption
Osteogenesis
Lipopolysaccharides
Bone
Bone and Bones
Coupling factors and exosomal packaging microRNAs involved in the regulation of bone remodelling
Zhu, S., Yao, F., Qiu, H., Zhang, G., Xu, H. & Xu, J. Feb 2018 In : Biological Reviews. 93, 1, p. 469-480 12 p.Research output: Contribution to journal › Article
Open Access
File
Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways
Cheng, J., Zhou, L., Liu, Q., Tickner, J., Tan, Z., Li, X., Liu, M., Lin, X., Wang, T., Pavlos, N. J., Zhao, J. & Xu, J. 1 Mar 2018 In : Journal of Cellular Physiology. 233, 3, p. 2502-2512 11 p.Research output: Contribution to journal › Article
Ovariectomy
Osteogenesis
Osteoporosis
Osteoclasts
Bone
Expression quantitative trait locus study of bone mineral density GWAS variants in human osteoclasts
Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J., Pavlos, N. J., Dudbridge, F., Walsh, J. P. & Wilson, S. G. 23 Feb 2018 In : Journal of Bone & Mineral Research.Research output: Contribution to journal › Article
Quantitative Trait Loci
Genome-Wide Association Study
Osteoclasts
Bone Density
Single Nucleotide Polymorphism
GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis
Liang, J., Li, J., Fu, Y., Ren, F., Xu, J., Zhou, M., Li, P., Feng, H. & Wang, Y. 1 Apr 2018 In : Cell Biochemistry and Function. 36, 3, p. 129-136 8 p.Research output: Contribution to journal › Article
Chondrogenesis
Kyphosis
Scoliosis
Knockout Mice
Bone