Jiake Xu

Winthrop Professor, MB BS Guangzhou, PhD W.Aust.

Winthrop Professor, Faculty of Health and Medical Sciences, Regenerative Biology
Head of Division, Faculty of Health and Medical Sciences, Regenerative Biology

Phone+61 8 6457 2739
Emailjiake.xu@uwa.edu.au

The University of Western Australia (M504), 35 Stirling Highway, Room 1.4H, M Block, QEII Medical Centre, Nedlands
6009 Perth
Australia

5606 Citations
43 h-Index

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Personal profile

Biography

Dr Jiake Xu is currently Winthrop Professor, Head of Molecular Laboratory, and Head of the Division of Regenerative Medicine, School of Biomedical Science, at the University of Western Australia.

He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, and has been appointed the President of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).

He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.

His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.

Roles and responsibilities

Prof Xu serves as a scientific program committee member for the Australian and New Zealand Orthopaedic Research Society (ANZORS), and as an elected member of the Board of Directors for the International Chinese Hard Tissue Society (ICHTS) since 2005. He also serves as a committee member in the Research Committee of the Australian and New Zealand Bone and Mineral Society (ANZBMS).

Funding overview

From 2000 to 2017 received
18 NHMRC as a chief investigator
1 ARC as a chief investigator

Teaching overview

Teaching and/or teaching Coordinator for
PATH2210
PATH3304

Research

• Osteoimmunology, osteolysis, and mechanisms of bone resorption.
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment

Keywords

Bone biology
Degenerative diseases
Molecular biology and pathogenesis of bone disease

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1994 2019

5606 Citations
43 h-Index
194 Article
21 Review article
11 Conference paper
2 Literature review
5 More

1 Citation (Scopus)

A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis

Lian, Z., Han, J., Huang, L., Wei, C., Fan, Y., Xu, J., Zhou, M., Feng, H., Liu, Q., Chen, L., Li, Z., Cheng, H., Yuan, G., Lin, X., Song, F., Su, Y., Wang, C., Huang, G., Qin, A., Song, Y. & 1 othersYao, G., 1 Jan 2019, In : Carcinogenesis. 40, 2, p. E1-E13

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase

Osteolysis

Osteosarcoma

Sirolimus

RANK Ligand

Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human

Yuan, J., Tickner, J., Mullin, B. H., Zhao, J., Zeng, Z., Morahan, G. & Xu, J., 2 Apr 2019, In : Frontiers in Genetics. 10, 13 p., 288.

Research output: Contribution to journal › Review article

Open Access

2 Citations (Scopus)

Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

He, L., Hong, G., Zhou, L., Zhang, J., Fang, J., He, W., Tickner, J., Han, X., Zhao, L. & Xu, J., Apr 2019, In : Journal of Cellular Physiology. 234, 4, p. 4267-4276 10 p.

Research output: Contribution to journal › Article

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways

Sun, Y., Liu, Y., He, W., Wang, C., Tickner, J., Kuek, V., Zhou, C., Wang, H., Zou, X., Hong, Z., Yang, F., Shao, M., Chen, L. & Xu, J., 1 Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11792-11804 13 p.

Research output: Contribution to journal › Article

Osteoclasts

Osteoporosis

Bone

Bone and Bones

Osteogenesis

2 Citations (Scopus)

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways

Lin, X., Song, F., Zhou, L., Wang, Z., Wei, C., Xu, J., Zhao, J. & Liu, Q., 1 Feb 2019, In : Journal of Cellular Biochemistry. 120, 2, p. 1990-1996 7 p.

Research output: Contribution to journal › Article

NFATC Transcription Factors

Cell signaling

Osteoclasts

Bone

Bone Diseases