Research output per year
Research output per year
Personal profile
Biography
Dr Jiake Xu is currently Winthrop Professor, Head of Molecular Laboratory, and Head of the Division of Regenerative Medicine, School of Biomedical Science, at the University of Western Australia.
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, and has been appointed the President of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, and has been appointed the President of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
Roles and responsibilities
Prof Xu serves as a scientific program committee member for the Australian and New Zealand Orthopaedic Research Society (ANZORS), and as an elected member of the Board of Directors for the International Chinese Hard Tissue Society (ICHTS) since 2005. He also serves as a committee member in the Research Committee of the Australian and New Zealand Bone and Mineral Society (ANZBMS).
Funding overview
From 2000 to 2017 received
18 NHMRC as a chief investigator
1 ARC as a chief investigator
18 NHMRC as a chief investigator
1 ARC as a chief investigator
Teaching overview
Teaching and/or teaching Coordinator for
PATH2210
PATH3304
PATH2210
PATH3304
Research
• Osteoimmunology, osteolysis, and mechanisms of bone resorption.
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
Research expertise keywords
- Bone biology
- Degenerative diseases
- Molecular biology and pathogenesis of bone disease
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Research output
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12 Survival-related differentially expressed genes based on the TARGET-osteosarcoma database
Rothzerg, E., Xu, J., Wood, D. & Kõks, S., 2021, (Accepted/In press) In : Experimental Biology and Medicine.Research output: Contribution to journal › Article
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AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats
Zhu, S., Ying, Y., Ye, J., Chen, M., Wu, Q., Dou, H., Ni, W., Xu, H. & Xu, J., Mar 2021, In : Cell Death and Disease. 12, 3, 274.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
An emerging role of Prevotella histicola on estrogen deficiency-induced bone loss through the gut microbiota-bone axis in postmenopausal women and in ovariectomized mice
Wang, Z., Chen, K., Wu, C., Chen, J., Pan, H., Liu, Y., Wu, P., Yuan, J., Huang, F., Lang, J., Du, J., Xu, J., Jin, K. & Chen, L., 10 Jun 2021, In : The American Journal of Clinical Nutrition.Research output: Contribution to journal › Article
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Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis
Li, Y., Lin, S., Liu, P., Huang, J., Qiu, J., Wen, Z., Yuan, J., Qiu, H., Liu, Y., Liu, Q., Zhou, T., Luo, P., Guo, H., Ma, Y., Guo, D., Mo, G., Tang, Y., Xu, L., Liang, D., Xu, J. & 2 others, , Mar 2021, In : Journal of Cellular Physiology. 236, 3, p. 1950-1966 17 p.Research output: Contribution to journal › Article
2 Citations (Scopus) -
Codelivery of epigallocatechin-3-gallate and diallyl trisulfide by near-infrared light-responsive mesoporous polydopamine nanoparticles for enhanced antitumor efficacy
Zhou, X., Liang, J., Liu, Q., Huang, D., Xu, J., Gu, H. & Xue, W., 5 Jan 2021, In : International Journal of Pharmaceutics. 592, 120020.Research output: Contribution to journal › Article
2 Citations (Scopus)
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The therapeutic effect and mechanism of actions of natural compounds in osteoporosis
Xu, J. & Tan, R.
University of Western Australia
1/01/20 → 31/12/21
Project: Research
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‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/19 → 31/12/22
Project: Research
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The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
Pavlos, N., Xu, J. & Teasdale, R.
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/21
Project: Research
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2020 - Aperio VERSA 8, Brightfield and Fluorescence (automated digital slide scanner) - Main System
Ganss, R., Laing, N., Filipovska, A., Lister, R., Forrest, A., Leedman, P., Yeoh, G., Keelan, J., Nowak, A., Xu, J., Blancafort, P., Trinder, D., Pavlos, N., Ravenscroft, G., Hamzah, J., Juan Pardo, E., Winteringham, L., Kennedy, B., Pixley, F. & Redwood, A.
National Health & Medical Research Council NHMRC
1/01/20 → 31/12/20
Project: Research
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MHRIF Round 23 - Jiake Xu
Government of Western Australia, Department of Health
1/01/20 → 31/12/20
Project: Research