Research output per year
Research output per year
Personal profile
Biography
Dr Jiake Xu is currently Winthrop Professor, Head of Molecular Laboratory, School of Biomedical Science, at the University of Western Australia. He served as Head of the Division of Regenerative Medicine (2017-2021).
He is also a founding Fellow, Faculty of Science, the Royal College of Pathologists of Australia, Fellow of American Society of Bone and Mineral Research (ASBMR); Fellow of International Orthopedic Research (FIOR), and ex-president of the Australian and New Zealand Orthopaedic Research Society (ANZORS, 2012-2015).
He finished his medical training in Guangzhou Medical College in China in 1985. After completing his PhD studies at UWA in 1994, he carried out his postdoctoral research at Stanford University from 1994 to 1998. He returned to UWA in 1998, and has since undertaken research and teaching in the Schools of Surgery and Pathology and Laboratory Medicine.
His current research activities are focused on molecular cross talks of osteoclast and osteoblast, bone marrow stem cell niche (HSC, MSC, EPC), as well as angiogenic and angiocrine dysregulation, which have significant implication in bone and joint diseases; including osteoporosis, osteoarthritis and cancer metastasis in bone.
Roles and responsibilities
Prof Xu serves as a scientific program committee member for the Australian and New Zealand Orthopaedic Research Society (ANZORS), and as an elected member of the Board of Directors for the International Chinese Hard Tissue Society (ICHTS) since 2005. He also serves as a committee member in the Research Committee of the Australian and New Zealand Bone and Mineral Society (ANZBMS).
Funding overview
From 2000 to 2022 received
19 NHMRC as a chief investigator
1 ARC as a chief investigator
Research
• Osteoimmunology, osteolysis, and mechanisms of bone resorption.
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
• Bone marrow-derived mesenchymal stem cells and pericytes
• Screening of natural compounds for the treatment of osteoporosis
• Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and cc mice
• Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
Teaching overview
Teaching and/or teaching Coordinator for
PATH2210 (Coordinator and teaching)
IMED3001, 3002, 3003, 3004
DENT3001, 3002, 3003, 3004
Research expertise keywords
- Bone biology
- Degenerative diseases
- Molecular biology and pathogenesis of bone disease
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Research output
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Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling
Wu, Z., Li, C., Chen, Y., Liu, Q., Li, N., He, X., Li, W., Shen, R., Li, L., Wei, C., Shao, S., Fu, F., Ding, J., Sun, X., Wang, D., Yuan, G., Su, Y., Zhao, J., Xu, J., Xu, R. & 2 others, , 23 Mar 2022, In: Frontiers in Pharmacology. 13, 793087.Research output: Contribution to journal › Article › peer-review
Open Access -
Cycloastragenol Attenuates Osteoclastogenesis and Bone Loss by Targeting RANKL-Induced Nrf2/Keap1/ARE, NF-κB, Calcium, and NFATc1 Pathways
Wang, G., Ma, C., Chen, K., Wang, Z., Qiu, H., Chen, D., He, J., Zhang, C., Guo, D., Lai, B., Zhang, S., Huang, L., Yang, F., Yuan, J., Chen, L., He, W. & Xu, J., 20 Jan 2022, In: Frontiers in Pharmacology. 12, 810322.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Web of Science) -
CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways
Li, J., Liang, J., Wu, L., Xu, Y., Xiao, C., Yang, X., Sun, R., Zhao, J., Xu, J., Liu, Q. & Zhou, B., 8 Mar 2022, In: Frontiers in Pharmacology. 13, 829862.Research output: Contribution to journal › Article › peer-review
Open Access -
Epoxymicheliolide inhibits osteoclastogenesis and resists OVX-induced osteoporosis by suppressing ERK1/2 and NFATc1 signaling
Long, F., Chen, R., Su, Y., Liang, J., Xian, Y., Yang, F., Lian, H., Xu, J., Zhao, J. & Liu, Q., Jun 2022, In: International Immunopharmacology. 107, 108632.Research output: Contribution to journal › Article › peer-review
Open Access -
Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis
Huang, L., Chen, W., Wei, L., Su, Y., Liang, J., Lian, H., Wang, H., Long, F., Yang, F., Gao, S., Tan, Z., Xu, J., Zhao, J. & Liu, Q., 1 Mar 2022, In: Frontiers in Pharmacology. 13, 848152.Research output: Contribution to journal › Article › peer-review
Open Access
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Investigation of novel therapeutic inhibitors of an angiogenic factor to inhibit osteosarcoma
1/08/22 → 1/08/23
Project: Research
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Fat or fuel: investigating the bone marrow adipose tissue in the osteoporotic bone
Chen, K., Jiang, H., Pavlos, N. & Xu, J.
Arthritis Foundation of Australia
1/01/22 → 31/12/22
Project: Research
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‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/19 → 31/12/22
Project: Research
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The therapeutic effect and mechanism of actions of natural compounds in osteoporosis
Xu, J. & Tan, R.
1/01/20 → 31/12/21
Project: Research
Prizes
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Fellow - American Society of Bone and Mineral Research (ASBMR)
Xu, Jiake (Recipient), 2020
Prize: Fellowship
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Activities
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Theranostics (Journal)
Jiake Xu (Member of editorial board)
2022 → …Activity: Editorial work or peer review of publications › Editorial activity
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Taming the Osteoclast: New Therapies for Bone Diseases
Jiake Xu (Invited speaker)
16 Mar 2022Activity: Service and engagement › Public lecture, debate or seminar
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Australia and New Zealand Bone and Mineral Society (ANZBMS) annual scientific meeting (ASM)
Jiake Xu (Member of programme committee)
1 Aug 2022 → 4 Aug 2022Activity: Conferences and workshops › Contribution or participation in a conference
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21st Asia Pacific Orthopaedic Association Congress 2021
Jiake Xu (Keynote speaker/Invited speaker)
29 Jul 2021 → 30 Jul 2021Activity: Conferences and workshops › Contribution or participation in a conference
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Uncovering a new case of human malignant osteopetrosis and its mechanistic insights
Jiake Xu (Invited speaker)
22 Oct 2021Activity: Service and engagement › Public lecture, debate or seminar