Research output per year
Research output per year
Personal profile
Biography
I completed my PhD degree in nanotechnology at the University of Western Australia, spending part of my doctoral studies as a Fulbright Scholar at the University of Massachusetts, Amherst (2018). My PhD focused on the design and evaluation of new materials for the delivery of gene therapeutics. From there, I was an Alexander von Humboldt Postdoctoral Fellow at the Technical University of Munich, where I worked on the design and implementation of DNA origami for biotechnological applications (2020 – 2022) with Prof Hendrik Dietz. I am now a Forrest Fellow, and I aim to establish DNA origami as a field of research within Western Australia.
Current projects
- DNA-based nano-sensors
- DNA origami for targeted gene and drug delivery
- Templated inorganic nanoparticle synthesis
- Cellular recognition and fate of DNA origami
- Assembly kinetics of nucleic acid nanostructures
Research interests
I model, build, and apply nanoscale interactions for applications such as biosensing and to improve delivery of drug and gene therapies. My research focus is based on designing and implementing bioengineered polymers and nanosystems for application in health, energy, and the environment. As such, my research interests and educational background are highly interdisciplinary.
Previous positions
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02.2020 – 06.2022 |
Alexander von Humboldt Postdoctoral Fellow, Technische Universität München. Engineering complex DNA origami structures for biomedical applications. |
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08.2019 – 01.2020 |
Research Assistant, Epigenetics and Genomics, Harry Perkins Institute of Medical Research. Used genome and epigenome engineering techniques to determine the roles and effects of multiplexed epimodifiers on cellular gene expression and epigenetic landscape. |
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07.2018 – 03.2019 |
Fulbright Scholar, University of Massachusetts, Amherst. Protein engineering, production, and synthesis, and then design of polymeric agents for the non-viral delivery of proteins. |
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06.2015 – 08.2019 |
Doctoral Candidate, The University of Western Australia and Harry Perkins Institute of Medical Research. Developing non-viral agents to deliver genome engineering technology for triple negative breast cancers in vitro and in vivo. |
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12.2014 – 06.2015 |
Research Assistant, School of Molecular Sciences, The University of Western Australia. Laboratory organisation and setting up and implementing new systems such as a detailed inventory, in addition to driving individual projects. |
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02.2014 – 07.2016 |
Laboratory Demonstrator, School of Molecular Sciences, The University of Western Australia. Teaching and assessing first year undergraduate chemistry students in the practical setting for the unit “CHEM1001 Chemistry – Properties and Energetics” |
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02.2014 – 11.2014 |
Honours Research, The University of Western Australia. Engineering different polymer architectures for gene delivery. |
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02.2013 – 11.2013 |
Undergraduate Research with F. Wood, The University of Western Australia and Fiona Wood Foundation. Establishing an in vitro scar model, and development of a polymeric nanoparticle system for the encapsulation of anti-fibrotic drugs. |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Human genomic DNA is widely interspersed with i-motif structures
Martinez, C. D. P., Zeraati, M., Rouet, R., Mazigi, O., Henry, J., Gloss, B. S., Kretzmann, J., Evans, C., Ruggiero, E., Zanin, I., Marušič, M., PLAVEC, JANEZ., RICHTER, SARA., Bryan, T., Smith, N., Dinger, M. E., Kummerfeld, S. & Christ, D., 29 Aug 2024, (E-pub ahead of print) In: The EMBO Journal. 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Active Nuclear Import of Mammalian Cell-Expressible DNA Origami
Liedl, A., Grießing, J., Kretzmann, J. A. & Dietz, H., 8 Mar 2023, In: Journal of the American Chemical Society. 145, 9, p. 4946-4950 5 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Gene-encoding DNA origami for mammalian cell expression
Kretzmann, J. A., Liedl, A., Monferrer, A., Mykhailiuk, V., Beerkens, S. & Dietz, H., 23 Feb 2023, In: Nature Communications. 14, 1, p. 1017 1017.Research output: Contribution to journal › Article › peer-review
Open Access36 Citations (Scopus) -
Polymer-mediated oligonucleotide delivery enables construction of barcoded 3D cultures for spatial single-cell analysis
King, J., Mowla, A., Kretzmann, J., Norret, M., Kadolsky, U., Iqbal, M., Saxena, A., Mamsa, S., Amos, S., Choi, Y. S., Kennedy, B., Swaminatha, I., Smith, N. & Evans, C., 21 Nov 2023.Research output: Working paper › Preprint
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Broad-Spectrum Virus Trapping with Heparan Sulfate-Modified DNA Origami Shells
Monferrer, A., Kretzmann, J., Sigl, C., Sapelza, P., Liedl, A., Wittmann, B. & Dietz, H., 27 Dec 2022, In: ACS Nano. 16, 12, p. 20002-20009 8 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus)
Projects
- 4 Active
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Core infrastructure: high-throughput nanodrop spectrophotometer
Kretzmann, J., Evans, C., Choi, Y. S., Waryah, C., Sarkar-Tyson, M., Wang, T., Bond, C., Vrielink, A., Smith, N., Lesterhuis, W., Marshall, A., Stubbs, K., Breese, K., Chen, K., Smithers, L., Wylie, B., Wang, E. & Blancafort, P.
NHMRC National Health and Medical Research Council
15/03/24 → 31/12/24
Project: Research
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Multifuge X4R refrigerated centrifuge
Bond, C., Vrielink, A., Fox, A., Stubbs, K., Kahler, C., Smith, N., Kretzmann, J., Evans, C., Marshall, A., Smithers, L., Debowski, A., Bzdyl, N., Chooi, H., Fritz, G., Small, I., Lesterhuis, W., Piggott, M. & Sarkar-Tyson, M.
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
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Avestin Emulsiflex C5 Cell Homogeniser for Protein Production
Bond, C., Vrielink, A., Fox, A., Stubbs, K., Kahler, C., Smith, N., Kretzmann, J., Marshall, A., Evans, C., Smithers, L., Debowski, A., Bzdyl, N., Chooi, H., Fritz, G., Small, I., Lesterhuis, W., Sarkar-Tyson, M. & Piggott, M.
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
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Preventing pandemics through future-proof viral diagnostic sensors using DNA origami
1/08/22 → 31/07/25
Project: Research
Prizes
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Women in Technology WA (WiTWA) STEM Academia and Research Rising Star Award
Kretzmann, Jessica (Recipient), 2023
Prize: Award
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Sausages and Science
Nic Taylor (Coordinator), Jessica Kretzmann (Coordinator) & Mark Waters (Mentor)
26 Apr 2024 → …Activity: Service and engagement › Public outreach/ public event
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DNA Origami Workshop 2023
Cameron Evans (Participant) & Jessica Kretzmann (Organiser)
14 Nov 2023Activity: Conferences and workshops › Participation in workshop, seminar or course
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Molecules, Models, and Morsels: Engaging Indigenous Youth in the Wonders of Science
Nic Taylor (Coordinator), Naomi Wheat (Coordinator), Cameron Evans (Coordinator), Jessica Kretzmann (Coordinator), Killugudi Swaminatha Iyer (Coordinator) & Paul Low (Mentor)
3 Apr 2023 → …Activity: Service and engagement › Public outreach/ public event
File
Press/Media
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Top Indigenous STEM students make finals of Premier's Science Awards
Dawn Freshwater, Jessica Kretzmann, Belinda Coral Martin, Haibo Jiang & Philipp Bayer
21/06/19
1 item of Media coverage
Press/Media: Press / Media