Research Output per year
Research Output per year
Personal profile
Biography
I obtained my PhD under the supervision of Professor Timothy Arnett at University College London, investigating the effects of hypoxia on bone cells, including osteoclasts and osteoblasts. I have held post-doctoral positions at University College London, the University of Surrey, and the University of Western Australia studying the cell biology of bone marrow, bone cells and underlying physiological and genetic regulators of bone cell activity and function. My current research interests focus on identification of novel genetic regulators of bone cell function utilising mouse models.
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Research Output
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A missense mutation sheds light on a novel structure–function relationship of RANKL
Qiu, H., Qin, A., Cheng, T., Chim, S. M., Smithers, L., Chen, K., Song, D., Liu, Q., Zhao, J., Wang, C., Teguh, D., Zhang, G., Tickner, J., Vrielink, A., Pavlos, N. J. & Xu, J., 23 Sep 2020, In : Journal of Cellular Physiology.Research output: Contribution to journal › Article
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Asiatic Acid Inhibits OVX-Induced Osteoporosis and Osteoclastogenesis Via Regulating RANKL-Mediated NF-κb and Nfatc1 Signaling Pathways
Hong, G., Zhou, L., Han, X., Sun, P., Chen, Z., He, W., Tickner, J., Chen, L., Shi, X. & Xu, J., 27 Mar 2020, In : Frontiers in Pharmacology. 11, 331.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
Mullin, B., Tickner, J., Zhu, K., Kenny, J., Mullin, S., Brown, S. J., Dudbridge, F., Pavlos, N., Mocarski, E. S., Walsh, J. P., Xu, J. & Wilson, S., 26 Mar 2020, In : Genome Biology. 21, 1, 80.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function
Li, S., He, T., Wu, D., Zhang, L., Chen, R., Liu, B., Yuan, J., Tickner, J., Qin, A., Xu, J. & Rong, L., 9 Jun 2020, In : Frontiers in Cell and Developmental Biology. 8, 450.Research output: Contribution to journal › Article
Open Access1 Citation (Scopus) -
Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways
Yuan, Y., Chen, K., Chen, X., Wang, C., Qiu, H., Cao, Z., Song, D., Sun, Y., Guo, J., Tickner, J., Xu, J. & Zou, J., 10 Mar 2020, In : Frontiers in Pharmacology. 11, 238.Research output: Contribution to journal › Article
Open Access
Projects
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‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/19 → 31/12/22
Project: Research
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2017 - The iCelligence system
Xu, J., Pavlos, N., Tickner, J., Meehan, K., Mullin, B. & Jiang, H.
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/18
Project: Research
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Gene mining for novel molecular determinants of the skeleton
Xu, J., Pavlos, N., Tickner, J., Wilson, S. & Walsh, J.
National Health & Medical Research Council NHMRC
1/01/17 → 31/12/19
Project: Research
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Furin: Carving-up vital substrates for bone remodelling and homeostasis
Xu, J., Pavlos, N. & Tickner, J.
National Health & Medical Research Council NHMRC
1/01/16 → 31/12/19
Project: Research
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Identification of novel molecules that regulate bone homeostasis using ENU-induced mutant mice models, and human genome-wide association studies and massive parallel sequencing
Leo, P., Tickner, J., Duncan, E., Brown, M., Wilson, S., Mullin, B. & Xu, J.
The University of Western Australia
1/01/15 → 31/12/15
Project: Research