• The University of Western Australia (M550), 35 Stirling Highway,

    6009 Perth

    Australia

  • The University of Western Australia (M504), 35 Stirling Highway,

    6009 Perth

    Australia

  • 5358 Citations
  • 39 h-Index
1994 …2021
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Personal profile

Biography

Jeff Keelan gained his PhD from the University of Auckland in 1994, moving from Auckland to Perth WA in 2007. Although his research was initially in the field of steroid biochemistry, where he specialised in assay development, his postdoctoral research has primarily focused on the study of the immunology, endocrinology and pharmacology of pregnancy.
He is Professor of Obstetrics and Head of Laboratories at the Division of Obstetrics & Gynaecology at King Edward Memorial Hospital (KEMH), University of Western Australia. He is also Director of the Women and Newborn Health Research Network at KEMH and Deputy Director of WIRF (Women and Infants Research Foundation). He is Associated Editor of Reproduction, Fertility and Development and on the Editorial Board of three other Journals. He has supervised more than 43 postgraduate students and is the Graduate Research Coordinator of the School of Women's and Infants' Health.
His has published over 185 articles in the fields of immunology, pharmacology, obstetrics and endocrinology (>6600 citations; h-index 45) and received more than $18 M in competitive grant funding. His current research is centred on the pharmacological treatment of intra-amniotic infection/inflammation, nanoparticle-based drug delivery in pregnancy, the intrauterine microbial and endocrine environment, amniotic fluid metagenomics, lipidomics and toxicology.

Roles and responsibilities

Head of School of Biomedical Sciences, QEII Medical Centre, Nedlands, Perth
Winthrop Research Professor, Division of Obstetrics & Gynaecology, University of Western Australia, Perth WA
Head, Women and Infants Health Research Laboratory (WIHRL), King Edward Memorial Hospital, Perth, WA
Director, Women and Newborn Health Research Network (WNHRN), King Edward Memorial Hospital, Perth, WA.
Deputy Director, Women and Infants Research Foundation (WIRF)
Honorary Research Associate, Telethon Kids Institute
Adjunct Professor, Curtin University
Board Member, Marshall Centre Advisory Board

Future research

Maternal immunity and its relationship to risk of preterm birth; early-life microbiome and its life-long impact; amniotic fluid and placental microbiomes and pregnancy outcome; amniotic fluid miRNAs; bioactive lipid mediators from omega-3 fatty acid metabolism; innate immune system in fetal membranes; nanoparticulate drug delivery systems and placental transfer; intraamniotic therapies for preterm birth; antibiotics is pregnancy; endocrine disruptors in pregnancy.

Funding overview

Since 2013:

2013: Co-applicant with MW Kemp, JP Newnham, J Rodgers and A Jobe: NHMRC Project Grant: “Second trimester intra-amniotic treatment for early preterm birth”, $378,877, 3 years.

2013:  Principal applicant, Channel 7 Telethon Trust: “Nanosized Fetal Therapeutics”, 1 year.

2013:  Co-applicant (CIE) with Prof E Moses and others: NHMRC equipment grants, “Agilent Tape Station System”, $39,952.

2013: Co-applicant with DJ Ireland, WIRF Starter Grant: “Characterisation of a new TAK1 inhibitor for the prevention of inflammation-induced preterm birth”, $15,000, 1 year.

2013: Co-applicant with M Walls, R Hart, WIRF Starter Grant: “Predictive markers of oocyte maturation and their relationship to oocyte quality and embryonic development”, $15,000, 1 year.

2014:  Principal applicant, Channel 7 Telethon Trust: “Predicting Pregnancy Problems: The Amniotic Fluid miRNome Project”, 1 year.

2014: Co-applicant with Dr M Payne and Prof J Newnham, WIRF Capacity Building Grant: “Prevention of infection-driven preterm birth through development of a universal diagnostic test to identify high-risk pregnancies”, $105,000, 3 years.

2014: Co-applicant with M Linden and others, NHMRC equipment grant: “BD FACS Canto II flow cytometer”, $50,000, 1 year.

2014: Chief applicant with CE Pennell and DA Doherty, Channel 7 Telethon Trust grant “Western Australian pregnancy Biobank for High Risk Women, 2 years

2014: Co-applicant (CIB) with JP Newnham, M Payne, D Doherty and R Allcock, NHMRC Project Grant: “Vaginal microbial biomarkers for the prevention of preterm birth”, $563,493, 3 years.

2015:  Co-applicant (CIF) with A Whitehouse, M Maybery, D Bishop, C Franks, S Fisher, A/Prof P Jacoby, A Murphy. ARC Discovery grant DP160101174: “The role of early testosterone and brain laterality in language development (the TALK study)”, $415,000, 5 years (2016-2020).

2015:  Co-applicant (CIB) with S Prescott, K Simmer, D Palmer & R Allcock. NHMRC Project grant APP1099480: “Dietary modulation of maternal gut flora with oligosaccharides in pregnancy as a novel allergy prevention strategy”, 5 years $1,649,000 (2016-2020)

2015: Chief applicant, Channel 7 Telethon Trust grant “Western Australian Pregnancy Biobank for High Risk Women 2016”, 1 year.

2016: Co-applicant (CIE) with F O’Gara, M Bunce, M Everard, S Prescott, P Richmond: “Establishing the West Australian Human Microbiome Collaborating Centre [WAHMCC]”, Telethon Perth Children’s Hospital Research Fund (TPCHRF, Strategic Research Initiative), 3 years $474,000 (2016-2018).

2016:  Co-applicant (CIC) with CE Pennell and W Ang: “Targeting treatment success to prevent preterm birth”, Telethon Perth Children’s Hospital Research Fund (TPCHRF), 2 years $217,980 (2016-2017).

2016: Co-applicant (CIB) with C Gomez (principal investigator) and S Prescott (CIC): “Longer outside, better inside: outdoor exposure and its impact on the gut microbiome and development of asthma and allergy”, Asthma Foundation of WA New Investigator Grant, 2 years $26,690 (2016-18).

2016: Chief applicant, Channel 7 Telethon Trust grant “Western Australian Pregnancy Biobank for High Risk Women: Phase II Funding”, 1.5 years.

2017:  Chief applicant (CIB) with John Newnham, Dorota Doherty, Matthew Payne. NHMRC project grant APP1111111: “A prospective, open-label, single-centre/multi-site, randomized clinical trial of a novel maternal microbiological “screen & treat” program compared with normal care for the prevention of preterm birth”. 4 years (2018-2021) $1,733,000

2017   Chief applicant (CIA) with David Olson, Sarah Robertson, Matthew Kemp and Hayley Dickinson. NHMRC project grant AP1145295: “Preclinical evaluation of a novel allosteric IL-1R inhibitor (rytvela) for the prevention of perinatal inflammation-induced fetal injury”, 4 years (2018-2021), $1,370,000.

2017   Chief applicant (CIB) with Sarah Robertson and Mark Hutchins. NHMRC project grant APP1140916: “Preclinical development of TLR signalling inhibitors for prevention of preterm labour and fetal inflammatory injury”, 3 years (2018-2020), $690,821.

2017   Co-applicant with Jiake Xu and others, NHMRC Equipment Grant: “iCelligence System”, $33,500

2017   Co-applicant with J Newnham and others, NHMRC Equipment Grant: “Kingfisher 96-Plex Purification System”, 50,000.

Previous positions

1985 – 94: Hospital Scientific Officer, Dept. Clinical Biochemistry, National Women’s Hospital, Auckland, NZ
1994 – 2001: Postdoctoral Research Fellow and Lecturer, University of Auckland, Dept Pharmacology and Clinical Pharmacology, Auckland, NZ
2001 – 2007: Senior Lecturer, University of Auckland, Auckland, NZ
2006 – 2007: Head, Pregnancy Research Group, Liggins Institute, University of Auckland

Current projects

Contact Jeff Keelan for details (project availability is constantly changing).
See also list on ResearchGate

Industrial relevance

Commercialization of a test to predict risk of infection-driven preterm birth

Teaching overview

Uni Auckland: MEDSCI201 (Introduction to Pharmacology and Toxicology): Lecturer and course coordinator.
Uni Auckland: MEDSCI720 (Biomedical research techniques) lecturer and course coordinator.

Uni Western Australia: Lecturer for ANHB3316; IMED 1108, IMED 2208; IMED 3308


Other lecturing: Molecular Pharmacology; Reproductive biology; Placental pharmacology; Pharmacology in pregnancy.

Uni Western Australia:
IMED1108; ANHB2216; APHB5501;
MD Course (Foundations)

Research

See this link for an online profile of Jeff's research:
http://www.scientia.global/professor-jeff-keelan-preventing-preterm-birth-improving-infant-outcomes/

Current research interests:
Inflammation- and infection-associated preterm labour.
Anti-inflammatory/anti-microbial modalities to prevent preterm labour.
Fetal membrane apoptosis and premature rupture
Placental drug transport.
Lipid-derived mediators in placental growth and function in pregnancy.
Nanoparticle transport and drug delivery in the placenta.
Endocrine disrupters in amniotic fluid and pregnancy.
The role and significance of the microbiome in pregnancy and fetal development.

Languages

English
Australian.

External positions

Adjunct Professor, Curtin University of Technology

2017 → …

Honorary Research Associate, Telethon Kids Institute

Feb 2015 → …

Keywords

  • Placental inflammation
  • Lipid-derived mediators in pregnancy
  • Preterm birth (prevention of)
  • Placental growth, development and apoptosis
  • Placental drug transporters
  • Placental nanoparticle transport
  • Pregnancy: obesity and inflammation
  • Antibiotic pharmacokinetics in pregnancy

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2021

Research Output 1994 2018

Open Access
Microbiota
Vaginal Diseases
Obesity
Dysbiosis
Maternal Age

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

Beaudry-Richard, A. , Nadeau-Vallée, M. , Prairie, É. , Maurice, N. , Heckel, É. , Nezhady, M. , Pundir, S. , Madaan, A. , Boudreault, A. , Hou, X. , Quiniou, C. , Sierra, E. M. , Beaulac, A. , Lodygensky, G. , Robertson, S. A. , Keelan, J. , Adams-Waldorf, K. , Olson, D. M. , Rivera, J. C. , Lubell, W. D. & 3 others Joyal, J. S., Bouchard, J. F. & Chemtob, S., 8 Aug 2018, In : Scientific Reports. 8, 1, 11875

Research output: Contribution to journalArticle

Open Access
Interleukin-1
Inflammation
Chorioamnionitis
Retinal Vessels
Hyperoxia
1 Citations
Open Access
Meconium
Microbiota
DNA
Bacterial DNA
Polymerase Chain Reaction

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D. W. , Kretzmann, J. , Norret, M. , Toshniwal, P. , Veder, J. P. , Jiang, H. , Guagliardo, P. , Munshi, A. M. A. , Chawla, R. , Evans, C. , Clemons, T. , Nguyen, M. , Kretzmann, A. , Blythe, A. , Saunders, M. , Archer, M. , Fitzgerald, M. , Keelan, J. , Bond, C. , Kilburn, M. & 3 others Hurley, L., Smith, N. & Swaminatha Iyer, K., 8 Oct 2018, In : Nature Nanotechnology.

Research output: Contribution to journalArticle

Nanorods
Gold
nanorods
DNA
deoxyribonucleic acid
4 Citations

Datasets

Data from: Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood

Whitehouse, A. (Creator), Gilani, S. (Creator), Shafait, F. (Creator), Mian, A. (Creator), Tan, W. (Creator), Maybery, M. (Creator), Keelan, J. (Creator), Hart, R. (Creator), Handelsman, D. J. (Creator), Goonawardene, M. (Creator), Eastwood, P. (Creator), Dryad Digital Repository, 8 Sep 2015

Dataset

Sex steroid values, composites and cognitive follow-up Raine Cohort Data

Jamnadass, E. S. (Creator), Keelan, J. (Creator), Russell-Smith, S. N. (Creator), Hickey, M. (Creator), Maybery, M. (Creator), Whitehouse, A. (Creator), Dryad Digital Repository, 29 Mar 2017

Dataset

Activities 2018 2018

  • 2 Invited talk
  • 1 Hosting an academic visitor
  • 1 Visiting an external academic institution

Robinson Research Institute

Keelan, J. (Visiting researcher)
15 Aug 2018

Activity: Visiting an external institutionVisiting an external academic institution

A molecular microbiological test for identifying women at high risk of preterm birth

Keelan, J. (Speaker)
6 Sep 2018

Activity: Talk or presentationInvited talk

David M. Olson

Keelan, J. (Host)
24 May 201825 May 2018

Activity: Hosting a visitorHosting an academic visitor