Personal profile
Biography
Jeff Keelan gained his PhD from the University of Auckland in 1994, moving from Auckland to Perth WA in 2007. Although his research was initially in the field of steroid biochemistry, where he specialised in assay development, his postdoctoral research has primarily focused on the study of the immunology, endocrinology and pharmacology of pregnancy.
He is Professor of Obstetrics and Head of School of Biomedical Sciences at QEII Medical Centre, Perth. He was previously Director of the Women and Newborn Health Research Network at King Edward Memorial Hospital. He has supervised more than 50 postgraduate students and published more than 220 articles in the fields of immunology, pharmacology, obstetrics and endocrinology (Google Scholar: >13,000 citations; h-index 68); he has received more than $20 M in competitive grant funding.
His current research is centred on the pharmacological treatment of intra-amniotic infection/inflammation, nanoparticle-based drug delivery in pregnancy, the intrauterine microbial and endocrine environment, and the use of melatonin in late pregnancy to reduce the rates of labour induction.
Roles and responsibilities
- Head of School of Biomedical Sciences, QEII Medical Centre, Nedlands, Perth
- Research Professor, Division of Obstetrics & Gynaecology
- Adjunct Professor, Curtin University
- Board Member, Marshall Centre Advisory Board
- Board Member, QEII Trust
Future research
I am interested in exploring the prognostic value of assessing maternal inflammation in pregnancy, and the use of drugs, probiotics and dietary supplements to mitigate the effects of inflammation in pregnancy.
Funding overview
Since 2017:
2017: Chief applicant (CIB) with John Newnham, Dorota Doherty, Matthew Payne. NHMRC project grant APP1111111: “A prospective, open-label, single-centre/multi-site, randomized clinical trial of a novel maternal microbiological “screen & treat” program compared with normal care for the prevention of preterm birth”
2017 Chief applicant (CIA) with David Olson, Sarah Robertson, Matthew Kemp and Hayley Dickinson. NHMRC project grant AP1145295: “Preclinical evaluation of a novel allosteric IL-1R inhibitor (rytvela) for the prevention of perinatal inflammation-induced fetal injury”
2017 Chief applicant (CIB) with Sarah Robertson and Mark Hutchins. NHMRC project grant APP1140916: “Preclinical development of TLR signalling inhibitors for prevention of preterm labour and fetal inflammatory injury”
2017 Co-applicant with Jiake Xu and others, NHMRC Equipment Grant: “iCelligence System”
2017 Co-applicant with J Newnham and others, NHMRC Equipment Grant: “Kingfisher 96-Plex Purification System”
2018 Chief applicant, Channel 7 Telethon Trust Grant: “Multi-omic analysis of cervicovaginal fluids for predicting preterm birth”
2019 Co-applicant, NHMRC Equipment Grant
2020 Co-applicant, NHMRC Equipment Grant
2021 Co-applicant with Matt Payne et al., WA Department of Health Innovation Seed Fund: “Refining a novel molecular diagnostic test for prediction of women at high risk of preterm birth”.
2022 Co-applicant with Zoe Bradford et al., MRFF Clinician Researchers Initiative: “Melatonin supplementation To reduce the Induction of labour rates in first-time MothErs: The MyTIME Clinical Trial”.
Previous positions
1985 – 94: Hospital Scientific Officer, Dept. Clinical Biochemistry, National Women’s Hospital, Auckland, NZ
1994 – 2001: Postdoctoral Research Fellow and Lecturer, University of Auckland, Dept Pharmacology and Clinical Pharmacology, Auckland, NZ
2001 – 2007: Senior Lecturer, University of Auckland, Auckland, NZ
2006 – 2007: Head, Pregnancy Research Group, Liggins Institute, University of Auckland
2007 - 2020: Head, Women and Infants Health Research Laboratories, KEMH, Perth WA.
Current projects
Contact Jeff Keelan for details
Industrial relevance
Teaching overview
Co-coordinator, Honours in Medical Research, School of Biomedical Sciences
Lecturing: Molecular Pharmacology; Reproductive biology; Placental pharmacology; Pharmacology in pregnancy.
Uni Western Australia: Lecturer for PHAR2220; ANHB2216; APHB5501; ANHB3316; IMED1108, IMED2208; IMED3308
Uni Auckland: MEDSCI201 (Introduction to Pharmacology and Toxicology): Lecturer and course coordinator.
Uni Auckland: MEDSCI720 (Biomedical research techniques) lecturer and course coordinator.
Research
http://www.scientia.global/professor-jeff-keelan-preventing-preterm-birth-improving-infant-outcomes/
Current research interests:
Inflammation- and infection-associated preterm labour.
Anti-inflammatory/anti-microbial modalities to prevent preterm labour.
Fetal membrane apoptosis and premature rupture
Placental drug transport.
Lipid-derived mediators in placental growth and function in pregnancy.
Nanoparticle transport and drug delivery in the placenta.
Endocrine disrupters in amniotic fluid and pregnancy.
The role and significance of the microbiome in pregnancy and fetal development.
Languages
Australian.
Education/Academic qualification
Obstetrics, PhD, University of Auckland
Award Date: 1 Jul 1994
Biochemistry, MSc, University of Auckland
Award Date: 1 Dec 1986
Applied Biology, BSc (Hons), Liverpool John Moores University
Award Date: 1 Sept 1979
External positions
Board Member, QEII trust, Queen Elizabeth II Medical Centre Trust
1 Jan 2020 → …
Adjunct Professor, Curtin University
2017 → …
Director, Research Governance, Women and Newborn Health Service
1 Oct 2009 → 1 Nov 2024
Industry keywords
- Medicine and Pharma
- Clinical Trials
- Diagnostics
Research expertise keywords
- Placental inflammation
- Lipid-derived mediators in pregnancy
- Preterm birth (prevention of)
- Placental growth, development and apoptosis
- Placental drug transporters
- Placental nanoparticle transport
- Pregnancy: obesity and inflammation
- Antibiotic pharmacokinetics in pregnancy
- Microbiome
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
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Colostrum as a Protective Factor Against Peanut Allergy: Evidence From a Birth Cohort
Bhasin, M., Cooper, M., Macchiaverni, P., Joys, R. S., O'Sullivan, T. A., Keelan, J. A., Venter, C., Palmer, D. J., Lowe, A. J., Prescott, S. L., Silva, D. & Verhasselt, V., Feb 2026, In: Allergy: European Journal of Allergy and Clinical Immunology. 81, 2, p. 552-562 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Optimising Vaginal Microbiome Profiling for Clinical Translation: A Comparative Assessment of Sample Storage Methods and a Vagina-Specific 16S rRNA Gene Database
Ali, A., Keelan, J. A., Penova-Veselinovic, B., Allentoft, M. E., Bunce, M. & Christophersen, C. T., 7 Jan 2026, In: Microorganisms. 14, 1, 17 p., 128.Research output: Contribution to journal › Article › peer-review
Open Access -
Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol
Bradfield, Z., White, S. W., Davies-Tuck, M., Sharp, M., Warland, J., Callander, E., Kuliukas, L., Rose, M., Pettitt, A., Ekin, K., Doherty, D. A. & Keelan, J. A., 23 Jan 2025, In: BMJ Open. 15, 8 p., e090370.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: A randomized controlled trial
Palmer, D. J., Cuthbert, A. R., Sullivan, T. R., Pretorius, R. A., Garssen, J., Rueter, K., Jenmalm, M. C., Keelan, J. A., Silva, D. & Prescott, S. L., Jan 2025, In: Journal of Allergy and Clinical Immunology. 155, 1, p. 144-152 9 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Citations (Scopus) -
Inhibition of interleukin-1 signaling protects against Group B streptococcus-induced preterm birth and fetal loss in mice
Chin, P. Y., Moldenhauer, L. M., Lubell, W. D., Olson, D. M., Chemtob, S., Keelan, J. A. & Robertson, S. A., Jun 2025, In: Journal of Reproductive Immunology. 169, p. 1-11 11 p., 104520.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Citations (Scopus)
Datasets
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Sex steroid values, composites and cognitive follow-up Raine Cohort Data
Jamnadass, E. S. (Creator), Keelan, J. A. (Creator), Russell-Smith, S. N. (Creator), Hickey, M. (Creator), Maybery, M. T. (Creator) & Whitehouse, A. J. (Creator), DRYAD, 29 Mar 2017
DOI: 10.5061/dryad.kn0h9, https://datadryad.org/resource/doi:10.5061/dryad.kn0h9
Dataset
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The MyTIME clinical trial
Bradfield, Z. (Creator), White, S. (Contributor), Sharp, M. (Contributor), Keelan, J. (Contributor), Rose, M. (Contributor), Warland, J. (Contributor), Kuliukas, L. (Contributor), Davies-Tuck, M. (Contributor), Callander, E. (Contributor), Ekin, K. (Contributor), Ladyman, C. (Contributor) & Doherty, D. (Contributor), Curtin University, 2024
DOI: 10.60854/4rqm-n332, https://hesandawa.org/mytime.html
Dataset
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Data from: Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood
Whitehouse, A. J. (Creator), Gilani, S. Z. (Creator), Shafait, F. (Creator), Mian, A. S. (Creator), Tan, D. W. (Creator), Maybery, M. T. (Creator), Keelan, J. A. (Creator), Hart, R. J. (Creator), Handelsman, D. J. (Creator), Goonawardene, M. (Creator) & Eastwood, P. R. (Creator), DRYAD, 8 Sept 2015
DOI: 10.5061/dryad.k5nr3, https://datadryad.org/resource/doi:10.5061/dryad.k5nr3
Dataset
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Melatonin supplementation to reduce the induction of labour rates in first time mothers: The MyTIME Trial
Bradfield, Z. (Investigator 01), White, S. (Investigator 02), Keelan, J. (Investigator 03), Warland, J. (Investigator 04), Doherty, D. (Investigator 05) & Kuliukas, L. (Investigator 06)
MRFF Medical Research Future Fund
1/02/23 → 1/01/27
Project: Research
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Lionheart FX Automated High-Content Microscope for the QEII Biomedical Research Precinct
Pavlos, N. (Chief Investigator), Barnett, T. (CoPI), Blancafort, P. (CoPI), Chen, K. (CoPI), Chooi, H. (CoPI), Hamzah, J. (CoPI), Hirvonen, L. (CoPI), Ingley, E. (CoPI), Johnstone, L. (CoPI), Kahler, C. (CoPI), Keelan, J. (CoPI), Kular, J. (CoPI), Mullin, B. (CoPI), Nicol, M. (CoPI), Pixley, F. (CoPI), Swaminatha Iyer, I. (CoPI), Waithman, J. (CoPI), Wilson, S. (CoPI) & Woodward, E. (CoPI)
The University of Western Australia
1/01/25 → 31/12/25
Project: Research
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Into the zero oxygen zone; towards a one-centre approach for microbiome workflows
Payne, M. (Investigator 01), Newnham, J. (Investigator 02), Doherty, D. (Investigator 03), Geddes, D. (Investigator 04), Keelan, J. (Investigator 05), Nicol, M. (Investigator 06), Kahler, C. (Investigator 07), Chang, B. (Investigator 08), Hammer, K. (Investigator 09), Strunk, T. (Investigator 10), Furfaro, L. (Investigator 11), Stinson, L. (Investigator 12) & Ghori, H. (Investigator 13)
NHMRC National Health and Medical Research Council
20/06/23 → 24/10/24
Project: Research
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Refining a novel molecular diagnostic test for prediction of women at high risk of preterm birth
Payne, M. (Investigator 01), Newnham, J. (Investigator 02), Keelan, J. (Investigator 03), Doherty, D. (Investigator 04), Masson, L. (Investigator 05) & Mokany, E. (Investigator 06)
Department of Health (Western Australia)
27/06/22 → 31/12/24
Project: Research
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2020 - Aperio VERSA 8, Brightfield and Fluorescence (automated digital slide scanner) - Main System
Ganss, R. (Investigator 01), Laing, N. (Investigator 02), Filipovska, A. (Investigator 03), Lister, R. (Investigator 04), Forrest, A. (Investigator 05), Leedman, P. (Investigator 06), Yeoh, G. (Investigator 07), Keelan, J. (Investigator 08), Nowak, A. (Investigator 09), Xu, J. (Investigator 10), Blancafort, P. (Investigator 11), Trinder, D. (Investigator 12), Pavlos, N. (Investigator 13), Ravenscroft, G. (Investigator 14), Hamzah, J. (Investigator 15), Juan Pardo, E. (Investigator 16), Winteringham, L. (Investigator 17), Kennedy, B. (Investigator 18), Pixley, F. (Investigator 19) & Redwood, A. (Investigator 20)
NHMRC National Health and Medical Research Council
1/01/20 → 31/12/20
Project: Research
Activities
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University of Adelaide
Keelan, J. (Visiting researcher)
15 Aug 2018Activity: External visits › Visiting an external academic institution
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A ‘screen and treat’ trial to prevent infection-driven preterm birth based on a novel vaginal microbial DNA screening test
Keelan, J. (Speaker)
30 Aug 2018Activity: Service and engagement › Public lecture, debate or seminar
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David M. Olson
Keelan, J. (Host)
24 May 2018 → 25 May 2018Activity: Hosting a visitor › Hosting an academic visitor
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A molecular microbiological test for identifying women at high risk of preterm birth
Keelan, J. (Speaker)
6 Sept 2018Activity: Service and engagement › Public lecture, debate or seminar