Jasreen Kular

Dr Kular completed her undergraduate (2007) and PhD studies (2012) at the University of Western Australia. Her PhD research focused on discovering novel regulators of bone homeostasis that could be translated into therapeutic targets for osteoporosis, arthritis, and Paget’s disease of bone. In 2013, Dr Kular commenced a postdoctoral position at the Centre for Cancer Biology, Adelaide in the laboratory of Professor Michael Samuel. Her work identified 14-3-3ζ as a novel negative regulator of mechano-reciprocity which limits epidermal regeneration, potentially halving the healing time for chronic wounds. Dr Kular moved back to Perth and joined The Kids Research Institute Australia in 2022, bringing her skills in cell biology and cell signalling pathways to Group A Streptococcus (GAS) research (Dr Tim Barnett’s Laboratory). Her research used microscopy techniques to elucidate how GAS invades cells to evade antibiotic treatment. She continues to be involved in GAS research through her Honorary position at The Kids Research Institute. In 2024 Dr Kular returned to research in bone biology at the University of Western Australia in the laboratory of A/Prof Nathan Pavlos. She currently leads the "Lyso-bone" theme within the Bone Biology and Diseases laboratoy. Her work seeks to understand the molecular mechanisms regulating secretory lysosomes and the role they play in modulating osteoclastic bone resorption. This leads to the overall aim to identify novel therapeutic targets for lysosomal storage disorders and debilitating musculoskeletal diseases including osteoporosis, osteoarthritis and Paget’s disease.