Research output per year
Research output per year
Personal profile
Biography
Associate Professor Jason Waithman leads the Cancer Immunotherapy Program within the School of Biomedical Sciences at the University of Western Australia. He is an expert in the field of dendritic cell biology and T cell immunity, with extensive experience in conceiving and applying a versatile range of tools for studying immunity to cancer, viral infections and self-tissue. This has resulted in significant practical and conceptual contributions to our understanding of health and disease. These models are now routinely used to facilitate translational outcomes into the clinical pipeline and pathway for potential commercialisation. More recently, this toolkit has been expanded to leverage advanced genomic data science, integrating this capacity across multiple projects focussed on identifying novel therapeutic targets to inform on improved strategies for cancer control within the community.
Education/Academic qualification
Immunology, PhD, Mechanisms of CD8 T cell tolerance, University of Melbourne
Award Date: 27 Aug 2008
Research expertise keywords
- Immunology—cellular
- Immunology—T cell
- immune tolerance
- Cancer immunology
- Immune cell signalling
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Collaborations and top research areas from the last five years
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Interleukin-4 modulates type I interferon to augment antitumor immunity
Newnes, H. V., Armitage, J. D., Buzzai, A. C., de Jong, E., Audsley, K. M., Barnes, S. A., Srinivasan, S., Serralha, M., Fear, V. S., Guo, B. B., Jones, M. E., Forrest, A. R. R., Foley, B., Darcy, P. K., Beavis, P. A., Bosco, A. & Waithman, J., 16 May 2025, In: Science Advances. 11, 20, 14 p., eadt3618.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
Bachem, A., Clarke, M., Kong, G., Tarasova, I., Dryburgh, L., Kosack, L., Lee, A. R., Newland, L. D., Wagner, T., Bawden, E., Yap, K. M., Wilson, M. D., Engel, S., Wilson, K. R., Russ, B. E., Tandon, K., Lau, P. K. H., McArthur, G., Marcelino, V. R. & Beavis, P. A. & 7 others, , 11 Nov 2025, In: Immunity. 58, 11, p. 2799-2813.e8Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Chen, A. X. Y., Yap, K. M., Kim, J. S., Sek, K., Huang, Y. K., Dunbar, P. A., Wiebking, V., Armitage, J. D., Munoz, I., Todd, K. L., Derrick, E. B., Nguyen, D., Tong, J., Chan, C. W., Hoang, T. X., Audsley, K. M., van Elsas, M. J., Middelburg, J., Lee, J. N. & de Menezes, M. N. & 14 others, , 7 Aug 2025, In: Nature. 644, 8075, p. 241-251 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
Sek, K., Chen, A. X. Y., Cole, T., Armitage, J. D., Tong, J., Yap, K. M., Munoz, I., Dunbar, P. A., Wu, S., van Elsas, M. J., Hidajat, O., Scheffler, C., Giuffrida, L., Henderson, M. A., Meyran, D., Souza-Fonseca-Guimaraes, F., Nguyen, D., Huang, Y.-K., de Menezes, M. N. & Derrick, E. B. & 16 others, , Dec 2025, In: Nature Communications. 16, 1, 17 p., 6123.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses
Bawden, E. G., Wagner, T., Schröder, J., Effern, M., Hinze, D., Newland, L., Attrill, G. H., Lee, A. R., Engel, S., Freestone, D., de Lima Moreira, M., Gressier, E., McBain, N., Bachem, A., Haque, A., Dong, R., Ferguson, A. L., Edwards, J. J., Ferguson, P. M. & Scolyer, R. A. & 10 others, , 19 Jan 2024, In: Science immunology. 9, 91, p. eadi9517 adi9517.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus)
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Development of aLow-Cost Hand-Held Skin Cancer Classification Probe
Kranold, L. (Investigator 01), Stanwix, P. (Investigator 02) & Waithman, J. (Investigator 03)
Department of Health (Western Australia)
9/06/25 → 6/06/26
Project: Research
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Lionheart FX Automated High-Content Microscope for the QEII Biomedical Research Precinct
Pavlos, N. (Chief Investigator), Barnett, T. (CoPI), Blancafort, P. (CoPI), Chen, K. (CoPI), Chooi, H. (CoPI), Hamzah, J. (CoPI), Hirvonen, L. (CoPI), Ingley, E. (CoPI), Johnstone, L. (CoPI), Kahler, C. (CoPI), Keelan, J. (CoPI), Kular, J. (CoPI), Mullin, B. (CoPI), Nicol, M. (CoPI), Pixley, F. (CoPI), Swaminatha Iyer, I. (CoPI), Waithman, J. (CoPI), Wilson, S. (CoPI) & Woodward, E. (CoPI)
The University of Western Australia
1/01/25 → 31/12/25
Project: Research
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Enhancing natural killer cell function to combat high-risk B-ALL with Tri-specific Killer Engagers (TriKEs)
Foley, B. (Investigator 01), Armitage, J. (Investigator 02), Malinge, S. (Investigator 03) & Waithman, J. (Investigator 04)
1/01/25 → 31/12/25
Project: Research
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Establishing TIL therapy For Immunotherapy-Resistant Melanoma
Nilsson, J. (Investigator 01), Gray, E. (Investigator 02), Waithman, J. (Investigator 03) & Lau, P. (Investigator 04)
1/04/24 → 31/12/28
Project: Research
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Enhancing adoptive cell therapy protocols to improve childhood and adolescent cancer control
Lister, R. (Investigator 01), Darcy, P. (Investigator 02), Beavis, P. (Investigator 03), Khaw, S. (Investigator 04), Velickovic, Z. (Investigator 05), Bosco, A. (Investigator 06), Armitage, J. (Investigator 07), Pflueger, C. (Investigator 08), Foley, B. (Investigator 09), Carnley, B. (Investigator 10), Wood, M. (Investigator 11), Woulfe, C. (Investigator 12), Herring, C. (Investigator 13) & Waithman, J. (Investigator 14)
Department of Health (Western Australia)
1/01/24 → 31/12/26
Project: Research