Research output per year
Research output per year
- 1 - 50 out of 89 results
Search results
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2024
Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze
Coenen, I., de Jong, E., Jones, A. C., Khoo, S. K., Foo, S., Howland, S. W., Ginhoux, F., Le Souëf, P. N., Holt, P. G., Strickland, D. H., Laing, I. A. & Leffler, J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1083-1094 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
2023
Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children
Ariff, A., Song, Y., Aguilar, R., Nhabomba, A., Manaca, M. N., Khoo, S. K., Wiertsema, S., Bassat, Q., Barbosa, A., Quintó, L., Laing, I. A., Guinovart, C., Alonso, P. L., Dobaño, C., Le Souëf, P. & Zhang, G., Dec 2023, In: Malaria Journal. 22, 1, 177.Research output: Contribution to journal › Article › peer-review
Open Access -
LPS binding protein and activation signatures are upregulated during asthma exacerbations in children
Jones, A. C., Leffler, J., Laing, I. A., Bizzintino, J., Khoo, S. K., LeSouef, P. N., Sly, P. D., Holt, P. G., Strickland, D. H. & Bosco, A., Dec 2023, In: Respiratory Research. 24, 1, p. 184 1 p., 184.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Rhinoviruses A and C elicit long-lasting antibody responses with limited cross-neutralization
Bochkov, Y. A., Devries, M., Tetreault, K., Gangnon, R., Lee, S., Bacharier, L. B., Busse, W. W., Camargo, C. A., Choi, T., Cohen, R., De, R., DeMuri, G. P., Fitzpatrick, A. M., Gergen, P. J., Grindle, K., Gruchalla, R., Hartert, T., Hasegawa, K., Khurana Hershey, G. K. & Holt, P. & 21 others, , Aug 2023, In: Journal of Medical Virology. 95, 8, e29058.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Web of Science) -
2022
The microRNA family, let-7, are predictive biomarkers of childhood asthma
Schwager, M., Laing, N. G., Dye, D., Khoo, S., Song, Y., Coombe, D., Le Souef, P. & Zhang, G., Mar 2022, In: Respirology. 27, p. 107-107 1 p.Research output: Contribution to journal › Abstract/Meeting Abstract › peer-review
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2021
Defining Age-specific Relationships of Respiratory Syncytial Virus and Rhinovirus Species in Hospitalized Children with Acute Wheeze
Oo, S. W. C., Khoo, S. K., Cox, D. W., Chidlow, G., Franks, K., Prastanti, F., Bochkov, Y. A., Borland, M. L., Zhang, G., Gern, J. E., Smith, D. W., Bizzintino, J. A., Laing, I. A. & Le Souëf, P. N., 1 Oct 2021, In: Pediatric Infectious Disease Journal. 40, 10, p. 873-879 7 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection
Choi, T., Devries, M., Bacharier, L. B., Busse, W., Camargo, C. A., Cohen, R., Demuri, G. P., Evans, M. D., Fitzpatrick, A. M., Gergen, P. J., Grindle, K., Gruchalla, R., Hartert, T., Hasegawa, K., Khurana Hershey, G. K., Holt, P., Homil, K., Jartti, T., Kattan, M. & Kercsmar, C. & 22 others, , 1 Apr 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 7, p. 822-830 9 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Citations (Scopus) -
Increased nasal Streptococcus pneumoniae presence in Western environment associated with allergic conditions in Chinese immigrants
Schwager, M. J., Song, Y., Laing, I. A., Saiganesh, A., Guo, J., Le Souëf, P. N. & Zhang, G., May 2021, In: International Journal of Hygiene and Environmental Health. 234, 113735.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezing
Coleman, L. A., Khoo, S. K., Franks, K., Prastanti, F., Le Souëf, P., Karpievitch, Y. V., Laing, I. A. & Bosco, A., Dec 2021, In: Journal of Personalized Medicine. 11, 12, 1293.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
The impact of cytokine levels in young South African children with and without HIV-associated acute lower respiratory infections
Annamalay, A. A., Abbott, S., Khoo, S. K., Hibbert, J., Bizzintino, J., Zhang, G., Laing, I., Currie, A., Le Souëf, P. N. & Green, R. J., Jun 2021, In: Journal of Medical Virology. 93, 6, p. 3647-3655 9 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis
Watkinson, R. L., Looi, K., Laing, I. A., Cianferoni, A. & Kicic, A., 29 Nov 2021, In: Frontiers in Immunology. 12, 773600.Research output: Contribution to journal › Review article › peer-review
Open Access6 Citations (Scopus) -
2020
Aberrant cell migration contributes to defective airway epithelial repair in childhood wheeze
Western Australian Epithelial Research Program (WAERP), Australian Respiratory Epithelium Consortium (AusREC), Buckley, A. G., Coleman, L., Ling, K. M., Garratt, L. W., Martinovich, K. M., Shaw, N. C., Karpievitch, Y. V., Le Souëf, P., Laing, I. A., Vijayasekaran, S., Stick, S. M. & Kicic, A., 24 Mar 2020, In: JCI Insight. 5, 7, e133125.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
Differential Gene Expression of Lymphocytes Stimulated with Rhinovirus A and C in Children with Asthma
Anderson, D., Jones, A. C., Gaido, C. M., Carter, K. W., Laing, I. A., Bosco, A., Thomas, W. R. & Hales, B. J., 15 Jul 2020, In: American Journal of Respiratory and Critical Care Medicine. 202, 2, p. 202-209 8 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Vitamin D receptor polymorphisms are associated with severity of wheezing illnesses and asthma exacerbations in children
Leiter, K., Franks, K., Borland, M. L., Coleman, L., Harris, L., Le Souëf, P. N. & Laing, I. A., Jul 2020, In: Journal of Steroid Biochemistry and Molecular Biology. 201, 105692.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2019
CC16: A biomarker of pollutant exposure and future lung disease?
Laing, I. A., 1 Sept 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 5, p. 529-530 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access3 Citations (Scopus) -
Glutathione S-Transferase Genotype Protects against In Utero Tobacco-linked Lung Function Deficits
Owens, L., Laing, I. A., Murdzoska, J., Zhang, G., Turner, S. W. & Le Souef, P. N., 15 Aug 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 4, p. 462-470 9 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C
Sikazwe, C. T., Laing, I. A., Imrie, A. & Smith, D. W., 7 Nov 2019, In: Viruses. 11, 11, 1038.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children
Leffler, J., Read, J. F., Jones, A. C., Mok, D., Hollams, E. M., Laing, I. A., Le Souef, P. N., Sly, P. D., Kusel, M. M. H., de Klerk, N. H., Bosco, A., Holt, P. G. & Strickland, D. H., Sept 2019, In: Pediatric Allergy and Immunology. 30, 6, p. 646-653 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)100 Downloads (Pure) -
Upper airway cell transcriptomics identify a major new immunological phenotype with strong clinical correlates in young children with acute wheezing
Khoo, S. K., Read, J., Franks, K., Zhang, G., Bizzintino, J., Coleman, L., McCrae, C., Öberg, L., Troy, N. M., Prastanti, F., Everard, J., Oo, S., Borland, M. L., Maciewicz, R. A., Le Souëf, P. N., Laing, I. A. & Bosco, A., 1 Jan 2019, In: Journal of Immunology. 202, 6, p. 1845-1858 14 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
Cuthbertson, L., Oo, S. W. C., Cox, M. J., Khoo, S. K., Cox, D. W., Chidlow, G., Franks, K., Prastanti, F., Borland, M. L., Gern, J. E., Smith, D. W., Bizzintino, J. A., Laing, I. A., Le Souëf, P. N., Moffatt, M. F. & Cookson, W. O. C., 1 Oct 2019, In: PLoS One. 14, 10, e0223990.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
2018
Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood
Owens, L., Laing, I. A., Zhang, G., Turner, S. & Le Souëf, P. N., 1 Aug 2018, In: Pediatric Pulmonology. 53, 8, p. 1082-1088 7 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Web of Science) -
Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma
Poulsen, N. N., Bjerregaard, A., Khoo, S. K., Laing, I. A., Le Souëf, P., Backer, V., Rapley, L., Cohen, S. E., Barrett, L., Thompson, P., Baltic, S. & Porsbjerg, C., 1 Jul 2018, In: Respiratory Medicine. 140, p. 50-56 7 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations
Leffler, J., Jones, A. C., Hollams, E. M., Prastanti, F., Le Souëf, P. N., Holt, P. G., Bosco, A., Laing, I. A. & Strickland, D. H., Nov 2018, In: The Journal of Allergy and Clinical Immunology. 142, 5, p. 1639-1641.e5Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
Song, Y., Aguilar, R., Guo, J., Manaca, M. N., Nhabomba, A., Berthoud, T. K., Khoo, S. K., Wiertsema, S., Barbosa, A., Quintó, L., Laing, I. A., Mayor, A., Guinovart, C., Alonso, P. L., Lesouëf, P. N., Dobaño, C. & Zhang, G. B., 1 Dec 2018, In: Scientific Reports. 8, 1, 10860.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Environmental exposure and parental collection does not affect detection or semi-quantitative load assessment of bacteria in nasal swab specimens from children
Townsi, N., Simpson, S. J., Sikazwe, C. T., Chidlow, G. R., Hall, G. L., Pillow, J. J., Wilson, A. C., Smith, D. W. & Laing, I. A., 3 Jun 2018, In: Infectious Diseases. 50, 6, p. 468-471 4 p.Research output: Contribution to journal › Comment/debate
1 Citation (Scopus) -
Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort
Owens, L., Laing, I. A., Zhang, G., Turner, S. & Le Souëf, P. N., 1 Jan 2018, In: Journal of Asthma and Allergy. 11, p. 173-180 8 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Citations (Scopus) -
Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children with and Without an Acute Wheezing Exacerbation
Lethbridge, R., Prastanti, F., Robertson, C., Oo, S., Khoo, S. K., Le Souëf, P. N. & Laing, I. A., 1 May 2018, In: Viral Immunology. 31, 4, p. 299-305 7 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions
Cox, D. W., Khoo, S. K., Zhang, G., Lindsay, K., Keil, A. D., Knight, G., Gern, J. E., Laing, I. A., Bizzintino, J. & Le Souëf, P. N., 1 Aug 2018, In: European Respiratory Journal. 52, 2, 1800207.Research output: Contribution to journal › Letter › peer-review
38 Citations (Scopus) -
T-cell responses against rhinovirus species A and C in asthmatic and healthy children
Gaido, C. M., Granland, C., Laing, I. A., Souëf, P. N. L., Thomas, W. R., Currie, A. J. & Hales, B. J., 1 Mar 2018, In: Immunity Inflammation and Disease. 6, 1, p. 143-153 11 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
The impact of respiratory viruses on lung health after preterm birth
Townsi, N., Laing, I. A., Hall, G. L. & Simpson, S. J., 1 Jan 2018, In: European Clinical Respiratory Journal. 5, 1, 11 p., 1487214.Research output: Contribution to journal › Review article › peer-review
Open Access46 Citations (Scopus) -
2017
Activation of inflammatory cells during asthma exacerbations is initiated prior to their migration to the lung
Jones, A. C., Bizzintino, J., Khoo, S., Rueter, K., Laing, I. A., Goldblatt, J., Le Soeuf, P. N., Sly, P. D., Strickland, D. H., Bosco, A. & Holt, P. G., Aug 2017, In: Allergy. 72, p. 50-51 2 p.Research output: Contribution to journal › Abstract/Meeting Abstract › peer-review
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ACUTE RESPIRATORY ILLNESSES AND RELATED RESPIRATORY MORBIDITY IN PRETERM INFANTS DURING THE FIRST 6 MONTHS OF LIFE
Townsi, N., Laing, I., Hall, G. L., Wilson, A., Pillow, J. & Simpson, S., Mar 2017, In: TSANZ & ANZSRS Annual Scientific Meetings. 22, p. 171-171 1 p.Research output: Contribution to journal › Abstract/Meeting Abstract › peer-review
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Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults
Bjerregaard, A., Laing, I. A., Poulsen, N., Backer, V., Sverrild, A., Fally, M., Khoo, S. K., Barrett, L., Baltic, S., Thompson, P. J., Chidlow, G., Sikazwe, C., Smith, D. W., Bochkov, Y. A., Le Souëf, P. & Porsbjerg, C., 1 Feb 2017, In: Respiratory Medicine. 123, p. 34-41 8 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Clinical characteristics of eosinophilic asthma exacerbations
Bjerregaard, A., Laing, I. A., Backer, V., Fally, M., Khoo, S. K., Chidlow, G., Sikazwe, C., Smith, D. W., Le Souëf, P. & Porsbjerg, C., 1 Feb 2017, In: Respirology. 22, 2, p. 295-300 6 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
EFFECTS OF IN UTERO SMOKE EXPOSURE ON LUNG FUNCTION FROM INFANCY TO ADULTHOOD AND THE CONTRIBUTION OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS
Owens, L., Laing, I., Zhang, G., Murdzoska, J., Turner, S., Mullane, D., Cox, D. & Le Souef, P., Mar 2017, In: Respirology. 22, p. 46-46 1 p.Research output: Contribution to journal › Abstract/Meeting Abstract › peer-review
1 Citation (Web of Science) -
Environment changes genetic effects on respiratory conditions and allergic phenotypes
Song, Y., Schwager, M. J., Backer, V., Guo, J., Porsbjerg, C., Khoo, S. K., Laing, I. A., Moses, E. K., LeSouëf, P. & Zhang, G., 24 Jul 2017, In: Scientific Reports. 7, 1, 6342.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations: A prospective cohort study
Bjerregaard, A., Laing, I. A., Backer, V., Sverrild, A., Khoo, S. K., Chidlow, G., Sikazwe, C., Smith, D. W., Le Souëf, P. & Porsbjerg, C., 1 Aug 2017, In: Clinical and Experimental Allergy. 47, 8, p. 1007-1013 7 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Citations (Scopus) -
Infant lung function predicts asthma persistence and remission in young adults
Owens, L., Laing, I. A., Zhang, G. & Le Souëf, P. N., 1 Feb 2017, In: Respirology. 22, 2, p. 289-294 6 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco
Annamalay, A. A., Jroundi, I., Bizzintino, J., Khoo, S. K., Zhang, G., Lehmann, D., Laing, I. A., Gern, J., Goldblatt, J., Mahraoui, C., Benmessaoud, R., Moraleda, C., Bassat, Q. & Le Souëf, P., 1 Apr 2017, In: Journal of Medical Virology. 89, 4, p. 582-588 7 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect
Sly, P. D., Varghese, J., Noor, F., Tang, M. L. K., Laing, I., Oo, S., Prastanti, F., Le Souef, P. & Holt, P. G., 1 Feb 2017, In: Journal of Allergy and Clinical Immunology. 139, 2, p. 703-705 2 p., e4.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2016
Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV
Annamalay, A. A., Abbott, S., Sikazwe, C., Khoo, S.-K., Bizzintino, J., Zhang, G., Laing, I., Chidlow, G. R., Smith, D. W., Gern, J., Goldblatt, J., Lehmann, D., Green, R. J. & Le Souef, P. N., 1 Aug 2016, In: Journal of Clinical Virology. 81, p. 58-63 6 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Rhinovirus-induced asthma exacerbations and risk populations
Coleman, L., Laing, I. A. & Bosco, A., 2016, In: Current Opinion in Allergy and Clinical Immunology. 16, 2, p. 179-185 7 p.Research output: Contribution to journal › Review article
9 Citations (Scopus) -
Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique
Annamalay, A. A., Lanaspa, M., Khoo, S.-K., Madrid, L., Acacio, S., Zhang, G., Laing, I. A., Gern, J., Goldblatt, J., Bizzintino, J., Lehmann, D., Le Souef, P. N. & Bassat, Q., 1 Sept 2016, In: TROPICAL MEDICINE & INTERNATIONAL HEALTH. 21, 9, p. 1171-1180 10 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Web of Science) -
Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia
Zhang, B., Wang, K., Schultz, E. N., Khoo, S.-K., Zhang, X., Annamalay, A., Laing, I., Hales, B., Goldblatt, J. & Le Souef, P., 1 Jan 2016, In: Environmental and Molecular Mutagenesis. 57, 1, p. 65-73 9 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
2015
Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations
Iwasaki, J., Chai, L., Khoo, S.-K., Bizzintino, J., Laing, I., Le Souef, P., Thomas, W. & Hales, B., 15 Sept 2015, In: Clinical and Experimental Allergy. 45, 10, p. 1523-1530 8 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
2014
Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection
Iwasaki, J., Smith, W.-A., Khoo, S.-K., Bizzintino, J., Zhang, B., Cox, D. W., Laing, I., Le Souef, P., Thomas, W. & Hales, B., Jul 2014, In: Journal of Allergy and Clinical Immunology. 134, 1, p. 25–32Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)319 Downloads (Pure) -
2013
HRV-C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions
Cox, D. W., Bizzintino, J., Ferrari, G., Khoo, S.-K., Zhang, B., Whelan, S., Lee, W. M., Bochkov, Y. A., Geelhoed, G., Goldblatt, J., Gern, J. E., Laing, I. & Le Souef, P., 2013, In: American Journal of Critical Care. 188, 11, p. 1358-1364Research output: Contribution to journal › Article › peer-review
145 Citations (Scopus) -
2012
Prevalence of and risk factors for human rhinovirus infection in healthy aboriginal and non-aboriginal western australian children
Annamalay, A., Khoo, S.-K., Jacoby, P., Bizzintino, J., Zhang, B., Chidlow, G., Lee, W.-M., Moore, H., Harnett, G. B., Smith, D., Gern, J. E., Le Souef, P., Laing, I. & Lehmann, D., 2012, In: Pediatric Infectious Disease Journal. 31, 7, p. 673-679Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Respiratory viral pathogens associated with lower respiratory tract disease among young children in the highlands of Papua New Guinea
Chidlow, G. R., Laing, I., Harnett, G. B., Greenhill, A. R., Phuanukoonnon, S., Siba, P. M., Pomat, W. S., Shellam, G., Smith, D. & Lehmann, D., 2012, In: Journal of Clinical Virology. 54, 3, p. 235-239Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Symptomatic and viral infection is associated with impaired response to treatment in children with acute asthma
Reuter, K., Bizzintino, J., Martin, A., Zhang, B., Hayden, C., Geelhoed, G., Goldblatt, J., Laing, I. & Le Souef, P., 2012, In: Journal of Pediatrics. 160, p. 82-87Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus)