Personal profile
Biography
Roles and responsibilities
Expertise: molecular biology, systems biology, bioinformatics
Future research
Funding overview
$22.3 million from the ARC for the ARC Centre of Excellence in Plant Energy Biology, 2005-2013
$400,000 from DIISR International Science Linkage
Previous positions
Research
Ian's research has focused on the cellular machinery involved in translating messenger RNAs into proteins (The Plant Cell, 1996; Proceedings of the National Academy of Sciences USA, 2005), and on the transport of RNA and proteins into organelles (EMBO Journal, 1992). However, his research interests evolved rapidly to take advantage of the functional genomics technology emerging from the sequencing of the Arabidopsis nuclear genome. He coordinated the large European Union Framework 5 project, AGRIKOLA, that has provided unparalleled tools to the scientific community for analysing gene function in Arabidopsis (Genome Research, 2004) by the exciting new technology of RNA interference. He is perhaps best-known for the discovery and characterisation of the pentatricopeptide repeat (PPR) family of proteins, a huge family of 450 proteins involved in controlling gene expression in mitochondria and chloroplasts (Trends in Biochemical Sciences, 2000; The Plant Cell, 2004, 2007, 2008, 2009).
Languages
French
Research expertise keywords
- Gene expression in plant organelles
- Large-scale Arabidopsis functional genomics research
- Plant RNA biology and bioinformatics
Fingerprint
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Collaborations and top research areas from the last five years
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Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins
Kwok van der Giezen, F. M. & Small, I., 6 Feb 2026, (E-pub ahead of print) In: FEBS Journal.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
CRISPRi-based circuits to control gene expression in plants
Khan, M. A., Herring, G., Zhu, J. Y., Oliva, M., Fourie, E., Johnston, B., Zhang, Z., Potter, J., Pineda, L., Pflueger, J., Swain, T., Pflueger, C., Lloyd, J. P. B., Secco, D., Small, I., Kidd, B. N. & Lister, R., Mar 2025, In: Nature Biotechnology. 43, 3, p. 416-430 15 p., 1844.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Link opens in a new tab Citations (Scopus)301 Downloads (Pure) -
De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome
10+ Wheat Genome Project, 6 Oct 2025, In: Nature Communications. 16, 15 p., 8538.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
GRASP: a modular toolkit for building synthetic pentatricopeptide repeat RNA-binding proteins
Dennis, M., Low, S. Y., Viljoen, A., Pullakhandam, A., Colas des Francs-Small, C., Campbell-Clause, L., Bond, C. S., Small, I. & Kwok van der Giezen, F. M., 11 Nov 2025, In: Nucleic Acids Research. 53, 20, 17 p., gkaf1169.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
High Conservation of Translation-Enabling RNA Editing Sites in Hyper-editing Ferns Implies They Are Not Selectively Neutral
Kwok van der Giezen, F. M., McDowell, R., Duncan, O., Zumkeller, S., Colas des Francs-Small, C. & Small, I., 1 Oct 2025, In: Molecular Biology and Evolution. 42, 10, msaf241.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Web of Science)
Datasets
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Supplementary data for manuscript:"High intraspecific diversity of Restorer-of-fertility-like genes in barley"
Melonek, J. (Creator), Zhou, R. (Creator), Bayer, P. (Creator), Edwards, D. (Creator), Stein, N. (Creator) & Small, I. (Creator), The University of Western Australia, 21 Sept 2018
Dataset
File -
Reversible CRISPRi-based circuits for genetic computation in plants
Khan, M. A. (Creator), Herring, G. (Creator), Oliva, M. (Creator), Fourie, E. (Creator), Zhu, J. Y. (Creator), Johnston, B. (Creator), Pflüger, J. (Creator), Swain, T. (Creator), Pflüger, C. (Creator), Lloyd, J. (Creator), Secco, D. (Creator), Small, I. (Creator), Kidd, B. (Creator) & Lister, R. (Creator), Zenodo, 2022
DOI: 10.5281/zenodo.6783186, https://zenodo.org/record/6783186
Dataset
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CRISPRi-based circuits for genetic computation in plants
Khan, M. A. (Creator), Herring, G. (Creator), Zhu, J. Y. (Creator), Oliva, M. (Creator), Fourie, E. (Creator), Johnston, B. (Creator), Zhang, Z. (Creator), Potter, J. (Creator), Pineda, L. (Creator), Pflueger, J. (Creator), Swain, T. (Creator), Pflueger, C. (Creator), Lloyd, J. (Creator), Secco, D. (Creator), Small, I. (Creator), Kidd, B. (Creator) & Lister, R. (Creator), Zenodo, 18 Jan 2024
DOI: 10.5281/zenodo.10528436, https://zenodo.org10528436
Dataset
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The genetic basis of cytoplasmic male sterility and fertility restoration in wheat
Small, I. (Creator), Melonek, J. (Creator), Duarte, J. (Creator), Martin, J. (Creator), Murigneux, A. (Creator), Varenne, P. (Creator), Comadran, J. (Creator), Specel, S. (Creator), Levadoux, S. (Creator), Bernath-Levin, K. (Creator), Beuf, L. (Creator), Torney, F. (Creator), Pichon, J.-P. (Creator) & Perez, P. (Creator), DRYAD, 8 Jan 2021
DOI: 10.5061/dryad.6djh9w10d, https://zenodo.org/record/4429247 and one more link, http://datadryad.org/stash/dataset/doi:10.5061/dryad.6djh9w10d (show fewer)
Dataset
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The GENOMES UNCOUPLED1 protein has an ancient, highly conserved role but not in retrograde signalling
Small, I. (Creator), Honkanen, S. (Creator) & Biology, A. C. O. E. I. P. E. (Contributor), DRYAD, 30 Jun 2022
DOI: 10.5061/dryad.x0k6djhmk, http://datadryad.org/stash/dataset/doi:10.5061/dryad.x0k6djhmk and one more link, https://zenodo.org/record/6783389 (show fewer)
Dataset
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Unleashing the potential of Restorer-of-fertility proteins for hybrid crops
Melonek, J. (Investigator 01) & Small, I. (Investigator 02)
ARC Australian Research Council
1/04/25 → 31/03/28
Project: Research
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Molecular "safety catches" for controlled modification of RNA
Bond, C. (Investigator 01) & Small, I. (Investigator 02)
ARC Australian Research Council
1/01/25 → 30/06/28
Project: Research
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ARC Centre of Excellence in Plants for Space
Small, I. (Investigator 01), Millar, H. (Investigator 02) & Lister, R. (Investigator 03)
ARC Australian Research Council
1/01/24 → 31/12/30
Project: Research
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A FRET-based protein sensor for RNA detection, localisation and analysis
Bond, C. (Investigator 01), Paudel, B. (Investigator 02), Small, I. (Investigator 03) & Agostino, M. (Investigator 04)
NHMRC National Health and Medical Research Council
1/01/22 → 31/12/26
Project: Research
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Multifuge X4R refrigerated centrifuge
Bond, C. (Investigator 01), Vrielink, A. (Investigator 02), Fox, A. (Investigator 03), Stubbs, K. (Investigator 04), Kahler, C. (Investigator 05), Smith, N. (Investigator 06), Kretzmann, J. (Investigator 07), Evans, C. (Investigator 08), Marshall, A. (Investigator 09), Smithers, L. (Investigator 10), Debowski, A. (Investigator 11), Bzdyl, N. (Investigator 12), Chooi, H. (Investigator 13), Fritz, G. (Investigator 14), Small, I. (Investigator 15), Lesterhuis, W. (Investigator 16), Piggott, M. (Investigator 17) & Sarkar-Tyson, M. (Investigator 18)
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
Prizes
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School of Molecular Sciences Award in Research Impact and Innovation
Small, I. (Recipient) & Melonek, J. (Recipient), 2022
Prize: Award
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Vice-Chancellor’s Award in Research Impact and Innovation
Melonek, J. (Recipient) & Small, I. (Recipient), 2022
Prize: Award
Courses
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BIOC3005: Cellular Biochemistry
Fritz, G., Arthur, P., Murcha, M., Small, I. & Chooi, H. 1/08/22 → …
Course
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SCIE5508: Synthetic Biology - Solving Global Challenges
Fritz, G., Chooi, H., Lister, R. & Small, I. 27/07/20 → …
Course
Press/Media
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University of Western Australia: Inspiring Researchers Honoured In Vice-Chancellor Awards
Zheng, M., Green, D., Wang, J., Geddes, D., Small, I., Marley, J., Ecker, U., Fang, Q., Melonek, J., Page, A. T. & Attwell, K.
22/11/22
1 item of Media coverage
Press/Media: Press / Media
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Breakthrough research finds keys to a major boost for hybrid wheat breeding
18/02/21
1 Media contribution
Press/Media: Press / Media
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Research Finds Key to a Major Boost for Hybrid Wheat Breeding
17/02/21
1 Media contribution
Press/Media: Press / Media
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UWA researchers crack major key to hybrids
16/02/21
1 item of Media coverage
Press/Media: Press / Media