Henry Hui

Dr, BSc BMedSci PhD W.Aust., Early Career Researcher in the Translational Cancer Pathology Laboratory

  • The University of Western Australia (M504), 35 Stirling Highway,

    6009 Perth

    Australia

  • The University of Western Australia (M500), 35 Stirling Highway,

    6009 Perth

    Australia

Calculated based on number of publications stored in Pure and citations from PlumX

Personal profile

Biography

I am a highly passionate early career research associate with an emerging international reputation in the development of advanced cell analysis technology and cutting-edge methodologies for both research and clinical applications. My work enables me to charter new frontiers in technology to advance knowledge and generate technical solutions to challenges in science, health and medicine.

Since 2013, I have had a key role in the expansion of an award-winning, multi-disciplinary research team that leads the world in imaging flow cytometry powered diagnostic developments for haematological malignancies and constitutional disorders in adults, children and neonates. I am the co-inventor of the world-first “Immuno-flowFISH” method, a game-changing diagnostic technology. This invention enables precision assessment of blood cancers that vastly exceeds current research and clinical testing modalities. In 2018, I was awarded the highly prestigious ANSTO 2018 Eureka Prize for Innovative Use of Technology by the Australian Museum.

My research has patented in many countries and my world-leading expertise has drawn investment and funding equivalent to $3.6M in value from industry partnerships, government grants and healthcare organisations. Currently, I have global multidisciplinary collaborative networks that intersect research, clinical and industry commercialisation pipelines. This includes both industry leading medical technology corporations (Sysmex Corporation, Japan & Cytek Biosciences, USA), world- class diagnostic cancer centres (MD Anderson Cancer Centre USA, Texas, Roswell Park Cancer USA, University of Cambridge, UK), clinical research groups (University of Oxford (UK), Queen’s University Belfast (UK), Manipal Institute of Regenerative Medicine (India) and National University of Malaysia (Malaysia)) and international government agencies (US National Institute of Standards and Technology).

I am currently leading the translational beta testing and commercialisation of immuno-flowFISH through this multi-disciplinary collaborative network to establish global adoption of this technology. My long-term goal as a scientist is to lead the innovation, application, influence, education, engagement, and outreach of medical research in both scientific and clinical domains, to advance knowledge and health globally.

Research

Prizes and Awards

2022 Raine Priming Grant

2021 Raine BrightSpark Research Collaboration Award

2021 Cancer Council Western Australia Early Career Researcher of the Year

2021 Marylou Ingram Scholar, International Society for Advancement of Cytometry (25 in the world)

2020 Laurence Catley Best Abstract Award at the 3rd National Myeloma Workshop Australia

2018 Australian Museum ANSTO Eureka Prize for Innovative Use of Technology

2018 UWA Innovation Quarter (IQ) Research Innovation and Enterprise Award

2018 “Top 20 PhD” student shortlist for the CSL Florey Award, Australian Institute of Policy and Science

2017 Travel Award, Australian Cytometry Society for CYTO Asia

2016 Travel Award from the International Society for Advancement of Cytometry

2016 University Postgraduate Award, University of WesternAustralia

2014 Runner Up, best presentation at the Students in Health and Medical Research conference

Roles and responsibilities

2024– Associate Lecturer, Medical Science and Genetics (IMED 1003 & 1004), UWA

2023– Australasian Cytometry Society (ACS) - Executive Secretary/council

2021 - 2022 Australasian Cytometry Society (ACS) – Advisory council 

2021– Research Associate, Translational Cancer Pathology Laboratory, UWA

2021– Marylou Ingram Scholar for the International Society for Advancement of Cytometry

2020– Australian Society for Medical Research WA (ASMR) State Committee member

2019 - 2021 Post-doctoral Research Scientist, Translational Cancer Pathology Laboratory, UWA

Funding overview

  • "Next-Generation Single Cell Diagnostics of Blood Cancers" Raine Priming Grants 2022 (Raine Medical Research Foundation). Chief Investigator A. Funds allocated: $$224,649 (2 years) 
  • "Precision Diagnostics for Blood Cancers" Future Health Research and Innovation Fund 2022 (Department of Health, Government of Western Australia). Chief Investigator C. Funds allocated: $499,632 (2 years)
  • "Developing a user-friendly machine learning enabled diagnostic tool for paediatric acute lymphoblastic leukaemia (ALL)" UWA Research Collaboration Awards (The University of Western Australia). Chief Investigator C. Funds allocated: $20,000 (1 year)
  • “Improving Survival in Childhood Leukaemia” Raine BrightSpark Research Collaboration Award (Raine Medical Research foundation). Chief Investigator A. Funds allocated: $29,864 (1 year)
  • Precision molecular diagnostics of single cells by imaging flow cytometry. National Health and Medical Research Council (NHRMC) Ideas grants. Chief Investigator C. Funds allocated: $875,110 (4 years)
  • Conquering Chronic Leukaemia in Children. The Channel 7 Telethon Trust. Chief Investigator C. Funds allocated:$124,000 (2 years)
  • Putting a new lens on childhood leukaemia. The Channel 7 Telethon Trust. Chief Investigator C. Funds allocated:$100,000 (2 years)
  • Development of the immuno-flowFISH method and analysis kit for the assessment of haematological and non- haematological cancers excluding plasma cell myeloma. Industry Sponsored Research Collaboration. Associate Investigator. Funds and instrument value allocated: $1.2 million (3 years)
  • Detecting high risk chromosomal aberrations in patients with myeloproliferative neoplasms using automated imaging flow cytometry for prognostication. Spinnaker Health Research Foundation. Associate Investigator. Funds allocated: $14,775 (1 year)
  • Australia-Japan Collaboration to Improve the Identification of Blood Cancers with Immuno-flowFISH. Foundation for Australia-Japan Studies. Associate Investigator. Funds allocated: $140,775 (2 years)
  • Automated imaging flow cytometry for disease monitoring and prognostication in myeloproliferative neoplasms. Faculty of Health and Medical Sciences Research Grants Scheme, UWA. Associate Investigator. Funds allocated: $99,000 (1 year)
  • Clinical validation of immuno-flowFISH for the assessment of plasma cell myeloma. SYSMEX Corporation Sponsored Research Collaboration. Associate Investigator. Funds allocated: $80,000 (3 years) 

Research

Oral Presentations at National/International Conferences (peer-reviewed abstracts):

2021 Science Lands in Parliament, Parliament house, Western Australia

2021 International Society for Advancement of Cytometry conference, USA

2020 3rd National Myeloma Workshop, Australia

2020 Lorne Cancer Conference,Australia

2019; 2021 Blood Annual Scientific Meeting, Australia

2018; 2023 Australian Cytometry Society Annual Scientific Meeting, Australia (invitation 2023)

2017 CYTOAsia 2017, Singapore.

2015 Australasian Society of Medical Research national conference, Australia

2014; 2019 Indian Ocean Rim Laboratory Haematology Congress,Australia

Industrial relevance

Industry or Government Engagement/Collaborations:

I have government and industry funded collaborations to develop novel diagnostic tests and medical technology to advance scientific knowledge and human health. I lead or provide consultation (both interllectual and technincal input) on the development, testing, data review and comercialisation in these goverment agency or industry networks:

2024-  Research collaboration with undisclosed company (USA)

2022-  Research collaboration with National Institute of Standards and Technology (USA government)

2021–  Research collaboration with Cytek Biosciences (USA) 

2021–  Research collaboration with Cytek Biosciences (USA) 

2020-2021 –  Research collaboration with Luminex Corporation (USA) 

2018–  SYSMEX Corporation (Japan) research collaboration

2019–  SCHOTT Minifab research collaboration

My work has been licensed and patented in multiple countries:

“Improvements in or relating to cell analysis” (WO/2019/079851) (PCT/AU2018/051148)

2020   USA (Standard) Patent US20200232019

2020   China (Standard) Patent CN111448324

2020   Europe (Standard) Patent EP2018870567

2018   Australia (Standard) PatentAU2018355889

Research

Journal Reviews and Thesis Examination

2022 Cytometry Part A peer review for research manuscript

2020 PLOS ONE peer review for research manuscript

2019 Thesis examiner for Master of Clinical Pathology, University of Western Australia 2022 Thesis examiner for Honours in Biomedical Sciences, University of Western Australia 2013 Journal of the American College of Cardiologists (peer review with research supervisor)

Teaching overview

2024- Associate Lecturer and co-unit coordicator for Medical Science and Genetics (IMED 1003 & 1004)

2014- Undergraduate and Masters units/majors in biomedical sciences (e.g. pathology, cancer pathology, immunobiology, microbiology, integrated medical sciences and medical genetics): PATH2220 Principles of Human Disease; IMED2001 Integrated Medical Sciences and Clinical Practice/Body defenses; MICR3305 Immunobiology; MICR5842 Principles of Infection and Immunity; PATH3309 Cancer Pathology; PATH3304 Drugs and Diseases (2016-2019); PATH3305 Medical Genetics; MCP Masters of Clinical Pathology (mentor for students undertaking "Humans of Haematology” or “Science journalism" Projects as an assignment of the Advanced Haematology unit)

2018- Honours, Masters and PhD (HDR) research projects/research team: I have directly mentored 3 PhD students (1 graduation), 3 clinical fellows, 4 honours students, 1 medical student, 3 Research Assistants, 1 Clinical Scientist and 1 Scientific Officer. In addition, I have provided training; supervision (supervised 2 honors student); mentoring; review of manuscripts and theses to the staff, students and clinical fellows.

2023- Advisory panel for HDR student (PhD) – project reviews and strategic input

Engagement

Wider Scientific Education & Engagement (Live, Virtual or Publicised):

2022- Hosted live education workshops/watch party for the Australian Cytometry Society (UWA/WA Cytometry hub)

2022- Published an online guide (Biotechniques) for a junior audience (Honours, PhD, Early Career level) to develop competency and proficiency in using cytometry technology for their research – “How to: life in the FACS lane of flow cytometry”: https://www.biotechniques.com/analytical- chemistry/how-to-life-in-the-facs-lane-of-flow-cytometry/

2023- National and international cytometry related news and media dissemination (via published online newsletters) for education, advocacy, policy, scientific meetings, workshops, webinars, and networking (Australian Cytometry Society); including profile management of the entire of membership of the organisation (>500)

2022- Abstract peer review (with feedback); poster and oral presentation adjudication; workshop and scientific presentation session chairing at national and international meetings

2023- Image Cytometry Subcommittee (Education) - oversees and develops International Society for the Advancement of Cytometry (ISAC) educational content in image cytometry and related medical technologies (including presenter program building and invitation to provide a workshop at CYTO 2024)

2023-2025- ACS/ISAC CYTO-Connect international Cytometry scientific meeting 2025 – Conference co-chair; strategic planning, program development, speaker and sponsor engagement and media dissemination

2016- Multidisciplinary training, consultation, mentoring and collaborative input in science, health, industry, and community (e.g. research scientists, clinical fellows, and technical staff) in diverse fields of haematology, immunology, respiratory medicine, micro-vesicle biomarkers, microbiology, marine biology, ecological conservation, bone pathology, neonatal/maternal health, and data science.

 

Publicised, media releases/community engagement, impact and outreach

Community engagement

My responsibility as an emerging leader in science has enabled me to promote medical research and technological innovation to a broad audience. This includes engagement of community groups through medical research advocacy, fundraisers, cancer patient education and charity events:

2021   8 on the Point gala dinner for leukaemia research fundraising

2020– Australian Society for Medical Research WA (ASMR) State Committee

2020– Telethon family festivals

2020   Dato Tk Low Joondalup Resort Charity Golf Day 

2018   University of Western Australia Health Campus Open Day

2013 – 2021  University of Western Australia Open Day – School of Biomedical Sciences

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Industry keywords

  • Diagnostics
  • Medical Devices
  • Biotechnology
  • Digital Health

Research expertise keywords

  • Flow cytometry
  • Imaging flow cytometry
  • Immunofluorescence & imaging
  • Fluorescence In Situ Hybridization
  • Cancer Biology
  • Protocol optimisation
  • Cutting-edge method development
  • Diagnostic tests
  • Medical technology
  • Innovation & Automation
  • Blood & genetic based diagnostics
  • Chronic Lymphocytic Leukaemia (CLL)
  • Multiple myeloma
  • Pediatric Leukaemia
  • Acute Lymphoblastic Leukaemia (ALL)
  • Intergrated platforms & systems
  • Automation

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