• The University of Western Australia (M310), 35 Stirling Highway, Room 2.58, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 1566 Citations
  • 23 h-Index
20102021
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Research Output 2010 2019

  • 1566 Citations
  • 23 h-Index
  • 45 Article
  • 2 Review article
2019

Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat

Thynne, E., Mead, O. L., Chooi, Y. H., McDonald, M. C. & Solomon, P. S., 1 Mar 2019, In : Genome Biology and Evolution. 11, 3, p. 890-905 16 p.

Research output: Contribution to journalArticle

Open Access
secondary metabolite
plant pathogens
secondary metabolites
Triticum
wheat
1 Citation (Scopus)

Biosynthesis of bioactive natural products from Basidiomycota

Lin, H-C., Hewage, R. T., Lu, Y-C. & Chooi, Y-H., 7 Feb 2019, In : Organic & Biomolecular Chemistry. 17, 5, p. 1027-1036 10 p.

Research output: Contribution to journalReview article

Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii

Li, H., Gilchrist, C. L. M., Lacey, H. J., Crombie, A., Vuong, D., Pitt, J. I., Lacey, E., Chooi, Y. H. & Piggott, A. M., 1 Mar 2019, In : Organic Letters. 21, 5, p. 1287-1291 5 p.

Research output: Contribution to journalArticle

Aspergillus
Aspergillus nidulans
biosynthesis
fungi
Biosynthesis
4 Citations (Scopus)

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system

Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K. A., Lacey, E., Stewart, S. G., Karton, A., Piggott, A. M. & Chooi, Y-H., 7 Feb 2019, In : Chemical Science. 10, 5, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

Open Access
2018
4 Citations (Scopus)

Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum

Li, H., Hu, J., Wei, H., Solomon, P. S., Vuong, D., Lacey, E., Stubbs, K. A., Piggott, A. M. & Chooi, Y. H., 5 Oct 2018, In : Organic Letters. 20, 19, p. 6148-6152 5 p.

Research output: Contribution to journalArticle

Pyrones
Polyketide Synthases
Polyketides
Oxygenases
wheat
2 Citations (Scopus)

Panning for gold in mould: Can we increase the odds for fungal genome mining?

Gilchrist, C. L. M., Li, H. & Chooi, Y. H., 1 Jan 2018, In : Organic and Biomolecular Chemistry. 16, 10, p. 1620-1626 7 p.

Research output: Contribution to journalArticle

Fungal Genome
genome
Multigene Family
Gold
genes
Triticum
Transcription Factors
Gene Expression
Deoxyribonuclease I
DNA Sequence Analysis
2017
11 Citations (Scopus)

Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils

Pitt, J. I., Lange, L., Lacey, A. E., Vuong, D., Midgley, D. J., Greenfield, P., Bradbury, M. I., Lacey, E., Busk, P. K., Pilgaard, B., Chooi, Y. H. & Piggott, A. M., 5 Apr 2017, In : PLoS One. 12, 4, 21 p., e0170254.

Research output: Contribution to journalArticle

Open Access
Aspergillus
Metabolites
Fungi
secondary metabolites
Soil
6 Citations (Scopus)

Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps

Zheng, X., Cheng, Q., Yao, F., Wang, X., Kong, L., Cao, B., Xu, M., Lin, S., Deng, Z., Chooi, Y. H. & You, D., 18 Apr 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4135-4140 6 p.

Research output: Contribution to journalArticle

Anisomycin
Protein Synthesis Inhibitors
Alkaloids
Genes
Multigene Family
7 Citations (Scopus)

Functional genomics-guided discovery of a light-activated phytotoxin in the wheat pathogen Parastagonospora nodorum via pathway activation

Chooi, Y. H., Zhang, G., Hu, J., Muria-Gonzalez, M. J., Tran, P. N., Pettitt, A., Maier, A. G., Barrow, R. A. & Solomon, P. S., 1 May 2017, In : Environmental Microbiology. 19, 5, p. 1975-1986 12 p.

Research output: Contribution to journalArticle

phytotoxins
Genomics
Triticum
Multigene Family
genomics
4 Citations (Scopus)

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Yap, H. Y. Y., Muria-Gonzalez, M. J., Kong, B. H., Stubbs, K. A., Tan, C. S., Ng, S. T., Tan, N. H., Solomon, P. S., Fung, S. Y. & Chooi, Y. H., 12 Jun 2017, In : Microbial Cell Factories. 16, 1, 103.

Research output: Contribution to journalArticle

Open Access
Sesquiterpenes
Agaricales
Yeast
Genes
Yeasts
12 Citations (Scopus)

Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway

Liu, N., Hung, Y. S., Gao, S. S., Hang, L., Zou, Y., Chooi, Y. H. & Tang, Y., 7 Jul 2017, In : Organic Letters. 19, 13, p. 3560-3563 4 p.

Research output: Contribution to journalArticle

Tricarboxylic Acids
Polyketide Synthases
Polyketides
Biosynthetic Pathways
Oxaloacetic Acid
2016
8 Citations (Scopus)

A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation

Kong, L., Zhang, W., Chooi, H., Wang, L., Cao, B., Deng, Z., Chu, Y. & You, D., 2016, In : Cell Chemical Biology. 23, 4, p. 508-516 9 p.

Research output: Contribution to journalArticle

Biosynthesis
Mixed Function Oxygenases
Anti-Bacterial Agents
Anthraquinones
Labeling
2015
14 Citations (Scopus)
Open Access
20 Citations (Scopus)

An In planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum

Chooi, H., Krill, C., Barrow, R. A., Chen, S., Trengove, R., Oliver, R. P. & Solomon, P. S., 2015, In : Applied and Environmental Microbiology. 81, 1, p. 177-186

Research output: Contribution to journalArticle

Polyketide Synthases
polyketide synthases
Plantae
Triticum
pathogen
28 Citations (Scopus)

Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System

Mao, X. M., Zhan, Z. J., Grayson, M. N., Tang, M. C., Xu, W., Li, Y. Q., Yin, W. B., Lin, H. C., Chooi, H., Houk, K. N. & Tang, Y., 2015, In : Journal of the American Chemical Society. 137, 37, p. 11904-11907

Research output: Contribution to journalArticle

Polyketides
Polyenes
Aurovertins
Biosynthesis
Pyrones
35 Citations (Scopus)

Elucidation of the concise biosynthetic pathway of the communesin indole alkaloids

Lin, H. C., Chiou, G., Chooi, H., Mcmahon, T. C., Xu, W., Garg, N. K. & Tang, Y., 2015, In : Angewandte Chemie - International Edition. 54, p. 3004-3007

Research output: Contribution to journalArticle

Indole Alkaloids
Penicillium
Biosynthetic Pathways
Gene Deletion
Multigene Family
29 Citations (Scopus)

Epigenetic genome mining of an endophytic fungus leads to the pleiotropic biosynthesis of natural products

Mao, X. M., Xu, W., Li, D., Yin, W. B., Chooi, H., Li, Y. Q., Tang, Y. & Hu, Y., 2015, In : Angewandte Chemie. 54, 26, p. 7592-7596

Research output: Contribution to journalArticle

Biological Products
Epigenomics
Fungi
Genome
Histone Deacetylases
12 Citations (Scopus)

Functional redundancy of necrotrophic effectors – consequences for exploitation for breeding

Tan, K. C., Phan, H. T. T., Rybak, K., John, E., Chooi, H., Solomon, P. S. & Oliver, R. P., 2015, In : Frontiers in Plant Science. 6, JULY, p. 1-9

Research output: Contribution to journalArticle

Open Access
culture filtrates
breeding
disease resistance
knockout mutants
cultivars
27 Citations (Scopus)

Involvement of lipocalin-like CghA in decalin-forming stereoselective intramolecular [4+2] cycloaddition

Sato, M., Yagishita, F., Mino, T., Uchiyama, N., Patel, A., Chooi, H., Goda, Y., Xu, W., Noguchi, H., Yamamoto, T., Hotta, K., Houk, K. N., Tang, Y. & Watanabe, K., 2015, In : ChemBioChem. 16, 16, p. 2294-2298

Research output: Contribution to journalArticle

214 Citations (Scopus)

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M. & 60 othersHaines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H. & Gross, H., 2015, In : Nature Chemical Biology. 11, 9, p. 625-631

Research output: Contribution to journalArticle

Open Access
Multigene Family
Information Storage and Retrieval
Fungi
Bacteria
34 Citations (Scopus)

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

Cacho, R. A., Tang, Y. & Chooi, H., 2015, In : Frontiers in Microbiology. 5, p. 1-16

Research output: Contribution to journalArticle

Open Access
Multigene Family
Fungi
Fungal Genome
Microbial Genome
Workflow
8 Citations (Scopus)
72 Downloads (Pure)

SnPKS19 encodes the polyketide synthase for alternariol mycotoxin biosynthesis in the wheat pathogen Parastagonospora nodorum

Chooi, H., Muria-Gonzalez, M. J., Mead, O. L. & Solomon, P. S., Aug 2015, In : Applied and Environmental Microbiology. 81, 16, p. 5309-5317

Research output: Contribution to journalArticle

Open Access
File
Polyketide Synthases
polyketide synthases
Mycotoxins
mycotoxins
Triticum
6 Citations (Scopus)

Transcriptome analysis revealed highly expressed genes encoding secondary metabolite pathways and small cysteine-rich proteins in the sclerotium of lignosus rhinocerotis

Yap, H. Y. Y., Chooi, H., Fung, S. Y., Ng, S. T., Tan, C. S. & Tan, N. H., 2015, In : PLoS One. 10, 11, p. e0143549

Research output: Contribution to journalArticle

Open Access
Sclerotium
Gene encoding
Gene Expression Profiling
Metabolites
transcriptomics
2014
11 Citations (Scopus)

A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum

Chooi, H., Muria-Gonzalez, M. J. & Solomon, P. S., 2014, In : Mycology. 5, 3, p. 192-206

Research output: Contribution to journalArticle

Open Access
secondary metabolites
Triticum
biosynthesis
Genome
wheat
19 Citations (Scopus)

Fungal polyketide synthase product chain-length control by partnering thiohydrolase

Zabala, A. O., Chooi, H., Choi, M. S., Lin, H. C. & Tang, Y., 2014, In : ACS Chemical Biology. 9, 7, p. 1576-1586

Research output: Contribution to journalArticle

Open Access
Polyketide Synthases
Chain length
Brefeldin A
Biosynthesis
Eupenicillium
42 Citations (Scopus)

Generation of complexity in fungal terpene biosynthesis: Discovery of a multifunctional cytochrome P450 in the fumagillin pathway

Lin, H. C., Tsunematsu, Y., Dhingra, S., Xu, W., Fukutomi, M., Chooi, H., Cane, D. E., Calvo, A. M., Watanabe, K. & Tang, Y., 2014, In : Journal of the American Chemical Society. 136, 11, p. 4426-4436

Research output: Contribution to journalArticle

Open Access
Terpenes
Biosynthesis
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Genes
22 Citations (Scopus)

The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties

Yap, H. Y. Y., Chooi, H., Firdaus-Raih, M., Fung, S. Y., Ng, S. T., Tan, C. S. & Tan, N. H., 2014, In : BMC Genomics. 15, 1, p. 1-12

Research output: Contribution to journalArticle

Open Access
Tigers
Agaricales
Milk
Genome
Polyporales
2013
39 Citations (Scopus)

A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis

Chooi, H., Hong, Y. J., Cacho, R. A., Tantillo, D. J. & Tang, Y., 2013, In : Journal of the American Chemical Society. 135, 45, p. 16805-16808

Research output: Contribution to journalArticle

Terpenes
Biosynthesis
Multigene Family
Cytochrome P-450 Enzyme System
Genes
46 Citations (Scopus)

Complexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin

Cacho, R. A., Chooi, H., Zhou, H. & Tang, Y., 2013, In : ACS Chemical Biology. 8, 10, p. 2322-2330

Research output: Contribution to journalArticle

Polyketides
Griseofulvin
Biosynthesis
Biological Products
Phloroglucinol
44 Citations (Scopus)

Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in aspergillus nidulans

Yin, W. B., Chooi, H., Smith, A. R., Cacho, R. A., Hu, Y., White, T. C. & Tang, Y., 2013, In : ACS Synthetic Biology. 2, 11, p. 629-634

Research output: Contribution to journalArticle

Polyketides
Aspergillus nidulans
Arthrodermataceae
Aspergillus
Metabolites
41 Citations (Scopus)

Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

Chooi, H., Fang, J., Liu, H., Filler, S. G., Wang, P. & Tang, Y., 2013, In : Organic Letters. 15, 4, p. 780-783

Research output: Contribution to journalArticle

Neosartorya
Dimethylallyltranstransferase
Polyketides
Aspergillus
Aspergillus fumigatus
43 Citations (Scopus)

LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

Xu, W., Chooi, H., Choi, J. W., Li, S., Vederas, J. C., Da Silva, N. A. & Tang, Y., 2013, In : Angewandte Chemie - International Edition. 52, 25, p. 6472-6475

Research output: Contribution to journalArticle

Lovastatin
Catalysis
Hydrolysis
dihydromonacolin L
63 Citations (Scopus)

The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene

Lin, H. C., Chooi, H., Dhingra, S., Xu, W., Calvo, A. M. & Tang, Y., 2013, In : Journal of the American Chemical Society. 135, 12, p. 4616-4619

Research output: Contribution to journalArticle

Terpenes
Aspergillus fumigatus
Aspergillus
Biosynthesis
Multigene Family
2012
57 Citations (Scopus)

Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation

Zabala, A. O., Xu, W., Chooi, H. & Tang, Y., 2012, In : Chemistry and Biology. 19, 8, p. 1049-1059

Research output: Contribution to journalArticle

Open Access
Polyketide Synthases
Pyrans
Hydroxylation
Aspergillus niger
Aspergillus
23 Citations (Scopus)

Characterization of the Suillus grevillei Quinone Synthetase GreA Supports a Nonribosomal Code for Aromatic α-Keto Acids

Wackler, B., Lackner, G., Chooi, H. & Hoffmeister, D., 2012, In : ChemBioChem. 13, 12, p. 1798-1804

Research output: Contribution to journalArticle

Peptide Synthases
Keto Acids
Ligases
Carboxylic acids
Genes
40 Citations (Scopus)

Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases

Chooi, H., Wang, P., Fang, J., Li, Y., Wu, K. & Tang, Y., 2012, In : Journal of the American Chemical Society. 134, 22, p. 9428-9437

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Polyketides
Genes
Neosartorya
Triacetoneamine-N-Oxyl
11 Citations (Scopus)

Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation

Liu, Q., Yao, F., Chooi, H., Kang, Q., Xu, W., Li, Y., Shao, Y., Shi, Y., Deng, Z., Tang, Y. & You, D., 2012, In : Chemistry and Biology. 19, 2, p. 243-253

Research output: Contribution to journalArticle

Open Access
Pyridones
Polyketide Synthases
Genes
Biosynthesis
Anti-Bacterial Agents
51 Citations (Scopus)

Identification and characterization of the echinocandin b biosynthetic gene cluster from Emericella rugulosa NRRL 11440

Cacho, R. A., Jiang, W., Chooi, H., Walsh, C. T. & Tang, Y., 2012, In : Journal of the American Chemical Society. 134, 40, p. 16781-16790

Research output: Contribution to journalArticle

Emericella
Echinocandins
Oxygenases
Multigene Family
Ornithine
113 Citations (Scopus)

Navigating the fungal polyketide chemical space: From genes to molecules

Chooi, H. & Tang, Y., 2012, In : Journal of Organic Chemistry. 77, 22, p. 9933-9953

Research output: Contribution to journalReview article

Polyketides
Genes
Molecules
Biological Products
Fungi
2011
42 Citations (Scopus)
Polyketides
Hydroxylation
Cyclization
Biosynthesis
Biosynthetic Pathways
76 Citations (Scopus)

Fungal indole alkaloid biosynthesis: Genetic and biochemical investigation of the tryptoquialanine pathway in penicillium aethiopicum

Gao, X., Chooi, H., Ames, B. D., Wang, P., Walsh, C. T. & Tang, Y., 2011, In : Journal of the American Chemical Society. 133, 8, p. 2729-2741

Research output: Contribution to journalArticle

Peptide Synthases
Indole Alkaloids
Quinazolines
Alkaloids
Penicillium
9 Citations (Scopus)

Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in streptomyces rimosus

Wang, P., Gao, X., Chooi, H., Deng, Z. & Tang, Y., 2011, In : Microbiology. 157, 8, p. 2401-2409

Research output: Contribution to journalArticle

Streptomyces rimosus
Oxytetracycline
Enzymes
Amides
Tetracyclines
68 Citations (Scopus)

Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1

Qiao, K., Chooi, H. & Tang, Y., 2011, In : Metabolic Engineering. 13, 6, p. 723-732

Research output: Contribution to journalArticle

Cytochalasins
Aspergillus
Multigene Family
Genes
Peptide Synthases
131 Citations (Scopus)

Metabolic engineering for the production of natural products

Pickens, L. B., Tang, Y. & Chooi, H., 2011, In : Annual Review of Chemical and Biomolecular Engineering. 2, p. 211-236

Research output: Contribution to journalArticle

Metabolic engineering
Biological Products
Production platforms
Genetic engineering
Biosynthesis
2010
89 Citations (Scopus)

Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

Chooi, H., Cacho, R. & Tang, Y., 2010, In : Chemistry and Biology. 17, 5, p. 483-494

Research output: Contribution to journalArticle

Polyketides
Griseofulvin
Antifungal Agents
Penicillium
Gene Deletion