• The University of Western Australia (M310), 35 Stirling Highway, Room 2.58, Bayliss Building, Perth campus

    6009 Perth


  • 1782 Citations
  • 23 h-Index
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Personal profile


Dr Chooi (PhD, Applied Biology and Biotechnology) worked as a postdoctoral researcher at University of California, Los Angeles, USA with Professor Yi Tang (2009-2013), focusing on the molecular genetic and biochemical basis of secondary metabolite biosynthesis in fungi. He moved to the Research School of Biology at the Australian National University in 2013 after winning a prestigious ARC Discovery Early Career Researcher Award (DECRA). In 2015, he joined the faculty at The University of Western Australia and took up a lectureship in the School of Chemistry & Biochemistry. His current research is focusing on secondary metabolite biosynthesis of fungi and understanding its roles in plant and animal fungal disease development. His work spans the field of genomics, genetics, molecular biology, synthetic biology, biochemistry and natural product chemistry. More recently in 2016, Dr Chooi was awarded the prestigious ARC Future Fellowship to continue his research in this exciting interdisciplinary field.

Funding overview

ARC Discovery Project (2017-2019) - Two new phytotoxins in Septoria nodorum blotch: Biosynthesis and functions

ARC Future Fellowship (2016-2019) - Uncovering the Hidden Secondary Metabolite Biosynthetic Potential of Fungi

ARC Discovery Early Career Researcher Award (DECRA) (2013-2015) - A Synthetic Biology Approach for Mining the Secondary Metabolomes of Fungal Phytopathogens

Current projects

PhD & Honours Research Opportunities:

1. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/metabolites

2. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/synthetic

3. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/genome-mining


- Secondary metabolite biosynthesis
- Fungal pathogen host-interactions
- Synthetic biology


  • Secondary metabolite biosynthesis
  • Fungal molecular genetics
  • Synthetic biology
  • Natural product isolation
  • Fungal pathogen-host interactions

Fingerprint Dive into the research topics where Heng Chooi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Multigene Family Medicine & Life Sciences
Genes Chemical Compounds
Biosynthesis Chemical Compounds
Polyketide Synthases Medicine & Life Sciences
Polyketides Chemical Compounds
Aspergillus Chemical Compounds
Fungi Medicine & Life Sciences
Triticum Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2010 2019

  • 1782 Citations
  • 23 h-Index
  • 50 Article
  • 2 Review article
2 Citations (Scopus)

Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat

Thynne, E., Mead, O. L., Chooi, Y. H., McDonald, M. C. & Solomon, P. S., 1 Mar 2019, In : Genome Biology and Evolution. 11, 3, p. 890-905 16 p.

Research output: Contribution to journalArticle

Open Access
secondary metabolite
plant pathogens
secondary metabolites
1 Citation (Scopus)

Biosynthesis of a Tricyclo[,7]dodecane System by a Berberine Bridge Enzyme-Like Aldolase

Li, H., Hu, J., Wei, H., Solomon, P. S., Stubbs, K. A. & Chooi, Y. H., 25 Sep 2019, In : Chemistry - A European Journal.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
3 Citations (Scopus)

Biosynthesis of bioactive natural products from Basidiomycota

Lin, H-C., Hewage, R. T., Lu, Y-C. & Chooi, Y-H., 7 Feb 2019, In : Organic & Biomolecular Chemistry. 17, 5, p. 1027-1036 10 p.

Research output: Contribution to journalReview article

Bipolenins K-N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

Phan, C. S., Li, H., Kessler, S., Solomon, P. S., Piggott, A. M. & Chooi, Y. H., 9 Aug 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2020-2028 9 p.

Research output: Contribution to journalArticle

Open Access
Biological Products
4 Citations (Scopus)

Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii

Li, H., Gilchrist, C. L. M., Lacey, H. J., Crombie, A., Vuong, D., Pitt, J. I., Lacey, E., Chooi, Y. H. & Piggott, A. M., 1 Mar 2019, In : Organic Letters. 21, 5, p. 1287-1291 5 p.

Research output: Contribution to journalArticle

Aspergillus nidulans

Projects 2015 2022