• The University of Western Australia (M310), 35 Stirling Highway, Room 2.58, Bayliss Building, Perth campus

    6009 Perth


  • 2115 Citations
  • 25 h-Index

Research output per year

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Personal profile


Dr Chooi (PhD, Applied Biology and Biotechnology) worked at University of California, Los Angeles (2009-2013) focusing on the molecular genetic and biochemical basis of secondary metabolite biosynthesis in fungi. He moved to the Research School of Biology at the Australian National University in 2013 after winning a prestigious ARC Discovery Early Career Researcher Award (DECRA). In 2015, he joined the faculty at The University of Western Australia and took up a lectureship in the School of Chemistry & Biochemistry. His current research is focusing on secondary metabolite biosynthesis of fungi, understanding secondary metabolite roles in plant and animal fungal disease development, enzyme and drug discovery by genome mining. His work spans the field of genomics and genetics, synthetic biology, chemical biology and natural product chemistry. In 2016, Dr Chooi was awarded the prestigious ARC Future Fellowship to continue his research in this exciting interdisciplinary field.

Funding overview

ARC Discovery Project (2020-2023) - Fungal Ribosomally Synthesised and Post-translationally Modified Peptides, Chooi, Y-H, Solomon, PS

Cooperative Research Centre Projects CRC-P (2018-2021) - BioAustralis: Towards the Future, Lacey, E; Page, S; Piggott, AP; Chooi, Y-H

ARC Discovery Project (2017-2019) - Two new phytotoxins in Septoria nodorum blotch: Biosynthesis and functions, Chooi, Y-H, Solomon, PS

ARC Future Fellowship (2016-2019) - Uncovering the Hidden Secondary Metabolite Biosynthetic Potential of Fungi, Chooi, Y-H

ARC Discovery Early Career Researcher Award (DECRA) (2013-2015) - A Synthetic Biology Approach for Mining the Secondary Metabolomes of Fungal Phytopathogens, Chooi, Y-H

Current projects

PhD & Honours Research Opportunities:

1. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/metabolites

2. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/synthetic

3. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/genome-mining


- Secondary metabolite biosynthesis

- Genome mining of bioactive natural products

- Fungal pathogen-host interactions

- Synthetic biology of antibiotic production

- Biocalytic enzyme discovery

Research expertise keywords

  • Secondary metabolite biosynthesis
  • Synthetic biology
  • Enzyme mechanism
  • Natural product chemistry
  • Fungal pathogen-host interactions
  • Microbial genetics

Industry keywords

  • Biotechnology
  • Drug Discovery
  • Agriculture and Food

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Research Output

  • 2115 Citations
  • 25 h-Index
  • 58 Article
  • 3 Review article
  • 1 Short survey
  • 2 Citations (Scopus)

    Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.

    Gilchrist, C. L. M., Lacey, H. J., Vuong, D., Pitt, J. I., Lange, L., Lacey, E., Pilgaard, B., Chooi, Y. H. & Piggott, A. M., Oct 2020, In : Fungal Genetics and Biology. 143, 103435.

    Research output: Contribution to journalArticle

  • Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin

    Lacey, H. J., Booth, T. J., Vuong, D., Rutledge, P. J., Lacey, E., Chooi, Y-H. & Piggott, A. M., 17 Jun 2020, In : Journal of Antibiotics. 10 p.

    Research output: Contribution to journalArticle

    CRISPR-Mediated Activation of Biosynthetic Gene Clusters for Bioactive Molecule Discovery in Filamentous Fungi

    Roux, I., Woodcraft, C., Hu, J., Gilchrist, C. L. M. & Chooi, Y-H., 17 Jul 2020, In : ACS Synthetic Biology. 9, 7, p. 1843-1854

    Research output: Contribution to journalArticle

  • Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum

    Li, H., Wei, H., Hu, J., Lacey, E., Sobolev, A. N., Stubbs, K. A., Solomon, P. S. & Chooi, Y. H., 17 Jan 2020, In : ACS Chemical Biology. 15, 1, p. 226-233

    Research output: Contribution to journalArticle

  • Projects