• The University of Western Australia (M310), 35 Stirling Highway, Room 2.58, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 1388 Citations
  • 21 h-Index
20102021
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Personal profile

Biography

Dr Chooi (PhD, Applied Biology and Biotechnology) worked as a postdoctoral researcher at University of California, Los Angeles, USA with Professor Yi Tang (2009-2013), focusing on the molecular genetic and biochemical basis of secondary metabolite biosynthesis in fungi. He moved to the Research School of Biology at the Australian National University in 2013 after winning a prestigious ARC Discovery Early Career Researcher Award (DECRA). In 2015, he joined the faculty at The University of Western Australia and took up a lectureship in the School of Chemistry & Biochemistry. His current research is focusing on secondary metabolite biosynthesis of fungi and understanding its roles in plant and animal fungal disease development. His work spans the field of genomics, genetics, molecular biology, synthetic biology, biochemistry and natural product chemistry. More recently in 2016, Dr Chooi was awarded the prestigious ARC Future Fellowship to continue his research in this exciting interdisciplinary field.

Funding overview

ARC Discovery Project (2017-2019) - Two new phytotoxins in Septoria nodorum blotch: Biosynthesis and functions

ARC Future Fellowship (2016-2019) - Uncovering the Hidden Secondary Metabolite Biosynthetic Potential of Fungi

ARC Discovery Early Career Researcher Award (DECRA) (2013-2015) - A Synthetic Biology Approach for Mining the Secondary Metabolomes of Fungal Phytopathogens

Current projects

PhD & Honours Research Opportunities:

1. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/metabolites

2. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/synthetic

3. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/genome-mining

Research

- Secondary metabolite biosynthesis
- Fungal pathogen host-interactions
- Synthetic biology

Keywords

  • Secondary metabolite biosynthesis
  • Fungal molecular genetics
  • Synthetic biology
  • Natural product isolation
  • Fungal pathogen-host interactions

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Multigene Family Medicine & Life Sciences
Genes Chemical Compounds
Biosynthesis Chemical Compounds
Polyketide Synthases Medicine & Life Sciences
Polyketides Chemical Compounds
Aspergillus Chemical Compounds
Genome Medicine & Life Sciences
Fungi Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2015 2021

Research Output 2010 2018

  • 1388 Citations
  • 21 h-Index
  • 41 Article
  • 1 Review article

Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum

Li, H., Hu, J., Wei, H., Solomon, P. S., Vuong, D., Lacey, E., Stubbs, K. A., Piggott, A. M. & Chooi, Y. H., 5 Oct 2018, In : Organic Letters. 20, 19, p. 6148-6152 5 p.

Research output: Contribution to journalArticle

Pyrones
Polyketide Synthases
Polyketides
Oxygenases
wheat
1 Citations

Panning for gold in mould: Can we increase the odds for fungal genome mining?

Gilchrist, C. L. M., Li, H. & Chooi, Y. H., 1 Jan 2018, In : Organic and Biomolecular Chemistry. 16, 10, p. 1620-1626 7 p.

Research output: Contribution to journalArticle

Fungal Genome
genome
Multigene Family
Gold
genes
Triticum
Transcription Factors
Gene Expression
Deoxyribonuclease I
DNA Sequence Analysis
8 Citations

Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils

Pitt, J. I., Lange, L., Lacey, A. E., Vuong, D., Midgley, D. J., Greenfield, P., Bradbury, M. I., Lacey, E., Busk, P. K., Pilgaard, B., Chooi, Y. H. & Piggott, A. M., 5 Apr 2017, In : PLoS One. 12, 4, 21 p., e0170254.

Research output: Contribution to journalArticle

Open Access
Aspergillus
Metabolites
Fungi
secondary metabolites
Soil
2 Citations

Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps

Zheng, X., Cheng, Q., Yao, F., Wang, X., Kong, L., Cao, B., Xu, M., Lin, S., Deng, Z., Chooi, Y. H. & You, D., 18 Apr 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4135-4140 6 p.

Research output: Contribution to journalArticle

Anisomycin
Protein Synthesis Inhibitors
Alkaloids
Genes
Multigene Family