• The University of Western Australia (M310), 35 Stirling Highway, Room 2.58, Bayliss Building, Perth campus

    6009 Perth


  • 2035 Citations
  • 24 h-Index

Research output per year

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Personal profile


Dr Chooi (PhD, Applied Biology and Biotechnology) worked at University of California, Los Angeles (2009-2013) focusing on the molecular genetic and biochemical basis of secondary metabolite biosynthesis in fungi. He moved to the Research School of Biology at the Australian National University in 2013 after winning a prestigious ARC Discovery Early Career Researcher Award (DECRA). In 2015, he joined the faculty at The University of Western Australia and took up a lectureship in the School of Chemistry & Biochemistry. His current research is focusing on secondary metabolite biosynthesis of fungi and understanding its roles in plant and animal fungal disease development. His work spans the field of genomics, genetics, molecular biology, synthetic biology, biochemistry and natural product chemistry. More recently in 2016, Dr Chooi was awarded the prestigious ARC Future Fellowship to continue his research in this exciting interdisciplinary field.

Funding overview

ARC Discovery Project (2020-2023) - Fungal Ribosomally Synthesised and Post-translationally Modified Peptides, Chooi, Y-H, Solomon, PS

Cooperative Research Centre Projects CRC-P (2018-2021) - BioAustralis: Towards the Future, Lacey, E; Page, S; Piggott, AP; Chooi, Y-H

ARC Discovery Project (2017-2019) - Two new phytotoxins in Septoria nodorum blotch: Biosynthesis and functions, Chooi, Y-H, Solomon, PS

ARC Future Fellowship (2016-2019) - Uncovering the Hidden Secondary Metabolite Biosynthetic Potential of Fungi, Chooi, Y-H

ARC Discovery Early Career Researcher Award (DECRA) (2013-2015) - A Synthetic Biology Approach for Mining the Secondary Metabolomes of Fungal Phytopathogens, Chooi, Y-H

Current projects

PhD & Honours Research Opportunities:

1. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/metabolites

2. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/synthetic

3. http://www.science.uwa.edu.au/future-students/postgrad/opportunities/chemistry/genome-mining


- Secondary metabolite biosynthesis
- Fungal pathogen host-interactions
- Synthetic biology

Research expertise keywords

  • Secondary metabolite biosynthesis
  • Fungal molecular genetics
  • Synthetic biology
  • Natural product isolation
  • Fungal pathogen-host interactions

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Research Output

  • 2035 Citations
  • 24 h-Index
  • 54 Article
  • 3 Review article
  • 1 Short survey

Biosynthesis of a New Benzazepine Alkaloid Nanangelenin A from Aspergillus nanangensis Involves an Unusual l-Kynurenine-Incorporating NRPS Catalyzing Regioselective Lactamization

Li, H., Gilchrist, C. L. M., Phan, C-S., Lacey, H. J., Vuong, D., Moggach, S. A., Lacey, E., Piggott, A. M. & Chooi, Y-H., 15 Apr 2020, In : Journal of the American Chemical Society. 142, 15, p. 7145-7152

Research output: Contribution to journalArticle

  • Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum

    Li, H., Wei, H., Hu, J., Lacey, E., Sobolev, A. N., Stubbs, K. A., Solomon, P. S. & Chooi, Y. H., 17 Jan 2020, In : ACS Chemical Biology. 15, 1, p. 226-233

    Research output: Contribution to journalArticle

  • Volatile Molecules Secreted by the Wheat Pathogen Parastagonospora nodorum Are Involved in Development and Phytotoxicity

    Muria-Gonzalez, M. J., Yeng, Y., Breen, S., Mead, O., Wang, C., Chooi, Y. H., Barrow, R. A. & Solomon, P. S., 25 Mar 2020, In : Frontiers in Microbiology. 11, 466.

    Research output: Contribution to journalArticle

    Open Access
  • Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat

    Thynne, E., Mead, O. L., Chooi, Y. H., McDonald, M. C. & Solomon, P. S., 1 Mar 2019, In : Genome Biology and Evolution. 11, 3, p. 890-905 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)

    Biosynthesis of a Tricyclo[,7]dodecane System by a Berberine Bridge Enzyme-Like Aldolase

    Li, H., Hu, J., Wei, H., Solomon, P. S., Stubbs, K. A. & Chooi, Y. H., 25 Sep 2019, In : Chemistry - A European Journal.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)