Helena Viola

Dr, BSc PhD W.Aust.

  • The University of Western Australia (M311), 35 Stirling Highway,

    6009 Perth

    Australia

  • 808 Citations
  • 16 h-Index
20052021
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

I am a cardiovascular physiologist with an 14 year track record in translatable cardiovascular research, for which I have won 28 prizes and awards. I received my PhD (with Distinction) from UWA in 2010, for which I was awarded the 2010 UWA Robert Street Prize for most outstanding PhD thesis (University-wide). I have held competitive CI funding since commencing my PhD in 2007, including a National Heart Foundation (NHF) & National Health and Medical Research Council (NHMRC) Postgraduate scholarship, NHF Postdoctoral Fellowship, NHF Future Leader Fellowship, and NHMRC (New Investigator) Grant.

Cardiovascular disease is the leading cause of death in the Western World. It is also the most costly, consuming $7.6 billion of Australian healthcare expenditure. I am internationally recognized as the very first to identify that the L-type calcium channel regulates mitochondrial function in the heart, and that this regulation is impaired in models of human heart disease. This has revolutionized the understanding of how mitochondrial function is regulated in the heart. I am also the first to test novel therapies that target the L-type calcium channel to repair this functional association in order to prevent heart disease.

Funding overview

2018-2021 NHF Future Leader Fellowship, PI Viola

2018-2020 NHMRC Project Grant (APP1143203), PI Viola

2018-2021 NHMRC Project Grant (APP1143321), CID Viola

2017-2018 Raine Priming Grant, PI Viola.

2015 UWA Early Career Fellowship Support Grant, PI Viola.

2012-2015 NHF Postdoctoral Fellowship, PI Viola.

2011 NHMRC Equipment Grant, Viola (Co-investigator).

2007-2010 NHMRC and NHF Postgraduate Biomedical Scholarship, PI Viola.

Previous positions

2015-2017, Research Associate
Cardiovascular Electrophysiology Laboratory
School of Human Sciences, The University of Western Australia.

2012-2015, NHF Postdoctoral Research Fellow
Cardiovascular Electrophysiology Laboratory
School of Anatomy, Physiology and Human Biology, The University of Western Australia.

2010-2012, Research Associate
Cardiovascular Electrophysiology Laboratory
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia

2007-2010, NHMRC/NHF Scholarship Recipient, PhD candidate
Cardiovascular Electrophysiology Laboratory
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia

2004-2007, Graduate Research Assistant
Cardiovascular Electrophysiology Laboratory
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia

Research

Regulation of the cardiac L-type Ca2+ channel under pathological conditions such as oxidative stress.
Regulation of mitochondrial function by the L-type Ca2+ channel (and mediation by the cytoskeleton).
Targeting the alpha-interacting domain of the L-type Ca2+ channel in reduction of ischemia reperfusion injury and familial cardiomyopathy.
Use of nanoparticle technology to improve efficacy of therapy.
Improving morpholino oligomer therapy in treatment of Duchenne Muscular Dystrophy cardiomyopathy.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 11 Similar Profiles
Calcium Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Cardiomyopathies Medicine & Life Sciences
L-Type Calcium Channels Medicine & Life Sciences
Muscle Cells Medicine & Life Sciences
Duchenne Muscular Dystrophy Medicine & Life Sciences
Superoxides Medicine & Life Sciences
Hypertrophic Cardiomyopathy Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2005 2019

Open Access
Hypertrophic Cardiomyopathy
Cardiac Myosins
Calcium
Drug therapy
Mutation

Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions

Olivé, M., Engvall, M., Ravenscroft, G., Cabrera-Serrano, M., Jiao, H., Bortolotti, C. A., Pignataro, M., Lambrughi, M., Jiang, H., Forrest, A. R. R., Benseny-Cases, N., Hofbauer, S., Obinger, C., Battistuzzi, G., Bellei, M., Borsari, M., Di Rocco, G., Viola, H. M., Hool, L. C., Cladera, J. & 24 othersLagerstedt-Robinson, K., Xiang, F., Wredenberg, A., Miralles, F., Baiges, J. J., Malfatti, E., Romero, N. B., Streichenberger, N., Vial, C., Claeys, K. G., Straathof, C. S. M., Goris, A., Freyer, C., Lammens, M., Bassez, G., Kere, J., Clemente, P., Sejersen, T., Udd, B., Vidal, N., Ferrer, I., Edström, L., Wedell, A. & Laing, N. G., 1 Dec 2019, In : Nature Communications. 10, 1, 1396.

Research output: Contribution to journalArticle

Open Access
myoglobin
Myoglobin
Muscular Diseases
inclusions
muscles
1 Citation (Scopus)

A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy

Viola, H. M., Johnstone, V. P. A., Adams, A. M., Fletcher, S. & Hool, L. C., 1 Jun 2018, In : JACC: Basic to Translational Science. 3, 3, p. 391-402 12 p.

Research output: Contribution to journalArticle

Open Access
Morpholinos
Duchenne Muscular Dystrophy
Cardiomyopathies
Walking
Clinical Trials
4 Citations (Scopus)

A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery

Hoffmann, K., Milech, N., Juraja, S. M., Cunningham, P. T., Stone, S. R., Francis, R. W., Anastasas, M., Hall, C. M., Heinrich, T., Bogdawa, H. M., Winslow, S., Scobie, M. N., Dewhurst, R. E., Florez, L., Ong, F., Kerfoot, M., Champain, D., Adams, A. M., Fletcher, S., Viola, H. M. & 10 othersHool, L. C., Connor, T., Longville, B. A. C., Tan, Y. F., Kroeger, K., Morath, V., Weiss, G. A., Skerra, A., Hopkins, R. M. & Watt, P. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 12538.

Research output: Contribution to journalArticle

Open Access
Cell-Penetrating Peptides
Cytoplasm
Peptide Nucleic Acids
Cell Engineering
Bacterial Genomes
4 Citations (Scopus)

Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z

Siira, S. J., Rossetti, G., Richman, T. R., Perks, K., Ermer, J. A., Kuznetsova, I., Hughes, L., Shearwood, A. M. J., Viola, H. M., Hool, L. C., Rackham, O. & Filipovska, A., 1 Oct 2018, In : EMBO Reports. 19, 10, e46198.

Research output: Contribution to journalArticle

Nuclear RNA
Untranslated RNA
Transfer RNA
MicroRNAs
Small Nucleolar RNA

Projects 2011 2021