Personal profile
Biography
I am an ARC Australian Laureate Fellow and the Director of the UWA Centre for Plant Energy Biology
I am a Chief Investigator in the ARC Centre of Excellence in Plants for Space
I am a fellow of the Australian Academy of Science.
I did my BSc (Hons) and PhD (1997) in plant biochemistry and molecular biology at the Australian National University in Canberra. I have held fellowships at The University of Oxford (HFSPO) and at UWA (ARC APD 2000-2002, ARC QEII 2002-2007, ARC APF 2008-2011, ARC Future Fellow 2012-2015, ARC Laureate Fellow 2021-).
I serve on the Editorial Board of The Plant Cell
Current projects
- Targeted Proteomics in Arabidopsis, Wheat and Barley
- Protein Profiles of cereal grains in response to development and the environment.
- Nitrogen use efficiency in plants with a focus on plant metabolism
- Measurement of protein turnover and protein aging in plants
- Protein complex assembly in plants
- Oxidative stress and mitochondrial function in plants
- Biogenesis of mitochondria during plant development
Research interests
Online Resources
I conduct research on the energy efficiency of plants in harsh environments in the Centre for Plant Energy Biology
I conduct research on protein production and biomass production systems in plants for controlled environments in the ARC Centre of Excellence in Plants for Space.
My team has developed online databases for:
The content and expression of proteins in wheat (wheat proteome)
The subcellular location of proteins in Arabidopsis (SUBA)
The subcellular location of proteins in plant crop species (CropPAL)
Funding overview
My research is funded by the Australian Research Council through the Discovery, Linkage and Centre's Programmes, by the UK Space Agency and Australian Space Agency, and by Industry funding from the Grains Reserarch and Development Corporation (GRDC) in collaborations with the wheat breeding companies Intergrain and Australian Grain Technologies.
Research
Mitochondrial function in plants
Our research focuses on mitochondrial function in plants and the role of metabolism is the energy efficiency of plants. My team's work has provided key new insights into antioxidant defence pathways in mitochondrial, diurnal rhythms in mitochondrial metabolism, tissue-specific mitochondrial functions, plant-specific features of the electron transport chain, regulatory networks governing respiratory activity in plants, and the mechanisms of mitochondria damage during oxidative stress.
Plant Protein Analysis
My group is working on advances in plant proteome analysis to allow:
1. measurements of protein turnover rates
2. targeted quantitation of enzymes in metabolic pathways in both model plants and crops.
3. rapid profiling of plant protein profiles to assess breeding scale and ecological scale sample size experiments to provide protein driven insight and decision making.
In international collaborations using novel dataset and software developments, we have been involved in building plant proteome databases, protein location prediction and protein-protein interaction prediction in plants.
Techniques and Expertise
- Recombinant Protein Production in Plants
-Organelle isolation from plants
- Protein subcellular location in plants
- Proteome analysis by peptide mass spectrometry
- Stable isotope labelling of plant components
- Protein purification: gel filtration, ion exchange, electrophoresis
- Enzymology of proteins and antioxidant defence systems
- Respiration measurements: whole tissues, organelles, in liquid and gas phase
- Metabolomics by GC-MS
- Bioenergetics of electron transport chains
Teaching overview
Undergraduate Teaching:
BIOC3003 Omics—Global Approaches to Cell Function
Research expertise keywords
- Biochemistry plant mitochondria
- Oxidative stress and antioxidant defence
- Protein mass spectrometry
- Respiration
- Metabolism
- Electron transport chain
- Oxygen consumption
- Plant proteomics
- Proteome analysis
- Protein turnover
- Energy use efficiency
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 7 Affordable and Clean Energy
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Continuous Directed Evolution of a Short-Lived Plant Histidinol Dehydrogenase
Oliveira-Filho, E. R., Gayen, A. K., Leong, B. J., Belt, K., Voiniciuc, C., Millar, A. H. & Hanson, A. D., 20 Mar 2026, In: ACS Synthetic Biology. 15, 3, p. 985-992 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Metabolic Responses to Salinity Identify a Role for Mitochondrial 2-Oxoglutarate Dehydrogenase in Wheat Tissue Tolerance
Wijeweera, S., Sharma, D., Millar, H. & Duncan, O., Mar 2026, In: Plant, Cell and Environment.. 49, 3, p. 1684-1698 15 p.Research output: Contribution to journal › Article › peer-review
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Turbocharging fundamental science translation through controlled environment agriculture
Gill, A. R., Miller, T., Wijeweera, S., Herrero, E., Massa, G. D., Mortimer, J. C., Webb, A. A. R., Millar, H. & Gilliham, M., 2026, (Accepted/In press) In: Trends in Plant Science.Research output: Contribution to journal › Review article › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
Understanding and overcoming protein production bottlenecks in plants
Coates, R. J., Miller, T. K. & Millar, A. H., 2026, (Accepted/In press) In: Trends in Plant Science.Research output: Contribution to journal › Review article › peer-review
Open Access -
Accounting for the impact of genotype and environment on variation in leaf respiration of wheat in Mexico and Australia
Gaju, O., Bloomfield, K. J., Negrini, A. C. A., Bowerman, A. F., Cullerne, D., Posch, B. C., Bryant, C., Fan, Y., Spence, M., Stone, B., Gilliham, M., Furbank, R. T., Molero, G., Pogson, B. J., Mathews, K., Millar, A. H., Pearson, A. L., Reynolds, M. P., Stroeher, E. & Taylor, N. L. & 2 others, , 25 Feb 2025, In: Journal of Experimental Botany. 76, 4, p. 1099-1115 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Citations (Web of Science)
Datasets
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The compendium of crop Proteins with Annotated Locations (cropPAL) version 2020
Hooper, C. (Creator), Castleden, I. (Data Manager), Aryamanesh, N. (Data Collector), Black, K. (Contributor), Grasso, S. (Data Collector) & Millar, H. (Creator), The University of Western Australia, Jan 2020
Dataset
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The compendium of crop Proteins with Annotated Locations (cropPAL) version 2
Hooper, C. (Creator), Millar, A. (Creator), Castleden, I. (Creator), Aryamanesh, N. (Contributor), Jacoby, R. (Data Collector) & Grasso, S. (Data Collector), The University of Western Australia, 1 Jun 2017
Dataset
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Subcellular Localisation database for Arabidopsis proteins version 5
Hooper, C. (Creator), Millar, H. (Funder), Black, K. (Contributor), Castleden, I. (Creator), Aryamanesh, N. (Contributor) & Grasso, S. (Contributor), The University of Western Australia, 31 Aug 2022
DOI: 10.26182/8dht-4017, https://suba.live/
Dataset
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The compendium of crop Proteins with Annotated Locations (cropPAL) version 1
Hooper, C. (Creator), Castleden, I. (Creator), Aryamanesh, N. (Creator), Jacoby, R. (Creator) & Millar, A. (Creator), The University of Western Australia, 2 Jun 2015
DOI: 10.4225/23/556e4e260e093, http://crop-pal.org/ and one more link, http://www.crop-pal.org/results.html (show fewer)
Dataset
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Data from: Protein degradation rate in Arabidopsis thaliana leaf growth and development
Li, L. (Creator), Nelson, C. J. (Creator), Trosch, J. (Creator), Castleden, I. R. (Creator), Huang, S. (Creator) & Millar, A. H. (Creator), DRYAD, 31 Jan 2017
DOI: 10.5061/dryad.q3h85, https://datadryad.org/resource/doi:10.5061/dryad.q3h85
Dataset
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Improving canola nitrogen use efficiency
Shabala, S. (Investigator 01), Batley, J. (Investigator 02), Cowling, W. (Investigator 03), Bolan, N. (Investigator 04), Siddique, K. (Investigator 05), Millar, H. (Investigator 06), Rengel, Z. (Investigator 07) & Chen, S. (Investigator 08)
Grains Research & Development Corporation
1/04/25 → 15/12/28
Project: Research
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FHRI Funding for Proteomics NCRIS 2024-2027
Millar, H. (Investigator 01)
Department of Health (Western Australia)
1/07/24 → 30/06/27
Project: Research
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State Government (JTSI) funding for BPA (Proteomics and Genomics WA) NCRIS 2024-2027
Taylor, N. (Investigator 01) & Millar, H. (Investigator 02)
Department of Jobs Tourism Science and Innovation (Western Australia)
1/07/24 → 30/06/27
Project: Research
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WA State Government co investment to APPN 2024-2027
Taylor, N. (Investigator 01) & Millar, H. (Investigator 02)
Department of Jobs Tourism Science and Innovation (Western Australia)
1/07/24 → 30/06/28
Project: Research
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ARC Training Centre in Predictive Breeding for Agricultural Futures
Edwards, D. (Investigator 01), Considine, M. (Investigator 02), Taylor, N. (Investigator 03), Millar, H. (Investigator 04) & Batley, J. (Investigator 05)
ARC Australian Research Council
1/04/24 → 31/03/29
Project: Research
Prizes
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Fellow of the Australian Academy of Science
Millar, H. (Recipient), 2020
Prize: Prize/award › Fellow of the Australian Academy of Science
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