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Hannah Crabb

Dr

  • The University of Western Australia (M309), 35 Stirling Highway,

    6009 Perth

    Australia

  • 930 Citations
  • 16 h-Index
20062019
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Research Output 2006 2019

  • 930 Citations
  • 16 h-Index
  • 19 Article
  • 1 Doctoral Thesis
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Article
2019

CD8+ cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy

Jackaman, C., Gardner, J. K., Tomay, F., Spowart, J., Crabb, H., Dye, D. E., Fox, S., Proksch, S., Metharom, P., Dhaliwal, S. S. & Nelson, D. J., 17 Jan 2019, In : OncoImmunology. 17 p.

Research output: Contribution to journal › Article

Open Access
Neoplasm Antigens
T-Lymphocytes
Drug Therapy
Epitopes
Neoplasms
2018
5 Citations (Scopus)

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T- and B-cell zones

Tomay, F., Wells, K., Duong, L., Tsu, J. W., Dye, D. E., Radley-Crabb, H., Grounds, M. D., Shavlakadze, T., Metharom, P., Nelson, D. J. & Jackaman, C., 30 Mar 2018, In : Immunology and Cell Biology.

Research output: Contribution to journal › Article

Lymphoid Tissue
Neutrophils
B-Lymphocytes
Lymph Nodes
Spleen
2016
19 Citations (Scopus)

Effects of loaded voluntary wheel exercise on performance and muscle hypertrophy in young and old male C57Bl/6J mice

Soffe, Z., Radley-Crabb, H., Mcmahon, C., Grounds, M. & Shavlakadze, T., Feb 2016, In : Scandinavian Journal of Medicine and Science in Sports. 26, 2, p. 172-188

Research output: Contribution to journal › Article

Hypertrophy
Muscles
Quadriceps Muscle
Skeletal Muscle
Extremities
2014
29 Citations (Scopus)

Dystropathology increases energy expenditure and protein turnover in the Mdx mouse model of Duchenne muscular dystrophy

Radley-Crabb, H., Marini, J. C., Sosa, H. A., Castillo, L. I., Grounds, M. & Fiorotto, M. L., 2014, In : PLoS One. 9, 2, p. 13pp

Research output: Contribution to journal › Article

Open Access
Inbred mdx Mouse
muscular dystrophy
Duchenne Muscular Dystrophy
protein metabolism
energy expenditure
16 Citations (Scopus)

Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice

Mcmahon, CD., Chai, R., Crabb, H., Watson, T., Matthews, KG., Sheard, P., Soffe, Z., Grounds, M. & Shavlakadze, T., Dec 2014, In : Scandinavian Journal of Medicine and Science in Sports. 24, 6, p. e423-e435

Research output: Contribution to journal › Article

Somatomedins
Muscles
Skeletal Muscle
Sarcopenia
Quadriceps Muscle
25 Citations (Scopus)

Lipid accumulation in dysferlin-deficient muscles

Grounds, M., Terrill, J., Radley-Crabb, H., Robertson, T., Papadimitriou, J., Spuler, S. & Shavlakadze, T., 2014, In : American Journal of Pathology. 184, 6, p. 1668-1676

Research output: Contribution to journal › Article

Muscular Diseases
Adipocytes
Psoas Muscles
Lipogenesis
Lipids
28 Citations (Scopus)

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice

Barns, M., Gondro, C., Tellam, R. L., Radley-Crabb, H., Grounds, M. & Shavlakadze, T., Aug 2014, In : International Journal of Biochemistry and Cell Biology. 53, p. 174-185

Research output: Contribution to journal › Article

Sarcopenia
Denervation
Muscle
Skeletal Muscle
Ribosomal Protein S6
2013
79 Citations (Scopus)

Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies

Terrill, J., Crabb, H., Iwasaki, T., Lemckert, F. A., Arthur, P. & Grounds, M., Sep 2013, In : The FEBS Journal. 280, 17, p. 4149-4164

Research output: Contribution to journal › Article

Open Access
Oxidative stress
Muscular Dystrophies
Pathology
Sulfhydryl Compounds
Oxidative Stress
2012
40 Citations (Scopus)

A single 30 min treadmill exercise session is suitable for 'proof-of concept studies' in adult mdx mice: A comparison of the early consequences of two different treadmill protocols

Radley-Crabb, H. G., Terrill, J., Shavlakadze, T., Tonkin, J. N., Arthur, P. & Grounds, M., 2012, In : Neuromuscular Disorders. 22, p. 170-182

Research output: Contribution to journal › Article

35 Citations (Scopus)

N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis

Terrill, J., Radley, H., Grounds, M. & Arthur, P., 2012, In : Neuromuscular Disorders. 22, p. 427-434

Research output: Contribution to journal › Article

2011
24 Citations (Scopus)

Blockade of TNF in vivo using cV1q antibody reduces contractile dysfunction of skeletal muscle in response to eccentric exercise in dystrophic mdx and normal mice

Piers, A., Lavin, T., Radley, H. G., Bakker, A. J., Grounds, M. & Pinniger, G. J., 2011, In : Neuromuscular Disorders. 21, p. 132-141

Research output: Contribution to journal › Article

18 Citations (Scopus)

Identification of muscle necrosis in the mdx mouse model of Duchenne muscular dystrophy using three-dimensional optical coherence tomography

Klyen, B., Shavlakadze, T., Radley-Crabb, H., Grounds, M. & Sampson, D., 2011, In : Journal of Biomedical Optics. 16, 7, p. 9 pages

Research output: Contribution to journal › Article

2008
55 Citations (Scopus)

Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle

Grounds, M., Radley, H. G., Gebski, B. L., Bogoyevitch, M. A. & Shavlakadze, T., 2008, In : Clinical and Experimental Pharmacology & Physiology. 35, 7, p. 846-851

Research output: Contribution to journal › Article

Somatomedins
Skeletal Muscle
Tumor Necrosis Factor-alpha
Necrosis
Inbred mdx Mouse
63 Citations (Scopus)

Reduced muscle necrosis and long-term benefits in dystrophic mdx mice after cVIq (blockade of TNF) treatment

Radley, H. G., Davies, M. & Grounds, M., 2008, In : Neuromuscular Disorders. 18, 3, p. 227-238

Research output: Contribution to journal › Article

Inbred mdx Mouse
Necrosis
Tumor Necrosis Factor-alpha
Muscles
Therapeutics
12 Citations (Scopus)

Three-dimensional optical coherence tomography of whole-muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice

Klyen, B., Armstrong, J., Adie, S. G., Radley, H. G., Grounds, M. & Sampson, D., 2008, In : Journal of Biomedical Optics. 13, 1, p. online - approx 5-20pp

Research output: Contribution to journal › Article

Optical tomography
Autografts
pathology
muscles
mice
195 Citations (Scopus)

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

Grounds, M., Radley, H. G., Lynch, G. S., Nagaraju, K. & De Luca, A., 2008, In : Neurobiology of Disease. 31, 1, p. 1-19

Research output: Contribution to journal › Article

Inbred mdx Mouse
Duchenne Muscular Dystrophy
Therapeutics
Pathology
Muscles
2007
69 Citations (Scopus)

Duchenne muscular dystrophy: Focus on pharmaceutical and nutricional interventions

Radley, H. G., De Luca, A., Lynch, G. S. & Grounds, M., 2007, In : The International Journal of Biochemistry & Cell Biology. 39, 3, p. 469-477

Research output: Contribution to journal › Article

2006
72 Citations (Scopus)

Cromolyn administration (to block mast cell degranulation) reduces necrosis of dystrophic muscle in mdx mice

Radley, H. & Grounds, M., 2006, In : Neurobiology of Disease. 23, 2, p. 387-397

Research output: Contribution to journal › Article

Inbred mdx Mouse
Cell Degranulation
Cromolyn Sodium
Mast Cells
Necrosis
146 Citations (Scopus)

Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNFα function with Etanercept in mdx mice

Hodgetts, S., Radley, H., Davies, M. & Grounds, M., 2006, In : Neuromuscular Disorders. 16, 9-10, p. 591-602

Research output: Contribution to journal › Article

Inbred mdx Mouse
Dystrophin
Neutrophils
Necrosis
Muscles