• The University of Western Australia (M519), 35 Stirling Highway,

    6009 Perth

    Australia

  • 6138 Citations
  • 36 h-Index
20012022
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Research Output 2001 2019

2019
1 Citation (Scopus)

Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human

Yuan, J., Tickner, J., Mullin, B. H., Zhao, J., Zeng, Z., Morahan, G. & Xu, J., 2 Apr 2019, In : Frontiers in Genetics. 10, 13 p., 288.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Common heritable immunological variations revealed in genetically diverse inbred mouse strains of the collaborative cross

Collin, R., Balmer, L., Morahan, G. & Lesage, S., 1 Feb 2019, In : Journal of Immunology. 202, 3, p. 777-786 10 p.

Research output: Contribution to journalArticle

Inbred Strains Mice
Forensic Anthropology
Genetic Loci
Immunologic Factors
Immune System

DECAY IN LINKAGE DISEQUILIBRIUM OF HLA HAPLOTYPE-DEFINING SNPS IN IRANIAN TYPE 1 DIABETES SUBJECTS

Solgi, G., Rezaei, H., Samadi, M., Jamehbozorg, S., Taheri, M., Hajilooi, M., Kiani, J. & Morahan, G., May 2019, In : Hla. 93, 5, p. 323-324 2 p.

Research output: Contribution to journalAbstract/Meeting Abstract

1 Citation (Scopus)

Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study

ENDIA Study Grp, Feb 2019, In : Open Forum Infectious Diseases. 6, 2, 8 p., 025.

Research output: Contribution to journalArticle

Open Access

Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease

Balmer, L. A., Whiting, R., Rudnicka, C., Gallo, L. A., Jandeleit, K. A., Chow, Y., Chow, Z., Richardson, K. L., Forbes, J. M. & Morahan, G., 1 Oct 2019, In : Kidney International. 96, 4, p. 918-926 9 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Kidney
Hypertrophy
Quantitative Trait Loci
Genes

The impact of angiogenesis inhibitors on survival of patients with small cell lung cancer

Shi, X., Dong, X., Young, S., Chen, A. M., Liu, X., Zheng, Z., Huang, K., Lu, D., Feng, S., Morahan, G. & Cai, K., 21 Aug 2019, In : Cancer Medicine.

Research output: Contribution to journalArticle

Open Access
Angiogenesis Inhibitors
Small Cell Lung Carcinoma
Thalidomide
Survival
Disease-Free Survival
2018
7 Citations (Scopus)
Electric charge
Hydrogel
Biocompatible Materials
Tissue Engineering
Bile Acids and Salts
15 Citations (Scopus)

Genome wide mapping identifies regulation of MAPKinase pathway as key genetic determinant of allergic contact dermatitis

Roy, E., Legrand, J., Baz, B., Wong, H., Morahan, G., Walker, G. & Khosrotehrani, K., May 2018, In : Journal of Investigative Dermatology. 138, 5, p. S167-S167 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

5 Citations (Scopus)

Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis

ENDIA Study Group, 1 Dec 2018, In : Scientific Reports. 8, 1, 4386.

Research output: Contribution to journalArticle

Open Access
rRNA Genes
Individuality
Polymerase Chain Reaction
Computational Biology
DNA Sequence Analysis
4 Citations (Scopus)

Profiling and genetic control of the murine immunoglobulin G glycome

Krištić, J., Zaytseva, O. O., Ram, R., Nguyen, Q., Novokmet, M., Vučković, F., Vilaj, M., Trbojević-Akmačić, I., Pezer, M., Davern, K. M., Morahan, G. & Lauc, G., 1 May 2018, In : Nature Chemical Biology. 14, 5, p. 516-524 9 p.

Research output: Contribution to journalArticle

Glycosylation
Immunoglobulin G
Genetic Crosses
Genetic Loci
Acetylglucosamine
4 Citations (Scopus)
Insulin-Secreting Cells
Biocompatible Materials
Capsules
Polymers
Molecular Weight
2 Citations (Scopus)

Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress

Neelankal John, A., Iqbal, Z., Colley, S., Morahan, G., Makishima, M. & Jiang, F. X., 1 Jun 2018, In : Diabetes and Metabolism. 44, 3, p. 269-280 12 p.

Research output: Contribution to journalArticle

Cell Dedifferentiation
Calcitriol Receptors
Cholecalciferol
Lithocholic Acid
Propionates
2017
2 Citations (Scopus)

A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia

Ram, R., Wakil, S. M., Muiya, N. P., Andres, E., Mazhar, N., Hagos, S., Alshahid, M., Meyer, B. F., Morahan, G. & Dzimiri, N., 1 Mar 2017, In : Clinical Genetics. 91, 3, p. 371-378 8 p.

Research output: Contribution to journalArticle

Hypertriglyceridemia
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Apolipoprotein A-I
Human Genome
45 Citations (Scopus)

A comprehensive draft genome sequence for lupin (Lupinus angustifolius), an emerging health food: insights into plant–microbe interactions and legume evolution

Hane, J. K., Ming, Y., Kamphuis, L. G., Nelson, M. N., Garg, G., Atkins, C. A., Bayer, P. E., Bravo, A., Bringans, S. D., Cannon, S., Edwards, D., Foley, R., Gao, L. L., Harrison, M. J., Huang, W., Hurgobin, B., Li, S., Liu, C. W., McGrath, A., Morahan, G. & 4 othersMurray, J., Weller, J. L., Jian, J. & Singh, K. B., 1 Mar 2017, In : Plant Biotechnology Journal. 15, 3, p. 318-330 13 p.

Research output: Contribution to journalArticle

Open Access
Lupinus
Lupinus angustifolius
health foods
Fabaceae
legumes
2 Citations (Scopus)
243 Downloads (Pure)

Analysis of early mesothelial cell responses to Staphylococcus epidermidis isolated from patients with peritoneal dialysis-associated peritonitis

McGuire, A. L., Mulroney, K. T., Carson, C. F., Ram, R., Morahan, G. & Chakera, A., 24 May 2017, In : PLoS One. 12, 5, 18 p., e0178151.

Research output: Contribution to journalArticle

Open Access
File
Staphylococcus epidermidis
Dialysis
peritonitis
Peritoneal Dialysis
dialysis
3 Citations (Scopus)

Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-Verified β Cells That Ameliorate Diabetes

Jiang, F. X., Li, K., Archer, M., Mehta, M., Jamieson, E., Charles, A., Dickinson, J. E., Matsumoto, M. & Morahan, G., May 2017, In : Stem Cells. 35, 5, p. 1341-1354

Research output: Contribution to journalArticle

Niacinamide
Transcriptome
Stem Cells
Islets of Langerhans
Gene Knockdown Techniques
6 Citations (Scopus)

Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression

Ram, R. & Morahan, G., Jun 2017, In : Genes. 8, 6, 14 p., 167.

Research output: Contribution to journalReview article

Open Access
220 Downloads (Pure)
Open Access
File
Gene Regulatory Networks
Atrial Fibrillation
Myocardium
Gene Expression
Lung

Genome wide association identifies MAPKinase pathway regulators as key genetic determinants of allergic contact dermatitis

Legrand, J., Baz, B., Mukhopadhyay, P., Wong, H., Ram, R., Morahan, G., Walker, G. & Khosrotehrani, K., Oct 2017, In : Journal of Investigative Dermatology. 137, 10, p. S224-S224 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

136 Citations (Scopus)

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Mariño, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J. & 4 othersClarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R., 27 Mar 2017, In : Nature Immunology. 18, 5, p. 552-562 11 p.

Research output: Contribution to journalArticle

Butyrates
Type 1 Diabetes Mellitus
Acetates
T-Lymphocytes
Diet
5 Citations (Scopus)

Incomplete Re-Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β-Cell Dedifferentiation

Neelankal John, A., Morahan, G. & Jiang, F. X., 1 Jan 2017, In : Journal of Neuroendocrinology. 29, 1, p. 1-12 12 p., JNE12450.

Research output: Contribution to journalArticle

Open Access
Cell Dedifferentiation
Neuroendocrine Cells
Stem Cells
Insulinoma
Glucose
13 Citations (Scopus)
139 Downloads (Pure)

Narrow-leafed lupin (Lupinus angustifolius L.) β-conglutin proteins modulate the insulin signaling pathway as potential type 2 diabetes treatment and inflammatory-related disease amelioration

Lima-Cabello, E., Alche, V., Foley, R. C., Andrikopoulos, S., Morahan, G., Singh, K. B., Alche, J. D. & Jimenez-Lopez, J. C., May 2017, In : Molecular Nutrition and Food Research. 61, 5, 1600819.

Research output: Contribution to journalArticle

Open Access
File
Lupinus
Lupinus angustifolius
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
insulin
6 Citations (Scopus)
49 Downloads (Pure)
File
Libraries
Phenotype
Bone and Bones
Genes
Chromosome Mapping
4 Citations (Scopus)

Variable cardiac α-actin (Actc1) expression in early adult skeletal muscle correlates with promoter methylation

Boutilier, J. K., Taylor, R. L., Ram, R., McNamara, E., Nguyen, Q., Goullée, H., Chandler, D., Mehta, M., Balmer, L., Laing, N. G., Morahan, G. & Nowak, K. J., 26 Aug 2017, In : Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1860, 10, p. 1025-1036 12 p.

Research output: Contribution to journalArticle

Methylation
Actins
Skeletal Muscle
Quantitative Trait Loci
Protein Isoforms
2016
13 Citations (Scopus)

A common variant association study reveals novel susceptibility loci for low HDL-cholesterol levels in ethnic Arabs

Wakil, S. M., Ram, R., Muiya, N. P., Andres, E., Mazhar, N., Hagos, S., Alshahid, M., Meyer, B. F., Morahan, G. & Dzimiri, N., 21 Nov 2016, In : Clinical Genetics. 90, 6, p. 518-525 8 p.

Research output: Contribution to journalArticle

HDL Cholesterol
Genes
LDL Cholesterol
Genome
Genetic Predisposition to Disease
18 Citations (Scopus)

A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs

Wakil, S. M., Ram, R., Muiya, N. P., Mehta, M., Andres, E., Mazhar, N., Baz, B., Hagos, S., Alshahid, M., Meyer, B. F., Morahan, G. & Dzimiri, N., Feb 2016, In : Atherosclerosis. 245, p. 62-70 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Coronary Artery Disease
Myocardial Infarction
Single Nucleotide Polymorphism
Population
5 Citations (Scopus)

A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K

Chitsazan, A., Ferguson, B., Ram, R., Mukhopadhyay, P., Handoko, H. Y. Y., Gabrielli, B., Soyer, P. H. H., Morahan, G. & Walker, G. J. J., 2016, In : PIGMENT CELL & MELANOMA RESEARCH. 29, 4, p. 459-464 6 p.

Research output: Contribution to journalArticle

Nevus
Genes
Mutation
Bearings (structural)
Melanocytes
6 Citations (Scopus)

Biological assessments of encapsulated pancreatic β-cells: their potential transplantation in diabetes

Mooranian, A., Negrulj, R., Jamieson, E., Morahan, G. & Al-Salami, H., Dec 2016, In : Cellular and Molecular Bioengineering. 9, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

Transplantation
Diabetes
Medical problems
Nozzles
Nozzle
2 Citations (Scopus)

Complex trait analyses of the collaborative cross: Tools and databases

Ram, R. & Morahan, G., 2016, Systems Genetics: Methods and Protocols. Schughart, K. & Williams, R. W. (eds.). Humana Press, Vol. 1488. p. 121-129 9 p. (Methods in Molecular Biology; vol. 1488).

Research output: Chapter in Book/Conference paperChapter

Chromosome Mapping
Databases

Data on common variants associated with coronary artery disease/myocardial infarction in ethnic Arabs

Wakil, S. M., Ram, R., Muiya, N. P., Mehta, M., Andres, E., Mazhar, N., Baz, B., Hagos, S., Alshahid, M., Meyer, B. F., Morahan, G. & Dzimiri, N., 2016, In : Data in Brief. 7, p. 172-176 5 p.

Research output: Contribution to journalArticle

Open Access
Coronary Artery Disease
Myocardial Infarction
Genome-Wide Association Study
Principal Component Analysis
Population
19 Citations (Scopus)

Designing Anti-Diabetic b-Cells Microcapsules Using Polystyrenic Sulfonate,Polyallylamine, and a Tertiary Bile Acid: Morphology, Bioenergetics,and Cytokine Analysis

Mooranian, A., Negrulj, R., Al‐salami, H., Morahan, G. & Jamieson, E., 22 Apr 2016, In : Biotechnology Progress. 32, 2, p. 501-509 9 p.

Research output: Contribution to journalArticle

Ursodeoxycholic Acid
Bile Acids and Salts
Energy Metabolism
Capsules
Drug Compounding
5 Citations (Scopus)

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice

Andrikopoulos, S., Fam, B. C., Holdsworth, A., Visiononi, S., Ruan, Z., Stathopoulos, M., Thorburn, A. W., Joannides, C. N., Cancilla, M., Balmer, L., Proietto, J. & Morahan, G., 1 Jan 2016, In : Journal of Endocrinology. 228, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

Open Access
Obese Mice
New Zealand
Type 2 Diabetes Mellitus
Insulin
Glucose

Insulin-secreting beta cells require a post-genomic concept

Jiang, F-X. & Morahan, G., 2016, In : WORLD JOURNAL OF DIABETES. 7, 10, p. 198-208 11 p.

Research output: Contribution to journalArticle

Open Access
Insulin-Secreting Cells
Pluripotent Stem Cells
Transcriptome
Terminology
Diabetes Mellitus

Pancreas-Derived Multipotent Progenitors

Jiang, F-X. & Morahan, G., 2016, Regenerative Medicine - from Protocol to Patient: 2. Stem Cell Science and Technology. Steinhoff, G. (ed.). 3rd ed. Springer, p. 345-362

Research output: Chapter in Book/Conference paperChapter

15 Citations (Scopus)

Systematic evaluation of genes and genetic variants associated with type 1 diabetes susceptibility

Ram, R., Mehta, M., Nguyen, Q., Larma, I., Boehm, B. O., Pociot, F., Concannon, P. & Morahan, G., 1 Apr 2016, In : Journal of Immunology. 196, 7, p. 3043-3053 11 p.

Research output: Contribution to journalArticle

Open Access
Type 1 Diabetes Mellitus
Alleles
Genes
Single Nucleotide Polymorphism
Gene Expression
1 Citation (Scopus)

Using systems genetics to understanding the etiology of complex disease

Ram, R. & Morahan, G., 2016, Systems Genetics: Methods and Protocols. Schughart, K. & Williams, R. W. (eds.). Humana Press, Vol. 1488. p. 597-606 10 p. (Methods in Molecular Biology; vol. 1488).

Research output: Chapter in Book/Conference paperChapter

Type 1 Diabetes Mellitus
Computational Biology
Genes
2015

Adapting Genome-wide Association Workflows for HPC Processing at Pawsey

Yang, C., Harrison, C., Young, S. & Morahan, G., Nov 2015.

Research output: Contribution to conferencePoster

Genes
Processing
Bioinformatics
Graphics processing unit

A mine of genetic information

Morahan, G., Ram, R., Balmer, L. & Nowak, K., 2015, International Innovation, p. 66-67 2 p.

Research output: Contribution to specialist publicationArticle

Challenge Remains for Directed Differentiation of Late Stage Pancreatic Islet Lineage

Jiang, F-X. & Morahan, G., 28 May 2015, In : Archives of Stem Cell Research. 2, 2, p. 1-3 3 p., 1011.

Research output: Contribution to journalLetter

Open Access
Regenerative Medicine
Insulin-Secreting Cells
Islets of Langerhans
Type 2 Diabetes Mellitus
Public Health
15 Citations (Scopus)
Open Access
Retinal Vessels
Diabetic Retinopathy
Ependymoglial Cells
Retina
Gliosis
196 Citations (Scopus)

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of casual variants with lymphoid gene enhancers

Onengut-Gumuscu, S., Chen, W-M., Burren, O., Cooper, N. J., Quinlan, A. R., Mychaleckyj, J. C., Farber, E., Bonnie, J. K., Szpak, M., Schofield, E., Achuthan, P., Guo, H., Fortune, M. D., Stevens, H., Walker, N. M., Ward, L. D., Kundaje, A., Kellis, M., Daly, M. J., Barrett, J. C. & 7 othersCooper, J. D., Deloukas, P., Morahan, G., Todd, J. A., Wallace, C., Concannon, P. & Rich, S. S., 2015, In : Nature Genetics. 47, p. 381-390

Research output: Contribution to journalArticle

16 Citations (Scopus)

Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression

Ferguson, B., Ram, R., Handoko, H. Y., Mukhopadhyay, P., Muller, H. K., Soyer, H. P., Morahan, G. & Walker, G. J., May 2015, In : Oncogene. 34, 22, p. 2879-2886

Research output: Contribution to journalArticle

Melanoma
Nevi and Melanomas
Neoplasms
Carcinogenesis
Environmental Carcinogens

Multipotent pancreas progenitors: Inconclusive but pivotal topic

Jiang, F-X. & Morahan, G., 26 Dec 2015, In : World Journal of Stem Cells. 7, 11, p. 1251-1261 11 p.

Research output: Contribution to journalArticle

Open Access
Pancreas
Endocrine Cells
Insulin-Secreting Cells
Translational Medical Research
Cell Transplantation
6 Citations (Scopus)

The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs

Wakil, S. M., Nguyen, C., Muiya, N. P., Andres, E., Lykowska-Tarnowska, A., Baz, B., Tahir, A. I., Meyer, B. F., Morahan, G. & Dzimiri, N. F., Feb 2015, In : Disease Markers. 2015, p. 1-8 8 p., Article ID 542543.

Research output: Contribution to journalArticle

Open Access
Precision Medicine
Enzymes
Pharmaceutical Preparations
Medicine
Screening