George Yeoh

Emeritus Professor

  • The University of Western Australia (M519), 35 Stirling Highway,

    6009 Crawley

    Australia

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Crawley

    Australia

  • 3477 Citations
  • 33 h-Index
1992 …2018

Research Output 1992 2018

2018
2 Citations

A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma

Kabir, T. D., Ganda, C., Brown, R. M., Beveridge, D. J., Richardson, K. L., Chaturvedi, V., Candy, P., Epis, M., Wintle, L., Kalinowski, F., Kopp, C., Stuart, L. M., Yeoh, G. C., George, J. & Leedman, P. J. 1 Jan 2018 In : Hepatology. 67, 1, p. 216-231 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Hepatocellular Carcinoma
Growth
Proto-Oncogene Proteins c-akt
1-Phosphatidylinositol 4-Kinase

Functional significance of TRIM35 In haematopoietic and hepatic homeostasis

Van Vuuren, J. H. 2018 (Unpublished)

Research output: ThesisDoctoral Thesis

File
Liver Neoplasms
Homeostasis
Inflammation
Ubiquitin-Protein Ligases
Liver

InForm software: A semi-Automated research tool to identify presumptive human hepatic progenitor cells, and other histological features of pathological significance

Kramer, A. S., Latham, B., Diepeveen, L. A., Mou, L., Laurent, G. J., Elsegood, C., Ochoa-Callejero, L. & Yeoh, G. C. 1 Dec 2018 In : Scientific Reports. 8, 1, 3418

Research output: Contribution to journalArticle

Open Access
Hepatocytes
Stem Cells
Software
Liver Diseases
Research
Open Access
Extracellular Matrix Proteins
Hepatocytes
Stem Cells
Serum
Liver
2017

Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma

Elsegood, C. L., Tirnitz-Parker, J. E. E., Olynyk, J. K. & Yeoh, G. C. T. 10 Nov 2017 In : Clinical & Translational Immunology. 6, 11 p., 161

Research output: Contribution to journalReview article

Open Access

Interleukin-6 secreted by bipotential murine oval liver stem cells induces apoptosis of activated hepatic stellate cells by activating NF-B-inducible nitric oxide synthase signaling

Gajalakshmi, P., Majumder, S., Viebahn, C. S., Swaminathan, A., Yeoh, G. C. & Chatterjee, S. 2017 In : Biochemistry and Cell Biology. 95, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Nitric Oxide Synthase Type II
Stem cells
Liver
Interleukin-6
2016
1 Citations

A Transcriptomic Signature of Mouse Liver Progenitor Cells

Passman, A., Low, J., London, R., Tirnitz-Parker, N., Miyajima, A., Tanaka, M., Strick-Marchand, H., Darlington, G. J., Finch-Edmondson, M., Ochsner, S., Zhu, C., Whelan, J., Callus, B. & Yeoh, G. Aug 2016 In : Stem cells international. 2016, p. 1-15

Research output: Contribution to journalArticle

Open Access
Stem Cells
Liver
Hepatocellular Carcinoma
Liver Diseases
Cell Line
1 Citations

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

Goodall, K. J., Finch-Edmondson, M., van Vuuren, J., Yeoh, G. C., Gentle, I. E., Vince, J. E., Ekert, P. G., Vaux, D. L. & Callus, B. A. 2 Nov 2016 In : PLoS One. 11, 11, p. 1-18

Research output: Contribution to journalArticle

Open Access
cycloheximide
Cell death
Myeloid Cells
Cycloheximide
cell death

Efficient generation of functional hepatocyte-like cells from mouse liver progenitor cells via indirect co-culture with immortalized human hepatic stellate cells

Pan, X. P., Wang, Y. N., Yu, X. P., Zhu, C. X., Li, J. Z., Du, W. B., Zhang, Y. M., Cao, H. C., Zhang, Y. H., Zhu, D. H., Yeoh, G. & Li, L. J. 6 Apr 2016 In : Hepatobiliary and Pancreatic Diseases International. 15, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Coculture Techniques
Hepatocytes
Stem Cells
Liver
1 Citations

Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib

Woo, K., Stewart, S. G., Kong, G. S., Finch-Edmondson, M. L., Dwyer, B. J., Yeung, S. Y., Abraham, L. J., Kampmann, S. S., Diepeveen, L. A., Passman, A. M., Elsegood, C. L., Tirnitz-Parker, J. E. E., Callus, B. A., Olynyk, J. K. & Yeoh, G. C. T. 14 Sep 2016 In : European Journal of Medicinal Chemistry. 120, p. 275-283

Research output: Contribution to journalArticle

Thalidomide
Liver
Stem Cells
Derivatives
Cells
2 Citations

Splice variant insertions in the C-terminus impairs YAP's transactivation domain

Finch-Edmondson, M. L., Strauss, R. P., Clayton, J. S., Yeoh, G. C. & Callus, B. A. 2016 In : Biochemistry and Biophysics Reports. 6, p. 24-31 8 p.

Research output: Contribution to journalArticle

Open Access
Transcriptional Activation
Protein Isoforms
Leucine Zippers
Proteins
Fusion reactions
2015
5 Citations

A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice

Passman, A., Strauss, R. P., Mcspadden, S., Finch-Edmondson, M., Woo, K., Diepeveen, L., London, R., Callus, B. & Yeoh, G. Dec 2015 In : DMM Disease Models and Mechanisms. 8, 12, p. 1635-1641

Research output: Contribution to journalArticle

Open Access
Ethionine
Nutrition
Choline
Liver
Stem Cells
1 Citations

Epigenetic Modulators Enhance Constitutive and Liver-Specific Reporter Expression in Murine Liver Progenitor Cell Lines

Diepeveen, L., Watson, M., Mcspadden, S., Strauss, R. P., Callus, B. & Yeoh, G. 1 Oct 2015 In : Tissue Engineering - Part C: Methods. 21, 10, p. 1080-1087 8 p.

Research output: Contribution to journalArticle

Open Access
File
Tyrosine Transaminase
Epigenomics
Liver
Modulators
Stem Cells
8 Citations

Glycosylation-related diagnostic and therapeutic drug target markers in hepatocellular carcinoma

Watson, M., Diepeveen, L., Stubbs, K. & Yeoh, G. Sep 2015 In : Journal of Gastrointestinal and Liver Diseases. 24, 3, p. 349-357

Research output: Contribution to journalArticle

Open Access
Glycosylation
Hepatocellular Carcinoma
Pharmaceutical Preparations
Apoptosis
Therapeutics
26 Citations

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

Elsegood, C., Chan, D., Degli-Esposti, M., Wikstrom, M., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J. K. & Yeoh, G. 29 Sep 2015 In : Hepatology. 62, 4, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Liver Regeneration
Kupffer Cells
Cell Communication
Monocytes
Stem Cells
19 Citations

Molecular imaging needles: Dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

Scolaro, L., Lorenser, D., Madore, W. J., Kirk, R., Kramer, A., Yeoh, G., Godbout, N., Sampson, D., Boudoux, C. & Mclaughlin, R. 2015 In : Biomedical Optics Express. 6, 5, p. 1767-1781

Research output: Contribution to journalArticle

Open Access
Molecular Imaging
Optical Imaging
Optical Coherence Tomography
antibodies
needles
5 Citations

Sub-cellular localisation studies may spuriously detect the yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function

Finch, M. L., Passman, A., Strauss, R. P., Yeoh, G. & Callus, B. 6 Feb 2015 In : PLoS One. 10, 2, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
cell nucleolus
Liver
hepatocytes
stem cells
Staining and Labeling
13 Citations

TAZ protein accumulation is negatively regulated by YAP abundance in mammalian cells

Finch-Edmondson, M. L., Strauss, R. P., Passman, A. M., Sudol, M., Yeoh, G. & Callus, B. 2015 In : Journal of Biological Chemistry. 290, 46, p. 27928-27938

Research output: Contribution to journalArticle

Protein Isoforms
Cells
Degradation
Long-Acting Thyroid Stimulator
Casein Kinase I
1 Citations

The synthesis and fluorescence profile of novel thalidomide analogues

Kampmann, S., Skelton, B., Yeoh, G., Abraham, L., Lengkeek, N. A., Stubbs, K., Heath, C. & Stewart, S. 21 Oct 2015 In : Tetrahedron. 71, 42, p. 8140-8149 10 p.

Research output: Contribution to journalArticle

Thalidomide
Fluorescence
Derivatives
Azides
Cycloaddition
2014

Dual-modality Imaging Needle for Combined Optical Coherence Tomography and Fluorescence Imaging of Fluorescently Labelled Tissue

Scolaro, L., Lorenser, D., Madore, W-J., Kramer, A., Yeoh, G., Godbout, N., Sampson, D., Boudoux, C. & Mclaughlin, R. 2014 Biomedical Optics 2014. United States: Optical Society of America, Vol. 1, p. BS2B.7 (1-3)

Research output: Chapter in Book/Report/Conference proceedingConference paper

28 Citations

Regulation of microRNAs and their role in liver development, regeneration and disease

Finch, M. L., Marquardt, J. U., Yeoh, G. & Callus, B. Sep 2014 In : International Journal of Biochemistry and Cell Biology. 54, p. 288-303

Research output: Contribution to journalReview article

Open Access
File
Liver Regeneration
MicroRNAs
Liver
Liver Diseases
Chronic Disease
2013
18 Citations

Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber

Yap, K. K., Dingle, A. M., Palmer, J. A., Dhillon, R. S., Lokmic, Z., Penington, A. J., Yeoh, G., Morrison, W. A. & Mitchell, G. M. 2013 In : Biomaterials. 34, p. 3992-4001

Research output: Contribution to journalArticle

7 Citations

Liver progenitor cell interactions with the extracellular matrix

Zhu, C., Coombe, D. R., Zheng, M., Yeoh, G. & Li, L. 2013 In : Journal of Tissue Engineering and Regenerative Medicine. 7, 10, p. 757-766

Research output: Contribution to journalReview article

2012

Kupffer cells induce liver progenitor cell proliferation in response to CDE diet-induced liver injury

Elsegood, C., Olynyk, J. & Yeoh, G. 2012 Australian Gastroenterology Week. Australia, Vol. 27, p. 3

Research output: Chapter in Book/Report/Conference proceedingConference paper

Liver Progenitor Cells, Cancer Stem Cells and Hepatocellular Carcinoma

Tirnitz-Parker, N., Yeoh, G. & Olynyk, J. 2012 Liver Regeneration. Baptista, P. M. (ed.). Croatia: InTech, p. 17-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

14 Citations

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues

Puxbaum, V., Nimmerfall, E., Bäuerl, C., Taub, N., Blaas, P-M., Wieser, J., Mikula, M., Mikulits, W., Ng, K. M., Yeoh, G. & Mach, L. 2012 In : Journal of Hepatology. 57, p. 337-343

Research output: Contribution to journalArticle

Open Access
5 Citations

TNF-inducible expression of lymphotoxin-β in hepatic cells: An essential role for NF-κB and Ets1 transcription factors

Subrata, L. S., Voon, D. C., Yeoh, G., Ulgiati, D., Quail, E. & Abraham, L. 2012 In : Cytokine. 60, p. 498-504

Research output: Contribution to journalArticle

2011
12 Citations

Expansion and Hepatocytic Differentiation of Liver Progenitor Cells In Vivo Using a Vascularized Tissue Engineering Chamber in Mice

Forster, N., Palmer, J. A., Yeoh, G., Ong, W. C., Mitchell, G. M., Slavin, J., Tirnitz-Parker, N. & Morrison, W. A. 2011 In : Tissue Engineering. Part C. Methods. 17, 3, p. 1-8

Research output: Contribution to journalArticle

1 Citations

Preface

Yeoh, G., Barton, S. & Kaestner, K. 2011 In : International Journal of Biochemistry and Cell Biology. 43, 2, p. 172

Research output: Contribution to journalReview article

2010
4 Citations

Human Liver Progenitor Cell Lines Are Readily Established From Non-Tumorous Tissue Adjacent to Hepatocellular Carcinoma

Zhang, A., London, R., Schulz, F. M., Giguere-Simmonds, P. W. R., Delriviere, L., Chandraratana, H., Hardy, K., Zheng, S., Olynyk, J. & Yeoh, G. 2010 In : Stem Cells and Development. 19, 8, p. 1277-1284

Research output: Contribution to journalArticle

31 Citations

Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury

Viebahn, C., Benseler, V., Holz, L. E., Elsegood, C., Vo, M., Bertolino, P., Ganss, R. & Yeoh, G. 2010 In : Journal of Hepatology. 53, 3, p. 500-507

Research output: Contribution to journalArticle

99 Citations

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Is a Mitogen for Liver Progenitor Cells

Tirnitz-Parker, N., Viebahn, C., Jakubowski, A., Klopcic, B., Olynyk, J., Yeoh, G. & Knight, B. 2010 In : Hepatology. 52, 1, p. 291-302

Research output: Contribution to journalArticle

63 Citations

Uptake and cytotoxicity of chitosan nanoparticles in human liver cells

Loh, J. W., Yeoh, G., Saunders, M. & Lim, L. Y. 2010 In : Toxicology and Applied Pharmacology. 249, p. 148-157

Research output: Contribution to journalArticle

2009
65 Citations

An Akt/hypoxia-inducible factor-1αplatelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells

Lau, C. K., Yang, Z. F., Ho, D. W., Ng, M. N., Yeoh, G., Poon, R. T. P. & Fan, S. T. 2009 In : Clinical cancer research. 15, 10, p. 3462-3471

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocytes
Intercellular Signaling Peptides and Proteins
Stem Cells
Autocrine Communication
10 Citations

Rapid Evaluation of Antrodia camphorata Natural Products and Derivatives in Tumourigenic Liver Progenitor Cells with a Novel Cell Proliferation Assay

Stewart, S., Ho, L., Polomska, M., Percival, A. & Yeoh, G. 2009 In : ChemMedChem. 4, 10, p. 1657-1667

Research output: Contribution to journalArticle

Antrodia
Cell proliferation
Biological Products
Maleic Anhydrides
Liver
2008
59 Citations

Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound

Jellicoe, M., Nichols, S. J., Callus, B. A., Baker, M., Barnard, P., Berners-Price, S., Whelan, J., Yeoh, G. & Filipovska, A. 2008 In : Carcinogenesis. 29, 6, p. 1124-1133

Research output: Contribution to journalArticle

Gold Compounds
Energy Metabolism
Stem Cells
Liver
Mitochondria
4 Citations

Bone marrow cells play only a very minor role in chronic liver regeneration induced by a choline-deficient, ethionine-supplemented diet

Tonkin, J., Knight, B., Curtis, D., Abraham, L. & Yeoh, G. 2008 In : Stem Cell Research. 1, 3, p. 195-204

Research output: Contribution to journalArticle

Ethionine
Liver Regeneration
Choline
Bone Marrow Cells
Diet
56 Citations

Liver stem cells: A scientific and clinical perspective

Dan, Y. Y. & Yeoh, G. 2008 In : Journal of Gastroenterology and Hepatology. 23, p. 687-698

Research output: Contribution to journalArticle

174 Citations

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα

Vince, J. E., Chau, D., Callus, B., Wong, W. W-L., Hawkins, C. J., Schneider, P., Mckinlay, M., Benetatos, C. A., Condon, S. M., Chunduru, S. K., Yeoh, G., Brink, R., Vaux, D. L. & Silke, J. 2008 In : The Journal of Cell Biology. 182, 1, p. 171-184

Research output: Contribution to journalArticle

Open Access
Tumor Necrosis Factor-alpha
Apoptosis
Neoplasms
NF-kappa B
Inhibitor of Apoptosis Proteins
32 Citations
2007
56 Citations

Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice

Knight, B., Akhurst, B., Matthews, V. B., Ruddell, R. G., Ramm, G. A., Abraham, L., Olynyk, J. & Yeoh, G. 2007 In : Journal of Hepatology. 46, 1, p. 134-141

Research output: Contribution to journalArticle

Ethionine
Inbred Strains Mice
Choline
Stem Cells
Interferon-gamma
81 Citations
Ethionine
Nutrition
Choline
Liver
Hepatocytes
60 Citations

Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation

Yeoh, G., Ernst, M., Rose-John, S., Akhurst, B., Payne, C., Long, S., Alexander, W., Croker, B., Grail, D. & Matthews, V. 2007 In : Hepatology. 45, 2, p. 486-494

Research output: Contribution to journalArticle

Cell Movement
Stem Cells
Ethionine
Cell Proliferation
Choline
114 Citations

Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation

Nguyen, L. N., Furuya, M. H., Wolfraim, L. A., Nguyen, A. P., Holdren, M. S., Campbel, J. S., Knight, B., Yeoh, G., Fausto, N. & Parks, W. T. 2007 In : Journal of Hepatology. 45, 1, p. 31-41

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Hepatocytes
Cell Proliferation
Growth
Ethionine
2006
50 Citations

Antiproliferative Effects of Interferon Alpha on Hepatic Progenitor Cells In Vitro and In Vivo

Lim, R., Knight, B., Patel, K., Mchutchison, J. G., Yeoh, G. & Olynyk, J. 2006 In : Hepatology. 43, 5, p. 1074-1083

Research output: Contribution to journalArticle

Interferon-alpha
Hepatocytes
Stem Cells
Chronic Hepatitis C
Liver
16 Citations

Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells

Viebahn, C., Tirnitz-Parker, N., Olynyk, J. & Yeoh, G. 2006 In : European Journal of Cell Biology. 85, 12, p. 1265-1274

Research output: Contribution to journalArticle

Stem Cells
Liver
Intercellular Signaling Peptides and Proteins
Suspensions
Cell Culture Techniques
37 Citations

Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor

Davies, R. A., Knight, B., Tian, Y., Yeoh, G. & Olynyk, J. 2006 In : Carcinogenesis. 27, 8, p. 1607-1616

Research output: Contribution to journalArticle

Ethionine
Cyclooxygenase Inhibitors
Choline
Hepatocytes
Liver
2005
79 Citations

Differential Lymphotoxin-β and Interferon Gamma Signaling During Mouse Liver Regeneration Induced by Chronic and Acute Injury

Akhurst, B., Matthews, V., Husk, K. L., Smyth, M. J., Abraham, L. & Yeoh, G. 2005 In : Hepatology. 41, 2, p. 327-335

Research output: Contribution to journalArticle

Lymphotoxin-beta
Liver Regeneration
Interferon-beta
Interferon-gamma
Lymphotoxin beta Receptor
65 Citations

Differential regulation of rodent hepatocyte and oval cell proliferation by interferon [gamma]

Brooling, J. T., Campbell, J. S., Mitchell, C., Yeoh, G. & Fausto, N. 2005 In : Hepatology. 41, 4, p. 906-915

Research output: Contribution to journalArticle

Interferon-gamma
Hepatocytes
Rodentia
Cell Proliferation
Lipopolysaccharides
21 Citations
Lymphotoxin-beta
Interleukin-1beta
Hepatocellular Carcinoma
Interleukin-6
Tumor Necrosis Factor-alpha