George Yeoh

Emeritus Professor, BSc PhD W.Aust.

  • The University of Western Australia (M519), 35 Stirling Highway, Room 259, Molecular and Chemical Sciences Building, Perth campus

    6009 Perth

    Australia

  • The University of Western Australia (M503), 35 Stirling Highway, Room 259, Molecular and Chemical Sciences Building, Perth campus

    6009 Perth

    Australia

  • 4602 Citations
  • 37 h-Index
1974 …2018
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Research Output 1974 2018

2018
9 Citations

A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma

Kabir, T. D., Ganda, C., Brown, R. M., Beveridge, D. J., Richardson, K. L., Chaturvedi, V., Candy, P., Epis, M., Wintle, L., Kalinowski, F., Kopp, C., Stuart, L. M., Yeoh, G. C., George, J. & Leedman, P. J., 1 Jan 2018, In : Hepatology. 67, 1, p. 216-231 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Hepatocellular Carcinoma
Growth
Proto-Oncogene Proteins c-akt
1-Phosphatidylinositol 4-Kinase
File
Carcinogenesis
Stem Cells
Liver
Cell- and Tissue-Based Therapy
Population

Functional significance of TRIM35 In haematopoietic and hepatic homeostasis

Van Vuuren, J. H., 2018, (Unpublished)

Research output: ThesisDoctoral Thesis

File
Liver Neoplasms
Homeostasis
Inflammation
Ubiquitin-Protein Ligases
Liver

InForm software: A semi-Automated research tool to identify presumptive human hepatic progenitor cells, and other histological features of pathological significance

Kramer, A. S., Latham, B., Diepeveen, L. A., Mou, L., Laurent, G. J., Elsegood, C., Ochoa-Callejero, L. & Yeoh, G. C., 1 Dec 2018, In : Scientific Reports. 8, 1, 3418

Research output: Contribution to journalArticle

Open Access
Hepatocytes
Stem Cells
Software
Liver Diseases
Research

The Vascularised Chamber as an In Vivo Bioreactor

Yap, K. K., Yeoh, G. C., Morrison, W. A. & Mitchell, G. M., Oct 2018, In : Trends in Biotechnology. 36, 10, p. 1011-1024

Research output: Contribution to journalArticle

Bioreactors
Tissue
Biomedical Engineering
Tissue Survival
Regenerative Medicine
1 Citations

Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins

Gratte, F. D., Pasic, S., Olynyk, J. K., Yeoh, G. C. T., Tosh, D., Coombe, D. R. & Tirnitz-Parker, J. E. E., 1 Dec 2018, In : Scientific Reports. 8, 1, 4385

Research output: Contribution to journalArticle

Open Access
Extracellular Matrix Proteins
Hepatocytes
Stem Cells
Serum
Liver
2017
9 Citations

Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma

Elsegood, C. L., Tirnitz-Parker, J. E. E., Olynyk, J. K. & Yeoh, G. C. T., 10 Nov 2017, In : Clinical & Translational Immunology. 6, 11 p., 161

Research output: Contribution to journalReview article

Open Access

Interleukin-6 secreted by bipotential murine oval liver stem cells induces apoptosis of activated hepatic stellate cells by activating NF-B-inducible nitric oxide synthase signaling

Gajalakshmi, P., Majumder, S., Viebahn, C. S., Swaminathan, A., Yeoh, G. C. & Chatterjee, S., 2017, In : Biochemistry and Cell Biology. 95, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Nitric Oxide Synthase Type II
Stem cells
Liver
Interleukin-6
2016
1 Citations

A Transcriptomic Signature of Mouse Liver Progenitor Cells

Passman, A., Low, J., London, R., Tirnitz-Parker, N., Miyajima, A., Tanaka, M., Strick-Marchand, H., Darlington, G. J., Finch-Edmondson, M., Ochsner, S., Zhu, C., Whelan, J., Callus, B. & Yeoh, G., Aug 2016, In : Stem Cells International. 2016, p. 1-15

Research output: Contribution to journalArticle

Open Access
Stem Cells
Liver
Hepatocellular Carcinoma
Liver Diseases
Cell Line
2 Citations

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

Goodall, K. J., Finch-Edmondson, M., van Vuuren, J., Yeoh, G. C., Gentle, I. E., Vince, J. E., Ekert, P. G., Vaux, D. L. & Callus, B. A., 2 Nov 2016, In : PLoS One. 11, 11, p. 1-18

Research output: Contribution to journalArticle

Open Access
cycloheximide
Cell death
Myeloid Cells
Cycloheximide
cell death
1 Citations

Efficient generation of functional hepatocyte-like cells from mouse liver progenitor cells via indirect co-culture with immortalized human hepatic stellate cells

Pan, X. P., Wang, Y. N., Yu, X. P., Zhu, C. X., Li, J. Z., Du, W. B., Zhang, Y. M., Cao, H. C., Zhang, Y. H., Zhu, D. H., Yeoh, G. & Li, L. J., 6 Apr 2016, In : Hepatobiliary and Pancreatic Diseases International. 15, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Coculture Techniques
Hepatocytes
Stem Cells
Liver
1 Citations

Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib

Woo, K., Stewart, S. G., Kong, G. S., Finch-Edmondson, M. L., Dwyer, B. J., Yeung, S. Y., Abraham, L. J., Kampmann, S. S., Diepeveen, L. A., Passman, A. M., Elsegood, C. L., Tirnitz-Parker, J. E. E., Callus, B. A., Olynyk, J. K. & Yeoh, G. C. T., 14 Sep 2016, In : European Journal of Medicinal Chemistry. 120, p. 275-283

Research output: Contribution to journalArticle

Open Access
File
Thalidomide
Liver
Stem Cells
Derivatives
Cells
3 Citations

Splice variant insertions in the C-terminus impairs YAP's transactivation domain

Finch-Edmondson, M. L., Strauss, R. P., Clayton, J. S., Yeoh, G. C. & Callus, B. A., 2016, In : Biochemistry and Biophysics Reports. 6, p. 24-31 8 p.

Research output: Contribution to journalArticle

Open Access
Transcriptional Activation
Protein Isoforms
Leucine Zippers
Proteins
Fusion reactions
2015
5 Citations

A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice

Passman, A., Strauss, R. P., Mcspadden, S., Finch-Edmondson, M., Woo, K., Diepeveen, L., London, R., Callus, B. & Yeoh, G., Dec 2015, In : DMM Disease Models and Mechanisms. 8, 12, p. 1635-1641

Research output: Contribution to journalArticle

Open Access
Ethionine
Nutrition
Choline
Liver
Stem Cells
1 Citations

Epigenetic Modulators Enhance Constitutive and Liver-Specific Reporter Expression in Murine Liver Progenitor Cell Lines

Diepeveen, L., Watson, M., Mcspadden, S., Strauss, R. P., Callus, B. & Yeoh, G., 1 Oct 2015, In : Tissue Engineering - Part C: Methods. 21, 10, p. 1080-1087 8 p.

Research output: Contribution to journalArticle

Open Access
File
Tyrosine Transaminase
Epigenomics
Liver
Modulators
Stem Cells
9 Citations

Glycosylation-related diagnostic and therapeutic drug target markers in hepatocellular carcinoma

Watson, M., Diepeveen, L., Stubbs, K. & Yeoh, G., Sep 2015, In : Journal of Gastrointestinal and Liver Diseases. 24, 3, p. 349-357

Research output: Contribution to journalArticle

Open Access
Glycosylation
Hepatocellular Carcinoma
Pharmaceutical Preparations
Apoptosis
Therapeutics
29 Citations

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

Elsegood, C., Chan, D., Degli-Esposti, M., Wikstrom, M., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J. K. & Yeoh, G., 29 Sep 2015, In : Hepatology. 62, 4, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

Liver Regeneration
Kupffer Cells
Cell Communication
Monocytes
Stem Cells
22 Citations

Molecular imaging needles: Dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

Scolaro, L., Lorenser, D., Madore, W. J., Kirk, R., Kramer, A., Yeoh, G., Godbout, N., Sampson, D., Boudoux, C. & Mclaughlin, R., 2015, In : Biomedical Optics Express. 6, 5, p. 1767-1781

Research output: Contribution to journalArticle

Open Access
Molecular Imaging
Optical Imaging
Optical Coherence Tomography
antibodies
needles
5 Citations

Sub-cellular localisation studies may spuriously detect the yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function

Finch, M. L., Passman, A., Strauss, R. P., Yeoh, G. & Callus, B., 6 Feb 2015, In : PLoS One. 10, 2, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
cell nucleolus
Liver
hepatocytes
stem cells
Staining and Labeling
16 Citations

TAZ protein accumulation is negatively regulated by YAP abundance in mammalian cells

Finch-Edmondson, M. L., Strauss, R. P., Passman, A. M., Sudol, M., Yeoh, G. & Callus, B., 2015, In : Journal of Biological Chemistry. 290, 46, p. 27928-27938

Research output: Contribution to journalArticle

Protein Isoforms
Cells
Degradation
Long-Acting Thyroid Stimulator
Casein Kinase I
1 Citations

The synthesis and fluorescence profile of novel thalidomide analogues

Kampmann, S., Skelton, B., Yeoh, G., Abraham, L., Lengkeek, N. A., Stubbs, K., Heath, C. & Stewart, S., 21 Oct 2015, In : Tetrahedron. 71, 42, p. 8140-8149 10 p.

Research output: Contribution to journalArticle

Thalidomide
Fluorescence
Derivatives
Azides
Cycloaddition
2014

Dual-modality Imaging Needle for Combined Optical Coherence Tomography and Fluorescence Imaging of Fluorescently Labelled Tissue

Scolaro, L., Lorenser, D., Madore, W-J., Kramer, A., Yeoh, G., Godbout, N., Sampson, D., Boudoux, C. & Mclaughlin, R., 2014, Biomedical Optics 2014. United States: Optical Society of America, Vol. 1, p. BS2B.7 (1-3)

Research output: Chapter in Book/Conference paperConference paper

2 Citations

Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease

Logan, G. J., De Alencastro, G., Alexander, I. E. & Yeoh, G. C., 1 Jan 2014, In : International Journal of Biochemistry and Cell Biology. 56, p. 141-152 12 p.

Research output: Contribution to journalReview article

Gene therapy
Cell- and Tissue-Based Therapy
Genetic Therapy
Liver
Liver Diseases
29 Citations

Regulation of microRNAs and their role in liver development, regeneration and disease

Finch, M. L., Marquardt, J. U., Yeoh, G. & Callus, B., Sep 2014, In : International Journal of Biochemistry and Cell Biology. 54, p. 288-303

Research output: Contribution to journalReview article

Open Access
File
Liver Regeneration
MicroRNAs
Liver
Liver Diseases
Chronic Disease
2013
23 Citations

Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber

Yap, K. K., Dingle, A. M., Palmer, J. A., Dhillon, R. S., Lokmic, Z., Penington, A. J., Yeoh, G., Morrison, W. A. & Mitchell, G. M., 2013, In : Biomaterials. 34, p. 3992-4001

Research output: Contribution to journalArticle

7 Citations

Liver progenitor cell interactions with the extracellular matrix

Zhu, C., Coombe, D. R., Zheng, M., Yeoh, G. & Li, L., 2013, In : Journal of Tissue Engineering and Regenerative Medicine. 7, 10, p. 757-766

Research output: Contribution to journalReview article

2012

Characteristics of liver stem/progenitor cells and their relation to cancer: Response to inflammatory and cell death signals

Viebahn, C. S., Callus, B. & Yeoh, G. C. T., 1 Dec 2012, Molecular Aspects of Hepatocellular Carcinoma. Qiao, L., Li, Y., Yan, X. & George, J. (eds.). United Arab Emirates: Bentham Science Publishers, p. 67-79 13 p.

Research output: Chapter in Book/Conference paperChapter

Cell Death
Stem Cells
Liver
Neoplasms
Liver Neoplasms

Kupffer cells induce liver progenitor cell proliferation in response to CDE diet-induced liver injury

Elsegood, C., Olynyk, J. & Yeoh, G., 2012, Australian Gastroenterology Week. Australia, Vol. 27, p. 3

Research output: Chapter in Book/Conference paperConference paper

Liver Progenitor Cells, Cancer Stem Cells and Hepatocellular Carcinoma

Tirnitz-Parker, N., Yeoh, G. & Olynyk, J., 2012, Liver Regeneration. Baptista, P. M. (ed.). Croatia: InTech, p. 17-42

Research output: Chapter in Book/Conference paperChapter

15 Citations

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues

Puxbaum, V., Nimmerfall, E., Bäuerl, C., Taub, N., Blaas, P-M., Wieser, J., Mikula, M., Mikulits, W., Ng, K. M., Yeoh, G. & Mach, L., 2012, In : Journal of Hepatology. 57, p. 337-343

Research output: Contribution to journalArticle

Open Access
5 Citations

TNF-inducible expression of lymphotoxin-β in hepatic cells: An essential role for NF-κB and Ets1 transcription factors

Subrata, L. S., Voon, D. C., Yeoh, G., Ulgiati, D., Quail, E. & Abraham, L., 2012, In : Cytokine. 60, p. 498-504

Research output: Contribution to journalArticle

2011
12 Citations

Expansion and Hepatocytic Differentiation of Liver Progenitor Cells In Vivo Using a Vascularized Tissue Engineering Chamber in Mice

Forster, N., Palmer, J. A., Yeoh, G., Ong, W. C., Mitchell, G. M., Slavin, J., Tirnitz-Parker, N. & Morrison, W. A., 2011, In : Tissue Engineering. Part C. Methods. 17, 3, p. 1-8

Research output: Contribution to journalArticle

1 Citations

Preface

Yeoh, G., Barton, S. & Kaestner, K., 2011, In : International Journal of Biochemistry and Cell Biology. 43, 2, p. 172

Research output: Contribution to journalReview article

2010
4 Citations

Human Liver Progenitor Cell Lines Are Readily Established From Non-Tumorous Tissue Adjacent to Hepatocellular Carcinoma

Zhang, A., London, R., Schulz, F. M., Giguere-Simmonds, P. W. R., Delriviere, L., Chandraratana, H., Hardy, K., Zheng, S., Olynyk, J. & Yeoh, G., 2010, In : Stem Cells and Development. 19, 8, p. 1277-1284

Research output: Contribution to journalArticle

31 Citations

Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury

Viebahn, C., Benseler, V., Holz, L. E., Elsegood, C., Vo, M., Bertolino, P., Ganss, R. & Yeoh, G., 2010, In : Journal of Hepatology. 53, 3, p. 500-507

Research output: Contribution to journalArticle

99 Citations

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Is a Mitogen for Liver Progenitor Cells

Tirnitz-Parker, N., Viebahn, C., Jakubowski, A., Klopcic, B., Olynyk, J., Yeoh, G. & Knight, B., 2010, In : Hepatology. 52, 1, p. 291-302

Research output: Contribution to journalArticle

69 Citations

Uptake and cytotoxicity of chitosan nanoparticles in human liver cells

Loh, J. W., Yeoh, G., Saunders, M. & Lim, L. Y., 2010, In : Toxicology and Applied Pharmacology. 249, p. 148-157

Research output: Contribution to journalArticle

2009
69 Citations

An Akt/hypoxia-inducible factor-1αplatelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells

Lau, C. K., Yang, Z. F., Ho, D. W., Ng, M. N., Yeoh, G., Poon, R. T. P. & Fan, S. T., 2009, In : Clinical Cancer Research. 15, 10, p. 3462-3471

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocytes
Intercellular Signaling Peptides and Proteins
Stem Cells
Autocrine Communication
10 Citations
Antrodia
Cell proliferation
Biological Products
Maleic Anhydrides
Liver
2008
59 Citations

Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound

Jellicoe, M., Nichols, S. J., Callus, B. A., Baker, M., Barnard, P., Berners-Price, S., Whelan, J., Yeoh, G. & Filipovska, A., 2008, In : Carcinogenesis. 29, 6, p. 1124-1133

Research output: Contribution to journalArticle

Gold Compounds
Energy Metabolism
Stem Cells
Liver
Mitochondria
4 Citations

Bone marrow cells play only a very minor role in chronic liver regeneration induced by a choline-deficient, ethionine-supplemented diet

Tonkin, J., Knight, B., Curtis, D., Abraham, L. & Yeoh, G., 2008, In : Stem Cell Research. 1, 3, p. 195-204

Research output: Contribution to journalArticle

Ethionine
Liver Regeneration
Choline
Bone Marrow Cells
Diet
58 Citations

Liver stem cells: A scientific and clinical perspective

Dan, Y. Y. & Yeoh, G., 2008, In : Journal of Gastroenterology and Hepatology. 23, p. 687-698

Research output: Contribution to journalArticle

177 Citations

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα

Vince, J. E., Chau, D., Callus, B., Wong, WW-L., Hawkins, C. J., Schneider, P., Mckinlay, M., Benetatos, C. A., Condon, S. M., Chunduru, S. K., Yeoh, G., Brink, R., Vaux, D. L. & Silke, J., 2008, In : The Journal of Cell Biology. 182, 1, p. 171-184

Research output: Contribution to journalArticle

Open Access
Tumor Necrosis Factor-alpha
Apoptosis
Neoplasms
NF-kappa B
Inhibitor of Apoptosis Proteins
33 Citations
2007
56 Citations

Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice

Knight, B., Akhurst, B., Matthews, V. B., Ruddell, R. G., Ramm, G. A., Abraham, L., Olynyk, J. & Yeoh, G., 2007, In : Journal of Hepatology. 46, 1, p. 134-141

Research output: Contribution to journalArticle

Ethionine
Inbred Strains Mice
Choline
Stem Cells
Interferon-gamma
84 Citations
Ethionine
Nutrition
Choline
Liver
Hepatocytes
67 Citations

Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation

Yeoh, G., Ernst, M., Rose-John, S., Akhurst, B., Payne, C., Long, S., Alexander, W., Croker, B., Grail, D. & Matthews, V., 2007, In : Hepatology. 45, 2, p. 486-494

Research output: Contribution to journalArticle

Cell Movement
Stem Cells
Ethionine
Cell Proliferation
Choline
117 Citations

Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation

Nguyen, L. N., Furuya, M. H., Wolfraim, L. A., Nguyen, A. P., Holdren, M. S., Campbel, J. S., Knight, B., Yeoh, G., Fausto, N. & Parks, W. T., 2007, In : Journal of Hepatology. 45, 1, p. 31-41

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Hepatocytes
Cell Proliferation
Growth
Ethionine
2006
50 Citations

Antiproliferative Effects of Interferon Alpha on Hepatic Progenitor Cells In Vitro and In Vivo

Lim, R., Knight, B., Patel, K., Mchutchison, J. G., Yeoh, G. & Olynyk, J., 2006, In : Hepatology. 43, 5, p. 1074-1083

Research output: Contribution to journalArticle

Interferon-alpha
Hepatocytes
Stem Cells
Chronic Hepatitis C
Liver
16 Citations

Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells

Viebahn, C., Tirnitz-Parker, N., Olynyk, J. & Yeoh, G., 2006, In : European Journal of Cell Biology. 85, 12, p. 1265-1274

Research output: Contribution to journalArticle

Stem Cells
Liver
Intercellular Signaling Peptides and Proteins
Suspensions
Cell Culture Techniques