George Yeoh

Emeritus Professor, BSc PhD W.Aust.

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth


  • 4810 Citations
  • 37 h-Index
1974 …2022
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Personal profile


Professor George Yeoh completed his undergraduate science degree with honours and a PhD at The University of Western Australia. He then worked in Physiology at UWA for two years before winning the prestigious postdoctoral award CJ Martin Fellowship from the NH&MRC, which allowed him to study at The University of Pennsylvania in Philadelphia and The Beatson Institute for Cancer Research in Glasgow and then UWA for three years. Prof Yeoh then worked in Physiology at UWA for twenty years before accepting a position as Associate Professor in Biochemistry.

Roles and responsibilities

As well as researching and teaching, Prof Yeoh is also the Associate Dean for Research in the Faculty of Medicine, Dentistry and Health Sciences.

Funding overview

Cancer Council

Current projects

Professor Yeoh has sent his cell lines to 18 different laboratories around the world, including research institutes and universities in Australia, USA, Czechoslovakia, France, Germany, India, and China.


The incidence of liver disease in Australia is rising, along with obesity and hepatitis . In China alone there are over 120 million people infected with viral hepatitis. Professor Yeoh’s group were among the first to suggest the link between progenitor cells and liver cancer. Normally the liver is able to regenerate from injury, regrowing from hepatocytes. However, in diseases such as hepatitis B and alcoholism, where the liver has to continuously repair chronic damage, liver progenitor cells are used but this can result in cancer. This restricts the use of progenitor cells in therapy, so Professor Yeoh is currently trying to determine exactly what prompts good progenitor cells to turn cancerous. This is done by researching and comparing both tumerogenic and normal cells.

It is important to understand progenitor cells for although hepatocyte cells can be used in therapy, they are not as long lasting so they have limited applications. Using liver progenitor cell lines, it should be possible to create therapeutic bioreactors, such as liver dialysis machines. The next step is to use these cells in bio-artificial livers, and ultimately, to use them as cell therapy to replace the need for organ transplants. At the current rate of research, Professor Yeoh hopes to have therapeutic bioreactors in the next 4-5 years, artificial livers within 10 years and in-person therapy within the next 15-20 years.

By marking progenitor cells with fluorescent proteins, Professor Yeoh has been able to trace the development of the cells in mouse models. This technique will now be used to monitor the efficacy of treatment by cell therapy in mouse models for Wilsons’ disease and Methylmalonic aciduria (MMA).


  • Cancer—liver
  • Cytokines
  • Liver progenitor cells
  • Liver regeneration
  • Liver cancer stem cells

Fingerprint Dive into the research topics where George Yeoh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Hepatocytes Medicine & Life Sciences
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Choline Medicine & Life Sciences
Transferrin Medicine & Life Sciences
Liver Regeneration Medicine & Life Sciences

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Research Output 1974 2019

Human Amnion Epithelial Cell Therapy for Chronic Liver Disease

Andrewartha, N. & Yeoh, G., 7 Aug 2019, In : Stem Cells International. 2019, 10 p., 8106482.

Research output: Contribution to journalReview article

Open Access

Immune-mediated ECM depletion improves tumour perfusion and payload delivery

Yeow, Y. L., Kotamraju, V. R., Wang, X., Chopra, M., Azme, N., Wu, J., Schoep, T. D., Delaney, D. S., Feindel, K., Li, J., Kennedy, K. M., Allen, W. M., Kennedy, B. F., Larma, I., Sampson, D. D., Mahakian, L. M., Fite, B. Z., Zhang, H., Friman, T., Mann, A. P. & 11 othersAziz, F. A., Kumarasinghe, M. P., Johansson, M., Ee, H. C., Yeoh, G., Mou, L., Ferrara, K. W., Billiran, H., Ganss, R., Ruoslahti, E. & Hamzah, J., 11 Nov 2019, In : EMBO Molecular Medicine. e10923.

Research output: Contribution to journalArticle

Open Access
Extracellular Matrix
Tumor Necrosis Factor-alpha

Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation

Ferreira, N., Perks, K. L., Rossetti, G., Rudler, D. L., Hughes, L. A., Ermer, J. A., Scott, L. H., Kuznetsova, I., Richman, T. R., Narayana, V. K., Abudulai, L. N., Shearwood, A-M. J., Cserne Szappanos, H., Tull, D., Yeoh, G. C., Hool, L. C., Filipovska, A. & Rackham, O., 16 Dec 2019, In : The EMBO Journal. 38, 24, 19 p., e102155.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Cell Proliferation
29 Citations (Scopus)

A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma

Kabir, T. D., Ganda, C., Brown, R. M., Beveridge, D. J., Richardson, K. L., Chaturvedi, V., Candy, P., Epis, M., Wintle, L., Kalinowski, F., Kopp, C., Stuart, L. M., Yeoh, G. C., George, J. & Leedman, P. J., 1 Jan 2018, In : Hepatology. 67, 1, p. 216-231 16 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Proto-Oncogene Proteins c-akt
1-Phosphatidylinositol 4-Kinase
253 Downloads (Pure)
Stem Cells
Cell- and Tissue-Based Therapy

Projects 1996 2022