George Yeoh

Emeritus Professor, BSc PhD W.Aust.

  • The University of Western Australia (M519), 35 Stirling Highway, Room 259, Molecular and Chemical Sciences Building, Perth campus

    6009 Crawley

    Australia

  • The University of Western Australia (M503), 35 Stirling Highway, Room 259, Molecular and Chemical Sciences Building, Perth campus

    6009 Crawley

    Australia

  • 3498 Citations
  • 33 h-Index
1992 …2018
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Personal profile

Biography

Professor George Yeoh completed his undergraduate science degree with honours and a PhD at The University of Western Australia. He then worked in Physiology at UWA for two years before winning the prestigious postdoctoral award CJ Martin Fellowship from the NH&MRC, which allowed him to study at The University of Pennsylvania in Philadelphia and The Beatson Institute for Cancer Research in Glasgow and then UWA for three years. Prof Yeoh then worked in Physiology at UWA for twenty years before accepting a position as Associate Professor in Biochemistry.

Roles and responsibilities

As well as researching and teaching, Prof Yeoh is also the Associate Dean for Research in the Faculty of Medicine, Dentistry and Health Sciences.

Funding overview

Cancer Council
NH&MRC

Current projects

Professor Yeoh has sent his cell lines to 18 different laboratories around the world, including research institutes and universities in Australia, USA, Czechoslovakia, France, Germany, India, and China.

Research

The incidence of liver disease in Australia is rising, along with obesity and hepatitis . In China alone there are over 120 million people infected with viral hepatitis. Professor Yeoh’s group were among the first to suggest the link between progenitor cells and liver cancer. Normally the liver is able to regenerate from injury, regrowing from hepatocytes. However, in diseases such as hepatitis B and alcoholism, where the liver has to continuously repair chronic damage, liver progenitor cells are used but this can result in cancer. This restricts the use of progenitor cells in therapy, so Professor Yeoh is currently trying to determine exactly what prompts good progenitor cells to turn cancerous. This is done by researching and comparing both tumerogenic and normal cells.

It is important to understand progenitor cells for although hepatocyte cells can be used in therapy, they are not as long lasting so they have limited applications. Using liver progenitor cell lines, it should be possible to create therapeutic bioreactors, such as liver dialysis machines. The next step is to use these cells in bio-artificial livers, and ultimately, to use them as cell therapy to replace the need for organ transplants. At the current rate of research, Professor Yeoh hopes to have therapeutic bioreactors in the next 4-5 years, artificial livers within 10 years and in-person therapy within the next 15-20 years.

By marking progenitor cells with fluorescent proteins, Professor Yeoh has been able to trace the development of the cells in mouse models. This technique will now be used to monitor the efficacy of treatment by cell therapy in mouse models for Wilsons’ disease and Methylmalonic aciduria (MMA).

Keywords

  • Cancer—liver
  • Cytokines
  • Liver progenitor cells
  • Liver regeneration
  • Liver cancer stem cells

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1996 2018

Research Output 1992 2018

3 Citations

A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma

Kabir, T. D., Ganda, C., Brown, R. M., Beveridge, D. J., Richardson, K. L., Chaturvedi, V., Candy, P., Epis, M., Wintle, L., Kalinowski, F., Kopp, C., Stuart, L. M., Yeoh, G. C., George, J. & Leedman, P. J. 1 Jan 2018 In : Hepatology. 67, 1, p. 216-231 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Hepatocellular Carcinoma
Growth
Proto-Oncogene Proteins c-akt
1-Phosphatidylinositol 4-Kinase
File
Carcinogenesis
Stem Cells
Liver
Cell- and Tissue-Based Therapy
Population

Functional significance of TRIM35 In haematopoietic and hepatic homeostasis

Van Vuuren, J. H. 2018 (Unpublished)

Research output: ThesisDoctoral Thesis

File
Liver Neoplasms
Homeostasis
Inflammation
Ubiquitin-Protein Ligases
Liver

InForm software: A semi-Automated research tool to identify presumptive human hepatic progenitor cells, and other histological features of pathological significance

Kramer, A. S., Latham, B., Diepeveen, L. A., Mou, L., Laurent, G. J., Elsegood, C., Ochoa-Callejero, L. & Yeoh, G. C. 1 Dec 2018 In : Scientific Reports. 8, 1, 3418

Research output: Contribution to journalArticle

Open Access
Hepatocytes
Stem Cells
Software
Liver Diseases
Research
Open Access
Extracellular Matrix Proteins
Hepatocytes
Stem Cells
Serum
Liver