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Personal profile

Research interests

With an interdisciplinary background in theoretical physics and microbiology, my research interests cover a broad spectrum of dynamic regulatory processes in living organisms. These include:

  • Mechanisms and regulation of antimicrobial resistance
  • Design and implementation of synthetic genetic circuits in bacteria
  • Computational modelling of biological networks
  • Single molecule dynamics in living cells
  • Co-evolution of protein-protein interaction interfaces

Biography

In 2012 I completed my PhD in theoretical physics at the Ludwigs-Maximilians University Munich, where I worked together with Prof. Ulrich Gerland on theoretical models of gene regulatory circuits, with a particular focus on the regulation of bacterial stress responses. From 2012-2014 I became a Postdoctoral fellow at the Biocenter in Munich in the laboratory of Prof. Thorsten Mascher, where I shifted focus to experimental work on antibiotic resistance mechanisms in Gram-positive bacteria. In 2014 I was appointed as research group leader at the LOEWE Center for Synthetic Microbiology in Marburg, Germany, which allowed me to build an interdisciplinary research profile focussed on systems and synthetic biology approaches to break antimicrobial resistance. Since 2019 I am pursuing this line of research as a ‘Be Inspired’ Senior Lecturer for Synthetic Biology at the School of Molecular Sciences.

Funding overview

Funding

2015-2019  German Research Foundation (DFG), Grant (FR 3673/1-2) awarded in the framework of the priority program SPP1617 (awarded funds: 200 k€)

2015-2019  Federal Ministry of Education and Research (BMBF), Grant awarded in the 2nd ERASynBio joint call for transnational research projects (awarded funds: 185 k€; total project budget 2.4 M€)

2012  DFG start-up grant through the priority program SPP 1617 (awarded funds: 10 k€)

 

Awards

2019  “Initiative Biotechnologie und Nanotechnologie e.V.”, Honouring Award to the iGEM-Team Marburg 2018 (awarded funds: 10k€)

2018  International Genetically Engineered Machine (iGEM) competition (Team Marburg), Grand Prize Winner Over-graduates, Best Basic Part Award, Best New Composite Part Award, Best Part Collection Award

2012  International Genetically Engineered Machine (iGEM) competition (Team LMU Munich), Finalist, Best New Application Award, Best Wiki Award

2008  Center for NanoScience (CeNS) Publication Award, Germany (awarded funds: 2k€)

Education/Academic qualification

Theoretical Physics, Dr., Ludwig-Maximilians University Munich

… → 2012

External positions

Group leader for Quantitative and Computational Microbiology, LOEWE Center for Synthetic Microbiology, University of Marburg

20142019

Postdoctoral Fellow, Department of Biology I, Ludwig-Maximilians University Munich

20122014

Keywords

  • Bioinformatics
  • Bioengineering
  • Drug Discovery
  • Antimicrobial resistance
  • Synthetic biology
  • Systems biology
  • Computational Biology
  • Mathematical modeling

Fingerprint Dive into the research topics where Georg Fritz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Bacillus subtilis Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cell Wall Medicine & Life Sciences
Microbial Drug Resistance Medicine & Life Sciences
Bacitracin Medicine & Life Sciences
Bacteria Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2019

  • 469 Citations
  • 13 h-Index
  • 32 Article
  • 2 Conference paper
  • 2 Review article
  • 1 Comment/debate
24 Downloads (Pure)

BceAB-type antibiotic resistance transporters appear to act by target protection of cell wall synthesis

Kobras, C. M., Piepenbreier, H., Emenegger, J., Sim, A., Fritz, G. & Gebhard, S., 11 Nov 2019, In : bioRxiv.

Research output: Contribution to journalArticle

Open Access
File
Microbial Drug Resistance
Cell Wall
Peptides
Pharmaceutical Preparations
Gram-Positive Bacteria
Open Access
Escherichia coli
Cloning
Plasmids
Networks (circuits)
Organism Cloning
1 Citation (Scopus)

Deconvolution of Luminescence Cross-Talk in High-Throughput Gene Expression Profiling

Mauri, M., Vecchione, S. & Fritz, G., 21 Jun 2019, In : ACS Synthetic Biology. 8, 6, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Deconvolution
Luminescence
Luciferases
Gene expression

From modules to networks: A systems-level analysis of the bacitracin stress response in Bacillus subtilis

Piepenbreier, H., Sim, A., Kobras, C. M., Radeck, J., Mascher, T., Gebhard, S. & Fritz, G., 1 Jan 2019, bioRxiv.

Research output: Contribution to specialist publicationArticle

File
Bacitracin
Bacillus subtilis
Bacterial Drug Resistance
Anti-Bacterial Agents
Cell Wall

Heterogeneous Timing of Gene Induction as a Regulation Strategy

Fritz, G., Walker, N. & Gerland, U., 1 Jan 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

Open Access
Genes
Proteins
Population
Starvation
Cell Survival