Research output per year
Research output per year
Dr
The University of Western Australia (M310), 35 Stirling Highway,
6009 Perth
Australia
Georg is a physicist with a strong interest in synthetic microbiology and works as a Senior Lecturer at the UWA School of Molecular Sciences. He completed his PhD in theoretical physics in 2012 at the Ludwigs-Maximilians University Munich, where he worked on theoretical models of gene regulatory circuits, with a particular focus on the regulation of bacterial stress responses. Georg then became a Postdoctoral fellow at the Biocenter in Munich, where he shifted focus to experimental work on antibiotic resistance mechanisms in Gram-positive bacteria. In 2014 he was appointed as a research group leader at the SYNMIKRO Center for Synthetic Microbiology in Marburg, Germany, which allowed him to build an interdisciplinary research profile focused on systems and synthetic biology approaches to break antimicrobial resistance. Since 2019 he has been pursuing this, as well as new lines of research on microbial plastic degradation and bioplastic production, as a ‘Be Inspired’ Senior Lecturer for Synthetic Biology at UWA.
Please visit his lab website at http://www.fritz-lab.org
With an interdisciplinary background in theoretical physics and microbiology, Georg's research interests cover a broad spectrum of regulatory processes and metabolic networks in living organisms. These include:
Selected publications
Stukenberg D., Hensel T., Hoff J., Daniel B., Inckemann R., Tedeschi J.N., Nousch F., and Fritz G. (2021) The Marburg Collection: A Golden Gate DNA Assembly Framework for Synthetic Biology Applications in Vibrio natriegens. ACS Synth. Biol. 10, 1904–1919
Casas-Pastor D., Müller R.R., Becker A., Buttner M., Gross C., Mascher T., Goesmann A., and Fritz G. (2021), Expansion and re-classification of the extracytoplasmic function (ECF) σ factor family. Nucl. Acids Res. 49, 986-1005
Iyer S.C., Casas-Pastor D., Kraus D., Mann P., Schirner K., Glatter T., Fritz G., Ringgaard S. (2020), Transcriptional regulation by σ-factor phosphorylation in bacteria. Nat. Microbiol. 5, 395–406
Piepenbreier H., Diehl A., and Fritz G. (2019), Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance. Nat. Comm., 10, 2733
Pinto D.*, Vecchione S.*, Wu H., Mauri M., Mascher T., and Fritz G. (2018), Engineering orthogonal synthetic timer circuits based on extracytoplasmic function σ factors. Nucl. Acids Res. 46, 7450–7464
Funding
2024 – 2027. Hwa T., van Teeffelen S., Pilizota, T., Fritz G. (2024) Elucidating physio-chemical forces setting the limit of bacterial growth. Human Frontier Science Program, Research Grant (RGP013/2024) (US$1,500k)
2024–2028. Fritz G., Establishing Vibrio natriegens as Ultra-Rapid Host for Synthetic Biology. Australian Research Council (ARC), Future Fellowship Level 2 (FT230100283) (AU$972k)
2023–2027. Fritz G., Low P., Iyer K.-S., Chooi Y.-H., Euler C., Taylor N., Koutsantonis G., Joshi, J. Building a carbon dioxide foundry for sustainable carbon capture and utilisation. Australian Research Council (ARC), Woodside Energy Ltd., Linkage Project (LP220100185) (AU$1,607k)
2023–2026. Fritz G., Gebhard S. Synthetic biology tools for just-in-time control of biosynthetic pathways. Australian Research Council (ARC), Discovery Project (DP230103107) (AU$459k)
2022–2023. Fritz G., Fae Neto W., Tomkins J., Waters M., Ludwig M., Taylor N., Chooi Y.-H. (2022) Exploring microalgae candidates and farming methods for CO2 sequestration and valorisation. OceanWorks Prototyping Project, Woodside FutureLabs Network ($10k)
2022-2023. Fritz G., Waters M., Chooi Y.-H., Millar H., Bond C., Low P., Stubbs K., Moggach, S. Towards building a carbon dioxide foundry, Woodside Energy Ltd. ($371k)
2021–2022. Fritz G. VibrioPET: Engineering the ultra-fast growing marine bacterium Vibrio natriegens into a microbial platform for rapid bio-degradation of polyethylene terephthalate (PET) plastics, Woodside Energy Ltd. ($30k)
2021-2022. Y.-H. Chooi, S. Abraham, P. Kaur, G. Flematti, M. O’Dea, G. Fritz, R. Abraham, COVIDexpress: High-throughput platform for screening of drugs to treat COVID-19 and rapid diagnosis, Future Health Research and Innovation (FHRI) Focus Grant ($862k)
2021-2023. Waters M., Flemmatti G., Fritz G., From energy stress to hormones: new signals in bacteria and plants. Australian Research Council (ARC), Discovery Project (DP210103078) ($462k)
2015-2019. Fritz G., Heterogeneous cell wall homeostasis as a survival strategy in stationary phase: balancing cell growth, antibiotic production, and envelope stress response in Bacillus subtilis, German Research Foundation (DFG), SPP1617 priority program (FR 3673/1-2) (€200k)
2015-2019. Becker A., Fritz G. and Goesmann A., ECFexpress: An orthogonal, organism-independent expression platform based on extracytoplasmic function (ECF) sigma factors, Federal Ministry of Education and Research (BMBF), ERASynBio transnational research project (031L0010B) (€828k)
2012. Fritz G., Temporal heterogeneity of gene induction in the BceRS-BceAB system of Bacillus subtilisGerman Research Foundation (DFG), Start-up grant (€10k)
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Theoretical Biophysics, Dr, Ludwig Maximilian University of Munich
… → 2012
Group leader for Quantitative and Computational Microbiology, LOEWE Center for Synthetic Microbiology, Philipps-Universität Marburg
2014 → 2019
Postdoctoral Fellow, Department of Biology I, Ludwig Maximilian University of Munich
2012 → 2014
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Letter › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator) & Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020
DOI: 10.1038/s41564-019-0648-6, https://static-content.springer.com/esm/art%3A10.1038%2Fs41564-019-0648-6/MediaObjects/41564_2019_648_MOESM10_ESM.pdf
Dataset
Casas-Pastor, D. (Creator), Müller, R. R. (Creator), Jaenicke, S. (Creator), Brinkrolf, K. (Creator), Becker, A. (Creator), Buttner, M. J. (Creator), Gross, C. A. (Creator), Mascher, T. (Creator), Goesmann, A. (Creator) & Fritz, G. (Creator), Zenodo, 2020
DOI: 10.5281/zenodo.3672545, https://zenodo.org/api/records/3672545
Dataset
Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator) & Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020
DOI: 10.1038/s41564-019-0648-6, https://static-content.springer.com/esm/art%3A10.1038%2Fs41564-019-0648-6/MediaObjects/41564_2019_648_MOESM8_ESM.pdf
Dataset
Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator) & Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020
DOI: 10.1038/s41564-019-0648-6, https://static-content.springer.com/esm/art%3A10.1038%2Fs41564-019-0648-6/MediaObjects/41564_2019_648_MOESM7_ESM.pdf
Dataset
Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator) & Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020
DOI: 10.1038/s41564-019-0648-6, https://static-content.springer.com/esm/art%3A10.1038%2Fs41564-019-0648-6/MediaObjects/41564_2019_648_MOESM4_ESM.treefile
Dataset
Hwa, T., van Teeffelen, S., Pilizota, T. & Fritz, G.
Human Frontier Science Program (HFSP)
1/09/24 → 1/09/27
Project: Research
ARC Australian Research Council
1/03/24 → 28/02/28
Project: Research
Fritz, G., Low, P., Swaminatha Iyer, K., Chooi, H., Euler, C., Koutsantonis, G., Taylor, N. & Joshi, J.
ARC Australian Research Council
1/06/23 → 1/06/27
Project: Research
Bond, C., Vrielink, A., Fox, A., Stubbs, K., Kahler, C., Smith, N., Kretzmann, J., Evans, C., Marshall, A., Smithers, L., Debowski, A., Bzdyl, N., Chooi, H., Fritz, G., Small, I., Lesterhuis, W., Piggott, M. & Sarkar-Tyson, M.
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
Bond, C., Vrielink, A., Fox, A., Stubbs, K., Kahler, C., Smith, N., Kretzmann, J., Marshall, A., Evans, C., Smithers, L., Debowski, A., Bzdyl, N., Chooi, H., Fritz, G., Small, I., Lesterhuis, W., Sarkar-Tyson, M. & Piggott, M.
NHMRC National Health and Medical Research Council
31/03/23 → 31/10/24
Project: Research
Fritz, Georg (Recipient), 1 Mar 2024
Prize: Fellowship
Fritz, Georg (Recipient), 12 Mar 2021
Prize: Award
Georg Fritz (Chair)
Activity: Conferences and workshops › Contribution or participation in a conference
Georg Fritz (Advisor)
Activity: Industry and government engagement/consultancy › Providing continuing professional development to industry/government/community
Georg Fritz (Consultant)
Activity: Industry and government engagement/consultancy › Providing continuing professional development to industry/government/community
Georg Fritz (Member)
Activity: Memberships › Membership of committee
Georg Fritz, Peter Arthur, Monika Murcha, Ian Small & Heng Chooi 1/08/22 → … |
Course
Georg Fritz, Heng Chooi, Ryan Lister & Ian Small 27/07/20 → … |
Course
12/03/24
1 Media contribution
Press/Media: Press / Media
25/01/24
1 Media contribution
Press/Media: Press / Media
Georg Fritz, Paul Low, Heng Chooi, Killugudi Swaminatha Iyer, Nic Taylor, George Koutsantonis & Jitendra Joshi
8/02/23
1 Media contribution
Press/Media: Press / Media