• The University of Western Australia (M310), 35 Stirling Highway,

    6009 Perth

    Australia

  • 547 Citations
  • 13 h-Index
20042020

Research output per year

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Personal profile

Research interests

With an interdisciplinary background in theoretical physics and microbiology, my research interests cover a broad spectrum of dynamic regulatory processes in living organisms. These include:

  • Mechanisms and regulation of antimicrobial resistance
  • Design and implementation of synthetic genetic circuits in bacteria
  • Computational modelling of biological networks
  • Single molecule dynamics in living cells
  • Co-evolution of protein-protein interaction interfaces

Biography

In 2012 I completed my PhD in theoretical physics at the Ludwigs-Maximilians University Munich, where I worked together with Prof. Ulrich Gerland on theoretical models of gene regulatory circuits, with a particular focus on the regulation of bacterial stress responses. From 2012-2014 I became a Postdoctoral fellow at the Biocenter in Munich in the laboratory of Prof. Thorsten Mascher, where I shifted focus to experimental work on antibiotic resistance mechanisms in Gram-positive bacteria. In 2014 I was appointed as research group leader at the LOEWE Center for Synthetic Microbiology in Marburg, Germany, which allowed me to build an interdisciplinary research profile focussed on systems and synthetic biology approaches to break antimicrobial resistance. Since 2019 I am pursuing this line of research as a ‘Be Inspired’ Senior Lecturer for Synthetic Biology at the School of Molecular Sciences.

Funding overview

Funding

2015-2019  German Research Foundation (DFG), Grant (FR 3673/1-2) awarded in the framework of the priority program SPP1617 (awarded funds: 200 k€)

2015-2019  Federal Ministry of Education and Research (BMBF), Grant awarded in the 2nd ERASynBio joint call for transnational research projects (awarded funds: 185 k€; total project budget 2.4 M€)

2012  DFG start-up grant through the priority program SPP 1617 (awarded funds: 10 k€)

 

Awards

2019  “Initiative Biotechnologie und Nanotechnologie e.V.”, Honouring Award to the iGEM-Team Marburg 2018 (awarded funds: 10k€)

2018  International Genetically Engineered Machine (iGEM) competition (Team Marburg), Grand Prize Winner Over-graduates, Best Basic Part Award, Best New Composite Part Award, Best Part Collection Award

2012  International Genetically Engineered Machine (iGEM) competition (Team LMU Munich), Finalist, Best New Application Award, Best Wiki Award

2008  Center for NanoScience (CeNS) Publication Award, Germany (awarded funds: 2k€)

Education/Academic qualification

Theoretical Physics, Dr., Ludwig Maximilian University of Munich

… → 2012

External positions

Group leader for Quantitative and Computational Microbiology, LOEWE Center for Synthetic Microbiology, University of Marburg

20142019

Postdoctoral Fellow, Department of Biology I, Ludwig Maximilian University of Munich

20122014

Research expertise keywords

  • Antimicrobial resistance
  • Synthetic biology
  • Systems biology
  • Microbial stress responses
  • Gene regulatory networks
  • Sigma factors
  • Computational Biology
  • Mathematical modeling
  • Bioengineering
  • Biostatistical methods
  • Differential equations
  • Stochastic processes
  • Nonlinear dynamics
  • Antibiotics
  • Antimicrobial compounds
  • Biosynthetic pathways
  • Cell wall biosynthesis
  • Lipid II cycle
  • Peptidoglycan
  • Metabolism

Industry keywords

  • Bioengineering
  • Bioinformatics
  • Drug Discovery
  • Medicine and Pharma

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Research Output

BceAB-type antibiotic resistance transporters appear to act by target protection of cell wall synthesis

Kobras, C. M., Piepenbreier, H., Emenegger, J., Sim, A., Fritz, G. & Gebhard, S., 2020, In : Antimicrobial Agents and Chemotherapy. 64, 3, e02241-19.

Research output: Contribution to journalArticle

Open Access
  • 2 Citations (Scopus)

    From Modules to Networks: a Systems-Level Analysis of the Bacitracin Stress Response in Bacillus subtilis

    Piepenbreier, H., Sim, A., Kobras, C. M., Radeck, J., Mascher, T., Gebhard, S. & Fritz, G., 2020, In : mSystems. 5, 1, e00687-19.

    Research output: Contribution to journalArticle

    Open Access

    Gene regulation by extracytoplasmic function (ECF) σ factors in alpha-rhizobia

    Meier, D., Casas-Pastor, D., Fritz, G. & Becker, A., 2020, In : Advances in Botanical Research. 94, p. 289-321

    Research output: Contribution to journalArticle

  • Transcriptional regulation by σ factor phosphorylation in bacteria

    Iyer, S. C., Casas-Pastor, D., Kraus, D., Mann, P., Schirner, K., Glatter, T., Fritz, G. & Ringgaard, S., 2020, In : Nature Microbiology. 24 p.

    Research output: Contribution to journalLetter

  • Vibrio natriegens: An ultrafast‐growing marine bacterium as emerging synthetic biology chassis

    Hoff, J., Daniel, B., Stukenberg, D., Thuronyi, B. W., Waldminghaus, T. & Fritz, G., 14 Jun 2020, In : Environmental Microbiology.

    Research output: Contribution to journalArticle

  • Datasets

    Source Data Fig. 2: Transcriptional regulation by σ factor phosphorylation in bacteria

    Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator), Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020

    Dataset

    Source Data Fig. 1: Transcriptional regulation by σ factor phosphorylation in bacteria

    Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator), Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020

    Dataset

    Source Data Fig. 4: Transcriptional regulation by σ factor phosphorylation in bacteria

    Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator), Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020

    Dataset

    Supplementary Data 2: Transcriptional regulation by σ factor phosphorylation in bacteria

    Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator), Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020

    Dataset

    Supplementary Data 3: Transcriptional regulation by σ factor phosphorylation in bacteria

    Iyer, S. C. (Creator), Casas-Pastor, D. (Creator), Kraus, D. (Creator), Mann, P. (Creator), Schirner, K. (Creator), Glatter, T. (Creator), Fritz, G. (Creator), Ringgaard, S. (Creator), Springer Nature, 27 Jan 2020

    Dataset