Geoff Laurent

Professor, BSc PhD W.Aust., FRCP(Hon), FRCPath, FMedSci

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Crawley

    Australia

  • 420 Citations
  • 10 h-Index
20082022
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Personal profile

Biography

Professor Geoffrey Laurent is the Director of the Centre for Cell Therapy and Regenerative Medicine at the University of Western Australia and an Honorary Fellow at University College London.

Roles and responsibilities

Prior to his appointment at the University of Western Australia in June 2012 he was the Vice-Dean of Enterprise and Head of the Department of Internal Medicine at University College London. Geoff has published over 300 peer reviewed articles in international journals of biomedical research and was awarded the European Respiratory Societies Presidential Award for his contribution to lung science. He is the Editor-in-Chief of the International Journal of Biochemistry and Cell Biology and has edited several books including a four volume Encyclopaedia of Respiratory Medicine. He is a Fellow of the Academy of Medical Sciences and Past President of the British Association for Lung Research.

Professor Laurent is also on the following editorial boards.

• Editor-in-Chief, International Journal of Biochemistry and Cell Biology (1994- present)
• Associate Editor, American Journal of Respiratory Cell and Molecular Biology (2002- present)
• British Lung Foundation, Member of Scientific Committee (1997-2000)
• Advisory Board for Biochemical Journal (1984-1989), The Biochemical Society, Great Britain,
• Associate Editor of Journal (Thorax) (1992-1996), British Thoracic Society
• Advisory Board (Thorax) (1992- present), British Thoracic Society
• Editorial Board of Molecular Aspects of Medicine (1992-1996)

Funding overview

• Professor Laurent has raised over $5,000,000 to support the development of the Centre for Cell Therapy and Regenerative Medicine.

• When at University College London in the United Kingdom (that is prior to June 2012) - Professor Laurent had grants from British government, charities and industries totalling £10,839,895 million This includes awards from the Medical Research Council of £2,853,270), the Wellcome Trust (awards including a Programme Grant) of £1,869,122 and over £6 million from industry and smaller charities.

Teaching overview

Geoff’s experience in course development and teaching at all levels of education includes teaching general biochemistry and molecular biology courses, through to supervising studies towards higher degrees. When at University College of London post-graduate degrees have to-date been awarded to 47 students (four MDs, five MSc’s, 38 PhDs). He has written and established undergraduate courses in general biochemistry and organized many international meetings. Currently at CCTRM Geoff is a joint coordinating supervisor for one PhD student.

Research

Professor Laurent has pioneered studies to assess matrix structure and turnover in the lung, demonstrating for the first time the diversity of matrix components and how rapidly they turned over. These studies changed our concepts on the dynamic nature of matrix and how changes in turnover lead to disease states. He has lead investigations of the role of extracellular matrix proteins in tissue growth and regeneration, including the role of mechanical forces in driving tissue growth and cell signalling networks. Professor Laurent has lead the development of the cell and molecular biology programme investigating key mediators regulating inflammation and tissue remodelling. He has also made discoveries relating to the key cytokines and proteases regulating fibroblast function as well as lipid mediators as inhibitors of cell function in respiratory disorders. These studies have led to new approaches in the pharmaceutical sector.

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Projects 2014 2022

Research Output 2008 2018

InForm software: A semi-Automated research tool to identify presumptive human hepatic progenitor cells, and other histological features of pathological significance

Kramer, A. S., Latham, B., Diepeveen, L. A., Mou, L., Laurent, G. J., Elsegood, C., Ochoa-Callejero, L. & Yeoh, G. C. 1 Dec 2018 In : Scientific Reports. 8, 1, 3418

Research output: Contribution to journalArticle

Open Access
Hepatocytes
Stem Cells
Software
Liver Diseases
Research
2 Citations

Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability

Pilyugin, M., André, P. A., Ratajska, M., Kuzniacka, A., Limon, J., Tournier, B. B., Colas, J., Laurent, G. & Irminger-Finger, I. 2017 In : Oncotarget. 8, 6, p. 9339-9353 15 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Chromosomal Instability
Cell Cycle Checkpoints
Telomere-Binding Proteins
Neoplasms
4 Citations

BARD1 serum autoantibodies for the detection of lung cancer

Pilyugin, M., Descloux, P., André, P. A., Laszlo, V., Dome, B., Hegedus, B., Sardy, S., Janes, S., Bianco, A., Laurent, G. J. & Irminger-Finger, I. 7 Aug 2017 In : PLoS ONE. 12, 8, e0182356

Research output: Contribution to journalArticle

Open Access
autoantibodies
lung neoplasms
blood serum
Autoantibodies
Tomography

Circulating BARD1 Antibodies for Early Detection of Lung Cancer

Irminger-Finger, I., Pilyugin, M., Bianco, A., Hegedus, B., Sardy, S., Descloux, P. & Laurent, G. Jan 2017 In : Journal of Thoracic Oncology. 12, 1, p. S623-S623 1 p.

Research output: Contribution to journalAbstract/Meeting Abstract

Diabetes: Present and future

Irminger-Finger, I., Kargul, J. & Laurent, G. J. 1 Jul 2017 In : International Journal of Biochemistry and Cell Biology. 88, p. 196 1 p.

Research output: Contribution to journalEditorial