• The University of Western Australia (M313), 35 Stirling Highway, Room 417, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 2772 Citations
  • 27 h-Index
20012020
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Personal profile

Biography

Dr Gavin Flematti completed his undergraduate and PhD studies at UWA, followed by post-doctoral studies and a prestigious Australian Future Fellowship award at UWA. He currently holds a teaching and research position in the School of Chemistry and Biochemistry at UWA.

Funding overview

ARC Discovery Grants
ARC Linkage Grant
ARC Future Fellowship

Current projects

Collaborators

Dr Kingsley Dixon, Kings Park and Botanic Garden
Dr David Merritt, Kings Park and Botanic Garden
Dr Jason Stephens, Kings Park and Botanic Garden
A/Prof Emilio Ghisalberti, Chemistry UWA
Prof Steven Smith, UWA
Dr David Nelson, University of Georgia, USA
A/Prof Rob Trengove, Murdoch University

Teaching overview

CHEM2001 Core Chemical Concepts and Techniques
CHEM2003 Chemical Synthesis
MSCI4006 Advanced Techniques in Molecular Sciences

Research

Natural Products and Chemical Ecology

The primary research interest in the Flematti Lab is the isolation and identification of bioactive natural products. The specific activity of these compounds ranges from antibacterial and anticancer activity, through to organism defence and chemical communication. As well as traditional natural product extraction and isolation, we make use of sophisticated analytical instruments including HPLC, GC-MS, HPLC-MS and more recently GC-EAD/MS, to aid in the detection and isolation of bioactive compounds, which are characterised using NMR spectroscopy and high resolution MS techniques. Depending on the structure and function, interesting compounds are confirmed through chemical synthesis.

Keywords

  • Natural products and chemical ecology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2007 2020

Research Output 2001 2018

  • 2772 Citations
  • 27 h-Index
  • 81 Article
  • 4 Review article
  • 3 Chapter
  • 1 Conference paper
1 Citations

An allelic series at the KARRIKIN INSENSITIVE 2 locus of Arabidopsis thaliana decouples ligand hydrolysis and receptor degradation from downstream signalling

Yao, J., Mashiguchi, K., Scaffidi, A., Akatsu, T., Melville, K. T., Morita, R., Morimoto, Y., Smith, S. M., Seto, Y., Flematti, G. R., Yamaguchi, S. & Waters, M. T., 1 Oct 2018, In : Plant Journal. 96, 1, p. 75-89 15 p.

Research output: Contribution to journalArticle

Arabidopsis
Hydrolysis
Arabidopsis thaliana
hydrolysis
Ligands

An Artificial Yeast Genetic Circuit Enables Deep Mutational Scanning of an Antimicrobial Resistance Protein

Scott, L. H., Mathews, J. C., Flematti, G. R., Filipovska, A. & Rackham, O., 17 Aug 2018, In : ACS Synthetic Biology. 7, 8, p. 1907-1917 11 p.

Research output: Contribution to journalArticle

Antibiotics
Tetracycline
Yeast
Flavin-Adenine Dinucleotide
Yeasts

Antibacterial compounds from the Australian native plant Eremophila glabra

Algreiby, A. A., Hammer, K. A., Durmic, Z., Vercoe, P. & Flematti, G. R., 1 Apr 2018, In : Fitoterapia. 126, p. 45-52 8 p.

Research output: Contribution to journalArticle

Eremophila Plant
Microbial Sensitivity Tests
Acids
Staphylococcus epidermidis
Flavonoids

Aurantoside C Targets and Induces Apoptosis in Triple Negative Breast Cancer Cells

Shrestha, S., Sorolla, A., Fromont, J., Blancafort, P. & Flematti, G. R., 1 Oct 2018, In : Marine Drugs. 16, 10

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Apoptosis
p38 Mitogen-Activated Protein Kinases
Breast Neoplasms
Doxorubicin