Fiona Pixley

Associate Professor, MB BS W.Aust., DPhil Oxf., MRCP(UK)

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth

    Australia

  • 4074 Citations
  • 28 h-Index
1985 …2018
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Research Output 1985 2018

  • 4074 Citations
  • 28 h-Index
  • 42 Article
  • 6 Chapter
  • 3 Review article
  • 1 Non-UWA Thesis
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Article
2018

F2-isoprostanes affect macrophage migration and CSF-1 signalling

Proudfoot, J. M., Murrey, M. W., McLean, S., Greenland, E. L., Barden, A. E., Croft, K. D., Galano, J. M., Durand, T., Mori, T. A. & Pixley, F. J., 8 Aug 2018, In : Free Radical Biology & Medicine. 126, p. 142-152 11 p.

Research output: Contribution to journalArticle

F2-Isoprostanes
Macrophage Colony-Stimulating Factor
Macrophages
Adhesion
Paxillin

Macrophage depletion in elderly mice improves response to tumor immunotherapy, increases anti-tumor T cell activity and reduces treatment-induced cachexia

Duong, L., Radley-Crabb, H. G., Gardner, J. K., Tomay, F., Dye, D. E., Grounds, M. D., Pixley, F. J., Nelson, D. J. & Jackaman, C., 6 Nov 2018, In : Frontiers in Genetics. 9, 14 p., 526.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Carter, K. W., Keane, K. N., Newsholme, P., Goodridge, H. S., Pixley, F. J. & Hart, P. H., 1 Jan 2018, In : Journal of Immunology. 200, 1, p. 260-270

Research output: Contribution to journalArticle

Chemotactic Factors
Bone Marrow
Macrophages
Macrophage Colony-Stimulating Factor
Inflammation
2017
2 Citations (Scopus)
43 Downloads (Pure)

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Keane, K. N., Newsholme, P., Goodridge, H. S., Zon, L. I., Pixley, F. J. & Hart, P. H., Dec 2017, In : Experimental Hematology. 56, p. 64-68

Research output: Contribution to journalArticle

Open Access
File
16,16-Dimethylprostaglandin E2
Dinoprostone
Bone Marrow Cells
Cell Movement
Monocytes
2 Citations (Scopus)

UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic Cells

McGonigle, T. A., Keane, K. N., Ghaly, S., Carter, K. W., Anderson, D., Scott, N. M., Goodridge, H. S., Dwyer, A., Greenland, E., Pixley, F. J., Newsholme, P. & Hart, P. H., 1 Sep 2017, In : American Journal of Pathology. 187, 9, p. 2046-2059 14 p.

Research output: Contribution to journalArticle

Dendritic Cells
Bone and Bones
Skin
Bone Marrow
3-Hydroxyanthranilate 3,4-Dioxygenase
2016
388 Downloads (Pure)

A three-dimensional co-culture system to investigate macrophage-dependent tumor cell invasion

Dwyer, A., Ellies, L., Holme, A. & Pixley, F., 2016, In : Journal of Biological Methods. 3, 3, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Coculture Techniques
Macrophages
Neoplasms
Breast Neoplasms
Neoplasm Metastasis
8 Citations (Scopus)

Src family kinase expression and subcellular localization in macrophages: Implications for their role in CSF-1-induced macrophage migration

Dwyer, A. R., Mouchemore, K. A., Steer, J. H., Sunderland, A. J., Sampaio, N. G., Greenland, E. L., Joyce, D. A. & Pixley, F. J., Jul 2016, In : Journal of Leukocyte Biology. 100, 1, p. 163-175 13 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
src-Family Kinases
Macrophages
Colony-Stimulating Factor Receptors
Phosphatidylinositol 3-Kinase
2014
13 Citations (Scopus)

CSF-1R signaling in health and disease: A focus on the mammary gland

Sullivan, A. & Pixley, F., 2014, In : Journal of Mammary Gland Biology and Neoplasia. 19, 2, p. 149-159

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Human Mammary Glands
Macrophages
Macrophage Colony-Stimulating Factor
Health
2013
21 Citations (Scopus)

Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity

Mouchemore, K., Sampaio, N. G., Murrey, M., Stanley, E. R., Lannutti, B. J. & Pixley, F., Nov 2013, In : FEBS Journal. 280, 21, p. 5228–5236

Research output: Contribution to journalArticle

Open Access
Macrophage Colony-Stimulating Factor
1-Phosphatidylinositol 4-Kinase
Macrophages
Phosphatidylinositols
Phosphotransferases
2012
38 Citations (Scopus)
44 Citations (Scopus)

Macrophage Migration and Its Regulation by CSF-1

Pixley, F., 2012, In : International Journal of Cell Biology. 2012, p. 1-12

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807

Yu, W., Chen, J., Xiong, Y., Pixley, F., Yeung, Y-G. & Stanley, E. R., 2012, In : Journal of Biological Chemistry. 287, 17, p. 13694-13704

Research output: Contribution to journalArticle

2011
37 Citations (Scopus)

Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion

Sampaio, N., Yu, W., Cox, D., Wycoff, J., Condeelis, J., Stanley, E. R. & Pixley, F., 2011, In : Journal of Cell Science. 124, p. 2021-2031

Research output: Contribution to journalArticle

2009
9 Citations (Scopus)

GLEPP1/Protein-tyrosine Phosphatase ϕ Inhibitors Block Chemotaxis in Vitro and in Vivo and Improve Murine Ulcerative Colitis

Gobert, R. P., Van Den Eijinden, M., Szyndralewiez, C., Jorand-Lebrun, C., Swinnen, D., Chen, L., Gillieron, C., Pixley, F., Juillard, P., Gerber, G., Johnson-Leger, C., Halazy, S., Camps, M., Bombrun, A., Shipp, M., Vitte, P. A., Ardissone, V., Ferrandi, C., Perrin, D., Rommel, C. & 1 othersHooft Van Huijsduijnen, R., 2009, In : Journal of Biological Chemistry. 284, 17, p. 11385-11395

Research output: Contribution to journalArticle

Leukocyte Chemotaxis
Paxillin
Protein Tyrosine Phosphatases
Chemotaxis
Ulcerative Colitis
2008
54 Citations (Scopus)

CSF-1 receptor structure/function in MacCsf1r-/-macrophages: Regulation of proliferation, differentiation, and morphology

Yu, W., Chen, J., Xiong, Y., Pixley, F. J., Dai, X. M., Yeung, Y. G. & Stanley, E. R., 1 Sep 2008, In : Journal of Leukocyte Biology. 84, 3, p. 852-863 12 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Macrophages
Macrophage Colony-Stimulating Factor
Tyrosine
Phosphorylation
223 Citations (Scopus)

PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells

Feng, R., Desbordes, S. C., Xie, H., Tillo, E. S., Pixley, F., Stanley, E. R. & Graf, T., 22 Apr 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 16, p. 6057-6062 6 p.

Research output: Contribution to journalArticle

Fibroblasts
Macrophages
NIH 3T3 Cells
Skin
Macrophage Colony-Stimulating Factor
2007
106 Citations (Scopus)

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

Owen, K. A., Pixley, F., Thomas, K. S., Vicente-Manzanares, M., Ray, B. J., Horwitz, A. F., Parsons, J. T., Beggs, H. E., Stanley, E. R. & Bouton, A. H., 2007, In : The Journal of Cell Biology. 179, 6, p. 1275-1287

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Macrophages
Phosphotransferases
Pseudopodia
Growth Factor Receptors
2006

A Syndrome of Holoprosencephaly, Recurrent Infections, and Monocytosis

Jubinsky, P. T., Shanske, A. L., Pixley, F., Montagna, C. & Short, M. K., 2006, In : American Journal of Medical Genetics Part A. 140A, 24, p. 2742-2748

Research output: Contribution to journalArticle

Holoprosencephaly
Brachydactyly
Failure to Thrive
Microcephaly
Phagocytes
110 Citations (Scopus)

Invadopodia and podosomes in tumor invasion

Yamaguchi, H., Pixley, F. & Condeelis, J., 2006, In : European Journal of Cell Biology. 85, 3-4, p. 213-218

Research output: Contribution to journalArticle

Neoplasms
Extracellular Matrix
Macrophages
Carcinoma
Podosomes
14 Citations (Scopus)

Rapid chemokinetic movement and the invasive potential of lung cancer cells ; a functional molecular study

Fok, S. Y., Rubin, J. S., Pixley, F., Condeelis, J., Braet, F. & Soon, L. L., 2006, In : BMC Cancer. 6, p. 1

Research output: Contribution to journalArticle

Open Access
Lung Neoplasms
Population
Chemotaxis
Microarray Analysis
Adhesives
2005
49 Citations (Scopus)

BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production

Yu, R. Y., Wang, X., Pixley, F., Yu, J., Dent, A. L., Broxmeyer, H. E., Stanley, E. R. & Ye, B. H., 2005, In : Blood. 105, 4, p. 1777-1784

Research output: Contribution to journalArticle

Macrophages
Interleukin-6
STAT3 Transcription Factor
Transcription
Gene expression
35 Citations (Scopus)

BCL6 suppresses RhoA activity to alter macrophage morphology and motility

Pixley, F., Xiong, Y., Yu, R. Y., Sahai, E. A., Stanley, E. R. & Ye, B. H., 2005, In : Journal of Cell Science. 118, 9, p. 1873-1883

Research output: Contribution to journalArticle

Macrophages
Phenotype
p120 GTPase Activating Protein
Actins
Cell Membrane
478 Citations (Scopus)

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

Goswami, S., Sahai, E., Wyckoff, J. B., Cammer, M., Cox, D., Pixley, F., Stanley, E. R., Segall, J. E. & Condeelis, J. S., 2005, In : Cancer Research. 65, 12, p. 5278-5283

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
Epidermal Growth Factor
Macrophages
Breast Neoplasms
Carcinoma
51 Citations (Scopus)

The PCH Family Members MAYP/PSTPIP2 Directly Regulates F-Actin Bundling and Enhances Filopodia Formation and Motility in Macrophages

Chitu, V., Pixley, F., Macaluso, F., Larson, D. R., Condeelis, J., Yeung, Y. & Stanley, E. R., 2005, In : Molecular Biology of the Cell. 16, p. 2947-2959

Research output: Contribution to journalArticle

2004
688 Citations (Scopus)

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

Wyckoff, J., Wang, W., Lin, E. Y., Wang, Y., Pixley, F., Stanley, E. R., Graf, T., Pollard, J. W., Segall, J. & Condeelis, J., 2004, In : Cancer Research. 64, 19, p. 7022-7029

Research output: Contribution to journalArticle

Cell Movement
Macrophages
Breast Neoplasms
Macrophage Colony-Stimulating Factor
Neoplasms
487 Citations (Scopus)

CSF-1 regulation of the wandering macrophage: complexity in action

Pixley, F. & Stanley, E. R., 2004, In : Trends in Cell Biology. 14, 11, p. 628-638

Research output: Contribution to journalArticle

2003
106 Citations (Scopus)

Cyclin D1 Governs Adhesion and Motility of Macrophages

Neumeister, P., Pixley, F., Xiong, Y., Xie, H., Wu, K., Ashton, A., Cammer, M., Chan, A., Symons, M., Stanley, E. R. & Pestell, R. G., 2003, In : Molecular Biology of the Cell. 14, p. 2005-2015

Research output: Contribution to journalArticle

Cyclin D1
Macrophages
Neoplasms
bcl-1 Genes
Neoplasm Metastasis
38 Citations (Scopus)

Expression and Tyrosine Phosphorylation of Cbl Regulates Macrophage Chemokinetic and Chemotactic Movement

Caveggion, E., Continolo, S., Pixley, F., Stanley, E. R., Bowtell, D. D. L., Lowell, C. A. & Berton, G., 2003, In : Journal of Cellular Physiology. 195, 2, p. 276-289

Research output: Contribution to journalArticle

Phosphorylation
Macrophages
Tyrosine
Acetates
Defects
2001
56 Citations (Scopus)

Protein tyrosine phosphatase φ regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages

Pixley, F. J., Lee, P. S. W., Condeelis, J. S. & Stanley, E. R., 26 Feb 2001, In : Molecular and Cellular Biology. 21, 5, p. 1795-1809 15 p.

Research output: Contribution to journalArticle

Paxillin
Protein Tyrosine Phosphatases
Macrophage Colony-Stimulating Factor
Tyrosine
Macrophages
80 Citations (Scopus)

Rho Family GTPases Regulate Mammary Epithelium Cell Growth and Metastasis Through Distinguishable Pathways

Bouzahzah, B., Albanese, C., Ahmed, F., Pixley, F., Lisanti, M. P., Segall, J. D., Condeelis, J., Joyce, D., Minden, A., Der, C. J., Chan, A., Symons, M. & Pestell, R. G., 2001, In : Molecular Medicine. 7, 12, p. 816-830

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Breast
Epithelium
Neoplasm Metastasis
Growth
2000
51 Citations (Scopus)

Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases: rapid communication

Reiser, J., Pixley, F. J., Hug, A., Kriz, W., Smoyer, W. E., Stanley, E. R. & Mundel, P., 1 Jan 2000, In : Kidney International. 57, 5, p. 2035-2042 8 p.

Research output: Contribution to journalArticle

Open Access
Podocytes
Protein Tyrosine Phosphatases
Communication
Protamines
Puromycin Aminonucleoside
1997

A survey of the postdoctoral population at Albert Einstein College of medicine identifies a need for better mentoring

Nierras, CR., Horig, H., Puech, A., Cohen, P., Pavelka, M. & Pixley, F., 1997, In : Einstein Quarterly Journal of Biology and Medicine. 14, p. 30-38

Research output: Contribution to journalArticle

1995
45 Citations (Scopus)

A heteromorphic protein-tyrosine phosphatase, PTPφ, is regulated by CSF-1 in macrophages

Pixley, F. J., Lee, P. S. W., Dominguez, M. G., Einstein, D. B. & Stanley, E. R., 10 Nov 1995, In : The Journal of Biological Chemistry. 270, 45, p. 27339-27347 9 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Macrophage Colony-Stimulating Factor
Macrophages
Messenger RNA
Brain
1992
97 Citations (Scopus)

Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1

Yeung, YG., Berg, KL., Pixley, F., Angeletti, RH. & Stanley, ER., 1992, In : The Journal of Biological Chemistry. 267, 33, p. 23447-23450

Research output: Contribution to journalArticle

1991
64 Citations (Scopus)

Mitochondrial gene sequences show fungal homology for Pneumocystis carinii

Pixley, F., Wakefield, AE., Banerji, S. & Hopkin, JM., Jun 1991, In : Molecular Microbiology. 5, 6, p. 1347-1351

Research output: Contribution to journalArticle

1990
155 Citations (Scopus)

Amplification of mitochondrial ribosomal RNA sequences from Pneumocystis carinii DNA of rat and human origin

Wakefield, AE., Pixley, F., Banerji, S., Sinclair, K., Miller, RF., Moxon, R. & Hopkin, JM., 1 Nov 1990, In : Molecular and Biochemical Parasitology. 43, 1, p. 69-76

Research output: Contribution to journalArticle

354 Citations (Scopus)

Detection of Pneumocystis carinii with DNA amplification

Wakefield, AE., Pixley, F., Banerji, S., Sinclair, K., Miller, RF., Moxon, ER. & Hopkin, JM., 25 Aug 1990, In : The Lancet. 336, 8713, p. 451-453

Research output: Contribution to journalArticle

12 Citations (Scopus)

Molecular probes for the detection of Pneumocystis carinii

Wakefield, AE., Banerji, S., Pixley, F. & Hopkin, JM., 1 Jan 1990, In : Transactions of the Royal Society of Tropical Medicine & Hygiene. 84, Supp 1, p. 17-18

Research output: Contribution to journalArticle

1989
5 Citations (Scopus)

Importance of beta 2‐adrenoceptor stimulation in the suppression of intradermal antigen challenge by adrenaline

Warren, J. B., Pixley, F. & Dollery, CT., Feb 1989, In : Bristish Journal of Clinical Pharmacology. 27, 2, p. 173-177

Research output: Contribution to journalArticle

1988
58 Citations (Scopus)

Dietary factors in the aetiology of gall stones: a case control study

Pixley, F. & Mann, J. I., 1 Nov 1988, In : Gut: an international journal of gastroenterology & hepatology. 29, 11, p. 1511-1515

Research output: Contribution to journalArticle

4 Citations (Scopus)

The importance of bradykinin and histamine in the skin response to antigen

Warren, JB., Newman, CM., Pixley, F., Fuller, RW. & Dollery, CT., Dec 1988, In : Bristish Journal of Clinical Pharmacology. 26, 6, p. 803-805

Research output: Contribution to journalArticle

1985
96 Citations (Scopus)

Effect of vegetarianism on development of gall stones in women

Pixley, F., Wilson, D., McPherson, K. & Mann, J. I., 6 Jul 1985, In : British Medical Journal. 291, 6487, p. 11 12 p.

Research output: Contribution to journalArticle