Fiona Pixley

Associate Professor, MB BS W.Aust., DPhil Oxf., MRCP(UK)

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth

    Australia

  • 4054 Citations
  • 28 h-Index
1985 …2018
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Personal profile

Biography

Fiona Pixley is a physician scientist with an MBBS(Hons) from the University of Western Australia and a DPhil in Clinical Medicine/Epidemiology from the University of Oxford where she was a Rhodes Scholar. After 5 years of physician training in Oxford and London hospitals, she became a member of the Royal College of Physicians (UK) and returned to biomedical research. With the understanding that the use of molecular approaches was critical to elucidating the causes of disease, she spent a year learning techniques in molecular and cell biology at the Weatherall Institute of Molecular Medicine in Oxford. Dr Pixley subsequently worked with Richard Stanley at the Albert Einstein College of Medicine in New York on the role of CSF-1 and tyrosine phosphorylation in the regulation of macrophage adhesion and motility. In 2007 she moved back to the University of Western Australia to start up her own laboratory in the Faculty of Health and Medical Sciences.

Roles and responsibilities

General:

  • Member, School of Biomedical Sciences Executive Committee

Research:

  • Chair, School of Biomedical Sciences Research Committee
  • Member, Faculty of Health and Medical Sciences Research Committee
  • Organiser, School of Biomedical Sciences seminar series

Teaching:

  • Curriculum development for Pharmacology, Pharmacology Major
  • Curriculum development for Pharmacology, MD course 

 

Teaching overview

  • PHAR3310 Molecular Pharmacology, unit coordinator
  • PHAR3311 Molecular Pharmacology Methods, unit coordinator
  • PHAR3321 Systems Pharmacology Methods, tutor  
  • PHAR1101 Drugs that Changed the World, lecturer
  • IMED2002 Blood and Drugs, lecturer and tutor
  • IMED2004 Human Development and Genetics, lecturer
  • IMED3003 Body Systems and Disease III, lecturer
  • IMED3004 Body Systems and Disease IV, lecturer
  • IMED4443 MD year 1, semester 1, lecturer and discipline co-lead
  • IMED4444 MD year 1, semester 2, lecturer and discipline co-lead
  • PODI4207 Pharmacology for Podiatrists, lecturer

 

Research

Expertise - macrophage biology, cancer biology, cell motility and invasion, breast cancer, optical and super resolution microscopy.

Overview - macrophages are found in every tissue and play an important role in tissue development and homeostasis. They also contribute to the progression of a number of diseases, including cancer. In particular, tumour associated macrophages encourage tumour invasion and metastasis by activating cancer cell motility and digging tunnels for cancer cells to move through tissue barriers. Examination of macrophage-specific motility and invasion proteins should help to identify potential therapeutic targets in the treatment of cancer. Dr Pixley’s laboratory is focussed on the role of the CSF-1 receptor signalling and tyrosine phosphorylation in the activation of downstream signal transduction pathways that regulate macrophage adhesion and motility. Compared with more commonly studied yet less motile cell types such as fibroblasts, motility is regulated quite differently in the professionally motile macrophage. A broad range of microscopic and biochemical techniques is employed in the laboratory to dissect the mechanisms by which CSF-1 receptor tyrosine phosphorylation activates specific downstream signalling pathways to stimulate macrophage motility. Dr Pixley also collaborates extensively to investigate the role of other tyrosine phosphorylated proteins, such as FAK, Pyk2 and cortactin, that are important in the regulation of macrophage differentiation, adhesion and motility. 

Funding (CIA):

  • NIH KO8 award
  • NHMRC Project grant
  • CCWA Project grants
  • Ada Bartholomew grant
  • UWA Near Miss award
  • UWA Research Collaboration award

External positions

Director of the Board, Western Australian Institute of Sport

1 Jun 2018 → …

Director of the Board, Water Polo Western Australia Inc.

1 Oct 201430 Apr 2018

Keywords

  • Macrophage biology
  • Macrophage imaging
  • Cancer biology
  • CSF-1R signal transduction
  • Tyrosine phosphorylation
  • Cell adhesion and motility
  • Invasion and metastasis
  • Breast cancer

Fingerprint Dive into the research topics where Fiona Pixley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Macrophages Medicine & Life Sciences
Macrophage Colony-Stimulating Factor Medicine & Life Sciences
Protein Tyrosine Phosphatases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Macrophage Colony-Stimulating Factor Receptors Medicine & Life Sciences
Cell Movement Medicine & Life Sciences
Paxillin Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1985 2018

  • 4054 Citations
  • 28 h-Index
  • 42 Article
  • 6 Chapter
  • 3 Review article
  • 1 Non-UWA Thesis

F2-isoprostanes affect macrophage migration and CSF-1 signalling

Proudfoot, J. M., Murrey, M. W., McLean, S., Greenland, E. L., Barden, A. E., Croft, K. D., Galano, J. M., Durand, T., Mori, T. A. & Pixley, F. J., 8 Aug 2018, In : Free Radical Biology & Medicine. 126, p. 142-152 11 p.

Research output: Contribution to journalArticle

F2-Isoprostanes
Macrophage Colony-Stimulating Factor
Macrophages
Adhesion
Paxillin

Macrophage depletion in elderly mice improves response to tumor immunotherapy, increases anti-tumor T cell activity and reduces treatment-induced cachexia

Duong, L., Radley-Crabb, H. G., Gardner, J. K., Tomay, F., Dye, D. E., Grounds, M. D., Pixley, F. J., Nelson, D. J. & Jackaman, C., 6 Nov 2018, In : Frontiers in Genetics. 9, 14 p., 526.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Carter, K. W., Keane, K. N., Newsholme, P., Goodridge, H. S., Pixley, F. J. & Hart, P. H., 1 Jan 2018, In : Journal of Immunology. 200, 1, p. 260-270

Research output: Contribution to journalArticle

Chemotactic Factors
Bone Marrow
Macrophages
Macrophage Colony-Stimulating Factor
Inflammation
31 Citations (Scopus)

Aging and cancer: The role of macrophages and neutrophils

Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P. & Nelson, D. J., 1 Jul 2017, In : Ageing Research Reviews. 36, p. 105-116 12 p.

Research output: Contribution to journalReview article

Macrophages
Neutrophils
Aging of materials
T-cells
Neoplasms
1 Citation (Scopus)
34 Downloads (Pure)

PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo

McGonigle, T. A., Dwyer, A. R., Greenland, E. L., Scott, N. M., Keane, K. N., Newsholme, P., Goodridge, H. S., Zon, L. I., Pixley, F. J. & Hart, P. H., Dec 2017, In : Experimental Hematology. 56, p. 64-68

Research output: Contribution to journalArticle

Open Access
File
16,16-Dimethylprostaglandin E2
Dinoprostone
Bone Marrow Cells
Cell Movement
Monocytes

Projects 2008 2017