Evan Ingley

Associate Professor

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth

    Australia

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Personal profile

Roles and responsibilities

Head of the Cell Signalling Group at the Perkins Institute

Funding overview

NHMRC
Cancer Council WA
RPH MRF

Research

Bone cancer metastasis and cardiac calcium channels

Biography

Associate Professor Evan Ingley heads the Cell Signalling Group, which has an interest in understanding the signalling networks or “information highways” of both normal and diseased cells. Evan’s Honours degree at the University of Canterbury (New Zealand) included a research project on the hormonal control of genes important for cockroach reproduction but developed an interest in understanding molecular interactions involved in cancer/leukaemia. Evan completed his PhD at The Australian National University in the John Curtin School of Medical Research (Canberra) under the direction of Professor Ian Young, working on the interaction between the cytokine Interleukin-5 (IL-5) and its receptor. For his postdoctoral studies he moved to Switzerland working with Dr Brian Hemmings at the Friedrich Miescher Institute, the flagship research institute of the pharmaceutical company Novartis AG. Dr Hemmings had recently identified the new oncogene Akt/PKB and Evan worked on its regulation through protein-protein as well as protein-lipid interactions. On returning to Australia Evan began using his expertise on protein-protein interactions involved in signal transduction to uncover novel pathways involved in red blood cell development and lineage determination. After his discovery of the importance of Lyn in erythropoiesis he began establishing a focus on the signalling pathways of this molecule and set up the Cell Signalling Group. His current research is focused on bone cancer (osteosarcoma) cell metastasis, and through a long standing collaboration with Prof. Livia Hool (UWA), cardiac ion channels. 

Current projects

The control of sarcoma cell metastasis through the novel AFAP1L1 pathway.

The control of red blood cell longevity and integrity through Lyn/Src Family Kinase pathways.

Identifying new therapy options for sarcoma patients through personalized genomic medicine.

Structure/function of clinically relevant variants of the cardiac calcium channel using CRSPR/Cas9 in vivo gene editing.

Studying the magnitude of the effect of enzyme variations on the ability of young cancer patients to handle High-Dose-Methotrexate (HDMTX) treatment, as HDMTX can causes severe toxicities.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Biochemistry and Molecular Biology, PhD, Molecular and Cellular Biology of Human Interleukin-5 and its Receptor, Australian National University

19881992

Award Date: 24 Apr 1992

Zoology, BScHons1, Control of Gene Amplification in the Left Collateral Gland of the American Cockroach, Periplaneta americana, University of Canterbury

19841988

Award Date: 6 May 1988

External positions

Raine Priming Grant Advisory Committee, Raine Foundation

2023 → …

WA Child Research Fund, Department of Health (Western Australia)

2020 → …

Lecturer, Murdoch University

27 Feb 2017 → …

Research Grants Advisory Committee, Cancer Council WA

2010 → …

Industry keywords

  • Bioengineering
  • Biotechnology
  • Drug Discovery
  • Education
  • Health

Research expertise keywords

  • Cancer Biology, Molecular Biology, Microbiology, Bioinformatics, Biochemistry
  • Cell signalling
  • Tyrosine kinases
  • Osteosarcoma
  • Protein purification
  • CRISPR
  • Gene editing
  • Bone tumour pathology
  • Erythropoietin

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