Debbie Trinder

Associate Professor, BSc PhD W.Aust.

  • 2325 Citations
  • 28 h-Index
19962019
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Research Output 1996 2019

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Article
2019

Detection of HFE Haemochromatosis in the clinic and community using standard erythrocyte tests

Adris, N., Hazedine, S., Bentley, P., Trinder, D., Chua, A. C. G., Powell, L. W., Ramm, L. E., Ramm, G. A. & Olyny, J. K., Feb 2019, In : Blood Cells, Molecules, and Diseases. 74, p. 18-24 7 p.

Research output: Contribution to journalArticle

Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis

Safaeian, R., Howarth, G. S., Lawrance, I. C., Trinder, D. & Mashtoub, S., 4 Mar 2019, In : Scandinavian Journal of Gastroenterology. 54, 3, p. 273-280 8 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Peroxidase
emu Oil
Dextran Sulfate
Mucositis
1 Citation (Scopus)

The Impact of Morning versus Afternoon Exercise on Iron Absorption in Athletes

McCormick, R., Moretti, D., McKay, A. K. A., Laarakkers, C. M., Vanswelm, R., Trinder, D., Cox, G. R., Zimmerman, M. B., Sim, M., Goodman, C., Dawson, B. & Peeling, P., 1 Oct 2019, In : Medicine and Science in Sports and Exercise. 51, 10, p. 2147-2155 9 p.

Research output: Contribution to journalArticle

Hepcidins
Athletes
Iron
Exercise
Meals
2018
Open Access
Erythrocyte Indices
Incidence
Health
Iron
Neoplasms
6 Citations (Scopus)

Emu Oil Improves Clinical Indicators of Disease in a Mouse Model of Colitis-Associated Colorectal Cancer

Chartier, L. C., Howarth, G. S., Lawrance, I. C., Trinder, D., Barker, S. J. & Mashtoub, S., 2018, In : Digestive Diseases and Sciences. 63, 1, p. 135–145 11 p.

Research output: Contribution to journalArticle

Colitis
Colorectal Neoplasms
Dextran Sulfate
Azoxymethane
Water Cycle
2017
2 Citations (Scopus)
Hepcidins
Oral Contraceptives
Interleukin-6
Hormones
Iron
2016
17 Citations (Scopus)

Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

Heidari, M., Johnstone, D. M., Bassett, B., Graham, R. M., Chua, A. C. G., House, M. J., Collingwood, J. F., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J. K., Trinder, D. & Milward, E. A., Nov 2016, In : Molecular Psychiatry. 21, 11, p. 1599-1607

Research output: Contribution to journalArticle

Open Access
Myelin Sheath
Rare Diseases
Iron
Brain
Transferrin Receptors
11 Citations (Scopus)
Transferrin
Ferritins
Iron
Serum
Neoplasms

Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases

Heidari, M., Gerami, S. H. H., Bassett, B., Graham, R. M. M., Chua, A. C. G., Aryal, R., House, M. J., Collingwood, J. F. F., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J. K. K., Trinder, D., Johnstone, D. M. M. & Milward, E. A. A., Jan 2016, In : Rare Diseases. 4, 1, 11 p., e1198458.

Research output: Contribution to journalArticle

Open Access
Brain Diseases
Myelin Sheath
Iron
Hemochromatosis
Rare Diseases
2015
5 Citations (Scopus)
Hepcidins
Contraception
Interleukin-6
Oral Contraceptives
Hormones
2014
14 Citations (Scopus)

A seven day running training period increases basal urinary hepcidin levels as compared to cycling

Sim, M., Dawson, B., Landers, G., Swinkels, D. W., Tjalsma, H., Wiegerinck, E. T., Trinder, D. & Peeling, P., 9 Apr 2014, In : Journal of the International Society of Sports Nutrition. 11, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
Hepcidins
Running
exercise
Iron
Exercise
13 Citations (Scopus)

Factors That Affect Serum Levels of Ferritin in Australian Adults and Implications for Follow-Up

Mckinnon, E. J., Rossi, E., Beilby, J., Trinder, D. & Olynyk, J. K., Jan 2014, In : Clinical Gastroenterology and Hepatology. 12, 1, p. 101-108

Research output: Contribution to journalArticle

Ferritins
Body Mass Index
Serum
Reference Values
Iron Overload
13 Citations (Scopus)
273 Downloads (Pure)
Open Access
File
Hepcidins
menstrual cycle
athletes
Menstrual Cycle
Athletes
59 Citations (Scopus)

Iron status and the acute post-exercise hepcidin response in athletes

Peeling, P., Sim, M., Badenhorst, C. E., Dawson, B., Govus, A. D., Abbiss, C. R., Swinkels, D. W. & Trinder, D., 2014, In : PLoS One. 9, 3, p. 6pp

Research output: Contribution to journalArticle

Open Access
Hepcidins
athletes
Ferritins
Athletes
ferritin
2013
10 Citations (Scopus)

Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation

Acikyol, B., Graham, R., Trinder, D., House, M., Olynyk, J. K., Scott, R. J., Milward, E. A. & Johnstone, D. M., 2013, In : Neuroscience. 235, p. 119

Research output: Contribution to journalArticle

36 Citations (Scopus)

Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signalling Promoting Colonic Tumor Development in Mice

Chua, A., Klopcic, B., Ho, D., Fu, S., Forrest, C., Croft, K., Olynyk, J., Lawrance, I. & Trinder, D., 2013, In : PLoS One. 8, 11, p. 12pp

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Micoarray Data Involving Small Changes

Johnstone, D. M., Riveros, C., Heidari, M., Graham, R., Trinder, D., Berretta, R., Olynyk, J. K., Scott, R. J., Moscato, P. & Milward, E. A., 2013, In : Microarrays. 2, p. 131-152

Research output: Contribution to journalArticle

Open Access

Non-Hfe Iron Overload: Is phlebotomy the Answer?

Hazeldine, S., Trinder, D. & Olynyk, J., 2013, In : Current Hepatitis Reports. 12, 1, p. 20-27

Research output: Contribution to journalArticle

2012
12 Citations (Scopus)

Brain transcriptome perturbations in the Hfe−/− mouse model of genetic iron loading

Johnstone, D., Graham, R., Trinder, D., Delima, R., Riveros, C., Olynyk, J., Scott, R., Moscato, P. & Milward, E., 2012, In : Brain Research. 1448, p. 144-152

Research output: Contribution to journalArticle

7 Citations (Scopus)

Changes in Brain Transcripts Related to Alzheimer's Disease in a Model of HFE Hemochromatosis are not Consistent with Increased Alzheimer's Disease Risk

Johnstone, D., Graham, R., Trinder, D., Riveros, C., Olynyk, J., Scott, R., Moscato, P. & Milward, E. A., 2012, In : Journal of Alzheimer's Disease. 30, p. 791-803

Research output: Contribution to journalArticle

32 Citations (Scopus)

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice

Delima, R., Chua, A., Tirnitz-Parker, N., Gan, E. K., Croft, K., Graham, R., Olynyk, J. & Trinder, D., 2012, In : Hepatology. 56, p. 585-592

Research output: Contribution to journalArticle

31 Citations (Scopus)

The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels

Sim, M., Dawson, B., Landers, G., Wiegerinck, E. T., Swinkels, D. W., Townsend, M-A., Trinder, D. & Peeling, P., 2012, In : European Journal of Applied Physiology. 112, p. 1889-1898

Research output: Contribution to journalArticle

2011
7 Citations (Scopus)

Liver and Serum Iron: Discrete Regulators of Hepatic Hepcidin Expression

Chua, A., Trinder, D. & Olynyk, J., 2011, In : Hepatology. 54, 1, p. 16-19

Research output: Contribution to journalArticle

2010
42 Citations (Scopus)

Hepatic Iron Loading in Mice Increases Cholesterol Biosynthesis

Graham, R., Chua, A., Carter, K., Delima, R. D., Johnstone, D., Herbison, C., Firth, M., O'Leary, R., Milward, E. A., Olynyk, J. & Trinder, D., 2010, In : Hepatology. 52, 2, p. 462-471

Research output: Contribution to journalArticle

42 Citations (Scopus)

Iron: An emerging factor in colorectal carcinogenesis

Chua, A., Klopcic, B., Lawrance, I., Olynyk, J. & Trinder, D., 2010, In : World Journal of Gastroenterology. 16, 6, p. 663-672

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis

Chua, A., Delima, R. D., Morgan, E., Herbison, C. E., Tirnitz-Parker, N., Graham, R., Fleming, R. E., Britton, R. S., Bacon, B. R., Olynyk, J. & Trinder, D., 2010, In : Journal of Hepatology. 52, 2010, p. 425-431

Research output: Contribution to journalArticle

28 Citations (Scopus)

Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease

Ferrari, P., Mallon, D., Trinder, D. & Olynyk, J., 2010, In : Nephrology. 15, (2010), p. 344-349

Research output: Contribution to journalArticle

8 Citations (Scopus)

Quantitative assay of urinary hepcidin using MALDI-TOF mass spectrometry

Gay, M. C. L., Mullaney, I., Trinder, D., Olynyk, J. & Trengove, R. D., 2010, In : Analytical Methods. 2, 2010, p. 268-274

Research output: Contribution to journalArticle

2009
64 Citations (Scopus)

Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W. & Trinder, D., 2009, In : European Journal of Applied Physiology. 106, 1, p. on-line

Research output: Contribution to journalArticle

Hepcidins
Ferritins
Hemolysis
Running
Interleukin-6
69 Citations (Scopus)

Effects of exercise on hepcidin response and iron metabolism during recovery

Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W. & Trinder, D., 2009, In : International Journal of Sport Nutrition & Exercise Metabolism. 19, 6, p. 583-597

Research output: Contribution to journalArticle

Hepcidins
exercise
Iron
Exercise
iron
2 Citations (Scopus)

Genetics of hereditary hemochromatosis : a clinical perspective

Gan, E. K., Trinder, D., Ayonrinde, O. T. & Olynyk, J., 2009, In : Expert review of endocrinology & metabolism. 4, 3, p. 225-239

Research output: Contribution to journalArticle

Hemochromatosis
Penetrance
Iron
Mutation
Inborn Genetic Diseases
Hemochromatosis
Penetrance
Population
Genes
Natural History
42 Citations (Scopus)

The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells

Herbison, C. E., Thorstensen, K., Chua, A., Graham, R., Leedman, P., Olynyk, J. & Trinder, D., 2009, In : American journal of physiology : cell physiology. 297, 6, p. C1567-C1575

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Hepatocellular Carcinoma
Iron
Coordination Complexes
73 Citations (Scopus)

Training surface and intensity : inflammation, hemolysis and hepcidin expression

Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W. & Trinder, D., 2009, In : Medicine & Science in Sports & Exercise. 41, 5, p. 1138-1145

Research output: Contribution to journalArticle

Hepcidins
Hemolysis
Running
Inflammation
Haptoglobins
2008
170 Citations (Scopus)
Sports
Iron
Hormones
Cytokines
Inflammation
19 Citations (Scopus)

Clinical Perspectives on hereditary Hemochromatosis

Ayonrinde, O. T., Milward, E. A., Chua, A. C. G., Trinder, D. & Olynyk, J., 2008, In : Critical Reviews in Clinical Laboratory Sciences. 45, 5, p. 451-484

Research output: Contribution to journalArticle

Hemochromatosis
Iron
Iron Overload
Hepcidins
Iron Metabolism Disorders
55 Citations (Scopus)

Hereditary Hemochromastosis in the Post-HFE Era

Olynyk, J., Trinder, D., Ramm, G. A., Britton, R. S. & Bacon, B. R., 2008, In : Hepatology. 48, 3, p. 991-1001

Research output: Contribution to journalArticle

Iron Overload
Hemochromatosis
Genetic Association Studies
Homeostasis
Iron
18 Citations (Scopus)

The Role of Hfe in Transferrin-Bound Iron Uptake by Hepatocytes

Chua, A. C. G., Herbison, C. E., Drake, S. F., Graham, R., Olynyk, J. & Trinder, D., 2008, In : Hepatology. 47, 5, p. 1737-1744

Research output: Contribution to journalArticle

Transferrin
Hepatocytes
Iron
Proteins
Transferrin Receptors
33 Citations (Scopus)

Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron

Graham, R., Reutens, G. M., Herbison, C. E., Delima, R. D., Chua, A. C. G., Olynyk, J. & Trinder, D., 2008, In : Journal of Hepatology. 48, 2, p. 327-334

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Iron
Cricetulus
Ovary
2007
39 Citations (Scopus)

Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3

Drake, S. F., Morgan, E., Herbison, C. E., Delima, R., Graham, R. M., Chua, A. C. G., Leedman, P., Fleming, R. E., Bacon, B. R., Olynyk, J. K. & Trinder, D., 2007, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 292, p. G323-G328

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Liver
Hepcidins
Gene Expression
112 Citations (Scopus)

The regulation of cellular iron metabolism

Chua, A. C. G., Graham, R., Trinder, D. & Olynyk, J., 2007, In : Critical Reviews in Clinical Laboratory Sciences. 44, 5-6, p. 413-459

Research output: Contribution to journalArticle

Hemochromatosis
Metabolism
Iron
Genes
Homeostasis
2006
13 Citations (Scopus)

Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse

Chua, A., Drake, S. F., Herbison, C. E., Olynyk, J., Leedman, P. & Trinder, D., 2006, In : Journal of Hepatology. 44, 1, p. 176-182

Research output: Contribution to journalArticle

Knockout Mice
Hepatocytes
Iron
Liver
Hemochromatosis

Normal Iron Metabolism and the Pathophysiology of Iron Overload Disorders

Siah, C. W., Ombiga, J., Adams, L., Trinder, D. & Olynyk, J., 2006, In : Clinical Biochemist Reviews. 27, p. 5-16

Research output: Contribution to journalArticle

2005
13 Citations (Scopus)

Screening for HFE and iron overload

Ombiga, J., Tang, K., Adams, L., Trinder, D. & Olynyk, J., 2005, In : Seminars in Liver Disease. 25, 4, p. 402-410

Research output: Contribution to journalArticle

Iron Overload
Genetic Testing
Phlebotomy
Hemochromatosis
Population Control
2004
68 Citations (Scopus)
Hemochromatosis
Knockout Mice
Hepatocytes
Iron
Ions
2003
24 Citations (Scopus)

Effects of Cell Proliferation on the Uptake of Transferrin-Bound Iron by Human Hepatoma Cells

Lee, A. W. M., Oates, P. & Trinder, D., 2003, In : Hepatology. 38, 4, p. 967-977

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Hepatocellular Carcinoma
Iron
Cell Proliferation
68 Citations (Scopus)
Transferrin Receptors
Metabolism
Iron
Molecules
Transferrin
2002

Effect of iron status on DMT1 expression in duodenal enterocytes from ß2-microglobulin knockout mice

Moos, T., Trinder, D., Morgan, E. H. & Morgan, E., 2002, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 283, September, p. G687-G694

Research output: Contribution to journalArticle

282 Citations (Scopus)

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

Frazer, D. M., Wilkins, S. J., Becker, E. M., Vulpe, C. D., Mckie, A. T., Trinder, D. & Anderson, G. J., 2002, In : Gastroenterology. 123, 3, p. 835-844

Research output: Contribution to journalArticle

Hepcidins
Iron
Diet
Intestinal Absorption
Transferrin