David Joyce

Professor, MB BS W.Aust., MD NSW, FRACP

  • The University of Western Australia (M510), 35 Stirling Highway,

    6009 Perth


  • 2116 Citations
  • 22 h-Index
1992 …2019
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Personal profile


Prof. David Joyce heads the Inflammation Pharmacology research laboratory in the Pharmacology unit at UWA, with specific research interests in the drug control of inflammatory diseases. The major areas of research are TNF-alpha suppression, the role of TNF-alpha in inflammatory and survival signalling in inflammatory cells and reactive oxygen interactions with mitochondrial function and intracellular signalling pathways in inflammatory cells.
As well as heading the Inflammation Pharmacology research laboratory, Prof. Joyce is head of the Clinical Pharmacology & Toxicology laboratory at PathWest Laboratory Medicine, and practices clinically in the areas of general internal medicine and clinical pharmacology & toxicology at Sir Charles Gairdner Hospital.
Prof. Joyce also coordinates undergraduate medical teaching in pharmacology and therapeutics at UWA.

Roles and responsibilities

Undergraduate teaching in medicine, science, dentistry
Postgraduate supervision
Clinical Practice

Funding overview

G. K. Rangan, D.A. Joyce. Regulation of tubular epithelial cell proliferation and cyclin D1 by NF-kB/Rel in proteinuric chronic renal diseases. ($35,000). Medical Research Foundation of WA. 2001
M-H Zheng, DA Joyce, Langdon W et al. Large Equipment Grant: BMG Polarstar Optima Microplate Fluorimeter/Luminometer ($82,045). University of WA Permanent Endowment for Medical Research. 2003
J. Xu, D.A. Joyce. Inhibition of RANKL-induced osteoclastogenesis through modulation of NF-кB signalling by PKC isoforms and parthenolide ($20,000). Arthritis Foundation of Western Australia. 2005
G. K. Rangan, D.A. Joyce, JH Steer. Regulation of tubular epithelial cell proliferation and cyclin D1 by NF-kB/Rel in proteinuric chronic renal diseases. ($10,000). Fremantle Hospital Medical Research Foundation. 2002
D.A. Joyce, J.H. Steer. Rac-ROS-NF-kB Pathways in Survival and Growth of Fibroblasts and Macrophages in Chronic Inflammatory Synovial Disease ($10,000). Sir Charles Gairdner Hospital Research Foundation. 2002
DA Joyce; PJ Henry. Macrophage uncoupling protein-2 regulation and expression in inflammatory joint disease and hyperoxic lung damage ($259,250). National Health & Medical Research Council. 2009 -2011
S Ching, C Newbound, DA Joyce, J Beilby. The development of improved pharmacogenomic reporting of thiopurine methyl transferase (TPMT) enzyme activity and genotypes. ($13,500). PathWest QEII Research Grant. 2009 -2010

Teaching overview

Undergraduate: IMED3345; IMED4451; IMED4452: PHAR8502; PHAR2230; PHAR3302; IDNT3382


Signalling for activation and survival in macrophage cells
Adaptation of signalling to redox, hypoxic, hyperoxic and nutritional conditions in inflammatory cell environment
Mitochondrial uncoupling as a response to oxygen radical stress


  • Clinical pharmacology
  • Pharmacology of inflammatory cell differentiation and survival intracellular signalling

Fingerprint Dive into the research topics where David Joyce is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Monocytes Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Tumor Necrosis Factor-alpha Medicine & Life Sciences
Glucocorticoids Medicine & Life Sciences
Osteogenesis Medicine & Life Sciences
Osteoclasts Medicine & Life Sciences
NF-kappa B Medicine & Life Sciences
Bone Resorption Medicine & Life Sciences

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Research Output 1992 2019

1 Citation (Scopus)
Opioid Analgesics
Cohort Studies
2 Citations (Scopus)

Placental transfer of paliperidone during treatment with a depot formulation

Binns, R., O'Halloran, S. J., Teoh, S., Doherty, K. & Joyce, D. A., 1 Aug 2017, In : Journal of Clinical Psychopharmacology. 37, 4, p. 474-475 2 p.

Research output: Contribution to journalLetter

6 Citations (Scopus)
Human Milk
Tandem Mass Spectrometry
Liquid Chromatography
Pharmaceutical Preparations

Projects 1995 2016