• The University of Western Australia (M316), 35 Stirling Highway,

    6009 Perth

    Australia

Personal profile

Biography

Darren Holland obtained a BSc (Hons) in organic and biochemistry from Griffith University, Gold Coast, Queensland. His PhD was awarded under the supervision of Prof Anthony Carroll and focused on the isolation, structure elucidation, and synthesis of bioactive marine natural products, alongside, cheminformatics analyses of large natural product databases. Darren has completed postdoctoral fellowships with Prof William Fenical at Scripps Institution of Oceanography, University of California San Diego and Assoc Prof Yit-Heng Chooi at the University of Western Australia. He is currently a research fellow working on the Biota Pipeline with A/Prof Gavin Flematti in collaboration with UWA and the Harry Perkins Institute examining WA marine invertebrates for selective liver cancer drug leads. His research interests include NMR structural elucidation, NMR and MS dereplication, MS metabolomics, NP synthesis and biosynthesis, marine chemistry, microbial genomics, and ab initio DFT-NMR and ECD calculations for orthogonal structure determination methods.

Education/Academic qualification

PhD, Marine Natural Products Biodiscovery and Meta-analysis of their Bioactivities to Improve their Potential for Drug Discovery, Griffith University (QLD)

Award Date: 14 Jul 2022

Bachelor of Science (Hons Class I), Griffith University (QLD)

Award Date: 18 Jul 2018

External positions

Postdoctoral Researcher, Scripps Institution of Oceanography

1 Jul 202230 Sept 2023

Research expertise keywords

  • Natural products and natural product synthesis
  • NMR spectroscopy
  • Cheminformatics
  • Quantum Chemical Calculations
  • Marine Chemistry
  • Marine biodiversity and conservation
  • Mass spectrometry
  • Secondary metabolites in plants and fungi
  • Natural Products Biosynthesis
  • Natural products and chemical ecology
  • Marine Ecology

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 14 - Life Below Water
    SDG 14 Life Below Water

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Collaborations and top research areas from the last five years

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  • Anthelmintic Potential of Agelasine Alkaloids from the Australian Marine Sponge Agelas axifera

    Wijesekera, K., Taki, A. C., Byrne, J. J., Holland, D. C., Jenkins, I. D., Ekins, M. G., Carroll, A. R., Gasser, R. B. & Davis, R. A., Jul 2025, In: Marine Drugs. 23, 7, 276.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Isolation of Verrucosins A–E from a Marine Verrucosispora sp. Reveals a Unifying Biosynthetic Hypothesis for Linear and Macrocyclic Polyketides

    Holland, D. C., Iizumi, R., Shende, V. V. & Fenical, W., 13 Jun 2025, In: Journal of Natural Products.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

    Zdouc, M. M., Blin, K., Louwen, N. L. L., Navarro, J., Loureiro, C., Bader, C. D., Bailey, C. B., Barra, L., Booth, T. J., Bozhüyük, K. A. J., Cediel-Becerra, J. D. D., Charlop-Powers, Z., Chevrette, M. G., Chooi, Y. H., D’Agostino, P. M., de Rond, T., Pup, E. D., Duncan, K. R., Gu, W. & Hanif, N. & 269 others, Helfrich, E. J. N., Jenner, M., Katsuyama, Y., Korenskaia, A., Krug, D., Libis, V., Lund, G. A., Mantri, S., Morgan, K. D., Owen, C., Phan, C. S., Philmus, B., Reitz, Z. L., Robinson, S. L., Singh, K. S., Teufel, R., Tong, Y., Tugizimana, F., Ulanova, D., Winter, J. M., Aguilar, C., Akiyama, D. Y., Al-Salihi, S. A. A., Alanjary, M., Alberti, F., Aleti, G., Alharthi, S. A., Arias Rojo, M. Y., Arishi, A. A., Augustijn, H. E., Avalon, N. E., Avelar-Rivas, J. A., Axt, K. K., Barbieri, H. B., Barbosa, J. C. J., Segato, L. G. B., Barrett, S. E., Baunach, M., Beemelmanns, C., Beqaj, D., Berger, T., Bernaldo-Agüero, J., Bettenbühl, S. M., Bielinski, V. A., Biermann, F., Borges, R. M., Borriss, R., Breitenbach, M., Bretscher, K. M., Brigham, M. W., Buedenbender, L., Bulcock, B. W., Cano-Prieto, C., Capela, J., Carrion, V. J., Carter, R. S., Castelo-Branco, R., Castro-Falcón, G., Chagas, F. O., Charria-Girón, E., Chaudhri, A. A., Chaudhry, V., Choi, H., Choi, Y., Choupannejad, R., Chromy, J., Chue Donahey, M. S., Collemare, J., Connolly, J. A., Creamer, K. E., Crüsemann, M., Cruz, A. A., Cumsille, A., Dallery, J. F., Damas-Ramos, L. C., Damiani, T., de Kruijff, M., Martín, B. D., Sala, G. D., Dillen, J., Doering, D. T., Dommaraju, S. R., Durusu, S., Egbert, S., Ellerhorst, M., Faussurier, B., Fetter, A., Feuermann, M., Fewer, D. P., Foldi, J., Frediansyah, A., Garza, E. A., Gavriilidou, A., Gentile, A., Gerke, J., Gerstmans, H., Gomez-Escribano, J. P., González-Salazar, L. A., Grayson, N. E., Greco, C., Gris Gomez, J. E., Guerra, S., Flores, S. G., Gurevich, A., Gutiérrez-García, K., Hart, L., Haslinger, K., He, B., Hebra, T., Hemmann, J. L., Hindra, H., Höing, L., Holland, D. C., Holme, J. E., Horch, T., Hrab, P., Hu, J., Huynh, T. H., Hwang, J. Y., Iacovelli, R., Iftime, D., Iorio, M., Jayachandran, S., Jeong, E., Jing, J., Jung, J. J., Kakumu, Y., Kalkreuter, E., Kang, K. B., Kang, S., Kim, W., Kim, G. J., Kim, H., Kim, H. U., Klapper, M., Koetsier, R. A., Kollten, C., Kovács, Á. T., Kriukova, Y., Kubach, N., Kunjapur, A. M., Kushnareva, A. K., Kust, A., Lamber, J., Larralde, M., Larsen, N. J., Launay, A. P., Le, N. T. H., Lebeer, S., Lee, B. T., Lee, K., Lev, K. L., Li, S. M., Li, Y. X., Licona-Cassani, C., Lien, A., Liu, J., Lopez, J. A. V., Machushynets, N. V., Macias, M. I., Mahmud, T., Maleckis, M., Martinez-Martinez, A. M., Mast, Y., Maximo, M. F., McBride, C. M., McLellan, R. M., Bhatt, K. M., Melkonian, C., Merrild, A., Metsä-Ketelä, M., Mitchell, D. A., Müller, A. V., Nguyen, G. S., Nguyen, H. T., Niedermeyer, T. H. J., O’Hare, J. H., Ossowicki, A., Ostash, B. O., Otani, H., Padva, L., Paliyal, S., Pan, X., Panghal, M., Parade, D. S., Park, J., Parra, J., Rubio, M. P., Pham, H. T., Pidot, S. J., Piel, J., Pourmohsenin, B., Rakhmanov, M., Ramesh, S., Rasmussen, M. H., Rego, A., Reher, R., Rice, A. J., Rigolet, A., Romero-Otero, A., Rosas-Becerra, L. R., Rosiles, P. Y., Rutz, A., Ryu, B., Sahadeo, L. A., Saldanha, M., Salvi, L., Sánchez-Carvajal, E., Santos-Medellin, C., Sbaraini, N., Schoellhorn, S. M., Schumm, C., Sehnal, L., Selem, N., Shah, A. D., Shishido, T. K., Sieber, S., Silviani, V., Singh, G., Singh, H., Sokolova, N., Sonnenschein, E. C., Sosio, M., Sowa, S. T., Steffen, K., Stegmann, E., Streiff, A. B., Strüder, A., Surup, F., Svenningsen, T., Sweeney, D., Szenei, J., Tagirdzhanov, A., Tan, B., Tarnowski, M. J., Terlouw, B. R., Rey, T., Thome, N. U., Ortega, L. R. T., Tørring, T., Trindade, M., Truman, A. W., Tvilum, M., Udwary, D. W., Ulbricht, C., Vader, L., van Wezel, G. P., Walmsley, M., Warnasinghe, R., Weddeling, H. G., Weir, A. N. M., Williams, K., Williams, S. E., Witte, T. E., Wood Rocca, S. M., Yamada, K., Yang, D., Yang, D., Yu, J., Zhou, Z., Ziemert, N., Zimmer, L., Zimmermann, A., Zimmermann, C., van der Hooft, J. J. J., Linington, R. G., Weber, T., Medema, M. H. & Nguyen, H., 6 Jan 2025, In: Nucleic Acids Research. 53, D1, p. D678-D690

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • NMR Fingerprints as a Predictive Model to Monitor Punaglandins in the Soft Coral Carijoa (Telesto) riisei (Duchassaing & Michelotti, 1860)

    Lindholm, P. E., Holland, D. C., Hayton, J. B., Stevens, T. & Carroll, A. R., 1 Nov 2025, In: Journal of Marine Science and Engineering. 13, 11, 2082.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Cheminformatics-Guided Exploration of Synthetic Marine Natural Product-Inspired Brominated Indole-3-Glyoxylamides and Their Potentials for Drug Discovery

    Holland, D. C., Prebble, D. W., Calcott, M. J., Schroder, W. A., Ferretti, F., Lock, A., Avery, V. M., Kiefel, M. J. & Carroll, A. R., 1 Aug 2024, In: Molecules. 29, 15, 3648.

    Research output: Contribution to journalArticlepeer-review

    Open Access