• The University of Western Australia (M316), 35 Stirling Highway,

    6009 Perth

    Australia

  • 414 Citations
  • 3 h-Index
20082020
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Research Output 2008 2020

  • 414 Citations
  • 3 h-Index
  • 7 Article
  • 4 Poster
  • 2 Non-UWA Thesis
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Article
2020

Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons

Martin, S., Poppe, D., Olova, N., O'Leary, C., Ivanova, E., Pflueger, J., Dechka, J., Simmons, R. K., Cooper, H. M., Reik, W., Lister, R. & Wolvetang, E., 9 Jan 2020, In : bioRxiv. 2020, 01.08, 61 p., 898429.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Embryonic Stem Cells
Neurons
Methylation
Nuclear Lamina
2019
1 Citation (Scopus)

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

Grubman, A., Chew, G., Ouyang, J. F., Sun, G., Choo, X. Y., McLean, C., Simmons, R. K., Buckberry, S., Vargas-Landin, D. B., Poppe, D., Pflueger, J., Lister, R., Rackham, O. J. L., Petretto, E. & Polo, J. M., 1 Dec 2019, In : Nature Neuroscience. 22, 12, p. 2087-2097

Research output: Contribution to journalArticle

Entorhinal Cortex
Atlases
Gene Expression Regulation
Alzheimer Disease
Astrocytes

Systematic bias assessment in solid tissue 10x scRNA-seq workflows

Denisenko, E., Guo, B., Jones, M., Hou, R., De Kock, L., Lassmann, T., Poppe, D., Clement, O., Simmons, R. K., Lister, R. & Forrest, A., 6 Nov 2019, (Submitted) In : bioRxiv. p. 1-47 47 p., 832444.

Research output: Contribution to journalArticle

Small Cytoplasmic RNA
Workflow
RNA Sequence Analysis
Chromium
Genomics
2018
2 Citations (Scopus)

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

Poppe, D., Doerr, J., Schneider, M., Wilkens, R., Steinbeck, J. A., Ladewig, J., Tam, A., Paschon, D. E., Gregory, P. D., Reik, A., Müller, C., Koch, P. & Brüstle, O., Jun 2018, In : Stem Cells Translational Medicine. 7, 6, p. 477-486 10 p., 29589874.

Research output: Contribution to journalArticle

Open Access
Neuroepithelial Cells
Stem cells
Adenosine
Neurons
Stem Cells
2013
21 Citations (Scopus)

Embryonic stem cell-based modeling of tau pathology in human neurons

Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O. & Koch, P., May 2013, In : American Journal of Pathology. 182, 5, p. 1769-1779 11 p.

Research output: Contribution to journalArticle

Open Access
Embryonic Stem Cells
Pathology
Neurons
Microtubules
Cell Death
2012
193 Citations (Scopus)

Small molecules enable highly efficient neuronal conversion of human fibroblasts

Ladewig, J., Mertens, J., Kesavan, J., Doerr, J., Poppe, D., Glaue, F., Herms, S., Wernet, P., Kögler, G., Müller, F-J., Koch, P. & Brüstle, O., 8 Apr 2012, In : Nature Methods. 9, 6, p. 575-578 4 p.

Research output: Contribution to journalArticle

Fibroblasts
Neurons
Glycogen Synthase Kinase 3
Molecules
Conversion efficiency
2011
197 Citations (Scopus)

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B., Wüllner, U. & Brüstle, O., 22 Dec 2011, In : Nature. 480, 7378, p. 543-546 4 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Neurons
Agglomeration
Genes
Proteolysis