• The University of Western Australia (M316), 35 Stirling Highway,

    6009 Perth

    Australia

  • 412 Citations
  • 3 h-Index
20082020
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Research Output 2008 2020

  • 412 Citations
  • 3 h-Index
  • 7 Article
  • 4 Poster
  • 2 Non-UWA Thesis
2020

Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons

Martin, S., Poppe, D., Olova, N., O'Leary, C., Ivanova, E., Pflueger, J., Dechka, J., Simmons, R. K., Cooper, H. M., Reik, W., Lister, R. & Wolvetang, E., 9 Jan 2020, In : bioRxiv. 2020, 01.08, 61 p., 898429.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Embryonic Stem Cells
Neurons
Methylation
Nuclear Lamina
2019
1 Citation (Scopus)

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

Grubman, A., Chew, G., Ouyang, J. F., Sun, G., Choo, X. Y., McLean, C., Simmons, R. K., Buckberry, S., Vargas-Landin, D. B., Poppe, D., Pflueger, J., Lister, R., Rackham, O. J. L., Petretto, E. & Polo, J. M., 1 Dec 2019, In : Nature Neuroscience. 22, 12, p. 2087-2097

Research output: Contribution to journalArticle

Entorhinal Cortex
Atlases
Gene Expression Regulation
Alzheimer Disease
Astrocytes

Systematic bias assessment in solid tissue 10x scRNA-seq workflows

Denisenko, E., Guo, B., Jones, M., Hou, R., De Kock, L., Lassmann, T., Poppe, D., Clement, O., Simmons, R. K., Lister, R. & Forrest, A., 6 Nov 2019, (Submitted) In : bioRxiv. p. 1-47 47 p., 832444.

Research output: Contribution to journalArticle

Small Cytoplasmic RNA
Workflow
RNA Sequence Analysis
Chromium
Genomics
2018

Cell culture-generated neurons show non-physiological DNA methylation signatures

Poppe, D., Martin, S., Pflueger, J., Wolvetang, E. & Lister, R., 22 Jun 2018.

Research output: Contribution to conferencePoster

DNA Methylation
Cell culture
Neurons
Cell Culture Techniques
Methylation
2 Citations (Scopus)

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

Poppe, D., Doerr, J., Schneider, M., Wilkens, R., Steinbeck, J. A., Ladewig, J., Tam, A., Paschon, D. E., Gregory, P. D., Reik, A., Müller, C., Koch, P. & Brüstle, O., Jun 2018, In : Stem Cells Translational Medicine. 7, 6, p. 477-486 10 p., 29589874.

Research output: Contribution to journalArticle

Open Access
Neuroepithelial Cells
Stem cells
Adenosine
Neurons
Stem Cells
2015
Open Access
Neural Stem Cells
Gene Targeting
Nervous System Diseases
Stem cells
Neurons
2013
21 Citations (Scopus)

Embryonic stem cell-based modeling of tau pathology in human neurons

Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O. & Koch, P., May 2013, In : American Journal of Pathology. 182, 5, p. 1769-1779 11 p.

Research output: Contribution to journalArticle

Open Access
Embryonic Stem Cells
Pathology
Neurons
Microtubules
Cell Death

Gene correction of an expanded CAG repeat in induced pluripotent stem cell-derived neural stem cells using adeno-associated virus-mediated targeting

Poppe, D., Breuer, P., Doerr, J., Jungverdorben, J., Peitz, M., Brüstle, O. & Koch, P., 22 Nov 2013, p. 1. 1 p.

Research output: Contribution to conferencePoster

Induced Pluripotent Stem Cells
Dependovirus
Neural Stem Cells
Machado-Joseph Disease
Genes

Generation of adenosine-kinase-deficient human neuroepthelial stem cells for cell-based delivery of adenosine into the central nervous system.

Poppe, D., Doerr, J., Steinbeck, J. A., Reik, A., Paschon, D. E., Gregory, P. D., Raedt, R., Boon, P., Koch, P. & Brüstle, O., 22 Nov 2013, p. 1. 1 p.

Research output: Contribution to conferencePoster

Adenosine Kinase
Adenosine
Stem Cells
Central Nervous System
Neuroepithelial Cells
2012
193 Citations (Scopus)

Small molecules enable highly efficient neuronal conversion of human fibroblasts

Ladewig, J., Mertens, J., Kesavan, J., Doerr, J., Poppe, D., Glaue, F., Herms, S., Wernet, P., Kögler, G., Müller, F-J., Koch, P. & Brüstle, O., 8 Apr 2012, In : Nature Methods. 9, 6, p. 575-578 4 p.

Research output: Contribution to journalArticle

Fibroblasts
Neurons
Glycogen Synthase Kinase 3
Molecules
Conversion efficiency
2011
195 Citations (Scopus)

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B., Wüllner, U. & Brüstle, O., 22 Dec 2011, In : Nature. 480, 7378, p. 543-546 4 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Neurons
Agglomeration
Genes
Proteolysis

Gene-correction in induced pluripotent stem cell derived neural stem cells using AAV-mediated targeting

Poppe, D., Breuer, P., Doerr, J., Jungverdorben, J., Peitz, M., Brüstle, O. & Koch, P., 12 Nov 2011, p. 1. 1 p.

Research output: Contribution to conferencePoster

Induced Pluripotent Stem Cells
Neural Stem Cells
Exons
Machado-Joseph Disease
Genes
2008
22 Downloads (Pure)
Open Access
File
Gene Targeting
Adenosine Kinase
Neural Stem Cells
Clone Cells
Genes