Research output per year
Research output per year
Personal profile
Biography
Daniel has a background in stem cell biology and neuroscience. During his PhD, he used human stem cell-derived neuronal cultures for disease modelling of Alzheimer’s disease and ataxias and used genetic manipulation to directly generate human neurons from fibroblasts or to generate therapeutic cell populations. He joined Ryan Listers lab at UWA in Perth to learn omics approaches to define cell states at high resolution and to learn bioinformatic skills to interpret them. He now combines stem cell biology, neuroscience, genomics and epigenetics to better understand human biology to improve cell culture systems in the hope of making them a better tool for biomedical research. He is using epigenomics, single cell technology and a broad range of cell culture systems to chart expression and epigenetic configuration of human tissues and their in vitro model systems.
Education/Academic qualification
Molecular Biomedicine, PhD, Gene targeting in human pluripotent cell-derived neural stem cells for the study and treatment of neurological disorders, University of Bonn
Award Date: 26 Oct 2015
Molecular Biomedicine, Diploma (equil. M. Sc.), Gene targeting in human embryonic stem cell derived neural precursor cells with adeno-associated viral vectors, University of Bonn
Award Date: 31 Mar 2008
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Epigenetic memory and differentiation bias in human iPS cells can be removed by a novel transient naive reprogramming strategy
Poppe, D., 14 Feb 2023, (Unpublished).Research output: Contribution to conference › Conference presentation/ephemera
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Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development
Martin, S., Poppe, D., Olova, N., O'Leary, C., Ivanova, E., Pflueger, J., Dechka, J., Simmons, R. K., Cooper, H. M., Reik, W., Lister, R. & Wolvetang, E. J., May 2023, In: Genes. 14, 5, 957.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Herring, C. A., Simmons, R. K., Freytag, S., Poppe, D., Moffet, J. J. D., Pflueger, J., Buckberry, S., Vargas Landin, D., Clement, O., Goni Echeverria, E., Sutton, G. J., Alvarez Franco, A., Hou, R., Pflueger, C., McDonald, K., Polo, J. M., Forrest, A. R. R., Nowak, A. K., Voineagu, I. & Martelotto, L. & 1 others, , 10 Nov 2022, In: Cell. 185, 23, p. 4428-4447.e28 20 p.Research output: Contribution to journal › Article › peer-review
Open Access134 Link opens in a new tab Citations (Scopus) -
From bottleneck to pipeline: Robotic EM-seq processing for population-scale methylome profiling
Poppe, D., Buckberry, S., Brown, A., Ludington, A., Breen, J., Howard, N. J., Massacci, H., Godwin, S., Llamas, B. & Lister, R., 16 Feb 2026.Research output: Contribution to conference › Conference presentation/ephemera
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Evaluating Non-CpG Methylation as a Marker of Neuronal Maturity in Human In Vitro Models
Poppe, D., 18 Nov 2025.Research output: Contribution to conference › Conference presentation/ephemera
Open AccessFile2 Downloads (Pure)
Datasets
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Comprehensive Evaluation of Human Brain Gene Expression Deconvolution Methods
Sutton, G. J. (Creator), Poppe, D. (Creator), Simmons, R. (Creator), Nawaz, U. (Creator), Lister, R. (Creator), Gagnon-Bartsch, J. A. (Creator) & Voineagu, I. (Creator), Gene Expression Omnibus (NCBI), 28 Aug 2021
DOI: 10.26182/2p1z-rx18, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE175772
Dataset
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Transient naive reprogramming corrects hiPS cells functionally and epigenetically [WGBS]
Buckberry, S. (Contributor), Liu, X. (Contributor), Poppe, D. (Contributor), Tan, J. P. (Contributor), Polo, J. M. (Contributor) & Lister, R. (Contributor), Gene Expression Omnibus (NCBI), 11 Aug 2023
DOI: 10.26182/3d4a-2129, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159296
Dataset
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Transient naive reprogramming corrects hiPS cells functionally and epigenetically [RNA-Seq]
Buckberry, S. (Contributor), Liu, X. (Contributor), Poppe, D. (Contributor), Tan, J. P. (Contributor), Polo, J. M. (Contributor) & Lister, R. (Contributor), Gene Expression Omnibus (NCBI), 11 Aug 2023
DOI: 10.26182/ans0-y578, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159114
Dataset
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Embryonic stem cell-derived neurons as a model system for epigenome maturation during development
Martin, S. (Creator), Poppe, D. (Creator), Olova, N. (Creator), O'Leary, C. (Creator), Ivanova, E. (Creator), Pflueger, J. (Creator), Dechka, J. (Creator), Simmons, R. (Creator), Cooper, H. M. (Creator), Reik, W. (Creator), Lister, R. (Creator) & Wolvetang, E. (Creator), Gene Expression Omnibus (NCBI), 25 Jul 2023
DOI: 10.26182/1gxr-k908, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137098
Dataset
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Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential
Carlessi, R. (Creator), Denisenko, E. (Creator), Boslem, E. (Creator), Köhn-Gaone, J. (Creator), Main, N. (Creator), Abu Bakar, N. D. B. (Creator), Shirolkar, G. (Creator), Jones, M. (Creator), Poppe, D. (Contributor), Dwyer, B. J. (Creator), Jackaman, C. (Creator), Tjiam, C. (Creator), Lister, R. (Creator), Karin, M. (Creator), Fallowfield, J. A. (Creator), Kendall, T. J. (Creator), Forbes, S. J. (Creator), Olynyk, J. K. (Creator), Yeoh, G. (Creator), Forrest, A. (Creator), Ramm, G. (Creator), Febbraio, M. A. (Creator) & Tirnitz-Parker, N. (Creator), Gene Expression Omnibus (NCBI), 12 Apr 2022
DOI: 10.26182/bhy9-q334, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE200366
Dataset
Projects
- 4 Active
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WA Centre for Cell and Genome Engineering
Lister, R. (Investigator 01), Lassmann, T. (Investigator 02), Fear, V. (Investigator 03), Ravenscroft, G. (Investigator 04), Poppe, D. (Investigator 05), Pflueger, C. (Investigator 06), Chen, F. (Investigator 07), Fox, A. (Investigator 08), Velickovic, Z. (Investigator 09), Gray, E. (Investigator 10), Tirnitz-Parker, N. (Investigator 11), Forrest, A. (Investigator 12), Koks, S. (Investigator 13), Rosenbluh, J. (Investigator 14) & Polo, J. (Investigator 15)
30/06/26 → 29/06/30
Project: Research
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Establishing a comprehensive iPS Cell-Based Platform for Modelling Neurodevelopmental Disorders of the Epigenetic Machinery
Polo, J. (Investigator 01), Lister, R. (Investigator 02), Sullivan, A. (Investigator 03), Poppe, D. (Investigator 04) & Bhattacharjee, R. (Investigator 05)
MRFF Medical Research Future Fund
1/06/25 → 31/05/27
Project: Research
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Mature neuronal cell culture systems for the study of human disease
Poppe, D. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/25 → 31/12/29
Project: Research
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White matter lesion single nuclei transcriptomics and epitope discovery to identify immune targets in multiple sclerosis
Kermode, A. (Investigator 01), Kaskow, B. (Investigator 02), Poppe, D. (Investigator 03), Patrick, E. (Investigator 04), Chopra, A. (Investigator 05), Lister, R. (Investigator 06), Mallal, S. (Investigator 07), Gaudieri, S. (Investigator 08), Pedrini, M. (Investigator 09), Lundin, S. (Investigator 10) & Zhong, X. (Investigator 11)
National Multiple Sclerosis Society (USA)
1/10/22 → 30/09/26
Project: Research
Prizes
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Acknowledgement of Contributions to Teaching and Learning
Poppe, D. (Recipient), 14 Nov 2022
Prize: Award
File -
School of Molecular Sciences Mid-Career Research Award
Poppe, D. (Recipient), 12 Sept 2025
Prize: Award
File -
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Harry Perkins Institute EMCR Innovators conference and collaboration award
Poppe, D. (Recipient), 19 Jan 2024
Prize
Activities
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Australasian Society for Stem Cell Research (External organisation)
Poppe, D. (Member)
4 Jul 2025 → …Activity: Memberships › Membership of professional association
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Transient Naive Treatment (TNT) reprogramming iPSC
Poppe, D. (Keynote speaker/Invited speaker)
20 Feb 2025Activity: Conferences and workshops › Participation in workshop, seminar or course
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Neurons in Two Worlds: What the Brain Teaches Us About In Vitro Cultures
Poppe, D. (Speaker)
21 Nov 2025Activity: Conferences and workshops › Participation in workshop, seminar or course
File -
Creating Stem Cells From Skin Cells | Solutions Science Podcast with Dr. Daniel Poppe
Poppe, D. (Invited speaker)
27 Aug 2023Activity: Service and engagement › Blog/ Podcast
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Meddling with DNA to make new-rons
Dottori, M. (Invited speaker) & Poppe, D. (Invited speaker)
2 Feb 2022Activity: Service and engagement › Public lecture, debate or seminar
File
Courses
Press/Media
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A map to illuminate how gene activity changes in our brains
3/11/22
1 item of Media coverage
Press/Media: Press / Media
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‘Cause I’m TNT: New Reprogramming Method Produces Naive Human Induced Pluripotent Stem Cells
16/08/23 → 17/08/23
4 items of Media coverage
Press/Media: Press / Media
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World-first human brain cell map shows gene activity changes
1/11/22 → 22/12/22
3 items of Media coverage
Press/Media: Press / Media
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The world’s first map of gene activity in the human brain from pre-birth to adulthood
4/11/22
2 items of Media coverage
Press/Media: Press / Media
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University of Western Australia: Australian Scientists Develop World-First Map Showing Gene Activity Changes In Diverse Human Brain Cell Types From Pre-Birth To Adulthood
2/11/22
1 item of Media coverage
Press/Media: Press / Media