Dane Cheasley

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Dane Cheasley

Dr

 https://orcid.org/0000-0002-1170-4690

  • The University of Western Australia (M504), 35 Stirling Highway,

    6009 Perth

    Australia

Accepting PhD and other Higher Degree by Research Students. View current PhD/HDR research project opportunities at https://researchdegrees.uwa.edu.au/projects

PhD/HDR research projects available:

In low-grade serous ovarian carcinoma (LGSOC), my PhD projects include identifying synergistic drug combinations using high-throughput screening of FDA-approved agents, kinase inhibitors, and epigenetic modulators. I am also establishing preclinical models, including organoids and patient-derived xenografts (PDX), to evaluate repurposed drugs. Additionally, my comprehensive multiomics analysis has revealed actionable genomic alterations in patients with poor survival outcomes. My work on cellular stress signalling has identified AAMDC as a key driver of treatment resistance, with ongoing studies testing targeted agents to restore therapy sensitivity. I am also investigating novel surface proteins in ovarian cancer as potential therapeutic targets.

In breast cancer research, my projects will explore the molecular drivers of breast cancer in women with high and low mammographic density. Another key area involves integrating germline and somatic mutation testing in breast cancer patients to guide treatment decisions, identify high-risk predisposition mutations, and assess the feasibility of implementing Universal Genetic Testing in Western Australia.

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