• The University of Western Australia (M310), 35 Stirling Highway, Room 4.32, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 4354 Citations
  • 36 h-Index
1993 …2020
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Personal profile

Biography

Charlie Bond first became interested in chemistry at school in the United Kingdom and went on to study at the University in Manchester. After completing his PhD on the structure of proteins he pursued this field as a post-doctoral researcher in Sydney and as a research fellow at the School of Life Sciences, University of Dundee, UK. He was recruited to UWA as a structural biologist in 2006. In addition to researching the structure of biomolecular complexes he has also developed and published related computer software programs.

Roles and responsibilities

Protein chemistry - Structural biology - Molecular biology - Biological chemistry - Protein:protein interactions - Protein:RNA interactions - Crystallography - Computational modelling - Biophysics - Synchrotron science

Future research

Prospective Research Students, with good prospects of gaining a scholarship, and interested in understanding the role of structure in gene regulation, RNA recognition and enzyme function are always sought in my lab. Please see bondxray.org for more information.

Funding overview

NHMRC Project Grants; ARC Linkage Project; ARC Discovery Project; ARC LIEF Grants; Cancer Council WA

Current projects

Please see http://bondxray.org/

Industrial relevance

Structure-based methods of studying proteins form the basis of any mechanistic approach to drug design and evaluation, as typified by pharmaceuticals such as Relenza and Gleevec.

Teaching overview

Undergraduate units, honours supervision and PhD supervision in both Chemistry and Biochemistry.

Research

As a structural biologist, Prof. Bond studies the three dimensional structure of biological molecules, such as nucleic acids and proteins, which helps to explain how the molecules function. The applications of Prof. Bond’s studies are very broad and far reaching. Protein structures can be used as a basis to design drugs to treat infectious diseases, and researching how proteins contribute to errors in DNA and RNA expression increases our understanding of how cancers and other disorders are caused, and how they might be treated.

Languages

English and German

Keywords

  • Enzyme structure, function and inhibition
  • Mechanisms of DNA repair
  • Protein crystallography
  • Protein–nucleic acid interactions
  • Structural biology

Fingerprint Dive into the research topics where Charlie Bond is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Proteins Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Long Noncoding RNA Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Crystal structure Chemical Compounds
RNA Medicine & Life Sciences
Protein Splicing Medicine & Life Sciences
Crithidia fasciculata Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1993 2019

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

Spackman, P. R., Yu, L. J., Morton, C. J., Parker, M. W., Bond, C. S., Spackman, M. A., Jayatilaka, D. & Thomas, S. P., 6 Aug 2019, In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Crystal engineering
Drug Discovery
Databases
Crystal structure
Crystals

Delineation of the integrase-attachment and origin-of-transfer regions of the symbiosis island ICEMlSym R7A

Verdonk, C. J., Sullivan, J. T., Williman, K. M., Nicholson, L., Bastholm, T. R., Hynes, M. F., Ronson, C. W., Bond, C. S. & Ramsay, J. P., 1 Jul 2019, In : Plasmid. 104, 102416.

Research output: Contribution to journalArticle

Genomic Islands
Integrases
Symbiosis
Genetic Recombination
Genes

Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s

Yui Eto, K., Firth, N., Davis, A. M., Kwong, S. M., Krysiak, M., Lee, Y. T., O'Brien, F. G., Grubb, W. B., Coombs, G. W., Bond, C. S. & Ramsay, J. P., 1 Nov 2019, In : Antimicrobial Agents and Chemotherapy. 63, 11

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Plasmids
Western Australia
Interspersed Repetitive Sequences
Penicillin Resistance
7 Citations (Scopus)

The macrocyclizing protease butelase 1 remains auto-catalytic and reveals the structural basis for ligase activity

James, A. M., Haywood, J., Leroux, J., Ignasiak, K., Elliott, A. G., Schmidberger, J. W., Fisher, M. F., Nonis, S. G., Fenske, R., Bond, C. S. & Mylne, J. S., Jun 2019, In : The Plant Journal. 98, 6, p. 988-999 12 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Ligases
ligases
automobiles
Peptide Hydrolases
4 Citations (Scopus)
169 Downloads (Pure)

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins

Huang, J., Casas Garcia, G. P., Perugini, M. A., Fox, A. H., Bond, C. S. & Lee, M., 27 Apr 2018, In : The Journal of Biological Chemistry. 293, 17, p. 6593-6602 10 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Splicing
Drosophila
Dimerization
Crystal structure
Dimers

Projects 2007 2020