Research output per year
Research output per year
Personal profile
Biography
Charlie Bond first became interested in chemistry at school in the United Kingdom and went on to study at the University in Manchester. After completing his PhD on the structure of proteins he pursued this field as a post-doctoral researcher in Sydney and as a research fellow at the School of Life Sciences, University of Dundee, UK. He was recruited to UWA as a structural biologist in 2006. In addition to researching the structure of biomolecular complexes he has also developed and published related computer software programs.
Roles and responsibilities
Protein chemistry - Structural biology - Molecular biology - Biological chemistry - Protein:protein interactions - Protein:RNA interactions - Crystallography - Computational modelling - Biophysics - Synchrotron science
Future research
Prospective Research Students, with good prospects of gaining a scholarship, and interested in understanding the role of structure in gene regulation, RNA recognition and enzyme function are always sought in my lab. Please see bondxray.org for more information.
Funding overview
NHMRC Project Grants; ARC Linkage Project; ARC Discovery Project; ARC LIEF Grants; Cancer Council WA
Current projects
Please see http://bondxray.org/
Industrial relevance
Structure-based methods of studying proteins form the basis of any mechanistic approach to drug design and evaluation, as typified by pharmaceuticals such as Relenza and Gleevec.
Teaching overview
Undergraduate units, honours supervision and PhD supervision in both Chemistry and Biochemistry.
Research
| As a structural biologist, Prof. Bond studies the three dimensional structure of biological molecules, such as nucleic acids and proteins, which helps to explain how the molecules function. The applications of Prof. Bond’s studies are very broad and far reaching. Protein structures can be used as a basis to design drugs to treat infectious diseases, and researching how proteins contribute to errors in DNA and RNA expression increases our understanding of how cancers and other disorders are caused, and how they might be treated. |
Languages
English and German
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Protein Crystallography, PhD, Trypanothione reductase: Structure, specificity and approaches to inhibitor identification, University of Manchester
1 Sept 1992 → 3 Dec 1995
Award Date: 26 Feb 1996
Chemistry with Industrial Experience, BSc (Hons) First Class, University of Manchester
9 Sept 1988 → 10 Jul 1992
Award Date: 10 Jul 1995
Industry keywords
- Biotechnology
- Drug Discovery
- Agriculture and Food
Research expertise keywords
- Enzyme structure, function and inhibition
- Mechanisms of DNA repair
- Protein crystallography
- Protein–nucleic acid interactions
- Structural biology
Fingerprint
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Applications of Synthetic Pentatricopeptide Repeat Proteins
Kwok van der Giezen, F., Honkanen, S., Colas des Francs-Small, C., Bond, C. & Small, I., 1 Apr 2024, In: Plant & Cell Physiology. 65, 4, p. 503-515 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Citations (Scopus) -
Single-molecule visualization of sequence-specific RNA binding by a designer PPR protein
Marzano, N., Johnston, B., Paudel, B. P., Schmidberger, J., Jergic, S., Bocking, T., Agostino, M., Small, I., van Oijen, A. M. & Bond, C. S., 11 Dec 2024, In: Nucleic Acids Research. 52, 22, p. 14154-14170 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural plasticity of the coiled-coil interactions in human SFPQ
Koning, H. J., Lai, J. Y., Marshall, A. C., Stroeher, E., Monahan, G., Pullakhandam, A., Knott, G. J., Ryan, T. M., Fox, A. H., Whitten, A., Lee, M. & Bond, C. S., 19 Dec 2024, (E-pub ahead of print) In: Nucleic Acids Research. 15 p., gkae1198.Research output: Contribution to journal › Article › peer-review
Open Access -
Welcoming five new Co-editors
Bond, C. S., Garman, E. F. & Read, R. J., 1 Mar 2024, In: Acta crystallographica. Section D, Structural biology. 80, p. 147-147 1 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Welcoming two new Co-editors
Bond, C. S., Garman, E. F. & Read, R. J., 1 Nov 2024, In: Acta crystallographica. Section D, Structural biology. 80, Pt 11, p. 765 1 p.Research output: Contribution to journal › Editorial › peer-review
Open Access
Datasets
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SFPQ PARCLIP HeLa data from: Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation
Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Gene Expression Omnibus (NCBI), 27 Jun 2018
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM3104135
Dataset
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Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation (Yamazaki et al.)
Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Mendeley Data, 28 Jun 2018
Dataset
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6WCK
Bond, C. (Creator), Protein Data Bank, Rutgers University, 15 Apr 2020
DOI: 10.2210/pdb6WCK/pdb
Dataset
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NONO PARCLIP U2OS data from: Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation
Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Gene Expression Omnibus (NCBI), 27 Jun 2018
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM3104132
Dataset
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A synthetic RNA editing factor edits its target site in chloroplasts and bacteria
Small, I. (Creator), Royan, S. (Creator), Gutmann, B. (Creator), Colas des Francs-Small, C. (Creator), Honkanen, S. (Creator), Schmidberger, J. (Creator), Soet, A. (Creator), Sun, K. (Creator), Vincis Pereira Sanglard, L. (Creator) & Bond, C. (Creator), DRYAD, 28 Sept 2021
DOI: 10.5061/dryad.b8gtht7c6, https://zenodo.org/record/5535124 and one more link, http://datadryad.org/stash/dataset/doi:10.5061/dryad.b8gtht7c6 (show fewer)
Dataset
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Molecular "safety catches" for controlled modification of RNA
Bond, C. (Investigator 01) & Small, I. (Investigator 02)
ARC Australian Research Council
1/01/25 → 31/12/27
Project: Research
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AKTA Pure Liquid Chromatography System
Bond, C. (CoPI), Chooi, H. (CoPI), Fox, A. (CoPI), Kretzmann, J. (CoPI), Melville, K. (CoPI), Rudler, D. (CoPI), Sarkar-Tyson, M. (CoPI), Smith, N. (CoPI), Smithers, L. (CoPI), Stubbs, K. (CoPI), Swaminatha Iyer, I. (CoPI), Vrielink, A. (CoPI), Wang, T. (CoPI) & Waters, M. (CoPI)
The University of Western Australia
1/01/25 → 31/12/25
Project: Research
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Intraoperative immunotherapy to prevent cancer recurrence after surgery (2.)
Lesterhuis, W. (Investigator 01), Veedu, R. (Investigator 02), Bond, C. (Investigator 03), Swaminatha Iyer, I. (Investigator 04) & Wang, T. (Investigator 05)
Department of Health (Western Australia)
28/06/22 → 27/06/25
Project: Research
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ARC Training Centre for Next-Gen Technologies in Biomedical Analysis
Swaminatha Iyer, I. (Investigator 01), Tilley, R. (Investigator 02), Gooding, J. (Investigator 03), Voelcker, N. (Investigator 04), Carneiro, G. (Investigator 05), Geddes, D. (Investigator 06), Wood, F. (Investigator 07), Bond, C. (Investigator 08), Elnathan, R. (Investigator 09), Kennedy, B. (Investigator 10), Bauer, D. (Investigator 11), Thirkettle-Watts, D. (Investigator 12), Smith, N. (Investigator 13), Nowak, K. (Investigator 14), Jiang, H. (Investigator 15), Stubbs, K. (Investigator 16), Taylor, N. (Investigator 17), Saxena, A. (Investigator 18), van Der Made, P. (Investigator 19) & Quick, A. (Investigator 20)
ARC Australian Research Council
1/06/22 → 28/03/27
Project: Research
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Engineering self-assembled intracellular biological condensates
Bond, C. (Investigator 01), Fox, A. (Investigator 02) & Hyman, T. (Investigator 03)
ARC Australian Research Council
29/03/22 → 31/12/25
Project: Research
Prizes
Courses
Press/Media
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UWA awarded $8 million to lead two new Industrial Training Centres
Wood, F., Geddes, D., Stubbs, K., Taylor, N., Saxena, A., Guzzomi, A., Bond, C. S., Smith, N., Kennedy, B., Kragt, M. & Jiang, H.
21/07/21
1 item of Media coverage
Press/Media: Press / Media