Charlie Bond

Professor, BSc PhD Manc., FRSC

  • The University of Western Australia (M310), 35 Stirling Highway,

    6009 Perth

    Australia

  • 4757 Citations
  • 38 h-Index
1993 …2020

Research output per year

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Personal profile

Biography

Charlie Bond first became interested in chemistry at school in the United Kingdom and went on to study at the University in Manchester. After completing his PhD on the structure of proteins he pursued this field as a post-doctoral researcher in Sydney and as a research fellow at the School of Life Sciences, University of Dundee, UK. He was recruited to UWA as a structural biologist in 2006. In addition to researching the structure of biomolecular complexes he has also developed and published related computer software programs.

Roles and responsibilities

Protein chemistry - Structural biology - Molecular biology - Biological chemistry - Protein:protein interactions - Protein:RNA interactions - Crystallography - Computational modelling - Biophysics - Synchrotron science

Future research

Prospective Research Students, with good prospects of gaining a scholarship, and interested in understanding the role of structure in gene regulation, RNA recognition and enzyme function are always sought in my lab. Please see bondxray.org for more information.

Funding overview

NHMRC Project Grants; ARC Linkage Project; ARC Discovery Project; ARC LIEF Grants; Cancer Council WA

Current projects

Please see http://bondxray.org/

Industrial relevance

Structure-based methods of studying proteins form the basis of any mechanistic approach to drug design and evaluation, as typified by pharmaceuticals such as Relenza and Gleevec.

Teaching overview

Undergraduate units, honours supervision and PhD supervision in both Chemistry and Biochemistry.

Research

As a structural biologist, Prof. Bond studies the three dimensional structure of biological molecules, such as nucleic acids and proteins, which helps to explain how the molecules function. The applications of Prof. Bond’s studies are very broad and far reaching. Protein structures can be used as a basis to design drugs to treat infectious diseases, and researching how proteins contribute to errors in DNA and RNA expression increases our understanding of how cancers and other disorders are caused, and how they might be treated.

Languages

English and German

Research expertise keywords

  • Enzyme structure, function and inhibition
  • Mechanisms of DNA repair
  • Protein crystallography
  • Protein–nucleic acid interactions
  • Structural biology

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Research Output

  • 4757 Citations
  • 38 h-Index
  • 95 Article
  • 7 Review article
  • 2 Abstract/Meeting Abstract

Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells

Bharadwaj, P., Solomon, T., Sahoo, B. R., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M. J., Bond, C. S., Ramamoorthy, A., Martins, R. N. & Newsholme, P., 1 Dec 2020, In : Scientific Reports. 10, 1, 10356.

Research output: Contribution to journalArticle

Open Access
  • Divergent receptor proteins confer responses to different karrikins in two ephemeral weeds

    Sun, K., Yao, J., Scaffidi, A., Melville, K., Davies, S., Bond, C., Smith, S. M., Flematti, G. & Waters, M., 1 Dec 2020, In : Nature Communications. 11, 1, 1264.

    Research output: Contribution to journalArticle

    Open Access
  • 41 Downloads (Pure)

    High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition

    Ou, A., Schmidberger, J., Wilson, K., Evans, C., Hargreaves, J., Grigg, M., O'Mara, M., Swaminatha Iyer, K., Bond, C. & Smith, N., 4 Jun 2020, In : Nucleic Acids Research. 48, 10, p. 5766-5776 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)

    The Expansion and Diversification of Pentatricopeptide Repeat RNA-Editing Factors in Plants

    Gutmann, B., Royan, S., Schallenberg-Rüdinger, M., Lenz, H., Castleden, I. R., McDowell, R., Vacher, M. A., Tonti-Filippini, J., Bond, C. S., Knoop, V. & Small, I. D., 3 Feb 2020, In : Molecular Plant. 13, 2, p. 215-230 16 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

    Spackman, P. R., Yu, L. J., Morton, C. J., Parker, M. W., Bond, C. S., Spackman, M. A., Jayatilaka, D. & Thomas, S. P., 6 Aug 2019, In : Angewandte Chemie - International Edition.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Datasets

    NONO PARCLIP U2OS data from: Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

    Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Gene Expression Omnibus (NCBI), 27 Jun 2018

    Dataset

    SFPQ PARCLIP U2OS data from: Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

    Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Gene Expression Omnibus (NCBI), 27 Jun 2018

    Dataset

    SFPQ PARCLIP HeLa data from: Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

    Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Gene Expression Omnibus (NCBI), 27 Jun 2018

    Dataset

    Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation (Yamazaki et al.)

    Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Mendeley Data, 28 Jun 2018

    Dataset

    NONO PARCLIP HeLa data from: Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

    Yamazaki, T. (Creator), Souquere, S. (Creator), Chujo, T. (Creator), Kobelke, S. (Creator), Chong, Y. S. (Creator), Fox, A. (Creator), Bond, C. (Creator), Nakagawa, S. (Creator), Pierron, G. (Creator) & Hirose, T. (Creator), Gene Expression Omnibus (NCBI), 27 Jun 2018

    Dataset

    Projects