• The University of Western Australia (M310), 35 Stirling Highway, Room 4.32, Bayliss Building, Perth campus

    6009 Perth

    Australia

  • 3870 Citations
  • 33 h-Index
1993 …2020
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Personal profile

Biography

Charlie Bond first became interested in chemistry at school in the United Kingdom and went on to study at the University in Manchester. After completing his PhD on the structure of proteins he pursued this field as a post-doctoral researcher in Sydney and as a research fellow at the School of Life Sciences, University of Dundee, UK. He was recruited to UWA as a structural biologist in 2006. In addition to researching the structure of biomolecular complexes he has also developed and published related computer software programs.

Roles and responsibilities

Protein chemistry - Structural biology - Molecular biology - Biological chemistry - Protein:protein interactions - Protein:RNA interactions - Crystallography - Computational modelling - Biophysics - Synchrotron science

Future research

Prospective Research Students, with good prospects of gaining a scholarship, and interested in understanding the role of structure in gene regulation, RNA recognition and enzyme function are always sought in my lab. Please see bondxray.org for more information.

Funding overview

NHMRC Project Grants; ARC Linkage Project; ARC Discovery Project; ARC LIEF Grants; Cancer Council WA

Current projects

Please see http://bondxray.org/

Industrial relevance

Structure-based methods of studying proteins form the basis of any mechanistic approach to drug design and evaluation, as typified by pharmaceuticals such as Relenza and Gleevec.

Teaching overview

Undergraduate units, honours supervision and PhD supervision in both Chemistry and Biochemistry.

Research

As a structural biologist, Prof. Bond studies the three dimensional structure of biological molecules, such as nucleic acids and proteins, which helps to explain how the molecules function. The applications of Prof. Bond’s studies are very broad and far reaching. Protein structures can be used as a basis to design drugs to treat infectious diseases, and researching how proteins contribute to errors in DNA and RNA expression increases our understanding of how cancers and other disorders are caused, and how they might be treated.

Languages

English and German

Keywords

  • Enzyme structure, function and inhibition
  • Mechanisms of DNA repair
  • Protein crystallography
  • Protein–nucleic acid interactions
  • Structural biology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Proteins Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Long Noncoding RNA Medicine & Life Sciences
Enzymes Medicine & Life Sciences
RNA Medicine & Life Sciences
Crystal structure Chemical Compounds
Protein Splicing Medicine & Life Sciences
Crithidia fasciculata Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2007 2020

Research Output 1993 2018

2 Citations

Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins

Huang, J., Casas Garcia, G. P., Perugini, M. A., Fox, A. H., Bond, C. S. & Lee, M., 27 Apr 2018, In : The Journal of Biological Chemistry. 293, 17, p. 6593-6602 10 p.

Research output: Contribution to journalArticle

Protein Splicing
Drosophila
Dimerization
Crystal structure
Dimers
11 Citations

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

Yamazaki, T., Souquere, S., Chujo, T., Kobelke, S., Chong, Y. S., Fox, A. H., Bond, C. S., Nakagawa, S., Pierron, G. & Hirose, T., 21 Jun 2018, In : Molecular Cell. 701, 6, p. 1038-1053.e7

Research output: Contribution to journalArticle

Long Noncoding RNA
Clustered Regularly Interspaced Short Palindromic Repeats
RNA
RNA Isoforms
Untranslated RNA

Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA

Ho, D. W. , Kretzmann, J. , Norret, M. , Toshniwal, P. , Veder, J. P. , Jiang, H. , Guagliardo, P. , Munshi, A. M. A. , Chawla, R. , Evans, C. , Clemons, T. , Nguyen, M. , Kretzmann, A. , Blythe, A. , Saunders, M. , Archer, M. , Fitzgerald, M. , Keelan, J. , Bond, C. , Kilburn, M. & 3 others Hurley, L., Smith, N. & Swaminatha Iyer, K., 8 Oct 2018, In : Nature Nanotechnology.

Research output: Contribution to journalArticle

Nanorods
Gold
nanorods
DNA
deoxyribonucleic acid

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

Lahaye, X., Gentili, M., Silvin, A., Conrad, C., Picard, L., Jouve, M., Zueva, E., Maurin, M., Nadalin, F., Knott, G. J., Zhao, B., Du, F., Rio, M., Amiel, J., Fox, A. H., Li, P., Etienne, L., Bond, C. S., Colleaux, L. & Manel, N., 4 Oct 2018, In : Cell. 175, 2, p. 488-501.e22

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Capsid
Chemical activation
HIV
HIV-2
14 Citations

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

Fox, A. H., Nakagawa, S., Hirose, T. & Bond, C. S., Feb 2018, In : Trends in Biochemical Sciences. 43, 2, p. 124-135 12 p.

Research output: Contribution to journalReview article

Long Noncoding RNA
Phase separation
RNA
Proteins
Gene expression