Research output per year
Research output per year
- 1 - 50 out of 78 results
Search results
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2024
AI is a viable alternative to high throughput screening: a 318-target study: a 318-target study
The Atomwise AIMS Program, 2 Apr 2024, In: Scientific Reports. 14, 1, p. 7526 1 p., 7526 (2024) .Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
The Atomwise AIMS Program, 16 Sept 2024, In: Scientific Reports. 14, 1, 21579.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Genomic Surveillance of Invasive Meningococcal Disease During a National MenW Outbreak in Australia, 2017-2018
Sotheran, E., Lane, C. R., Horan, K., Stevens, K., Guglielmino, C., Bradbury, S., Kennedy, K., Cooley, L., McEwan, B., Kahler, C. M., Mowlaboccus, S., Speers, D. J., Baird, R., Freeman, K., Leong, L., Warner, M., Williamson, D. A., McVernon, J., Lahra, M., Jennison, A. V., & 2 others, Jun 2024, In: Open Forum Infectious Diseases. 11, 6, 9 p., ofae249.Research output: Contribution to journal › Article › peer-review
Open Access -
Obstetric and Neonatal Invasive Meningococcal Disease Caused by Neisseria meningitidis Serogroup W, Western Australia, Australia
Hart, J., Dowse, G. K., Porter, M., Speers, D. J., Keil, A. D., Bew, J. D., Mowlaboccus, S. & Kahler, C. M., Feb 2024, In: Emerging Infectious Diseases. 30, 2, p. 368-371 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The genomic epidemiology of Neisseria meningitidis carriage from a randomised controlled trial of 4CMenB vaccination in an asymptomatic adolescent population
Leong, L. E. X., Coldbeck-Shackley, R. C., McMillan, M., Bratcher, H. B., Turra, M., Lawrence, A., Kahler, C., Maiden, M. C. J., Rogers, G. B. & Marshall, H., Feb 2024, In: The Lancet Regional Health - Western Pacific. 43, 100966.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
2023
Compounds and uses therefor
Vrielink, A., Stubbs, K. & Kahler, C., 19 May 2023, Patent No. WO2023081967, 10 Nov 2022, Priority date 19 May 2023Research output: Patent
File53 Downloads (Pure) -
Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis
Mikucki, A. & Kahler, C. M., Dec 2023, In: Microorganisms. 11, 12, 3005.Research output: Contribution to journal › Review article › peer-review
Open Access -
Phosphoethanolamine Transferases as Drug Discovery Targets for Therapeutic Treatment of Multi-Drug Resistant Pathogenic Gram-Negative Bacteria
Thai, V., Stubbs, K., Sarkar-Tyson, M. & Kahler, C., Sept 2023, In: Antibiotics. 12, 9, 1382.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus) -
Travel-associated lineages and unique endemic antimicrobial-susceptible lineages of Neisseria gonorrhoeae predominate in Western Australia
Al Suwayyid, B. A., Haese, E. C., Mowlaboccus, S., Pearson, J. C., Whiley, D. M., Armstrong, P. K., Giele, C. M., Mak, D. B., Bastian, L., Wise, M. J., Coombs, G. W. & Kahler, C. M., 29 Mar 2023, In: Microbial Genomics. 9, 3, 14 p., 000969.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
B Part of It School Leaver Study: A Repeat Cross-Sectional Study to Assess the Impact of Increasing Coverage with Meningococcal B (4CMenB) Vaccine on Carriage of Neisseria meningitidis
McMillan, M., Koehler, A. P., Lawrence, A., Sullivan, T. R., Bednarz, J., MacLennan, J. M., Maiden, M. C. J., Ladhani, S. N., Ramsay, M. E., Trotter, C., Borrow, R., Finn, A., Kahler, C. M., Whelan, J., Vadivelu, K., Richmond, P. C. & Marshall, H. S., 15 Feb 2022, In: Journal of Infectious Diseases. 225, 4, p. 637-649 13 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major
Iwasaki, J., Lorimer, D. D., Vivoli-Vega, M., Kibble, E. A., Peacock, C. S., Abendroth, J., Mayclin, S. J., Dranow, D. M., Pierce, P. G., Fox, D., Lewis, M., Bzdyl, N. M., Kristensen, S. S., Inglis, T. J. J., Kahler, C. M., Bond, C. S., Hasenkopf, A., Seufert, F., Schmitz, J., Marshall, L. E., & 6 others, 1 Jun 2022, In: Journal of Antimicrobial Chemotherapy. 77, 6, p. 1625-1634 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid: A phosphoethanolamine transferase
Mullally, C., Stubbs, K. A., Thai, V. C., Anandan, A., Bartley, S., Scanlon, M. J., Jarvis, G. A., John, C. M., Lim, K. Y. L., Sullivan, C. M., Sarkar-Tyson, M., Vrielink, A. & Kahler, C. M., 1 Sept 2022, In: The Journal of antimicrobial chemotherapy. 77, 9, p. 2441-2447 7 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis
Mikucki, A., McCluskey, N. R. & Kahler, C. M., 22 Apr 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 862935.Research output: Contribution to journal › Review article › peer-review
Open Access9 Citations (Scopus) -
2021
Anti-virulence therapeutic approaches for neisseria gonorrhoeae
Lim, K. Y. L., Mullally, C. A., Haese, E. C., Kibble, E. A., McCluskey, N. R., Mikucki, E. C., Thai, V. C., Stubbs, K. A., Sarkar-Tyson, M. & Kahler, C. M., Feb 2021, In: Antibiotics. 10, 2, p. 1-32 32 p., 103.Research output: Contribution to journal › Review article › peer-review
Open Access13 Citations (Scopus) -
Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme-substrate recognition
Anandan, A., Dunstan, N. W., Ryan, T. M., Mertens, H. D. T., Lim, K. Y. L., Evans, G. L., Kahler, C. M. & Vrielink, A., 1 Sept 2021, In: IUCrJ. 8, p. 732-746 15 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Modelling evolutionary pathways for commensalism and hypervirulence in neisseria meningitidis
Mullally, C. A., Mikucki, A., Wise, M. J. & Kahler, C. M., 2021, In: Microbial Genomics. 7, 10, 000662.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Neisseria species and their complicated relationships with human health
Kahler, C. M., Jun 2021, In: Microbiology Australia. 42, 2, p. 79-83 5 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Vaccine candidates for the control and prevention of the sexually transmitted disease gonorrhea
Haese, E. C., Thai, V. C. & Kahler, C. M., Jul 2021, In: Vaccines. 9, 7, 804.Research output: Contribution to journal › Review article › peer-review
Open Access14 Citations (Scopus) -
2020
Meningococcal B vaccine and meningococcal carriage in adolescents in Australia
Marshall, H. S., McMillan, M., Koehler, A. P., Lawrence, A., Sullivan, T. R., MacLennan, J. M., Maiden, M. C. J., Ladhani, S. N., Ramsay, M. E., Trotter, C., Borrow, R., Finn, A., Kahler, C. M., Whelan, J., Vadivelu, K. & Richmond, P., 23 Jan 2020, In: New England Journal of Medicine. 382, 4, p. 318-327 10 p.Research output: Contribution to journal › Article › peer-review
142 Citations (Scopus) -
Meningococcal Disease-Associated Prophage-Like Elements Are Present in Neisseria gonorrhoeae and Some Commensal Neisseria Species
Al Suwayyid, B. A., Rankine-Wilson, L., Speers, D. J., Wise, M. J., Coombs, G. W. & Kahler, C. M., 8 Feb 2020, In: Genome Biology and Evolution. 12, 2, p. 3938-3950 13 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
The Goldilocks Zone: Searching for a Phylogenetic Approach for the Recombinogenic Neisseria gonorrhoeae
Kahler, C. M., 1 Dec 2020, In: The Journal of infectious diseases. 222, 11, p. 1762-1763 2 p.Research output: Contribution to journal › Editorial › peer-review
2 Citations (Scopus) -
2019
B part of it school leaver protocol: An observational repeat cross-sectional study to assess the impact of a meningococcal serogroup b (4cmenb) vaccine programme on carriage of neisseria meningitidis
Marshall, H. S., McMillan, M., Koehler, A., Lawrence, A., MacLennan, J., Maiden, M., Ramsay, M., Ladhani, S. N., Trotter, C., Borrow, R., Finn, A., Sullivan, T., Richmond, P., Kahler, C., Whelan, J. & Vadivelu, K., 1 May 2019, In: BMJ Open. 9, 5, 7 p., e027233.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Communication ambassadors—an Australian social media initiative to develop communication skills in early career scientists
Wang, J. T. H., Power, C. J., Kahler, C. M., Lyras, D., Young, P. R., Iredell, J. & Robins-Browne, R., 1 Jan 2019, In: Journal of Microbiology and Biology Education. 19, 1, 1428.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates
Furfaro, L. L., Chang, B. J., Kahler, C. M. & Payne, M. S., 1 Oct 2019, In: PLoS One. 14, 10, e0223256.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei
Bzdyl, N. M., Scott, N. E., Norville, I. H., Scott, A. E., Atkins, T., Pang, S., Sarovich, D. S., Coombs, G., Inglis, T. J. J., Kahler, C. M. & Sarkar-Tyson, M., Oct 2019, In: Infection and Immunity. 87, 10, e00528-19.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)144 Downloads (Pure) -
Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens
Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 26 Oct 2019, In: Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
The Detroit 562 pharyngeal immortalized cell line model for the assessment of infectivity of pathogenic neisseria sp.
Kibble, E. A., Sarkar-Tyson, M., Coombs, G. W. & Kahler, C. M., 16 Mar 2019, Neisseria meningitidis: Methods and Protocols. Seib, K. L. & Peak, I. R. (eds.). USA: Humana Press Inc., Vol. 1969. p. 123-133 11 p. (Methods in Molecular Biology; vol. 1969).Research output: Chapter in Book/Conference paper › Chapter › peer-review
2 Citations (Scopus) -
2018
B Part of It protocol: A cluster randomised controlled trial to assess the impact of 4CMenB vaccine on pharyngeal carriage of Neisseria meningitidis in adolescents
Marshall, H. S., McMillan, M., Koehler, A., Lawrence, A., Maclennan, J. M., Maiden, M. C. J., Ramsay, M., Ladhani, S. N., Trotter, C., Borrow, R., Finn, A., Sullivan, T., Richmond, P., Kahler, C. M., Whelan, J. & Vadivelu, K., 1 Jul 2018, In: BMJ Open. 8, 7, e020988.Research output: Contribution to journal › Article › peer-review
Open Access30 Citations (Scopus) -
Enzyme targets for drug design of new anti-virulence therapeutics
Kahler, C. M., Sarkar-Tyson, M., Kibble, E. A., Stubbs, K. A. & Vrielink, A., 1 Dec 2018, In: Current Opinion in Structural Biology. 53, p. 140-150 11 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Citations (Scopus)472 Downloads (Pure) -
Genomic epidemiology and population structure of Neisseria gonorrhoeae from remote highly endemic Western Australian populations
Al Suwayyid, B. A., Coombs, G. W., Speers, D. J., Pearson, J., Wise, M. J. & Kahler, C. M., 27 Feb 2018, In: BMC Genomics. 19, 1, 165.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease
Blakeway, L. V., Tan, A., Lappan, R., Ariff, A., Pickering, J. L., Peacock, C. S., Blyth, C. C., Kahler, C. M., Chang, B. J., Lehmann, D., Kirkham, L-A. S., Murphy, T. F., Jennings, M. P., Bakaletz, L. O., Atack, J. M., Peak, I. R. & Seib, K. L., 1 Nov 2018, In: Genome Biology and Evolution. 10, 11, p. 2932-2946 15 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Multidrug-resistant Neisseria gonorrhoeae: Future therapeutic options
Kahler, C. M., 1 Apr 2018, In: Future Microbiology. 13, 5, p. 499-501 3 p.Research output: Contribution to journal › Review article › peer-review
3 Citations (Scopus) -
Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis
Smith, R. P., Whitten, A. E., Paxman, J. J., Kahler, C. M., Scanlon, M. J. & Heras, B., 2018, In: Acta Crystallographica. Section F: Structural Biology Communications. 74, 1, p. 31-38 8 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targeting
Kahler, C. M., Nawrocki, K. L., Anandan, A., Vrielink, A. & Shafer, W. M., 21 Aug 2018, In: Frontiers in Microbiology. 9, JUL, 1922.Research output: Contribution to journal › Review article › peer-review
Open Access16 Citations (Scopus) -
2017
Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis
Bartley, S. N., Mowlaboccus, S., Mullally, C. A., Stubbs, K. A., Vrielink, A., Maiden, M. C. J., Harrison, O. B., Perkins, T. T. & Kahler, C. M., 14 Mar 2017, In: Scientific Reports. 7, 14 p., 44442.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Clonal expansion of new penicillin-resistant clade of neisseria meningitidis serogroup w clonal complex 11, Australia
Mowlaboccus, S., Jolley, K. A., Bray, J. E., Pang, S., Lee, Y. T., Bew, J. D., Speers, D. J., Keil, A. D., Coombs, G. W. & Kahler, C. M., 1 Aug 2017, In: Emerging Infectious Diseases. 23, 8, p. 1364-1367 4 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Citations (Scopus) -
Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia
Mowlaboccus, S., Mullally, C. A., Richmond, P. C., Howden, B. P., Stevens, K., Speers, D. J., Keil, A. D., Bjørnstad, O. N., Perkins, T. T. & Kahler, C. M., 1 Oct 2017, In: PLoS One. 12, 10, e0186839.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Emergence of a Urogenital Pathotype of Neisseria meningitidis
Kahler, C. M., 1 Jul 2017, In: Trends in Microbiology. 25, 7, p. 510-512 3 p.Research output: Contribution to journal › Short survey › peer-review
7 Citations (Scopus) -
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
Anandan, A., Evans, G. L., Condic-Jurkic, K., O'Mara, M. L., John, C. M., Phillips, N. J., Jarvis, G. A., Wills, S. S., Stubbs, K. A., Moraes, I., Kahler, C. M. & Vrielink, A., 28 Feb 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2218-2223 6 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Citations (Scopus) -
2016
Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity
Reimer, A., Seufert, F., Weiwad, M., Ebert, J., Bzdyl, N. M., Kahler, C. M., Sarkar-Tyson, M., Holzgrabe, U., Rudel, T. & Kozjak-Pavlovic, V., 1 Oct 2016, In: International Journal of Antimicrobial Agents. 48, 4, p. 401-408 8 p.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus) -
Temporal changes in BEXSERO® antigen sequence type associated with genetic lineages of Neisseria meningitidis over a 15-year period in Western Australia
Mowlaboccus, S., Perkins, T., Smith, H., Sloots, T., Tozer, S., Prempeh, L., Tay, A. C. Y., Peters, F., Speers, D., Keil, A. D. & Kahler, C., 29 Jun 2016, In: PLoS One. 11, 6, e0158315.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Web of Science) -
2015
Influence of in situ progressive N-terminal is still controversial truncation of glycogen branching enzyme in Escherichia coli DH5α on glycogen structure, accumulation, and bacterial viability
Wang, L., Regina, A., Butardo, V. M., Kosar-Hashemi, B., Larroque, O., Kahler, C. & Wise, M., 2015, In: BMC Microbiology. 15, 96, p. 1-14Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
Novel Moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity
Ariff, A., Wise, M., Kahler, C., Tay, A. C. Y., Peters, F., Perkins, T. & Chang, B., 24 Oct 2015, In: BMC Genomics. 16, 1, p. 1-19 19 p., 860.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
2014
Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention
Davies, JK. & Kahler, CM., 2014, Caister Academic Press. 260 p.Research output: Book/Report › Edited book/Anthology › peer-review
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The Glycome of Neisseria spp.: How does this Relate to Pathogenesis?
Bartley, S. & Kahler, C., 2014, Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention. Davies, J. K. & Kahler, C. M. (eds.). Norfolk, UK: Caister Academic Press, p. 115-145Research output: Chapter in Book/Conference paper › Chapter › peer-review
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The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin
Piek, S., Wang, Z., Ganguly, J., Lakey, A., Bartley, S., Mowlaboccus, S., Anandan, A., Stubbs, K., Scanlon, M. J., Vrielink, A., Azadi, P., Carlson, R. W. & Kahler, C., 12 Sept 2014, In: PLoS One. 9, 9, p. e106513Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
The Use of High-Throughput DNA Sequencing in the Investigation of Antigenic Variation: Application to Neisseria Species
Davies, J. K., Harrison, P. F., Lin, Y-H., Bartley, S., Khoo, C. A., Seemann, T., Ryan, C. S., Kahler, C. & Hill, S. A., 22 Jan 2014, In: PLoS One. 9, 1, p. e86704Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
2013
Attachment and Invasion of Neisseria meningitidis to Host Cells Is Related to Surface Hydrophobicity, Bacterial Cell Size and Capsule
Bartley, S., Tzeng, Y-L., Heel, K., Lee, C. W., Mowlaboccus, S., Seemann, T., Lu, W., Lin, Y-H., Ryan, C. S., Peacock, C., Stephens, D. S., Davies, J. K. & Kahler, C., 2013, In: PLoS One. 8, 2, p. 15ppResearch output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)334 Downloads (Pure) -
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin
Wanty, C., Anandan, A., Piek, S., Walshe, J., Ganguly, J., Carlson, R. W., Stubbs, K., Kahler, C. & Vrielink, A., 2013, In: Journal of Molecular Biology. 425, 18, p. 3389-3402Research output: Contribution to journal › Article › peer-review
91 Citations (Scopus) -
2012
A comparison of the endotoxin biosynthesis and protein oxidation pathways in the biogenesis of the outer membrane of Escherichia coli and Neisseria meningitidis
Piek, S. & Kahler, C., 2012, In: Frontiers in Cellular and Infection Microbiology. 2, p. 1-23Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus)