Cecilia Prele

Associate Professor, PhD Coll.Lond.

  • The University of Western Australia (M503), 35 Stirling Highway,

    6009 Perth

    Australia

  • 834 Citations
  • 17 h-Index
20022020
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Research Output 2002 2019

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Article
2019
1 Citation (Scopus)

Ephrin-A2 affects wound healing and scarring in a murine model of excisional injury

Wijeratne, D., Rodger, J., Stevenson, A., Wallace, H., Prêle, C. M., Wood, F. M. & Fear, M. W., May 2019, In : Burns. 45, 3, p. 682-690 9 p.

Research output: Contribution to journalArticle

Ephrin-A2
Ephrins
Ephrin-A5
Wound Healing
Cicatrix
1 Citation (Scopus)

Inhibition of collagen production delays malignant mesothelioma tumor growth in a murine model

Abayasiriwardana, K. S., Wood, M. K., Prêle, C. M., Birnie, K. A., Robinson, B. W., Laurent, G. J., McAnulty, R. J. & Mutsaers, S. E., 5 Mar 2019, In : Biochemical and Biophysical Research Communications. 510, 2, p. 198-204 7 p.

Research output: Contribution to journalArticle

Tumors
Collagen
Mesothelioma
Growth
Neoplasms

MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions

Birnie, K. A., Prele, C. M., Musk, A. W. B., de Klerk, N., Lee, Y. C. G., Fitzgerald, D., Allcock, R. J. N., Thompson, P. J., Creaney, J., Badrian, B. & Mutsaers, S. E., 31 Jul 2019, In : Disease Markers. 9 p., 8628612.

Research output: Contribution to journalArticle

Open Access
Malignant Pleural Effusion
Pleural Effusion
MicroRNAs
Biomarkers
Cytology
8 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Cell Aging
Genes
Alleles
Genome-Wide Association Study
5 Citations (Scopus)
329 Downloads (Pure)

STAT3 regulates the onset of oxidant-induced senescence in lung fibroblasts

Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Wei, L., Schuliga, M., Jaffar, J., Westall, G. P., Hansbro, P. M., Prele, C. M., Mutsaers, S. E., Bartlett, N. W., Burgess, J. K., Grainge, C. L. & Knight, D. A., Jul 2019, In : American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journalArticle

Open Access
File
STAT3 Transcription Factor
Fibroblasts
Oxidants
Lung
Chemical activation
2018

Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF

Hynds, R. E., Gowers, K. H. C., Nigro, E., Butler, C. R., Bonfanti, P., Giangreco, A., Prêle, C. M. & Janes, S. M., 2018, In : PLoS One. 13, 5, p. e0197129 e0197129.

Research output: Contribution to journalArticle

Open Access
STAT6 Transcription Factor
hepatocyte growth factor
Feeder Cells
Hepatocyte Growth Factor
epithelial cells
8 Citations (Scopus)

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

Schuliga, M., Pechkovsky, D. V., Read, J., Waters, D. W., Blokland, K. E. C., Reid, A. T., Hogaboam, C. M., Khalil, N., Burgess, J. K., Prêle, C. M., Mutsaers, S. E., Jaffar, J., Westall, G., Grainge, C. & Knight, D. A., Dec 2018, In : Journal of Cellular and Molecular Medicine. 22, 12, p. 5847-5861 15 p.

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
Fibroblasts
Phenotype
Superoxides
Lung
20 Citations (Scopus)

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

Celada, L. J., Kropski, J. A., Herazo-Maya, J. D., Luo, W., Creecy, A., Abad, A. T., Chioma, O. S., Lee, G., Hassell, N. E., Shaginurova, G. I., Wang, Y., Johnson, J. E., Kerrigan, A., Mason, W. R., Baughman, R. P., Ayers, G. D., Bernard, G. R., Culver, D. A., Montgomery, C. G., Maher, T. M. & 10 othersMolyneaux, P. L., Noth, I., Mutsaers, S. E., Prele, C. M., Stokes Peebles, R., Newcomb, D. C., Kaminski, N., Blackwell, T. S., Van Kaer, L. & Drake, W. P., 26 Sep 2018, In : Science Translational Medicine. 10, 460, 15 p., eaar8356.

Research output: Contribution to journalArticle

Open Access
STAT3 Transcription Factor
Interleukin-17
Pulmonary Fibrosis
Transforming Growth Factors
Cell Death
2017
17 Citations (Scopus)

Idiopathic pulmonary fibrosis and a role for autoimmunity

Hoyne, G. F., Elliott, H., Mutsaers, S. E. & Prele, C., 25 Apr 2017, In : Immunology and Cell Biology. 95, p. 577–583 7 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Autoimmunity
Fibrosis
B-Lymphocytes
Idiopathic Interstitial Pneumonias
2016
1 Citation (Scopus)
158 Downloads (Pure)

A subset of malignant mesothelioma tumors retain osteogenic potential

Lansley, S. M., Pedersen, B., Robinson, C., Searles, R. G., Sterrett, G., Van Bruggen, I., Lake, R. A., Mutsaers, S. E. & Prele, C., 25 Nov 2016, In : Scientific Reports. 6, 36349.

Research output: Contribution to journalArticle

Open Access
File
Neoplasms
Osteoblasts
Osteogenesis
Malignant Mesothelioma
Osteonectin
24 Citations (Scopus)

Mesothelial cells and peritoneal homeostasis

Mutsaers, S. E., Prele, C., Pengelly, S. & Herrick, S. E., 1 Oct 2016, In : Fertility and Sterility. 106, 5, p. 1018-1024 7 p.

Research output: Contribution to journalArticle

Homeostasis
Epithelium
Serous Membrane
Cell Physiological Phenomena
Intraperitoneal Injections
2015
15 Citations (Scopus)

BARD1 mediates TGF-β signaling in pulmonary fibrosis

André, P. A., Prele, C., Vierkotten, S., Carnesecchi, S., Donati, Y., Chambers, R. C., Pache, J. C., Crestani, B., Barazzone-Argiroffo, C., Königshoff, M., Laurent, G. & Irminger-Finger, I., 29 Sep 2015, In : Respiratory Research. 16, 1, p. 1-14 14 p., 118.

Research output: Contribution to journalArticle

Open Access
Pulmonary Fibrosis
Lung
Idiopathic Pulmonary Fibrosis
Fibrosis
Protein Isoforms
25 Citations (Scopus)

Loss of miR-223 and JNK signaling contribute to elevated stathmin in malignant pleural mesothelioma

Birnie, K. A., Yip, Y. Y., Ng, D. C. H., Kirschner, M. B., Reid, G., Prêle, C., Musk, A., Lee, G., Thompson, P., Mutsaers, S. & Badrian, B., 2015, In : Molecular Cancer Research. 13, 7, p. 1106-1118

Research output: Contribution to journalArticle

Stathmin
JNK Mitogen-Activated Protein Kinases
Cell Movement
Cell Line
Malignant Mesothelioma
22 Citations (Scopus)
195 Downloads (Pure)

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis

Lim, C. B., Prêle, C., Baltic, S., Arthur, P., Creaney, J., Neil Watkins, D., Thompson, P. & Mutsaers, S., 16 Jan 2015, In : Oncotarget. 6, 3, p. 1519-1530

Research output: Contribution to journalArticle

Open Access
File
Mesothelioma
Reactive Oxygen Species
Mitochondria
Apoptosis
Superoxides
2014
16 Citations (Scopus)

Fibulin-1 predicts disease progression in patients with idiopathic pulmonary fibrosis

Jaffar, J., Unger, S., Corte, T. J., Keller, M., Wolters, P. J., Richeldi, L., Cerri, S., Prele, C., Hansbro, P., Argraves, W. S., Oliver, R. A., Oliver, B. G., Black, J. L. & Burgess, J. K., Oct 2014, In : Chest. 146, 4, p. 1055-1063

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
Disease Progression
Lung
Fibroblasts
Serum
9 Citations (Scopus)

Harnessing the potential of lung stem cells for regenerative medicine

Mcqualter, J. L., Anthony, D. A., Bozinovski, S., Prêle, C. & Laurent, G., 2014, In : International Journal of Biochemistry and Cell Biology. 56, p. 82-91

Research output: Contribution to journalArticle

Regenerative Medicine
Stem cells
Repair
Stem Cells
Tissue regeneration
2013
19 Citations (Scopus)

Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma

Lim, C. B., Prêle, C., Cheah, H., Cheng, Y. Y., Klebe, S., Reid, G., Watkins, D. N., Baltic, S., Thompson, P. & Mutsaers, S., 2013, In : PLoS One. 8, 6, p. 12pp

Research output: Contribution to journalArticle

Open Access
2012
57 Citations (Scopus)

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

O'Donoghue, R. J. J., Knight, D. A., Richards, C. D., Prele, C., Lau, H., Jarnicki, A. G., Jones, J., Bozinovski, S., Vlahos, R., Thiem, S., Mckenzie, B. S., Wang, B., Stumbles, P., Laurent, G. J., Mcanulty, R. J., Rose-John, S., Zhu, H. J., Anderson, G. P., Ernst, M. R. & Mutsaers, S., 2012, In : EMBO Molecular Medicine. 4, 9, p. 939-951

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

Prele, C., Reichelt, M. E., Mutsaers, S., Davies, M., Delbridge, L. M., Headrick, J. P., Rosenthal, N., Bogoyevitch, M. A. & Grounds, M., 2012, In : Cardiovascular Pathology. 21, p. 17-27

Research output: Contribution to journalArticle

56 Citations (Scopus)

STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF

Pechkovsky, D., Prele, C., Wong, J., Hogaboam, C. M., Mcanulty, R. J., Laurent, G., Zhang, S. M., Selman, M., Mutsaers, S. & Knight, D. A., 2012, In : The American Journal of Pathology. 180, 4, p. 1398-1412

Research output: Contribution to journalArticle

9 Citations (Scopus)

The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2

Woodward, E., Kolesnik, T. B., Nicholson, S. E., Prele, C. & Hart, P., 2012, In : Cytokine. 58, 3, p. 415-423

Research output: Contribution to journalArticle

2011
46 Citations (Scopus)

Mesothelial Cell Differention into Osteoblast- and Adipocyte-Like Cells

Lansley, S., Searles, R. G., Hoi, A., Thomas, C., Moneta, H., Herrick, S. E., Thompson, P., Newman, M., Sterrett, G., Prele, C. & Mutsaers, S., 2011, In : Journal of Cellular and Molecular Medicine. 15, 10, p. 2095-2105

Research output: Contribution to journalArticle

34 Citations (Scopus)

STAT3 in tissue fibrosis: Is there a role in the lung?

Knight, D., Mutsaers, S. & Prêle, C., 2011, In : Pulmonary Pharmacology and Therapeutics. 24, p. 193-198

Research output: Contribution to journalArticle

2010
19 Citations (Scopus)

The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1)

Woodward, E., Prele, C., Nicholson, S. E., Kolesnik, T. B. & Hart, P., 2010, In : Immunology. 131, 1, p. 118-127

Research output: Contribution to journalArticle

2009
34 Citations (Scopus)

SOCS1 regulates the IFN but not NFκB pathway in TLR-stimulated human monocytes and macrophages

Prêle, C. M., Woodward, E. A., Bisley, J., Keith-Magee, A., Nicholson, S. E. & Hart, P. H., 1 Dec 2009, In : Journal of Immunology. 181, 11, p. 8018-8026 9 p.

Research output: Contribution to journalArticle

Monocytes
Macrophages
Messenger RNA
Synovial Fluid
Infection
2008

SOCS1 Regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human Monocytes and Macrophages

Prele, C., Woodward, E. A., Bisley, J., Keith-Magee, A., Nicholson, S. E. & Hart, P., 2008, In : Journal of Immunology. 181, 11, p. 8018-8026

Research output: Contribution to journalArticle

NF-kappa B
Monocytes
Macrophages
Messenger RNA
Synovial Fluid

SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages

Prele, C., Woodward, E., Bisely, J., Keith-Magee, A., Nicholson, S. & Hart, P., 2008, In : The Journal of Immunology. 181

Research output: Contribution to journalArticle

2007
13 Citations (Scopus)
STAT3 Transcription Factor
Monocytes
Lipopolysaccharides
Interleukin-10
Tumor Necrosis Factor-alpha
2006
13 Citations (Scopus)
Interleukin-10
Lipopolysaccharides
Monocytes
Cytokines
Tumor Necrosis Factor-alpha
2004
9 Citations (Scopus)

Aberrant p53 alters DNA damage checkpoints in response to cisplatin: downregulation of CDK expression and activity

Wrighton, K. H., Prêle, C. M., Sunters, A. & Yeudall, W. A., 10 Dec 2004, In : International Journal of Cancer. 112, 5, p. 760-70 11 p.

Research output: Contribution to journalArticle

Cisplatin
DNA Damage
Down-Regulation
Cyclin A
Apoptosis
73 Citations (Scopus)

Pathogenesis of Pleural Fibrosis

Mutsaers, S. E., Prele, C. A., Brody, A. R. & Idell, S., 2004, In : Respirology. 9, p. 428-440

Research output: Contribution to journalArticle

2003
28 Citations (Scopus)

Identification of the molecular mechanisms contributing to polarized trafficking in osteoblasts

Prêle, C. M., Horton, M. A., Caterina, P. & Stenbeck, G., 1 Jan 2003, In : Experimental Cell Research. 282, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

Osteoblasts
Vesicle-Associated Membrane Protein 1
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
SNARE Proteins
Bone Matrix
2002
114 Citations (Scopus)

Evidence for incorporation of free-floating mesothelial cells as a mechanism of serosal healing

Foley-Comer, A. J., Herrick, S. E., Al-Mishlab, T., Prêle, C. M., Laurent, G. J. & Mutsaers, S. E., 1 Apr 2002, In : Journal of Cell Science. 115, Pt 7, p. 1383-9 7 p.

Research output: Contribution to journalArticle

Epithelium
Peritoneal Lavage
Wounds and Injuries
Proliferating Cell Nuclear Antigen
Cultured Cells