Cecilia Prele

Search results

• 2023

  Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Peljto, A. L., Blumhagen, R. Z., Walts, A. D., Cardwell, J., Powers, J., Corte, T. J., Dickinson, J. L., Glaspole, I., Moodley, Y. P., Vasakova, M. K., Bendstrup, E., Davidsen, J. R., Borie, R., Crestani, B., Dieude, P., Bonella, F., Costabel, U., Gudmundsson, G., Donnelly, S. C., & 96 othersEgan, J., Henry, M. T., Keane, M. P., Kennedy, M. P., McCarthy, C., McElroy, A. N., Olaniyi, J. A., O'Reilly, K. M. A., Richeldi, L., Leone, P. M., Poletti, V., Puppo, F., Tomassetti, S., Luzzi, V., Kokturk, N., Mogulkoc, N., Fiddler, C. A., Hirani, N., Jenkins, G., Maher, T. M., Molyneaux, P. L., Parfrey, H., Braybrooke, R., Blackwell, T. S., Jackson, P. D., Nathan, S. D., Porteous, M. K., Brown, K. K., Christie, J. D., Collard, H. R., Eickelberg, O., Foster, E. E., Gibson, K. F., Glassberg, M., Kass, D., Kropski, J. A., Lederer, D., Linderholm, A. L., Loyd, J., Mathai, S. K., Montesi, S. B., Noth, I., Oldham, J. M., Palmisciano, A. J., Reichner, C. A., Rojas, M., Roman, J., Schluger, N., Shea, B. S., Swigris, J. J., Wolters, P. J., Zhang, Y., Prele, C. M. A., Enghelmayer, J. I., Otaola, M., Ryerson, C. J., Salinas, M., Sterclova, M., Gebremariam, T. H., Myllärniemi, M., Carbone, R., Furusawa, H., Hirose, M., Inoue, Y., Miyazaki, Y., Ohta, K., Ohta, S., Okamoto, T., Kim, D. S., Pardo, A., Selman, M., Aranda, A. U., Park, M. S., Park, J. S., Song, J. W., Molina-Molina, M., Planas-Cerezales, L., Westergren-Thorsson, G., Smith, A. V., Manichaikul, A. W., Kim, J. S., Rich, S. S., Oelsner, E. C., Barr, R. G., Rotter, J. I., Dupuis, J., O'Connor, G., Vasan, R. S., Cho, M. H., Silverman, E. K., Schwarz, M. I., Steele, M. P., Lee, J. S., Yang, I. V., Fingerlin, T. E. & Schwartz, D. A., 5 Jan 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine. 207, 9, p. 1194-1202 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene 100%
  • Nested Gene 100%
  • Association 75%
  • Genetic Variability 50%
  • Heritability 50%

• Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells

  Ong, H. T., Prêle, C. M. & Dilley, R. J., Dec 2023, In: BMC Molecular and Cell Biology. 24, 1, 15 p., 16.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  Plasma cell but not CD20-mediated B cell depletion protects from bleomycin-induced lung fibrosis

  Prêle, C. M., Miles, T., Pearce, D. R., O'Donoghue, R. J., Grainge, C., Barrett, L., Birnie, K., Lucas, A. D., Baltic, S., Ernst, M., Rinaldi, C., Laurent, G. J., Knight, D. A., Fear, M., Hoyne, G., McAnulty, R. J. & Mutsaers, S. E., 1 Nov 2022, In: The European Respiratory Journal. 60, 5, 2101469.

  Research output: Contribution to journal › Article › peer-review

  • B Cell 100%
  • Bleomycin-Induced Pulmonary Fibrosis 71%
  • Bleomycin 71%
  • CD20 57%
  • Plasma Cell 57%
  3 Citations (Scopus)
• 2021

  A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: A potential drug target in IPF

  Schuliga, M., Kanwal, A., Read, J., Blokland, K. E. C., Burgess, J. K., Prêle, C. M., Mutsaers, S. E., Grainge, C., Thomson, C., James, A., Bartlett, N. W. & Knight, D. A., Nov 2021, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 321, 5, p. L859-L871

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Senescence 100%
  • Epithelial Cells 100%
  • Genes 100%
  • Idiopathic Pulmonary Fibrosis 76%
  • Cellular Senescence 75%
  6 Citations (Web of Science)

• A senescence bystander effect in human lung fibroblasts

  Waters, D. W., Schuliga, M., Pathinayake, P. S., Wei, L., Tan, H. Y., Blokland, K. E. C., Jaffar, J., Westall, G. P., Burgess, J. K., Prêle, C. M., Mutsaers, S. E., Grainge, C. L. & Knight, D. A., Sep 2021, In: Biomedicines. 9, 9, 1162.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lung Fibroblast 100%
  • Primary Culture 100%
  • Fibroblast 100%
  • Senescence 75%
  • Idiopathic Pulmonary Fibrosis 43%
  4 Citations (Scopus)

• Keloid fibroblasts have elevated and dysfunctional mechanotransduction signaling that is independent of TGF-β

  Deng, Z., Subilia, M., Chin, I. L., Hortin, N., Stevenson, A. W., Wood, F. M., Prêle, C. M., Choi, Y. S. & Fear, M. W., Oct 2021, In: Journal of Dermatological Science. 104, 1, p. 11-20 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fibroblast 100%
  • Keloid 70%
  • Protein 22%
  • Phenotype 17%
  • Mechanotransduction 17%
  4 Citations (Scopus)

• Reduced socs1 expression in lung fibroblasts from patients with ipf is not mediated by promoter methylation or mir155

  Prêle, C. M., Iosifidis, T., McAnulty, R. J., Pearce, D. R., Badrian, B., Miles, T., Jamieson, S. E., Ernst, M., Thompson, P. J., Laurent, G. J., Knight, D. A. & Mutsaers, S. E., 2021, In: Biomedicines. 9, 5, 498.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Idiopathic Pulmonary Fibrosis 100%
  • Fibroblast 100%
  • Pulmonary Fibrosis 100%
  • Methylation 33%
  • STAT3 33%
  1 Citation (Scopus)

• The epigenetics of keloids

  Stevenson, A. W., Deng, Z., Allahham, A., Prêle, C. M., Wood, F. M. & Fear, M. W., Aug 2021, In: Experimental Dermatology. 30, 8, p. 1099-1114 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Keloid 100%
  • Epigenomics 57%
  • Diseases 28%
  • Epigenetic Modification 28%
  • DNA 14%
  7 Citations (Scopus)
• 2020

  Identification of Differentially Methylated CpG Sites in Fibroblasts from Keloid Scars

  Alghamdi, M. A., Wallace, H. J., Melton, P. E., Moses, E. K., Stevenson, A., Al-Eitan, L. N., Rea, S., Duke, J. M., Danielsen, P. L., Prêle, C. M., Wood, F. M. & Fear, M. W., Jul 2020, In: Biomedicines. 8, 7, 16 p., 181.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytosine 100%
  • Fibroblast 80%
  • Skin Fibroblast 60%
  • Methylation 40%
  • Scar Formation 40%
  8 Citations (Web of Science)

• Immunopathobiology of chronic lung disease

  Prêle, C. M. & Hoyne, G. F., Jan 2020, In: Clinical & Translational Immunology. 9, 8, e1170.

  Research output: Contribution to journal › Editorial

  Open Access
  1 Citation (Scopus)

• Mesothelial cells regulate immune responses in health and disease: role for immunotherapy in malignant mesothelioma

  Mutsaers, S. E., Pixley, F. J., Prêle, C. M. & Hoyne, G. F., Jun 2020, In: Current Opinion in Immunology. 64, p. 88-109 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Immunotherapy 100%
  • Immune System 66%
  • Mesothelium 66%
  • Immunity 33%
  • Immune Response 33%
  7 Citations (Scopus)

• Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner

  Schuliga, M., Read, J., Blokland, K. E., Waters, D. W., Burgess, J., Prele, C., Mutsaers, S. E., Jaffar, J., Westall, G., Reid, A., James, A., Grainge, C. & Knight, D. A., 1 Apr 2020, In: Clinical Science. 134, 7, p. 889-905 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Senescence 100%
  • Idiopathic Pulmonary Fibrosis 100%
  • DNA 100%
  • Fibroblast 100%
  • Genes 100%
  22 Citations (Web of Science)

  43 Downloads (Pure)

• Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing

  Blokland, K. E. C., Waters, D. W., Schuliga, M., Read, J., Pouwels, S. D., Grainge, C. L., Jaffar, J., Westall, G., Mutsaers, S. E., Prêle, C. M., Burgess, J. K. & Knight, D. A., 24 Apr 2020, In: Pharmaceutics. 12, 4, 389.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lung Fibroblast 100%
  • Fibroblast 100%
  • Proliferation 100%
  • Idiopathic Pulmonary Fibrosis 70%
  • Epithelial Cell 40%
  19 Citations (Scopus)

• The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis

  Miles, T., Hoyne, G. F., Knight, D. A., Fear, M. W., Mutsaers, S. E. & Prêle, C. M., 1 Jan 2020, In: Clinical & Translational Immunology. 9, 7, p. e1153 e1153.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immune System 100%
  • Pulmonary Fibrosis 100%
  • Idiopathic Pulmonary Fibrosis 100%
  • Diseases 50%
  • Pathogenesis 50%
  10 Citations (Scopus)

• The extracellular matrix and mechanotransduction in pulmonary fibrosis

  Deng, Z., Fear, M. W., Suk Choi, Y., Wood, F. M., Allahham, A., Mutsaers, S. E. & Prêle, C. M., Sep 2020, In: The International Journal of Biochemistry & Cell Biology. 126, p. 105802 105802.

  Research output: Contribution to journal › Article › peer-review

  • Extracellular Matrix 100%
  • Pulmonary Fibrosis 80%
  • Cell Function 40%
  • Diseases 20%
  • Collagen 20%
  34 Citations (Scopus)

• The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

  Johnson, B. Z., Stevenson, A. W., Prêle, C. M., Fear, M. W. & Wood, F. M., 1 May 2020, In: Biomedicines. 8, 5, 101.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin 6 100%
  • Wound Healing 37%
  • Skin Injury 37%
  • Diabetes 12%
  • Fibrosis 12%
  126 Citations (Scopus)
• 2019

  Ephrin-A2 affects wound healing and scarring in a murine model of excisional injury

  Wijeratne, D., Rodger, J., Stevenson, A., Wallace, H., Prêle, C. M., Wood, F. M. & Fear, M. W., May 2019, In: Burns. 45, 3, p. 682-690 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ephrin A2 100%
  • Ligand 85%
  • Ephrin 71%
  • Ephrin A5 71%
  • Wound Healing 57%
  3 Citations (Scopus)

• Inhibition of collagen production delays malignant mesothelioma tumor growth in a murine model

  Abayasiriwardana, K. S., Wood, M. K., Prêle, C. M., Birnie, K. A., Robinson, B. W., Laurent, G. J., McAnulty, R. J. & Mutsaers, S. E., 5 Mar 2019, In: Biochemical and Biophysical Research Communications. 510, 2, p. 198-204 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Collagen 100%
  • Mesothelioma 88%
  • Neoplasm 66%
  • Tumor Progression 44%
  • In Vitro 22%
  7 Citations (Scopus)

• MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions

  Birnie, K. A., Prele, C. M., Musk, A. W., de Klerk, N., Lee, Y. C. G., Fitzgerald, D., Allcock, R. J. N., Thompson, P. J., Creaney, J., Badrian, B. & Mutsaers, S. E., 31 Jul 2019, In: Disease Markers. 2019, 9 p., 8628612.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pleura Effusion 100%
  • microRNA 100%
  • Pleura Mesothelioma 90%
  • Biomarkers 66%
  • Biological Marker 40%
  14 Citations (Scopus)

• Resequencing study confirms host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis

  Global IPF Consortium, 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 199-208 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Allele 100%
  • Cellular Senescence 100%
  • Measurement 50%
  • DNA 50%
  • Genome-Wide Association Study 50%
  62 Citations (Scopus)

• STAT3 regulates the onset of oxidant-induced senescence in lung fibroblasts

  Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Wei, L., Schuliga, M., Jaffar, J., Westall, G. P., Hansbro, P. M., Prele, C. M., Mutsaers, S. E., Bartlett, N. W., Burgess, J. K., Grainge, C. L. & Knight, D. A., Jul 2019, In: American Journal of Respiratory Cell and Molecular Biology. 61, 1, p. 61-73 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Senescence 100%
  • Fibroblast 100%
  • Respiration 100%
  • STAT3 Protein 80%
  • Translocation 50%
  45 Citations (Web of Science)

  488 Downloads (Pure)
• 2018

  Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF

  Hynds, R. E., Gowers, K. H. C., Nigro, E., Butler, C. R., Bonfanti, P., Giangreco, A., Prêle, C. M. & Janes, S. M., May 2018, In: PLoS One. 13, 5, p. e0197129 e0197129.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transducers 100%
  • Activator 100%
  • Hepatocytes 100%
  • Hepatocyte Growth Factor 100%
  • Feeder Cell 71%
  8 Citations (Web of Science)

• Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

  Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Burgess, J. K., Mutsaers, S. E., Prêle, C. M., Schuliga, M., Grainge, C. L. & Knight, D. A., Aug 2018, In: American Journal of Physiology: Lung Cellular and Molecular Physiology. 315, 2, p. L162-L172 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Fibroblast 100%
  • Idiopathic Pulmonary Fibrosis 100%
  • Pathology 100%
  • Senescence 85%
  • Wound Healing 42%
  88 Citations (Scopus)

• Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

  Schuliga, M., Pechkovsky, D. V., Read, J., Waters, D. W., Blokland, K. E. C., Reid, A. T., Hogaboam, C. M., Khalil, N., Burgess, J. K., Prêle, C. M., Mutsaers, S. E., Jaffar, J., Westall, G., Grainge, C. & Knight, D. A., Dec 2018, In: Journal of Cellular and Molecular Medicine. 22, 12, p. 5847-5861 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Idiopathic Pulmonary Fibrosis 100%
  • Fibroblast 100%
  • DNA Damage 80%
  • Senescence 70%
  • Superoxide 60%
  48 Citations (Scopus)

• PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

  Celada, L. J., Kropski, J. A., Herazo-Maya, J. D., Luo, W., Creecy, A., Abad, A. T., Chioma, O. S., Lee, G., Hassell, N. E., Shaginurova, G. I., Wang, Y., Johnson, J. E., Kerrigan, A., Mason, W. R., Baughman, R. P., Ayers, G. D., Bernard, G. R., Culver, D. A., Montgomery, C. G., Maher, T. M., & 10 othersMolyneaux, P. L., Noth, I., Mutsaers, S. E., Prele, C. M., Stokes Peebles, R., Newcomb, D. C., Kaminski, N., Blackwell, T. S., Van Kaer, L. & Drake, W. P., 26 Sep 2018, In: Science Translational Medicine. 10, 460, 15 p., eaar8356.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Programmed Cell Death 100%
  • Programmed Cell Death 1 75%
  • CD4 58%
  • T Cells 50%
  • T Cell 50%
  170 Citations (Scopus)
• 2017

  Idiopathic pulmonary fibrosis and a role for autoimmunity

  Hoyne, G. F., Elliott, H., Mutsaers, S. E. & Prele, C., 1 Aug 2017, In: Immunology and Cell Biology. 95, 7, p. 577–583 7 p.

  Research output: Contribution to journal › Article › peer-review

  • T Cells 100%
  • B Cell 100%
  • Immune Tolerance 100%
  • T Cell 100%
  • Idiopathic Pulmonary Fibrosis 100%
  44 Citations (Scopus)

• Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

  Birnie, K. A., Prêle, C. M., Thompson, P. J., Badrian, B. & Mutsaers, S. E., 2017, In: Oncotarget. 8, 44, p. 78193-78207 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Asbestos 100%
  • microRNA 100%
  • Mesothelioma 100%
  • MicroRNA 100%
  • Biomarkers 33%
  19 Citations (Scopus)
• 2016

  A subset of malignant mesothelioma tumors retain osteogenic potential

  Lansley, S. M., Pedersen, B., Robinson, C., Searles, R. G., Sterrett, G., Van Bruggen, I., Lake, R. A., Mutsaers, S. E. & Prele, C., 25 Nov 2016, In: Scientific Reports. 6, 36349.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Lines 100%
  • Osteoblast 100%
  • Proteins 50%
  • Asbestos 50%
  • Phenotype 50%
  2 Citations (Scopus)

  217 Downloads (Pure)

• Mesothelial cells and peritoneal homeostasis

  Mutsaers, S. E., Prele, C., Pengelly, S. & Herrick, S. E., 1 Oct 2016, In: Fertility and Sterility. 106, 5, p. 1018-1024 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelium 100%
  • Homeostasis 100%
  • Intraperitoneal Injection 100%
  • Serosa 100%
  • Cell Physiology 100%
  78 Citations (Scopus)

• Mesothelial cells and pleural immunology (Textbook Chapter)

  Mutsaers, S. E., Jaurand, M. C. C., Lee, G. C. & Prele, C. M., 2016, Textbook of Pleural Diseases. R. W. L. . G. L. (ed.). United States, Vol. CRC Press Talyor & Francis.

  Research output: Chapter in Book/Conference paper › Other chapter contribution

• Structure and function of the mesothelial cell

  Mutsaers, S., Prêle, C. M. A. & Herrick, S. E., 2016, Intraperitoneal Cancer Therapy: Principles and Practice. Ceelen, W. P. & Levine, E. A. (eds.). CRC Press, p. 9-25 17 p.

  Research output: Chapter in Book/Conference paper › Chapter › peer-review
• 2015

  BARD1 mediates TGF-β signaling in pulmonary fibrosis

  André, P. A., Prele, C., Vierkotten, S., Carnesecchi, S., Donati, Y., Chambers, R. C., Pache, J. C., Crestani, B., Barazzone-Argiroffo, C., Königshoff, M., Laurent, G. & Irminger-Finger, I., 29 Sep 2015, In: Respiratory Research. 16, 1, p. 1-14 14 p., 118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pulmonary Fibrosis 100%
  • BARD1 100%
  • Pathogenesis 40%
  • Epithelial Cell 40%
  • Fibroblast 40%
  20 Citations (Web of Science)

• Loss of miR-223 and JNK signaling contribute to elevated stathmin in malignant pleural mesothelioma

  Birnie, K. A., Yip, Y. Y., Ng, D. C. H., Kirschner, M. B., Reid, G., Prêle, C., Musk, A., Lee, G., Thompson, P., Mutsaers, S. & Badrian, B., 2015, In: Molecular Cancer Research. 13, 7, p. 1106-1118

  Research output: Contribution to journal › Article › peer-review

  • microRNA 223 100%
  • Kinase 58%
  • Amino Terminal Sequence 58%
  • N-Terminus 58%
  • Cell Motility 25%
  39 Citations (Scopus)

• Mesothelial cells in tissue repair and fibrosis

  Mutsaers, S. E., Birnie, K., Lansley, S., Herrick, S. E., Lim, C. B. & Prele, C., 2015, In: Frontiers in Pharmacology. 6, 113.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Mesothelial Cell 100%
  • Homeostasis 100%
  • Tissue Repair 100%
  • Fibrinolysis 100%
  • Fibrogenesis 66%
  123 Citations (Scopus)

  263 Downloads (Pure)

• Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis

  Lim, C. B., Prêle, C., Baltic, S., Arthur, P., Creaney, J., Neil Watkins, D., Thompson, P. & Mutsaers, S., 16 Jan 2015, In: Oncotarget. 6, 3, p. 1519-1530

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Apoptosis 100%
  • Reactive Oxygen Metabolite 100%
  • Mitochondrion 37%
  • Inorganic Peroxide 37%
  • Cell Death 25%
  27 Citations (Scopus)

  189 Downloads (Pure)
• 2014

  Fibulin-1 predicts disease progression in patients with idiopathic pulmonary fibrosis

  Jaffar, J., Unger, S., Corte, T. J., Keller, M., Wolters, P. J., Richeldi, L., Cerri, S., Prele, C., Hansbro, P., Argraves, W. S., Oliver, R. A., Oliver, B. G., Black, J. L. & Burgess, J. K., Oct 2014, In: Chest. 146, 4, p. 1055-1063

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Idiopathic Pulmonary Fibrosis 100%
  • Fibroblast 100%
  • Fibulin 63%
  • Serum 36%
  • Immunohistochemistry 33%
  34 Citations (Scopus)

• Harnessing the potential of lung stem cells for regenerative medicine

  Mcqualter, J. L., Anthony, D. A., Bozinovski, S., Prêle, C. & Laurent, G., 2014, In: International Journal of Biochemistry and Cell Biology. 56, p. 82-91

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell 100%
  • Progenitor Cell 100%
  • Lung Stem Cell 25%
  • Regenerative Medicine 25%
  • Homeostasis 25%
  14 Citations (Scopus)
• 2013

  Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma

  Lim, C. B., Prêle, C., Cheah, H., Cheng, Y. Y., Klebe, S., Reid, G., Watkins, D. N., Baltic, S., Thompson, P. & Mutsaers, S., 2013, In: PLoS One. 8, 6, p. 12pp

  Research output: Contribution to journal › Article › peer-review

  Open Access
  30 Citations (Scopus)
• 2012

  Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

  O'Donoghue, R. J. J., Knight, D. A., Richards, C. D., Prele, C., Lau, H., Jarnicki, A. G., Jones, J., Bozinovski, S., Vlahos, R., Thiem, S., Mckenzie, B. S., Stumbles, P., Laurent, G. J., Mcanulty, R. J., Rose-John, S., Zhu, H. J., Anderson, G. P., Ernst, M. R., Mutsaers, S. & Wang, B., 2012, In: EMBO Molecular Medicine. 4, 9, p. 939-951

  Research output: Contribution to journal › Article › peer-review

  Open Access
  107 Citations (Scopus)

• Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

  Prele, C., Reichelt, M. E., Mutsaers, S., Davies, M., Delbridge, L. M., Headrick, J. P., Rosenthal, N., Bogoyevitch, M. A. & Grounds, M., 2012, In: Cardiovascular Pathology. 21, p. 17-27

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• STAT3: A central mediator of pulmonary fibrosis?

  Prele, C., Yao, E., O'Donoghue, R. J. J., Mutsaers, S. E. & Knight, D. A., 15 Jul 2012, Proceedings of the American Thoracic Society. Laurent, G. J. (ed.). 3 ed. United States: American Thoracic Society, Vol. 9. p. 177-182 6 p.

  Research output: Chapter in Book/Conference paper › Conference paper › peer-review

  • Fibrosis 100%
  • Wound Healing 100%
  • STAT3 100%
  • Pulmonary Fibrosis 66%
  • Idiopathic Pulmonary Fibrosis 66%
  46 Citations (Scopus)

• STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF

  Pechkovsky, D., Prele, C., Wong, J., Hogaboam, C. M., Mcanulty, R. J., Laurent, G., Zhang, S. M., Selman, M., Mutsaers, S. & Knight, D. A., 2012, In: The American Journal of Pathology. 180, 4, p. 1398-1412

  Research output: Contribution to journal › Article › peer-review
  92 Citations (Scopus)

• The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2

  Woodward, E., Kolesnik, T. B., Nicholson, S. E., Prele, C. & Hart, P., 2012, In: Cytokine. 58, 3, p. 415-423

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)
• 2011

  Mesothelial Cell Differention into Osteoblast- and Adipocyte-Like Cells

  Lansley, S., Searles, R. G., Hoi, A., Thomas, C., Moneta, H., Herrick, S. E., Thompson, P., Newman, M., Sterrett, G., Prele, C. & Mutsaers, S., 2011, In: Journal of Cellular and Molecular Medicine. 15, 10, p. 2095-2105

  Research output: Contribution to journal › Article › peer-review
  59 Citations (Scopus)

• STAT3 in tissue fibrosis: Is there a role in the lung?

  Knight, D., Mutsaers, S. & Prêle, C., 2011, In: Pulmonary Pharmacology and Therapeutics. 24, p. 193-198

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)
• 2010

  The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1)

  Woodward, E., Prele, C., Nicholson, S. E., Kolesnik, T. B. & Hart, P., 2010, In: Immunology. 131, 1, p. 118-127

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)
• 2009

  SOCS1 regulates the IFN but not NFκB pathway in TLR-stimulated human monocytes and macrophages

  Prêle, C. M., Woodward, E. A., Bisley, J., Keith-Magee, A., Nicholson, S. E. & Hart, P. H., 1 Dec 2009, In: Journal of Immunology. 181, 11, p. 8018-8026 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Monocyte 100%
  • TLR4 57%
  • Macrophage 42%
  • Signal Transduction 42%
  • Signaling Pathway 28%
  41 Citations (Scopus)
• 2008

  SOCS1 Regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human Monocytes and Macrophages

  Prele, C., Woodward, E. A., Bisley, J., Keith-Magee, A., Nicholson, S. E. & Hart, P., 2008, In: Journal of Immunology. 181, 11, p. 8018-8026

  Research output: Contribution to journal › Article › peer-review

  • Monocyte 100%
  • TLR4 57%
  • Macrophage 42%
  • Macrophages 42%
  • Signaling Pathway 28%

• SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages

  Prele, C., Woodward, E., Bisely, J., Keith-Magee, A., Nicholson, S. & Hart, P., 2008, In: The Journal of Immunology. 181

  Research output: Contribution to journal › Article › peer-review
• 2007

  Activated signal transducer and activator of transcription-3 (STAT3) is a poor regulator of tumour necrosis factor-α production by human monocytes

  Prele, C., Keith-Magee, A. L., Murcha, M. & Hart, P., 2007, In: Clinical and Experimental Immunology. 147, 3, p. 564-572

  Research output: Contribution to journal › Article › peer-review

  • Monocyte 100%
  • STAT3 Protein 100%
  • Lipopolysaccharide 100%
  • Tumor Necrosis Factors 66%
  • Interleukin 10 50%
  15 Citations (Scopus)